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Front Cover: Design, Synthesis, and Characterization of Novel Styryl Dyes as Fluorescent Probes for Tau Aggregate Detectionin Vitroand in Cells (Chem. Asian J. 6/2024)

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Chemistry – An Asian Journal 2024年第6期19卷

作者： Withsakorn Sangsuwan Kriangsak Faikhruea Kotchakorn Supabowornsathit Don Sangsopon Praewphan Ingrungruanglert Hathaichanok Chuntakaruk Napatsaporn Nuntavanotayan Kittiporn Nakprasit Nipan Israsena Thanyada Rungrotmongkol Pitak Chuawong Tirayut Vilaivan Chanat Aonbangkhen Center of Excellence in Natural Products Chemistry (CENP) Department of Chemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science Special Research Unit for Advanced Magnetic Resonance (AMR) Kasetsart University Bangkok 10900 Thailand These authors are contributed equally. Organic Synthesis Research Unit Department of Chemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Stem Cell and Cell Therapy Research Unit and Department of Pharmacology Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Bangkok 10330 Thailand Center of Excellence in Structural and Computational Biology Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand

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D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity induced by doxorubicin

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Chemico-Biological Interactions 2025年 418卷 111580页

作者： Aimée Obolari Durço Diego Santos Souza Michael Ramon de Lima Conceição Samuel dos Santos Beserra Jorge Lucas Teixeira da Fonseca Leonardo Loch Michel Augusto Silva Aldeidia Pereira de Oliveira Adriano Antunes de Souza Araujo Carla Maria Lins de Vasconcelos Jader Santos Cruz Danilo Roman-Campos Márcio Roberto Viana dos Santos Health Science Graduate Program Federal University of Sergipe Aracaju 49060-108 Brazil Department of Biophysics Federal University of São Paulo São Paulo 04023-062 Brazil Department of Physiology Federal University of Sergipe Aracaju 49107-230 Brazil Department of Microbiology Immunology and Parasitology Federal University of São Paulo São Paulo 04023-062 Brazil Department of Structural and Functional Biology Federal University of São Paulo São Paulo 04023-062 Brazil Department of Biophysics and Physiology Federal University of Piauí Teresina 64049-550 Brazil Department of Pharmacy Federal University of Sergipe Aracaju 49107-230 Brazil Department of Biochemistry and Immunology Federal University of Minas Gerais Belo Horizonte 31.270-901 Brazil

Doxorubicin (Dox) is one of the most used drugs in the treatment of various cancers, but its cardiotoxicity limits its use. The aim of this study was to investigate the cardioprotective effect of the formulation d -limonene-hydroxypropyl-β-cyclodextrin (HβDL) on a murine model of Dox-induced cardiotoxicity. Mice were divided into groups: Control (NaCl 0.9 %), Dox (20 mg/kg), and Dox + HβDL (10 mg/kg). Drugs were administered intraperitoneally once every five days. Heart histological parameters, L-type Ca 2+ current (I Ca,L ), intracellular and mitochondrial reactive species and mitochondrial mass, calcium transient, sarcomeric shortening, redox status (lipoperoxidation, oxidant, and antioxidant enzymes activity), apoptotic and antiapoptotic proteins expression as well NOX-related proteins were evaluated. HβDL prevented heart histological changes, including cellular infiltrate and vacuoles caused by Dox, and also prevented the increases in calcium waves, I Ca,L , cytoplasmic and mitochondrial reactive species and mitochondrial mass, expression of Bax, Caspase-3, gp91 phox , NOX4 and p22phox, and lipoperaxidation induced by Dox. Moreover, sarcomeric shortening was reduced in the Dox group, but preserved in HβDL treated animals. Glutathione peroxidase activity, which was reduced in Dox group, was also restored in the HβDL group. Our results show the potential cardioprotective effect of HβDL in Dox-induced cardiotoxicity through improved redox status and excitation-contraction coupling and the suppression of apoptotic pathways in cardiomyocytes.

关键词： Cardiotoxicity Cyclodextrin D-limonene Doxorubicin Oxidative stress

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Correction to: Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3

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Journal of clinical immunology 2021年第4期41卷 791-794页

作者： Kay Tanita Fumiaki Sakura Ryusuke Nambu Miyuki Tsumura Yusuke Imanaka Hidenori Ohnishi Zenichiro Kato Jie Pan Akihiro Hoshino Koji Suzuki Motoko Yasutomi Shuichiro Umetsu Chizuru Okada Masatoshi Takagi Kohsuke Imai Osamu Ohara Alexo M Muise Satoshi Okada Tomohiro Morio Hirokazu Kanegane Department of Pediatrics and Developmental Biology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan. Department of Pediatrics Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan. Division of Gastroenterology and Hepatology Saitama Children's Medical Center Saitama Japan. SickKids Inflammatory Bowel Disease Center The Hospital for Sick Children Toronto ON Canada. Cell Biology Program Research Institute The Hospital for Sick Children Toronto ON Canada. Department of Pediatrics Gifu University Graduate School of Medicine Gifu Japan. Structural Medicine United Graduate School of Drug Discovery and Medical Information Sciences Gifu University Gifu Japan. Department of Pediatrics Faculty of Medical Sciences University of Fukui Fukui Japan. Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama-shi Tobu Hospital Yokohama Kanagawa Japan. Hiroshima Chuodori Children Clinic Hiroshima Japan. Department of Community Pediatrics Perinatal and Maternal Medicine Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan. Department of Technology Development Kazusa DNA Research Institute Chiba Japan. Laboratory for Integrative Genomics RIKEN Center for Integrative Medical Sciences Yokohama Japan. Department of Pediatrics Institute of Medical Science and Biochemistry University of Toronto the Hospital for Sick Children Toronto ON Canada. Department of Child Health and Development Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) 1-5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan. hkanegane.ped@tmd.ac.jp.

A Correction to this paper has been published: https://***/10.1007/s10875-021-01014-6

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RETRACTED ARTICLE: Antihyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Artocarpus heterophyllus lam stem bark in streptozotocin-induced diabetic rats

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Cogent Medicine 2019年第1期6卷 Article: 1649628页

作者： Ajiboye, Basiru Olaitan Ojo, Oluwafemi Adeleke Oyinloye, Babatunji Emmanuel Okesola, Mary Abiola Oluwatosin, Adeyonu Boligon, Aline Augusti Kappo, Abidemi Paul Wei, Jun Nutraceutical and Phytomedicine Research Laboratory Biochemistry Programme Department of Chemical Sciences Afe Babalola University Ado-Ekiti Ekiti State Nigeria Biotechnology and Structural Biology (BSB) Group Department of Biochemistry and Microbiology University of Zululand KwaDlangezwa 3886 South Africa Graduate Program in Pharmaceutical Sciences Federal University of Santa Maria Build 26 room 1115 Santa Maria CEP 97105-900 Brazil Afe Babalola University NIGERIA

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SARS-CoV-2 identified through crystallographic screening and computational docking

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Science Advances 2021年第16期7卷

作者： Schuller, Marion Correy, Galen J. Gahbauer, Stefan Fearon, Daren Wu, Taiasean Díaz, Roberto Efraín Young, Iris D. Martins, Luan Carvalho Smith, Dominique H. Schulze-Gahmen, Ursula Owens, Tristan W. Deshpande, Ishan Merz, Gregory E. Thwin, Aye C. Biel, Justin T. Peters, Jessica K. Moritz, Michelle Herrera, Nadia Kratochvil, Huong T. Aimon, Anthony Bennett, James M. Neto, Jose Brandao Cohen, Aina E. Dias, Alexandre Douangamath, Alice Dunnett, Louise Fedorov, Oleg Ferla, Matteo P. Fuchs, Martin R. Gorrie-Stone, Tyler J. Holton, James M. Johnson, Michael G. Krojer, Tobias Meigs, George Powell, Ailsa J. Rack, Johannes Gregor Matthias Rangel, Victor L. Russi, Silvia Skyner, Rachael E. Smith, Clyde A. Soares, Alexei S. Wierman, Jennifer L. Zhu, Kang O Brien, Peter Jura, Natalia Ashworth, Alan Irwin, John J. Thompson, Michael C. Gestwicki, Jason E. Von Delft, Frank Shoichet, Brian K. Fraser, James S. Ahel, Ivan Sir William Dunn School of Pathology University of Oxford South Parks Road OxfordOX1 3RE United Kingdom Department of Bioengineering and Therapeutic Sciences University of California San Francisco San FranciscoCA94158 United States Department of Pharmaceutical Chemistry University of California San Francisco San FranciscoCA94158 United States Diamond Light Source Ltd. Harwell Science and Innovation Campus DidcotOX11 0DE United Kingdom Institute for Neurodegenerative Disease University of California San Francisco San FranciscoCA94158 United States Chemistry and Chemical Biology Graduate Program University of California San Francisco San FranciscoCA94158 United States Tetrad Graduate Program University of California San Francisco San FranciscoCA94158 United States Coronavirus Research Group Structural Biology Consortium University of California San Francisco San FranciscoCA94158 United States Biochemistry Department Institute for Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil Helen Diller Family Comprehensive Cancer University of California San Francisco San FranciscoCA94158 United States Centre for Medicines Discovery University of Oxford South Parks Road HeadingtonOX3 7DQ United Kingdom Stanford Synchrotron Radiation Lightsource Slac National Accelerator Center Menlo ParkCA94025 United States Wellcome Centre for Human Genetics University of Oxford Old Road Campus OxfordOX3 7BN United Kingdom National Synchrotron Light Source Ii Brookhaven National Laboratory UptonNY11973 United States Department of Biochemistry and Biophysics University of California San Francisco San FranciscoCA94158 United States Department of Molecular Biophysics and Integrated Bioimaging Lawrence Berkeley National Laboratory BerkeleyCA94720 United States ChemPartner Corporation South San FranciscoCA94080 United States Structural Genomics Consortium University of Oxford Old Road Campus HeadingtonOX3 7DQ United Kingdom School of

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate ribosylation signaling. This enzyme is a promising antiviral target because catalytic mutations render viruses nonpathogenic. Here, we report a massive crystallographic screening and computational docking effort, identifying new chemical matter primarily targeting the active site of the macrodomain. Crystallographic screening of 2533 diverse fragments resulted in 214 unique macrodomain-binders. An additional 60 molecules were selected from docking more than 20 million fragments, of which 20 were crystallographically confirmed. X-ray data collection to ultra-high resolution and at physiological temperature enabled assessment of the conformational heterogeneity around the active site. Several fragment hits were confirmed by solution binding using three biophysical techniques (differential scanning fluorimetry, homogeneous time-resolved fluorescence, and isothermal titration calorimetry). The 234 fragment structures explore a wide range of chemotypes and provide starting points for development of potent SARS-CoV-2 macrodomain inhibitors. © 2021 American Association for the Advancement of Science. All rights reserved.

关键词： Coronavirus

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Going Deeper in Cryo Electron Tomography with Neural Networks

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Microscopy and Microanalysis 2017年第S1期23卷 814-815页

作者： Muyuan Chen Wei Dai Stella Y. Sun Michael F. Schmid Wah Chiu Steven J. Ludtke Graduate Program in Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine Houston TX Verna Marrs and McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston TX

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Retraction notice to "Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?" [Sci. Total Environ. 813 (2022) / 152345]

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The Science of the total environment 2024年 957卷 177653页

作者： Bianca H Ventura Fernandes Natália Martins Feitosa Ana Paula Barbosa Camila Gasque Bomfim Anali M B Garnique Ivana F Rosa Maira S Rodrigues Lucas B Doretto Daniel F Costa Bruno Camargo-Dos-Santos Gabrielli A Franco João Favero Neto Juliana Sartori Lunardi Marina Sanson Bellot Nina Pacheco Capelini Alves Camila C Costa Mayumi F Aracati Letícia F Rodrigues Rafaela Hemily Cirilo Raul Marcelino Colagrande Francisco I F Gomes Rafael T Nakajima Marco A A Belo Percília Cardoso Giaquinto Susana Luporini de Oliveira Silas Fernandes Eto Dayanne Carla Fernandes Wilson G Manrique Gabriel Conde Roberta R C Rosales Iris Todeschini Ilo Rivero Edgar Llontop Germán G Sgro Gabriel Umaji Oka Natalia Fernanda Bueno Fausto K Ferraris Mariana T Q de Magalhães Renata J Medeiros Juliana M Mendonça-Gomes Mara Souza Junqueira Kátia Conceição Leticia Gomes de Pontes Antonio Condino-Neto Andrea C Perez Leonardo J G Barcellos José Dias Correa Júnior Erick Gustavo Dorlass Niels O S Camara Edison Luiz Durigon Fernando Q Cunha Rafael H Nóbrega Glaucia M Machado-Santelli Chuck S Farah Flavio P Veras Jorge Galindo-Villegas Letícia V Costa-Lotufo Thiago M Cunha Roger Chammas Luciani R Carvalho Cristiane R Guzzo Guilherme Malafaia Ives Charlie-Silva Laboratório de Controle Genético e Sanitário Diretoria Técnica de Apoio ao Ensino e Pesquisa Faculdade de Medicina da Universidade de São Paulo Brazil. Laboratório Integrado de Biociências Translacionais (LIBT) Instituto de Biodiversidade e Sustentabilidade (NUPEM) Universidade Federal do Rio de Janeiro (UFRJ) Macaé RJ Brazil. Department of Microbiology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil. Department of Cell Biology Institute of Biomedical Sciences University of São Paulo Brazil. Reproductive and Molecular Biology Group Department of Morphology Institute of Biosciences Sao Paulo State University Botucatu São Paulo Brazil. Department of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University SP Brazil. Department of Preventive Veterinary Medicine São Paulo State University (UNESP) Jaboticabal Brazil. Department of Pharmacology Center of Research in Inflammatory Diseases Ribeirao Preto Medical School University of São Paulo Brazil. Brasil University Descalvado São Paulo Brazil. Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências - Departamento de Fisiologia São Paulo Brazil. Universidade Estadual Paulista Júlio de Mesquita Filho São Paulo Brazil. Postgraduate Program in Health Sciences PROCISA Federal University of Roraima Brazil. Immunochemistry Laboratory Butantan Institute São Paulo Brazil. Aquaculture Health Research and Extension Group GRUPESA Aquaculture Health Laboratory LABSA Department of Veterinary Medicine Federal University of Rondônia Rolim de Moura Campus Rondônia Brazil. Department of Preventive Veterinary Medicine São Paulo State University Jaboticabal Brazil. Department of Cell and Molecular Biology Ribeirao Preto Medical School University of São Paulo Ribeirão Preto Brazil. Departamento de Bioquímica Instituto de Química Universidade de São Paulo Brazil. Pontifícia Universidade Católica de Minas Gerais Brazil. Departamento de B

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New Strategies for Improving CryoEM Single Particle Analysis in EMAN2.2

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Microscopy and Microanalysis 2017年第S1期23卷 810-811页

作者： Steven J. Ludtke Tunay Durmaz Muyuan Chen James M. Bell Verna and Marrs McLean Dept. of Biochemistry Baylor College of Medicine Houston TX USA. Graduate Program in Structural and Computational Biology & Molecular Biophysics Baylor College of Medicine Houston TX USA.

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