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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Convolutional neural networks for automated annotation of cellular cryo-electron tomograms

arXiv

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arXiv 2017年

作者： Chen, Muyuan Dai, Wei Sun, Stella Y. Jonasch, Darius He, Cynthia Y. Schmid, Michael F. Chiu, Wah Ludtke, Steven J. Graduate Program in Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine HoustonTX77030 United States Verna Marrs and McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine HoustonTX77030 United States Department of Biological Science Centre for BioImaging Sciences National University of Singapore 14 Science Drive 4 Singapore117543 Singapore

Cellular Electron Cryotomography (CryoET) offers the ability to look inside cells and observe macromolecules frozen in action. A primary challenge for this technique is identifying and extracting the molecular components within the crowded cellular environment. We introduce a method using neural networks to dramatically reduce the time and human effort required for subcellular annotation and feature extraction. Subsequent subtomogram classification and averaging yields in-situ structures of molecular components of interest. © 2017, CC BY.

关键词： Cellular neural networks

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Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?

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The Science of the total environment 2022年 813卷 152345页

作者： Bianca H Ventura Fernandes Natália Martins Feitosa Ana Paula Barbosa Camila Gasque Bomfim Anali M B Garnique Ivana F Rosa Maira S Rodrigues Lucas B Doretto Daniel F Costa Bruno Camargo-Dos-Santos Gabrielli A Franco João Favero Neto Juliana Sartori Lunardi Marina Sanson Bellot Nina Pacheco Capelini Alves Camila C Costa Mayumi F Aracati Letícia F Rodrigues Rafaela Hemily Cirilo Raul Marcelino Colagrande Francisco I F Gomes Rafael T Nakajima Marco A A Belo Percília Cardoso Giaquinto Susana Luporini de Oliveira Silas Fernandes Eto Dayanne Carla Fernandes Wilson G Manrique Gabriel Conde Roberta R C Rosales Iris Todeschini Ilo Rivero Edgar Llontop Germán G Sgro Gabriel Umaji Oka Natalia Fernanda Bueno Fausto K Ferraris Mariana T Q de Magalhães Renata J Medeiros Juliana M Mendonça-Gomes Mara Souza Junqueira Kátia Conceição Leticia Gomes de Pontes Antonio Condino-Neto Andrea C Perez Leonardo J G Barcellos José Dias Correa Júnior Erick Gustavo Dorlass Niels O S Camara Edison Luiz Durigon Fernando Q Cunha Rafael H Nóbrega Glaucia M Machado-Santelli Chuck S Farah Flavio P Veras Jorge Galindo-Villegas Letícia V Costa-Lotufo Thiago M Cunha Roger Chammas Luciani R Carvalho Cristiane R Guzzo Guilherme Malafaia Ives Charlie-Silva Laboratório de Controle Genético e Sanitário Diretoria Técnica de Apoio ao Ensino e Pesquisa Faculdade de Medicina da Universidade de São Paulo Brazil. Laboratório Integrado de Biociências Translacionais (LIBT) Instituto de Biodiversidade e Sustentabilidade (NUPEM) Universidade Federal do Rio de Janeiro (UFRJ) Macaé RJ Brazil. Department of Microbiology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil. Department of Cell Biology Institute of Biomedical Sciences University of São Paulo Brazil. Reproductive and Molecular Biology Group Department of Morphology Institute of Biosciences Sao Paulo State University Botucatu São Paulo Brazil. Department of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University SP Brazil. Department of Preventive Veterinary Medicine São Paulo State University (UNESP) Jaboticabal Brazil. Department of Pharmacology Center of Research in Inflammatory Diseases Ribeirao Preto Medical School University of São Paulo Brazil. Brasil University Descalvado São Paulo Brazil. Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências - Departamento de Fisiologia São Paulo Brazil. Universidade Estadual Paulista Júlio de Mesquita Filho São Paulo Brazil. Postgraduate Program in Health Sciences PROCISA Federal University of Roraima Brazil. Immunochemistry Laboratory Butantan Institute São Paulo Brazil. Aquaculture Health Research and Extension Group GRUPESA Aquaculture Health Laboratory LABSA Department of Veterinary Medicine Federal University of Rondônia Rolim de Moura campus Rondônia Brazil. Department of Preventive Veterinary Medicine São Paulo State University Jaboticabal Brazil. Department of Cell and Molecular Biology Ribeirao Preto Medical School University of São Paulo Ribeirão Preto Brazil. Departamento de Bioquímica Instituto de Química Universidade de São Paulo Brazil. Pontifícia Universidade Católica de Minas Gerais Brazil. Departamento de B

Despite the significant increase in the generation of SARS-CoV-2 contaminated domestic and hospital wastewater, little is known about the ecotoxicological effects of the virus or its structural components in freshwater vertebrates. In this context, this study evaluated the deleterious effects caused by SARS-CoV-2 Spike protein on the health of Danio rerio, zebrafish. We demonstrated, for the first time, that zebrafish injected with fragment 16 to 165 (rSpike), which corresponds to the N-terminal portion of the protein, presented mortalities and adverse effects on liver, kidney, ovary and brain tissues. The conserved genetic homology between zebrafish and humans might be one of the reasons for the intense toxic effects followed inflammatory reaction from the immune system of zebrafish to rSpike which provoked damage to organs in a similar pattern as happen in severe cases of COVID-19 in humans, and, resulted in 78,6% of survival rate in female adults during the first seven days. The application of spike protein in zebrafish was highly toxic that is suitable for future studies to gather valuable information about ecotoxicological impacts, as well as vaccine responses and therapeutic approaches in human medicine. Therefore, besides representing an important tool to assess the harmful effects of SARS-CoV-2 in the aquatic environment, we present the zebrafish as an animal model for translational COVID-19 research.

关键词： Acute respiratory syndrome Coronavirus Danio rerio Environmental impacts Infection diseases

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Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

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Archives of virology 2021年第12期166卷 3567-3579页

作者： Jens H Kuhn Scott Adkins Bernard R Agwanda Rim Al Kubrusli Sergey V Alkhovsky Gaya K Amarasinghe Tatjana Avšič-Županc María A Ayllón Justin Bahl Anne Balkema-Buschmann Matthew J Ballinger Christopher F Basler Sina Bavari Martin Beer Nicolas Bejerman Andrew J Bennett Dennis A Bente Éric Bergeron Brian H Bird Carol D Blair Kim R Blasdell Dag-Ragnar Blystad Jamie Bojko Wayne B Borth Steven Bradfute Rachel Breyta Thomas Briese Paul A Brown Judith K Brown Ursula J Buchholz Michael J Buchmeier Alexander Bukreyev Felicity Burt Carmen Büttner Charles H Calisher Mengji Cao Inmaculada Casas Kartik Chandran Rémi N Charrel Qi Cheng Yuya Chiaki Marco Chiapello Il-Ryong Choi Marina Ciuffo J Christopher S Clegg Ian Crozier Elena Dal Bó Juan Carlos de la Torre Xavier de Lamballerie Rik L de Swart Humberto Debat Nolwenn M Dheilly Emiliano Di Cicco Nicholas Di Paola Francesco Di Serio Ralf G Dietzgen Michele Digiaro Olga Dolnik Michael A Drebot J Felix Drexler William G Dundon W Paul Duprex Ralf Dürrwald John M Dye Andrew J Easton Hideki Ebihara Toufic Elbeaino Koray Ergünay Hugh W Ferguson Anthony R Fooks Marco Forgia Pierre B H Formenty Jana Fránová Juliana Freitas-Astúa Jingjing Fu Stephanie Fürl Selma Gago-Zachert George Fú Gāo María Laura García Adolfo García-Sastre Aura R Garrison Thomas Gaskin Jean-Paul J Gonzalez Anthony Griffiths Tony L Goldberg Martin H Groschup Stephan Günther Roy A Hall John Hammond Tong Han Jussi Hepojoki Roger Hewson Jiang Hong Ni Hong Seiji Hongo Masayuki Horie John S Hu Tao Hu Holly R Hughes Florian Hüttner Timothy H Hyndman M Ilyas Risto Jalkanen Dàohóng Jiāng Gilda B Jonson Sandra Junglen Fujio Kadono Karia H Kaukinen Michael Kawate Boris Klempa Jonas Klingström Gary Kobinger Igor Koloniuk Hideki Kondō Eugene V Koonin Mart Krupovic Kenji Kubota Gael Kurath Lies Laenen Amy J Lambert Stanley L Langevin Benhur Lee Elliot J Lefkowitz Eric M Leroy Shaorong Li Longhui Li Jiànróng Lǐ Huazhen Liu Igor S Lukashevich Piet Maes William Marciel de Souza Marco Marklewitz Sergio H Marshall Shin-Yi L Marzano Se Integrated Research Facility at Fort Detrick National Institute of Allergy and Infectious Diseases National Institutes of Health Frederick MD USA. kuhnjens@mail.nih.gov. United States Department of Agriculture Agricultural Research Service US Horticultural Research Laboratory Fort Pierce FL USA. Zoology Department National Museums of Kenya Nairobi Kenya. Jomo Kenyatta University of Agriculture & Technology Nairobi Kenya. Division Phytomedicine Faculty of Life Sciences Humboldt-Universität zu Berlin Berlin Germany. D.I. Ivanovsky Institute of Virology of N.F. Gamaleya National Center on Epidemiology and Microbiology of Ministry of Health of Russian Federation Moscow Russia. Department of Pathology and Immunology Washington University School of Medicine St. Louis MO USA. Faculty of Medicine University of Ljubljana Ljubljana Slovenia. Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Campus de Montegancedo Pozuelo de Alarcón Madrid Spain. Departamento de Biotecnología-Biología Vegetal Escuela Técnica Superior de Ingeniería Agronómica Alimentaria y de Biosistemas Universidad Politécnica de Madrid Madrid Spain. Center for Ecology of Infectious Diseases Department of Infectious Diseases Department of Epidemiology and Biostatistics Insitute of Bioinformatics University of Georgia Athens GA USA. Institute of Novel and Emerging Infectious Diseases Friedrich-Loeffler-Institut Federal Research Institute for Animal Health Greifswald-Insel Riems Germany. Department of Biological Sciences Mississippi State University Mississippi State MS USA. Center for Microbial Pathogenesis Institute for Biomedical Sciences Georgia State University Atlanta GA USA. Edge BioInnovation Consulting and Mgt Frederick MD USA. Institute of Diagnostic Virology Friedrich-Loeffler-Institut Greifswald-Insel Riems Germany. UFyMA INTA-CONICET Cordoba Argentina. Genomics and Bioinformatics D

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Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

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BMC pharmacology & toxicology 2017年第SUPPL 1期18卷 64-64页

作者： Todd Milne, G. Sandner, Peter Lincoln, Kathleen A. Harrison, Paul C. Chen, Hongxing Wang, Hong Clifford, Holly Qian, Hu Sheng Wong, Diane Sarko, Chris Fryer, Ryan Richman, Jeremy Reinhart, Glenn A. Boustany, Carine M. Pullen, Steven S. Andresen, Henriette Moltzau, Lise Román Cataliotti, Alessandro Levy, Finn Olav Lukowski, Robert Frankenreiter, Sandra Friebe, Andreas Calamaras, Timothy Baumgartner, Robert McLaughlin, Angela Aronovitz, Mark Baur, Wendy Wang, Guang-Rong Kapur, Navin Karas, Richard Blanton, Robert Hell, Stefan Waldman, Scott A. Lin, Jieru E. Colon-Gonzalez, Francheska Kim, Gilbert W. Blomain, Erik S. Merlino, Dante Snook, Adam Erdmann, Jeanette Wobst, Jana Kessler, Thorsten Schunkert, Heribert Walter, Ulrich Pagel, Oliver Walter, Elena Gambaryan, Stepan Smolenski, Albert Jurk, Kerstin Zahedi, Rene Klinger, James R. Benza, Raymond L. Corris, Paul A. Langleben, David Naeije, Robert Simonneau, Gérald Meier, Christian Colorado, Pablo Chang, Mi Kyung Busse, Dennis Hoeper, Marius M. Masferrer, Jaime L. Jacobson, Sarah Liu, Guang Sarno, Renee Bernier, Sylvie Zhang, Ping Flores-Costa, Roger Currie, Mark Hall, Katherine Möhrle, Dorit Reimann, Katrin Wolter, Steffen Wolters, Markus Mergia, Evanthia Eichert, Nicole Geisler, Hyun-Soon Ruth, Peter Feil, Robert Zimmermann, Ulrike Koesling, Doris Knipper, Marlies Rüttiger, Lukas Tanaka, Yasutake Okamoto, Atsuko Nojiri, Takashi Kumazoe, Motofumi Tokudome, Takeshi Miura, Koichi Hino, Jun Hosoda, Hiroshi Miyazato, Mikiya Kangawa, Kenji Kapil, Vikas Ahluwalia, Amrita Paolocci, Nazareno Eaton, Philip Campbell, James C. Henning, Philipp Franz, Eugen Sankaran, Banumathi Herberg, Friedrich W. Kim, Choel Wittwer, M. Luo, Q. Kaila, V. Dames, S. A. Tobin, Andrew Alam, Mahmood Rudyk, Olena Krasemann, Susanne Hartmann, Kristin Prysyazhna, Oleksandra Zhang, Min Zhao, Lan Weiss, Astrid Schermuly, Ralph Moyes, Amie J. Chu, Sandy M. Baliga, Reshma S. Hobbs, Adrian J. Michalakis, Stylianos Mühlfriedel, Regine Schön, Christian Fischer, Dominik M. Wilhelm, Barbara Zobor, Ditta Kohl, Ironwood Pharmaceuticals Cambridge USA Bayer AG Drug Discovery - Cardiovascular Research Wuppertal Germany Department of Cardiometabolic Diseases Research Boehringer Ingelheim Pharmaceuticals Ridgefield USA Department of Small Molecule Drug Research Boehringer Ingelheim Pharmaceuticals Ridgefield USA Department of Pharmacology University of Oslo and Oslo University Hospital Oslo Norway Institute of Experimental Medical Research University of Oslo and Oslo University Hospital Oslo Norway Center for Heart Failure Research University of Oslo and Oslo University Hospital Oslo Norway Department of Pharmacology Toxicology and Clinical Pharmacy Institute of Pharmacy University of Tuebingen Tuebingen Germany Physiologisches Institut Universität Würzburg Würzburg Germany Molecular Cardiology Research Institute Tufts Medical Center Boston USA Present Affiliation: Division of Cardiology University of Pittsburgh Medical Center Pittsburgh USA Present Affiliation: Department of Medicine Brown University School of Medicine Providence USA Division of Cardiology Tufts Medical Center Boston USA Max Planck Institute for Biophysical Chemistry Göttingen and German Cancer Research Center (DKFZ) Heidelberg Germany Department of Pharmacology and Experimental Therapeutics Thomas Jefferson University Philadelphia USA Institut für Kardiogenetik and Universitäres Herzzentrum Lübeck Universität zu Lübeck Lübeck Germany & DZHK e.V. (German Center for Cardiovascular Research) Partner Site Hamburg/Kiel/Lübeck Lübeck Germany Deutsches Herzzentrum München Klinik für Herz- und Kreislauferkrankungen Technische Universität München Munich Germany Center for Thrombosis & Hemostasis Universitätsklinikum der Johannes Gutenberg-Universität Mainz Mainz Germany Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V Dortmund Germany Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences St. Petersburg Russia UCD Conway Institute UCD School of Medicine

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structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II

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BMC Pharmacology and Toxicology 2015年第1期16卷 1-2页

作者： James C. Campbell John E. Ladbury Choel Kim Kevin Y. Li Jeong Joo Kim Albert S. Reger Gilbert Huang Shinya Matsuda Keizo Yuasa Banumathi Sankaran Todd M. Link Structural and Computational Biology and Molecular Biophysics Program Baylor College of Medicine Houston Texas USA Department of Biochemistry and Molecular Biology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Pharmacology Baylor College of Medicine Houston Texas USA Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston Texas USA Department of Biochemistry & Cell Biology Rice University Houston USA Department of Biological Science and Technology The University of Tokushima Graduate School Tokushima 770-8506 Japan Berkeley Center for Structural Biology Lawrence Berkeley National Laboratory Berkeley California USA

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Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2

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Journal of structural and Functional Genomics 2015年第1期16卷 11-23页

作者： Tanabe, Hiroaki Motoyama, Kanna Ikeda, Mariko Wakiyama, Motoaki Terada, Takaho Ohsawa, Noboru Hosaka, Toshiaki Hato, Masakatsu Fujii, Yoshifumi Nakamura, Yoshihiro Ogasawara, Satoshi Hino, Tomoya Murata, Takeshi Iwata, So Okada-Iwabu, Miki Iwabu, Masato Hirata, Kunio Kawano, Yoshiaki Yamamoto, Masaki Kimura-Someya, Tomomi Shirouzu, Mikako Yamauchi, Toshimasa Kadowaki, Takashi Yokoyama, Shigeyuki RIKEN Systems and Structural Biology Center 1-7-22 Suehiro-cho Tsurumi-ku Yokohama 230-0045 Japan Department of Biophysics and Biochemistry and Laboratory of Structural Biology Graduate School of Science The University of Tokyo Hongo Bunkyo-ku Tokyo 113-0033 Japan Division of Structural and Synthetic Biology RIKEN Center for Life Science Technologies 1-7-22 Suehiro-cho Tsurumi-ku Yokohama 230-0045 Japan RIKEN Structural Biology Laboratory 1-7-22 Suehiro-cho Tsurumi-ku Yokohama 230-0045 Japan Department of Cell Biology Graduate School of Medicine Kyoto University Yoshida-Konoe-cho Sakyo-ku Kyoto 606-8501 Japan JST Research Acceleration Program Membrane Protein Crystallography Project Yoshida-Konoe-cho Sakyo-ku Kyoto 606-8501 Japan Department of Chemistry Graduate School of Science Chiba University Yayoi-cho Inage Chiba 263-8522 Japan Division of Molecular Biosciences Membrane Protein Crystallography Group Imperial College London SW7 2AZ United Kingdom Diamond Light Source Harwell Science and Innovation Campus Chilton Didcot Oxfordshire OX11 0DE United Kingdom RIKEN SPring-8 Center Harima Institute Kouto Sayo 679-5148 Hyogo Japan Department of Diabetes and Metabolic Diseases Graduate School of Medicine The University of Tokyo Hongo Bunkyo-ku Tokyo 113-0033 Japan Department of Integrated Molecular Science on Metabolic Diseases 22nd Century Medical and Research Center The University of Tokyo Hongo Bunkyo-ku Tokyo 113-0033 Japan CREST Japan Science and Technology Agency Kawaguchi 332-0012 Saitama Japan

The adiponectin receptors (AdipoR1 and AdipoR2) are membrane proteins with seven transmembrane helices. These receptors regulate glucose and fatty acid metabolism, thereby ameliorating type 2 diabetes. The full-length human AdipoR1 and a series of N-terminally truncated mutants of human AdipoR1 and AdipoR2 were expressed in insect cells. In small-scale size exclusion chromatography, the truncated mutants AdipoR1Δ88 (residues 89–375) and AdipoR2Δ99 (residues 100–386) eluted mostly in the intact monodisperse state, while the others eluted primarily as aggregates. However, gel filtration chromatography of the large-scale preparation of the tag-affinity-purified AdipoR1Δ88 revealed the presence of an excessive amount of the aggregated state over the intact state. Since aggregation due to contaminating nucleic acids may have occurred during the sample concentration step, anion-exchange column chromatography was performed immediately after affinity chromatography, to separate the intact AdipoR1Δ88 from the aggregating species. The separated intact AdipoR1Δ88 did not undergo further aggregation, and was successfully purified to homogeneity by gel filtration chromatography. The purified AdipoR1Δ88 and AdipoR2Δ99 proteins were characterized by thermostability assays with 7-diethylamino-3-(4-maleimidophenyl)-4-methyl coumarin, thin layer chromatography of bound lipids, and surface plasmon resonance analysis of ligand binding, demonstrating their structural integrities. The AdipoR1Δ88 and AdipoR2Δ99 proteins were crystallized with the anti-AdipoR1 monoclonal antibody Fv fragment, by the lipidic mesophase method. X-ray diffraction data sets were obtained at resolutions of 2.8 and 2.4 Å, respectively. © 2015, The Author(s).

关键词： Adiponectin receptors AdipoR1 and AdipoR2 Antibody Crystallization Lipidic mesophase Membrane protein Purification

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Seeing the Portal in Membrane-containing Bacteriophage PRD1 by Cryo-EM

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Microscopy and Microanalysis 2014年第S3期20卷 1250-1251页

作者： Chuan Hong Xiangan Liu Hanna M. Oksanen Joanita Jakana Dennis H. Bamford Wah Chiu Graduate Program in Structural and Computational Biology and Molecular Biophysics Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston TX 77030 USA Institute of Biotechnology and Department of Biosciences University of Helsinki FIN-00014 Helsinki Finland

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EMAN2.1 - A New Generation of Software for Validated Single Particle Analysis and Single Particle Tomography

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Microscopy and Microanalysis 2014年第S3期20卷 832-833页

作者： SC Murray JG Galaz-Montoya G Tang JF Flanagan SJ Ludtke Graduate Program in Structural and Computational Biology & Molecular Biophysics Baylor College of Medicine One Baylor Plaza Houston TX 77025 National Center for Macromolecular Imaging Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine One Baylor Plaza Houston TX 77025 Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine One Baylor Plaza Houston TX 77025

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Cover Picture: Time-Dependent Diaryl Ether Inhibitors of InhA: Structure–Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy (ChemMedChem 4/2014)

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ChemMedChem 2014年第4期9卷 673-673页

作者： Dr. Pan Pan Dr. Susan E. Knudson Dr. Gopal R. Bommineni Dr. Huei-Jiun Li Cheng-Tsung Lai Dr. Nina Liu Prof. Miguel Garcia-Diaz Prof. Carlos Simmerling Dr. Sachindra S. Patil Prof. Richard A. Slayden Prof. Peter J. Tonge Institute for Chemical Biology & Drug Discovery Department of Chemistry Stony Brook University Stony Brook NY 11794-3400 (USA) Department of Microbiology Immunology & Pathology Colorado State University 1619 Campus Delivery Fort Collins CO 80523-2025 (USA) Biochemistry & Structural Biology Stony Brook University Stony Brook NY 11794-3400 (USA) Pharmacological Sciences Graduate Program Stony Brook University Stony Brook NY 11794-3400 (USA) Kanashi Biotech Pvt Ltd A-27 H Block MIDC Pimpri Pune 411018 (India) Richard A. Slayden Department of Microbiology Immunology & Pathology Colorado State University 1619 Campus Delivery Fort Collins CO 80523-2025 (USA)=== Peter J. Tonge Institute for Chemical Biology & Drug Discovery Department of Chemistry Stony Brook University Stony Brook NY 11794-3400 (USA)===

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