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检索条件"机构=Graduate Program in Bioinformatics"
773 条 记 录,以下是461-470 订阅
排序:
Targeting protein-protein interaction interfaces with antiviral N protein inhibitor in SARS-CoV-2
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Biophysical Journal 2024年 第4期123卷 478-488页
作者: Hong, Jhen-Yi Lin, Shih-Chao Kehn-Hall, Kylene Zhang, Kai-Min Luo, Shun-Yuan Wu, Hung-Yi Chang, Sui-Yuan Hou, Ming-Hon Institute of Genomics and Bioinformatics and Department of Life Sciences National Chung Hsing University Taichung Taiwan Bachelor Degree Program in Marine Biotechnology College of Life Sciences National Taiwan Ocean University Keelung Taiwan Department of Biomedical Sciences and Pathobiology Virginia-Maryland College of Veterinary Medicine Virginia Polytechnic Institute and State University Blacksburg VA United States Center for Emerging Zoonotic and Arthropod-borne Pathogens Virginia Polytechnic Institute and State University Blacksburg VA United States Department of Chemistry National Chung Hsing University Taichung Taiwan Graduate Institute of Veterinary Pathobiology College of Veterinary Medicine National Chung Hsing University. Taichung Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Taipei Taiwan PhD Program in Medical Biotechnology National Chung Hsing University Taichung Taiwan Biotechnology Center National Chung Hsing University Taichung Taiwan
Coronaviruses not only pose significant global public health threats but also cause extensive damage to livestock-based industries. Previous studies have shown that 5-benzyloxygramine (P3) targets the Middle East resp...
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Assessing Family Medicine Residency programs’ Training on Human Trafficking: A National Survey of program Directors
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Journal of Human Trafficking 2020年 第4期7卷 1-13页
作者: Mishori, Ranit Stolarz, Katherine Ravi, Anita Korostyshevskiy, Valeriy R. Chambers, Ronald Cronholm, Peter Global Health Initiatives Georgetown University School of Medicine Washington DC United States Global Health Dept. of Family Medicine MedStar Franklin Square Medical Center Baltimore MD United States The Institute for Family Health Department of Family Medicine Community Health Icahn School of Medicine at Mount Sinai New York NY United States Graduate Studies Department of Biostatistics Bioinformatics and Biomathematics Georgetown University Washington DC United States DIO Family Medicine Residency Program Chair Family Medicine Department Medical Director Mercy Family Health Center and Mercy Human Trafficking Clinic Sacramento CA United States Family Medicine and Community Health Perelman School of Medicine University of Pennsylvania Philadelphia PA United States
Background: Human trafficking (HT) affects millions globally, and is linked to significant health effects. Studies suggest victims interact with the healthcare system while exploited, yet go unrecognized. We sought to... 详细信息
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Ecological landscapes guide the assembly of optimal microbial communities
arXiv
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arXiv 2021年
作者: George, Ashish B. Korolev, Kirill S. Department of Physics Boston University BostonMA02215 United States Biological Design Center Boston University BostonMA02215 United States Carl R. Woese Institute for Genomic Biology Department of Plant Biology University of Illinois at Urbana-Champaign UrbanaIL61801 United States Graduate Program in Bioinformatics Boston University BostonMA02215 United States
Assembling optimal microbial communities is key for various applications in biofuel production, agriculture, and human health. Finding the optimal community is challenging because the number of possible communities gr... 详细信息
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Core packing of well-defined x-ray and NMR structures is the same
arXiv
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arXiv 2022年
作者: Grigas, Alex T. Liu, Zhuoyi Regan, Lynne O’Hern, Corey S. Graduate Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Institute of Quantitative Biology Biochemistry and Biotechnology Centre for Synthetic and Systems Biology School of Biological Sciences University of Edinburgh United Kingdom Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States
Numerous studies have investigated the differences and similarities between protein structures determined by solution NMR spectroscopy and those determined by x-ray crystallography. A fundamental question is whether a... 详细信息
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Improving quantitation accuracy in isobaric-labeling mass spectrometry experiments with spectral library searching and feature-based peptide-spectrum match filter
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Scientific Reports 2023年 第1期13卷 1-10页
作者: Kuo, Tzu-Yun Wang, Jen-Hung Huang, Yung-Wen Sung, Ting-Yi Chen, Ching-Tai Department of Biochemical Science and Technology National Taiwan University Taipei 10617 Taiwan Bioinformatics Program Taiwan International Graduate Program Institute of Statistical Science Academia Sinica Taipei 11529 Taiwan Institute of Information Science Academia Sinica Taipei 11529 Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taipei 11221 Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei 10617 Taiwan Department of Bioinformatics and Biomedical Engineering Asia University Taichung 41354 Taiwan Center for Precision Health Research Asia University Taichung 41354 Taiwan
Isobaric labeling relative quantitation is one of the dominating proteomic quantitation technologies. Traditional quantitation pipelines for isobaric-labeled mass spectrometry data are based on sequence database searc...
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Protein folding as a jamming transition
arXiv
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arXiv 2024年
作者: Grigas, Alex T. Liu, Zhuoyi Logan, Jack A. Shattuck, Mark D. O’Hern, Corey S. Graduate Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Benjamin Levich Institute and Physics Department The City College of New York New YorkNY10031 United States Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States
Proteins fold to a specific functional conformation with a densely packed hydrophobic core that controls their stability. We develop a geometric, yet all-atom model for proteins that explains the universal core packin... 详细信息
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Evolution of olfactory receptor genes in East Asian loaches
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Zoological Studies 2009年 第2期48卷 223-237页
作者: Wang, Daryi Wang, Tzi-Yuan Weng, Li-Chuan Emori, Yasufumi Tzeng, Chyng-Shyan Li, Wen-Hsiung Biodiversity Research Center Academia Sinica Taipei 115 Taiwan Genomics Research Center Academia Sinica Taipei 115 Taiwan Department of Biophysics and Biochemistry Graduate School of Science University of Tokyo Bunkyo Tokyo 113-0033 7-3-1 Hongo Japan Undergraduate Program for Bioinformatics and System Biology University of Tokyo Bunkyo Tokyo 113-0033 7-3-1 Hongo Japan Institute of Bioinformatics and Structural Biology Department of Life Sciences National Tsing Hua University Hsinchu 300 Taiwan
Daryi Wang, Tzi-Yuan Wang, Li-Chuan Weng, Yasufumi Emori, Chyng-Shyan Tzeng, and Wen-Hsiung Li (2009) Evolution of olfactory receptor genes in East Asian loaches. Zoological Studies 48(2): 223-237. It is well known th... 详细信息
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The connection between polymer collapse and the onset of jamming
arXiv
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arXiv 2023年
作者: Grigas, Alex T. Fisher, Aliza Shattuck, Mark D. O’Hern, Corey S. Graduate Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Benjamin Levich Institute and Physics Department The City College of New York New YorkNY10031 United States Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States
Previous studies have shown that the interiors of proteins are densely packed, reaching packing fractions that are as large as those found for static packings of individual amino-acid-shaped particles. How can the int... 详细信息
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Tegavivint triggers TECR-dependent nonapoptotic cancer cell death
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Nature chemical biology 2025年 2025 May 26页
作者: Logan Leak Ziwei Wang Alby J Joseph Brianna Johnson Alyssa A Chan Cassandra M Decosto Leslie Magtanong Pin-Joe Ko Weaverly Colleen Lee Joan Ritho Sophia Manukian Alec Millner Shweta Chitkara Jennifer J Salinas Rachid Skouta Matthew G Rees Melissa M Ronan Jennifer A Roth Chad L Myers Jason Moffat Charles Boone Steven J Bensinger David A Nathanson G Ekin Atilla-Gokcumen Everett J Moding Scott J Dixon Department of Biology Stanford University Stanford CA USA. Department of Radiation Oncology Stanford University School of Medicine Stanford CA USA. Department of Chemistry University at Buffalo The State University of New York Buffalo NY USA. Department of Molecular and Medical Pharmacology University of California Los Angeles Los Angeles CA USA. Department of Chemistry University of Massachusetts Amherst Amherst MA USA. Department of Biology University of Massachusetts Amherst Amherst MA USA. Broad Institute of MIT and Harvard Cambridge MA USA. Department of Computer Science and Engineering Bioinformatics and Computational Biology Graduate Program University of Minnesota-Twin Cities Minneapolis MN USA. Program in Genetics & Genome Biology The Hospital for Sick Children Toronto Ontario Canada. Department of Molecular Genetics University of Toronto Toronto Ontario Canada. Donnelly Centre University of Toronto Toronto Ontario Canada. RIKEN Center for Sustainable Resource Science Saitama Japan. Department of Microbiology Immunology and Molecular Genetics University of California Los Angeles Los Angeles CA USA. UCLA Lipidomics Laboratory University of California Los Angeles Los Angeles CA USA. Jonsson Comprehensive Cancer Center David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA. Department of Biology Stanford University Stanford CA USA. sjdixon@stanford.edu.
Small molecules that induce nonapoptotic cell death are of fundamental mechanistic interest and may be useful to treat certain cancers. Here we report that tegavivint, a drug candidate undergoing human clinical trials...
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Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects
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Nucleic acids research 2024年 第15期52卷 9303-9316页
作者: Shih-Chun Huang Chia-Wei Chen Roshan Satange Chang-Chih Hsieh Chih-Chun Chang Shun-Ching Wang Chi-Li Peng Tai-Lin Chen Ming-Hsi Chiang Yih-Chern Horng Ming-Hon Hou Doctoral Program in Medical Biotechnology National Chung Hsing University Taichung 402 Taiwan. Graduate Institute of Genomics and Bioinformatics National Chung Hsing University Taichung 402 Taiwan. Department of Chemistry National Changhua University of Education Changhua 50058 Taiwan. Institute of Chemistry Academia Sinica Taipei 11528 Taiwan. Graduate Institute of Biotechnology National Chung Hsing University Taichung 402 Taiwan. Post Baccalaureate Medicine School of Medicine National Chung Hsing University Taichung 402 Taiwan. Biotechnology Center National Chung Hsing University Taichung 402 Taiwan.
Targeting inter-duplex junctions in catenated DNA with bidirectional bis-intercalators is a potential strategy for enhancing anticancer effects. In this study, we used d(CGTATACG)2, which forms a tetraplex base-pair j...
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