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Glycopolymer Microarrays with Sub-Femtomolar Avidity for Glycan Binding Proteins Prepared by Grafted-To/Grafted-From Photopolymerizations

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Angewandte Chemie 2021年第37期133卷

作者： Daniel J. Valles Yerzhan S. Zholdassov Joanna Korpanty Samiha Uddin Yasir Naeem Prof. David R. Mootoo Prof. Nathan C. Gianneschi Prof. Adam B. Braunschweig The PhD program in Chemistry Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA Advanced Science Research Center at the Graduate Center The City University of New York 85 St. Nicholas Terrace New York NY 10031 USA Department of Chemistry Hunter College 695 Park Ave New York NY 10065 USA Department of Chemistry Northwestern University Evanston IL 60208 USA Department of Materials Science and Engineering Northwestern University Evanston IL 60208 USA Department of Biomedical Engineering Northwestern University Evanston IL 60208 USA The PhD program in Biochemistry Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA

We report a novel glycan array architecture that binds the mannose-specific glycan binding protein, concanavalin A (ConA), with sub-femtomolar avidity. A new radical photopolymerization developed specifically for this application combines the grafted-from thiol–(meth)acrylate polymerization with thiol–ene chemistry to graft glycans to the growing polymer brushes. The propagation of the brushes was studied by carrying out this grafted-to/grafted-from radical photopolymerization (GTGFRP) at >400 different conditions using hypersurface photolithography, a printing strategy that substantially accelerates reaction discovery and optimization on surfaces. The effect of brush height and the grafting density of mannosides on the binding of ConA to the brushes was studied systematically, and we found that multivalent and cooperative binding account for the unprecedented sensitivity of the GTGFRP brushes. This study further demonstrates the ease with which new chemistry can be tailored for an application as a result of the advantages of hypersurface photolithography.

关键词： glycopolymers lectins lithography microarrays thiol–ene

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Control of microswimmers by spiral nematic vortices: Transition from individual to collective motion and contraction, expansion, and stable circulation of bacterial swirls

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Physical Review Research 2020年第3期2卷 033060-033060页

作者： Runa Koizumi Taras Turiv Mikhail M. Genkin Robert J. Lastowski Hao Yu Irakli Chaganava Qi-Huo Wei Igor S. Aranson Oleg D. Lavrentovich Advanced Materials and Liquid Crystal Institute Materials Science Graduate Program Kent State University Kent Ohio 44242 USA Cold Spring Harbor Laboratory 1 Bungtown Road Cold Spring Harbor New York 11724 USA Department of Chemistry University of Scranton Scranton Pennsylvania 18510 USA Institute of Cybernetics of Georgian Technical University Tbilisi 0186 Georgia Georgian State Teaching University of Physical Education and Sport Tbilisi 0162 Georgia Department of Physics Kent State University Kent Ohio 44242 USA Department of Biomedical Engineering Pennsylvania State University University Park Pennsylvania 16802 USA

Active systems composed of self-propelled units show fascinating transitions from Brownian-like dynamics to collective coherent motion. Swirling of swimming bacteria is a spectacular example. This study demonstrates that a nematic liquid crystal environment patterned as a spiral vortex controls individual-to-collective transition in bacterial swirls and defines whether they expand or shrink. In dilute dispersions, the bacteria swim along open spiral trajectories, following the preimposed molecular orientation. The trajectories are nonpolar. As their concentration exceeds some threshold, the bacteria condense into unipolar circular swirls resembling stable limit cycles. This collective circular motion is controlled by the spiral angle that defines the splay-to-bend ratio of the background director. Vortices with dominating splay shrink the swirls toward the center, while vortices with dominating bend expand them to the periphery. Spiraling vortices of 45∘ with splay-bend parity produce the most stable swirls. All the dynamic scenarios are explained by hydrodynamic interactions of bacteria mediated by the patterned passive nematic environment and by the coupling between the concentration and orientation. The acquired knowledge of how to control individual and collective motion of microswimmers by a nematic environment can help in the development of microscopic mechanical systems.

关键词： Applications of soft matter Biomimetic & bio-inspired materials

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Author Correction: A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

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Nature biomedical engineering 2025年第2期9卷 285页

作者： Christopher L Yankaskas Keyata N Thompson Colin D Paul Michele I Vitolo Panagiotis Mistriotis Ankit Mahendra Vivek K Bajpai Daniel J Shea Kristen M Manto Andreas C Chai Navin Varadarajan Aikaterini Kontrogianni-Konstantopoulos Stuart S Martin Konstantinos Konstantopoulos Department of Chemical and Biomolecular Engineering The Johns Hopkins University Baltimore MD USA. Johns Hopkins Institute for NanoBioTechnology The Johns Hopkins University Baltimore MD USA. Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD USA. Graduate Program in Molecular Medicine University of Maryland School of Medicine Baltimore MD USA. Department of Physiology University of Maryland School of Medicine Baltimore MD USA. Department of Chemical and Biomolecular Engineering University of Houston Houston TX USA. Department of Chemical and Systems Biology Stanford University Stanford CA USA. Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Baltimore MD USA. Department of Chemical and Biomolecular Engineering The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Johns Hopkins Institute for NanoBioTechnology The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Department of Biomedical Engineering The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Department of Oncology The Johns Hopkins University School of Medicine Baltimore MD USA. konstant@jhu.edu.

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Correction: Development of muscular dystrophy in a CRISPR-engineered mutant rabbit model with frame-disrupting ANO5 mutations

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Cell death & disease 2020年第6期11卷 468页

作者： Tingting Sui Li Xu Yeh Siang Lau Di Liu Tingjun Liu Yandi Gao Liangxue Lai Renzhi Han Zhanjun Li Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University 130062 Changchun China. Department of Surgery Davis Heart and Lung Research Institute Biomedical Sciences Graduate Program Biophysics Graduate Program The Ohio State University Wexner Medical Center Columbus OH 43210 United States. Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University 130062 Changchun China. lai_liangxue@***. Department of Surgery Davis Heart and Lung Research Institute Biomedical Sciences Graduate Program Biophysics Graduate Program The Ohio State University Wexner Medical Center Columbus OH 43210 United States. renzhi.han@osumc.edu. Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University 130062 Changchun China. lizj_1998@***.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Retraction Note: The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma

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Cellular oncology (Dordrecht, Netherlands) 2024年第6期47卷 2461-2462页

作者： Ti-Chun Chan Cheng-Tang Pan Hsin-Yu Hsieh Pichpisith Pierre Vejvisithsakul Ren-Jie Wei Bi-Wen Yeh Wen-Jeng Wu Lih-Ren Chen Meng-Shin Shiao Chien-Feng Li Yow-Ling Shiue Department of Medical Research Chi-Mei Medical Center Tainan 71004 Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan 71004 Taiwan. Institute of Precision Medicine College of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Department of Mechanical and Electro-Mechanical Engineering National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Institute of Advanced Semiconductor Packaging and Testing College of Semiconductor and Advanced Technology Research National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Institute of Biomedical Sciences College of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Program in Translational Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand. Department of Pathology Kaohsiung Armed Forces General Hospital Kaohsiung 80284 Taiwan. Institute of Medical Science and Technology School of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Department of Medical Laboratory Sciences and Biotechnology Fooyin University Kaohsiung 83102 Taiwan. Department of Urology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Department of Urology Kaohsiung Medical University Hospital Kaohsiung 80708 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan. Division of Physiology Livestock Research Institute Tainan 71246 Taiwan. Research Center Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand. Department of Medical Research Chi-Mei Medical Center Tainan 71004 Taiwan. angelo.p@yahoo.com.tw. National Institute of Cancer Research National Health Research Institutes Tainan 71004 Taiwan. angelo.p@yahoo.com.tw. Institute of Precision Medicine College of Medicine Nat

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Narciclasine suppresses oral cancer metastasis by modulating cathepsin B and extracellular signal-related kinase pathways

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023年 158卷 114159页

作者： Mu-Kuei Shieu Hsin-Yu Ho Chia-Chieh Lin Yu-Sheng Lo Yi-Ching Chuang Ming-Ju Hsieh Mu-Kuan Chen Division of General Practice Department of Medical Education Changhua Christian Hospital Changhua 500 Taiwan. Oral Cancer Research Center Changhua Christian Hospital Changhua 500 Taiwan. Oral Cancer Research Center Changhua Christian Hospital Changhua 500 Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung 402 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung 404 Taiwan. Electronic address: 170780@cch.org.tw. Department of Otorhinolaryngology Head and Neck Surgery Changhua Christian Hospital Changhua 500 Taiwan. Electronic address: 53780@cch.org.tw.

Oral cancer is a malignancy with unfavorable prognosis due to its high rates of recurrence and lymph node metastasis. Narciclasine is extracted from Narcissus species (Amaryllidaceae), which have antitumor and anti-inflammatory properties. However, the antitumor properties of narciclasine toward oral cancer remain unclear. The present study explored the antimetastatic effects of narciclasine in oral cancer as well as the underlying molecular mechanisms. We treated three oral cancer cell lines with noncytotoxic concentrations of narciclasine and discovered a dose-dependent antimetastatic effect. Mitogen-activated protein kinase (MAPK) pathways, including extracellular signal-related kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), were regulated by narciclasine. We further discovered the ERK pathway to directly affect narciclasine-induced metastasis inhibition by combining treatment with narciclasine and ERK inhibitor. Furthermore, downregulation of cathepsin B (CTSB) in the SAS and SCC-47 cell lines revealed the critical role of CTSB in the antimetastatic effect of narciclasine. Our findings indicate that narciclasine inhibits oral cancer metastasis by regulating the ERK pathway and CTSB. This study provides evidence of the mechanism of narciclasine-induced inhibition oral cancer metastasis and suggests potential targets for use in oral cancer treatment.

关键词： Cathepsin B Metastasis Narciclasine Oral cancer

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#33: Single-cell RNA sequencing analysis of Zika virus infection in human stem cell-derived neuroprogenitor cells and cerebral organoids

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Journal of the Pediatric Infectious Diseases Society 2021年第SUPPLEMENT_2期10卷 S11-S12页

作者： Ocwieja, K E Hughes, T K Baker, C C M Stanton, A C Antonucci, J M Richards, A L Shalek, A Jaenisch, R Gehrke, L Inst. for Medical Engineering and Science Massachusetts Inst. of Technology (MIT) Dept. of Pediatrics Boston Children’s Hospital Harvard Medical School Virology Graduate Program Harvard Medical School (HMS) Whitehead Inst. for Biomedical Research Dept. of Chemistry and Koch Institute for Integrative Cancer Research MIT Ragon Institute of MGH MIT and Harvard Broad Institute of MIT and Harvard

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Percutaneous Coronary Intervention With a Drug-Eluting Stent Versus Coronary Artery Bypass Grafting in Patients Receiving Dialysis: A National Study From Taiwan

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Kidney medicine 2024年第2期6卷 100768页

作者： Szu-Yu Pan Ju-Yeh Yang Nai-Chi Teng Yun-Yi Chen Shi-Heng Wang Chien-Lin Lee Kang-Lung Chen Yen-Ling Chiu Shih-Ping Hsu Yu-Sen Peng Yung-Ming Chen Shuei-Liong Lin Likwang Chen Department of Integrated Diagnostics and Therapeutics National Taiwan University Hospital Taipei Taiwan. Division of Nephrology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan. Division of Nephrology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan. Institute of Health Policy and Management College of Public Health National Taiwan University Taipei Taiwan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Research Shin-Kong Wu Ho-Su Memorial Hospital Taipei Taiwan. Institute of Hospital and Health Care Administration National Yang Ming Chiao Tung University Taipei Taiwan. National Center for Geriatrics and Welfare Research National Health Research Institutes Yunlin Taiwan. Department of Cardiology Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Cardiovascular Surgery Far Eastern Memorial Hospital New Taipei City Taiwan. Graduate Program in Biomedical Informatics Department of Computer Science and Engineering College of Informatics Yuan Ze University Taoyuan Taiwan. Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan. Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan.

Rationale & Objective:We aimed to study the comparative effectiveness of percutaneous coronary intervention with drug-eluting stent and coronary artery bypass grafting in patients receiving dialysis. Study Design:This was a retrospective observational cohort study. Setting & Participants:This population-based study identified patients receiving dialysis hospitalized for coronary revascularization between January 1, 2009 and December 31, 2015, in the Taiwan National Health Insurance Research Database. Exposures:Patients received percutaneous coronary intervention with drug-eluting stent versus coronary artery bypass grafting. Outcomes:The study outcomes were all-cause mortality, in-hospital mortality, and repeat revascularization. Analytical Approach:Propensity scores were used to match patients. Cox proportional hazards models and logistic regression models were constructed to examine associations between revascularization strategies and mortality. Interval Cox models were fitted to estimate time-varying hazards during different periods. Results:A total of 1,840 propensity score-matched patients receiving dialysis were analyzed. Coronary artery bypass grafting was associated with higher in-hospital mortality (coronary artery bypass grafting vs percutaneous coronary intervention with drug-eluting stent; crude mortality rate 12.5% vs 3.3%; adjusted OR, 5.22; 95% CI, 3.42-7.97; < 0.001) and longer hospitalization duration (median [IQR], 20 [14-30] days vs 3 [2-8] days; < 0.001). After discharge, repeat revascularization, acute coronary syndrome, and repeat hospitalization all occurred more frequently in the percutaneous coronary intervention with drug-eluting stent group. Importantly, with a median follow-up of 2.8 years, coronary artery bypass grafting was significantly associated with a higher risk of all-cause overall mortality (adjusted HR, 1.19; 95% CI, 1.05-1.35; = 0.006) in the multivariable Cox proportional hazard model. Sensitivity and subgroup analyses yie

关键词： Coronary artery bypass grafting coronary revascularization dialysis drug-eluting stent end-stage kidney disease mortality percutaneous coronary intervention survival

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Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies

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Nature 2024年第8004期627卷 E9页

作者： Corina Amor Judith Feucht Josef Leibold Yu-Jui Ho Changyu Zhu Direna Alonso-Curbelo Jorge Mansilla-Soto Jacob A Boyer Xiang Li Theodoros Giavridis Amanda Kulick Shauna Houlihan Ellinor Peerschke Scott L Friedman Vladimir Ponomarev Alessandra Piersigilli Michel Sadelain Scott W Lowe Louis V. Gerstner Jr Graduate School of Biomedical Sciences Memorial Sloan Kettering Cancer Center New York NY USA. Department of Cancer Biology and Genetics Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA. Center for Cell Engineering Memorial Sloan Kettering Cancer Center New York NY USA. Immunology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA. Molecular Pharmacology and Chemistry Program Memorial Sloan Kettering Cancer Center New York NY USA. Weill Cornell Graduate School of Medical Sciences New York NY USA. Department of Laboratory Medicine Memorial Sloan Kettering Cancer Center New York NY USA. Division of Liver Diseases Icahn School of Medicine at Mount Sinai New York NY USA. Department of Radiology Memorial Sloan Kettering Cancer Center New York NY USA. Laboratory of Comparative Pathology Rockefeller University Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center New York NY USA. Center for Cell Engineering Memorial Sloan Kettering Cancer Center New York NY USA. m-sadelain@***. Immunology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA. m-sadelain@***. Department of Cancer Biology and Genetics Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA. lowes@***. Howard Hughes Medical Institute Chevy Chase MD USA. lowes@***.

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Corrigendum to "Acute in vivo testing of a polymer cuff electrode with integrated microfluidic channels for stimulation, recording, and drug delivery on rat sciatic nerve" [J. Neurosci. Methods 336 (April) (2020) 108634]

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Journal of neuroscience methods 2020年 338卷 108696页

作者： Sahar Elyahoodayan Christopher Larson Angelica Cobo Ellis Meng Dong Song Department of Biomedical Engineering University of Southern California Los Angeles CA 90089 USA. Electronic address: elyahood@usc.edu. Department of Biomedical Engineering University of Southern California Los Angeles CA 90089 USA. Department of Biomedical Engineering University of Southern California Los Angeles CA 90089 USA Department of Electrical and Computer Engineering University of Southern California Los Angeles CA 90089 USA. Neuroscience Graduate Program University of Southern California Los Angeles CA 90089 USA.

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