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JOURNAL OF SPINAL CORD MEDICINE 2021年第SUPPL 1期44卷 S278-S324页

作者： [Anonymous] Department of Medicine Division of Physical Medicine and Rehabilitation University of Toronto Toronto ON CA KITE - Toronto Rehabilitation Institute University Health Network Toronto ON CA Institute for Health Policy Management and Evaluation University of Toronto Toronto ON CA Rehabilitation Sciences Institute University of Toronto Toronto ON CA Institute of Medical Sciences University of Toronto Toronto ON CA. Rehabilitation Sciences Institute University of Toronto ON CA KITE Research Institute-Toronto Rehab-University Health Network Toronto ON CA Physical Therapy Department University of Toronto ON CA Praxis Spinal Cord Institute Vancouver BC Université de Montréal (École de réadaptation) Montreal QC CA Institut de réadaptation Gingras-Linsay-de-Montréal Montreal QC CA Division of Physical Medicine & Rehabilitation Department of Medicine Faculty of Medicine & Dentistry University of Alberta Edmonton AB CA University of Calgary Calgary AB CA Alberta Health Services Centre for Family Medicine Kitchener ON CA McMaster University Department of Family Medicine Hamilton ON CA Dept. of Physical Therapy University of Toronto Toronto ON CA KITE-University Health Network Toronto ON CA Praxis Spinal Cord Institute Vancouver BC CA Center for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS) Quebec City QC CA Dept. of Rehabilitation Laval University Quebec City QC CA Institute of Health Policy Management and Evaluation University of Toronto Toronto ON CA School of Rehabilitation Science University of Saskatchewan Saskatoon SK CA Ontario Neurotrauma Foundation Toronto ON CA Canadian Spinal Research Organization Toronto ON CA CIUSSS du Centre-Sud-de-l ‘Île-de-Montréal (Installation Gingras-Lindsay) Montréal QC CA École de réadaptation Université de Montréal Montréal QC CA First Steps Wellness Centre Regina SK CA Stan Cassidy Centre for Rehabilitation Horizon Health Network Fredericton NB CA Departmen

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Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance

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Journal of experimental & clinical cancer research : CR 2023年第1期42卷 171页

作者： Ting-Wan Kao Geng-Hao Bai Tian-Li Wang Ie-Ming Shih Chi-Mu Chuang Chun-Liang Lo Meng-Chen Tsai Li-Yun Chiu Chu-Chien Lin Yao-An Shen Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. Department of Internal Medicine National Taiwan University Hospital College of Medicine National Taiwan University Taipei City 100225 Taiwan. Departments of Pathology Oncology and Gynecology and Obstetrics Johns Hopkins Medical Institutions 1550 Orleans StreetRoom 306 Baltimore MD CRB221231 USA. Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD USA. Faculty of Medicine School of Medicine National Yang-Ming Chiao Tung University Taipei 112304 Taiwan. Department of Obstetrics and Gynecology Taipei Veterans General Hospital Taipei 112201 Taiwan. Department of Midwifery and Women Health Care National Taipei University of Nursing and Health Sciences Taipei 112303 Taiwan. Department of Biomedical Engineering National Yang-Ming Chiao Tung University Taipei 112304 Taiwan. Medical Device Innovation and Translation Center National Yang Ming Chiao Tung University Taipei 112304 Taiwan. Department of General Medicine Taipei Medical University Hospital Taipei 110301 Taiwan. Department of General Medicine Mackay Memorial Hospital Taipei 104217 Taiwan. School of Medicine College of Medicine Taipei Medical University Taipei City 110301 Taiwan. Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw. International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw.

Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their demonstrated efficacy against tumors and favorable safety profiles or tolerability. Nevertheless, treatment resistance continues to be one of the most pressing unsolved conundrums in cancer treatment. Hypoxia-inducible factors (HIFs) are a family of transcription factors that regulate cellular responses to hypoxia by activating genes involved in various adaptations, including erythropoiesis, glucose metabolism, angiogenesis, cell proliferation, and apoptosis. Despite this critical function, overexpression of HIFs has been observed in numerous cancers, leading to resistance to therapy and disease progression. In recent years, much effort has been poured into developing innovative cancer treatments that target the HIF pathway. Combining HIF inhibitors with current cancer therapies to increase anti-tumor activity and diminish treatment resistance is one strategy for combating therapeutic resistance. This review focuses on how HIF inhibitors could be applied in conjunction with current cancer treatments, including those now being evaluated in clinical trials, to usher in a new era of cancer therapy.

关键词： Chemotherapy Combination therapy HIF-1 HIF-2 Hypoxia Immunotherapy Metabolic therapy Radiotherapy Target therapy Therapeutic resistance

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Correction: Extended visible to near-infrared harvesting of earth-abundant FeS2–TiO2 heterostructures for highly active photocatalytic hydrogen evolution

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Green Chemistry 2018年第11期20卷 2663-2663页

作者： Tsung-Rong Kuo Hsiang-Ju Liao Yu-Ting Chen Chuan-Yu Wei Chia-Che Chang Yi-Chia Chen Yi-Hsuan Chang Jou-Chun Lin Yi-Cheng Lee Cheng-Yen Wen Shao-Sian Li Kung-Hsuan Lin Di-Yan Wang Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Department of Chemistry Tunghai University Taichung 40704 Taiwan Institute of Physics Academia Sinica Taipei 11529 Taiwan Department of Materials Science and Engineering National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan

Correction for ‘Extended visible to near-infrared harvesting of earth-abundant FeS2–TiO2 heterostructures for highly active photocatalytic hydrogen evolution’ by Tsung-Rong Kuo et al., Green Chem., 2018, 20, 1640–...

Correction for ‘Extended visible to near-infrared harvesting of earth-abundant FeS₂–TiO₂ heterostructures for highly active photocatalytic hydrogen evolution’ by Tsung-Rong Kuo et al., Green Chem., 2018, 20, 1640–1647.

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Erratum to 'Quantitative Analysis of Needle Navigation under Ultrasound Guidance in a Simulated Central Venous Line Procedure'[Ultrasound Med Biol 44 (2018) 1891-1900]

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Ultrasound in medicine & biology 2019年第1期45卷 264页

作者： Golafsoun Ameri Daniel Bainbridge Terry M Peters Elvis C S Chen Biomedical Engineering Graduate Program Western University London Ontario Canada Robarts Research Institute London Ontario Canada. Electronic address: gameri@robarts.ca. Department of Anesthesiology and Perioperative Medicine University Hospital-London Health Sciences CentreWestern University London Ontario Canada. Robarts Research Institute London Ontario Canada.

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Mechanical Analysis of Multi-Component Tissues

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World Journal of Mechanics 2017年第4期7卷 121-132页

作者： Frederick H. Silver Ruchit G. Shah Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School Rutgers The State University of New Jersey Piscataway USA Graduate Program in Biomedical Engineering Rutgers The State University of New Jersey Piscataway USA

Collagen is the major structural fiber found in mammalian tissues. It is a protein in the form of a triple-helix which is found in several subfamilies, the most abundant of which is the fiber forming group containing Types I, II and III. Type I collagen is found in tendons, skin, cornea, bone, lung and vessel walls. This collagen is thought to give rise to the high tensile strengths of collagen fibers in tissues;in addition, it is actively involved in other physiologic processes such mechanotransduction. However, the non-linear mechanical behavior and viscoelasticity of collagen fibers make analysis of the mechanical properties of tissues complicated. Mechanistically, during mechanical loading, a tensional increase in the D period is observed with increasing strain that is associated with: 1) molecular elongation at the triple-helical level of structure;2) increases in the gap distance between the end of one triple-helix and the start of the next one in the microfibril;and 3) molecular slippage. In this paper, we discuss the relationship between collagen hierarchical structure and its non-linear mechanical properties. Using vibrational analysis and optical coherence tomography, it is hoped that the mechanical properties of collagenous tissues can be studied in vivo in order to better understand tissue mechanics and to be better able to offer early diagnosis and differentiation of different disease states.

关键词： Collagen Fibers Mechanical Properties Optical Coherence Tomography Vibrational Analysis Tendon Skin Cartilage Elastic Arteries

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Low-intensity electrical stimulation and stem cells in a dog with acute spinal cord injury

Low-intensity electrical stimulation and stem cells in a dog...

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International Conference on biomedical engineering (IBIOMED)

作者： Eddy Krueger Lidiane M. S. Magri Agatha S. Botelho Fernando S. Bach Carmen L. K. Rebellato Letícia Fracaro Felipe Y. I. Fragoso José A. Villanova Paulo R. S. Brofman Lana Popović-Maneski Graduate Program in Biomedical Engineering Technological Federal University Curitiba Paraná Brazil Master and Doctoral Program in Rehabilitation Sciences UEL-I TNOPAR State University of Londrina Londrina Brazil Graduate Program in Biomedical Engineering Technological Federal University - Paraná Curitiba Brazil Federal University of Paraná Curitiba Brazil Pontificial Catholical University of Paraná Curitiba Brazil Institute of Technical Sciences of the Serbian Academy of Sciences and Arts Belgrade Serbia

Spinal cord injury (SCI) is classified as neurological disorder that affects motor and sensory function below the injury level. Studies show that application of low-intensity electrical stimulation (LIES) to neural tissue increases neurochemical factors responsible for regeneration as nerve growth factor. Stem cell (SC) therapy for patients with SCI can result in the replacement of injured neurons after trauma. The electromechanical delay (EMD) is defined as time elapsed between the onset of muscle electrical activation and onset of force production. A dog diagnosed with incomplete thoracolumbar SCI followed by disc hernia between the vertebral segments LI and L2, was evaluated by electromyography and mechanomyography after surgical decompression procedure, one SC transplantation and LIES. We observed motor response and decrease in the EMD from 8.25ms to 5.75ms after the procedures. The wavelet decomposition of EMG signals showed reestablishment of vastus lateralis muscle activity 30 days after the procedure. In addition, the EMG RMS increased from 3.3 µV RMS to 157 µV RMS . The preliminary results of this case report indicate positive effects of the hybrid therapy involving stem cells and low-intensity electrical stimulation after surgical decompression.

关键词： Dogs Injuries Stem cells Surgery

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Analysis of Mechanical Behavior of Composite Tissues Using Vibrational Optical Coherence Tomography

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World Journal of Mechanics 2017年第10期7卷 271-282页

作者： Frederick H. Silver Ruchit G. Shah Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School Rutgers The State University of New Jersey Piscataway NJ USA Graduate Program in Biomedical Engineering Rutgers The State University of New Jersey Piscataway NJ USA

Extracellular matrices (ECMs) found in vertebrate tissues are fiber reinforced composite materials that prevent premature mechanical failure, store, transmit, and dissipate mechanical energy generated by the musculoskeletal system. We have developed a new method using optical cohesion tomography and vibrational analysis to non-destructively and non-invasively measure the mechanical properties of composite tissues and polymeric materials. In addition, this method can be used to measure the moduli of individual components of composite materials and perform “mechanical spectroscopy” on materials. In addition, we propose that measurement of the resonant frequency of a material minimizes the viscoelastic behavior of a composite material. This approach simplifies the analysis of mechanical behavior of polymers and others materials that demonstrate time-dependence to their properties.

关键词： Collagen Fibers Elastic Fibers Dermis Mechanical Properties Optical Coherence Tomography Vibrational Analysis Skin Cartilage Bone Composites

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Desirability, availability, credit assignment, category learning, and attention: Cognitive-emotional and working memory dynamics of orbitofrontal, ventrolateral, and dorsolateral prefrontal cortices

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Brain and neuroscience advances 2018年 2卷

作者： Stephen Grossberg Center for Adaptive Systems Graduate Program in Cognitive and Neural Systems Departments of Mathematics & Statistics Psychological & Brain Sciences Biomedical Engineering Boston University Boston MA USA.

BACKGROUND:The prefrontal cortices play an essential role in cognitive-emotional and working memory processes through interactions with multiple brain regions. METHODS:This article further develops a unified neural architecture that explains many recent and classical data about prefrontal function and makes testable predictions. RESULTS:Prefrontal properties of desirability, availability, credit assignment, category learning, and feature-based attention are explained. These properties arise through interactions of orbitofrontal, ventrolateral prefrontal, and dorsolateral prefrontal cortices with the inferotemporal cortex, perirhinal cortex, parahippocampal cortices; ventral bank of the principal sulcus, ventral prearcuate gyrus, frontal eye fields, hippocampus, amygdala, basal ganglia, hypothalamus, and visual cortical areas V1, V2, V3A, V4, middle temporal cortex, medial superior temporal area, lateral intraparietal cortex, and posterior parietal cortex. Model explanations also include how the value of visual objects and events is computed, which objects and events cause desired consequences and which may be ignored as predictively irrelevant, and how to plan and act to realise these consequences, including how to selectively filter expected versus unexpected events, leading to movements towards, and conscious perception of, expected events. Modelled processes include reinforcement learning and incentive motivational learning; object and spatial working memory dynamics; and category learning, including the learning of object categories, value categories, object-value categories, and sequence categories, or list chunks. CONCLUSION:This article hereby proposes a unified neural theory of prefrontal cortex and its functions.

关键词： Category learning amygdala basal ganglia cognitive-emotional interactions contextual cueing dorsolateral prefrontal cortex frontal eye fields incentive motivational learning inferotemporal cortex orbitofrontal cortex parahippocampal cortex perirhinal cortex reinforcement learning ventral bank of the principal sulcus ventral prearcuate gyrus ventrolateral prefrontal cortex working memory

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Author Correction: Effect of de novo transcriptome assembly on transcript quantification

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Scientific reports 2019年第1期9卷 18041页

作者： Ping-Han Hsieh Yen-Jen Oyang Chien-Yu Chen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei 10617 Taiwan. Department of Computer Science and Information Engineering National Taiwan University Taipei 10617 Taiwan. Department of Bio-Industrial Mechatronics Engineering National Taiwan University Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw. Genome and Systems Biology Program National Taiwan University and Academia sinica Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Corrigendum to: Local Perturbations of Cortical Excitability Propagate Differentially Through Large-Scale Functional Networks

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Cerebral cortex (New York, N.Y. : 1991) 2020年第5期30卷 3431页

作者： Zachary P Rosenthal Ryan V Raut Ping Yan Deima Koko Andrew W Kraft Leah Czerniewski Benjamin Acland Anish Mitra Lawrence H Snyder Adam Q Bauer Abraham Z Snyder Joseph P Culver Marcus E Raichle Jin-Moo Lee Medical Scientist Training Program Washington University School of Medicine St. Louis MO 63110 USA. Graduate Program of Neuroscience Washington University School of Medicine St. Louis MO 63110 USA. Department of Neurology Washington University School of Medicine St. Louis MO 63110 USA. Department of Radiology Washington University School of Medicine St. Louis MO 63110 USA. Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA. Department of Biomedical Engineering Washington University School of Medicine St. Louis MO 63110 USA. Department of Neuroscience Washington University School of Medicine St. Louis MO 63110 USA. Department of Physics Washington University School of Medicine St. Louis MO 63110 USA.

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