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Analysis of Mechanical Behavior of Composite Tissues Using Vibrational Optical Coherence Tomography

World Journal of Mechanics 2017年第10期7卷 271-282页

作者： Frederick H. Silver Ruchit G. Shah Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School Rutgers The State University of New Jersey Piscataway NJ USA Graduate Program in Biomedical Engineering Rutgers The State University of New Jersey Piscataway NJ USA

Extracellular matrices (ECMs) found in vertebrate tissues are fiber reinforced composite materials that prevent premature mechanical failure, store, transmit, and dissipate mechanical energy generated by the musculoskeletal system. We have developed a new method using optical cohesion tomography and vibrational analysis to non-destructively and non-invasively measure the mechanical properties of composite tissues and polymeric materials. In addition, this method can be used to measure the moduli of individual components of composite materials and perform “mechanical spectroscopy” on materials. In addition, we propose that measurement of the resonant frequency of a material minimizes the viscoelastic behavior of a composite material. This approach simplifies the analysis of mechanical behavior of polymers and others materials that demonstrate time-dependence to their properties.

关键词： Collagen Fibers Elastic Fibers Dermis Mechanical Properties Optical Coherence Tomography Vibrational Analysis Skin Cartilage Bone Composites

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Desirability, availability, credit assignment, category learning, and attention: Cognitive-emotional and working memory dynamics of orbitofrontal, ventrolateral, and dorsolateral prefrontal cortices

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Brain and neuroscience advances 2018年 2卷 2398212818772179页

作者： Stephen Grossberg Center for Adaptive Systems Graduate Program in Cognitive and Neural Systems Departments of Mathematics & Statistics Psychological & Brain Sciences Biomedical Engineering Boston University Boston MA USA.

BACKGROUND:The prefrontal cortices play an essential role in cognitive-emotional and working memory processes through interactions with multiple brain regions. METHODS:This article further develops a unified neural architecture that explains many recent and classical data about prefrontal function and makes testable predictions. RESULTS:Prefrontal properties of desirability, availability, credit assignment, category learning, and feature-based attention are explained. These properties arise through interactions of orbitofrontal, ventrolateral prefrontal, and dorsolateral prefrontal cortices with the inferotemporal cortex, perirhinal cortex, parahippocampal cortices; ventral bank of the principal sulcus, ventral prearcuate gyrus, frontal eye fields, hippocampus, amygdala, basal ganglia, hypothalamus, and visual cortical areas V1, V2, V3A, V4, middle temporal cortex, medial superior temporal area, lateral intraparietal cortex, and posterior parietal cortex. Model explanations also include how the value of visual objects and events is computed, which objects and events cause desired consequences and which may be ignored as predictively irrelevant, and how to plan and act to realise these consequences, including how to selectively filter expected versus unexpected events, leading to movements towards, and conscious perception of, expected events. Modelled processes include reinforcement learning and incentive motivational learning; object and spatial working memory dynamics; and category learning, including the learning of object categories, value categories, object-value categories, and sequence categories, or list chunks. CONCLUSION:This article hereby proposes a unified neural theory of prefrontal cortex and its functions.

关键词： Category learning amygdala basal ganglia cognitive-emotional interactions contextual cueing dorsolateral prefrontal cortex frontal eye fields incentive motivational learning inferotemporal cortex orbitofrontal cortex parahippocampal cortex perirhinal cortex reinforcement learning ventral bank of the principal sulcus ventral prearcuate gyrus ventrolateral prefrontal cortex working memory

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Author Correction: Effect of de novo transcriptome assembly on transcript quantification

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Scientific reports 2019年第1期9卷 18041页

作者： Ping-Han Hsieh Yen-Jen Oyang Chien-Yu Chen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei 10617 Taiwan. Department of Computer Science and Information Engineering National Taiwan University Taipei 10617 Taiwan. Department of Bio-Industrial Mechatronics Engineering National Taiwan University Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw. Genome and Systems Biology Program National Taiwan University and Academia sinica Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Corrigendum to: Local Perturbations of Cortical Excitability Propagate Differentially Through Large-Scale Functional Networks

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Cerebral cortex (New York, N.Y. : 1991) 2020年第5期30卷 3431页

作者： Zachary P Rosenthal Ryan V Raut Ping Yan Deima Koko Andrew W Kraft Leah Czerniewski Benjamin Acland Anish Mitra Lawrence H Snyder Adam Q Bauer Abraham Z Snyder Joseph P Culver Marcus E Raichle Jin-Moo Lee Medical Scientist Training Program Washington University School of Medicine St. Louis MO 63110 USA. Graduate Program of Neuroscience Washington University School of Medicine St. Louis MO 63110 USA. Department of Neurology Washington University School of Medicine St. Louis MO 63110 USA. Department of Radiology Washington University School of Medicine St. Louis MO 63110 USA. Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA. Department of Biomedical Engineering Washington University School of Medicine St. Louis MO 63110 USA. Department of Neuroscience Washington University School of Medicine St. Louis MO 63110 USA. Department of Physics Washington University School of Medicine St. Louis MO 63110 USA.

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1014 Sleep Monitoring in Mild Cognitive Impairment Using Noninvasive, Under the Sheet Sensors

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Sleep 2018年第SUPPL_1期41卷 A376-A376页

作者： Almaghasilah, A Daigle, K Gilbert, C Sulinski, E Aronis, J Bouchard, A Delp, T Singer, C Abedi, A Hayes, M Electrical and Computer Engineering University of Maine Orono ME Psychological Sciences University of Maine Orono ME Geriatric Neuropsychiatry Program Acadia Hospital Bangor ME Graduate School of Biomedical Sciences & Engineering Orono ME

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Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study

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Alzheimer's & dementia : the journal of the Alzheimer's Association 2025年第6期21卷 e70311页

作者： Haeok Lee Marian Tzuang Tiffany W Chow Younhee Kang Boon Lead Tee Clara Li Eleanor Lam Yian Gu SangA Lee Pei-Chuan Ho Guerry Peavy Eun Hyun Seo Kyungmin Kim Binh Tran Wonjeong Chae Dat Nguyen Namkhue Vo Deanna Dang Jessica Spat-Lemus Yun-Beom Choi Howard Feldman Gyungah R Jun Li-San Wang Wai Haung Yu Van Ta M Park Meyers College of Nursing New York University New York New York USA. Department of Community Health Systems University of California San Francisco School of Nursing San Francisco California USA. Penn Neurodegeneration Genomics Center Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. College of Nursing Graduate Program in System Health Science and Engineering Ewha Womans University Seoul Republic of Korea. Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California San Francisco California USA. Global Brain Health Institute University of California San Francisco California USA. Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA. Brain Health and Imaging Center and Geriatric Mental Health Services Centre for Addiction and Mental Health Toronto Ontario Canada. Department of Neurology Columbia University Medical Center New York New York USA. Mo-Im Kim Nursing Research Institute College of Nursing Yonsei University Seoul Republic of Korea. The Leonard and Davis Institute of Health Economics University of Pennsylvania Philadelphia Pennsylvania USA. Department of Neurosciences University of California San Diego La Jolla California USA. Premedical Science College of Medicine Chosun University Gwangju Republic of Korea. Department of Child Development and Family Studies College of Human Ecology Seoul National University Seoul Republic of Korea. American Pacific Health Foundation La Jolla California USA. Graduate School of Public Health Yonsei University Seoul Republic of Korea. Retired Fountain Valley California USA. Alzheimer's Disease Cooperative Study University of California San Diego La Jolla California USA. Institute for Memory Impairments and Neurological Disorders University of California Irvine Irvine California USA. Department of Medicine/Neurology Englewood Health Engle

INTRODUCTION:The availability of sociocultural and language-appropriate study materials and instruments is critical for the assessment of cognitive function in people from diverse backgrounds. This report describes the translations and cultural adaptations of study materials for the Asian Cohort for Alzheimer's Disease (ACAD) study. METHODS:We performed translations and cultural adaptations in accordance with the World Health Organization (WHO) translation guidelines to ensure reliable, complete, and culturally appropriate translations from English to the specified Asian languages. RESULTS:We developed Asian language versions of the ACAD documents (consent, data collection packet, and community and social media outreach materials) reflecting the sociocultural backgrounds of the ACAD target population (i.e., older Asian adults) DISCUSSION: The multistep translation process accounting for distinctive Asian sociocultural and language backgrounds provides an important guideline for Alzheimer's disease and related dementias (ADRD) researchers to promote health literacy and research with underrepresented Asian American and Canadian adults. HIGHLIGHTS:Asian American and Asian Canadian older adults are the fastest-growing populations. A lack of linguistically and culturally appropriate cognitive assessment tools creates barriers for quality healthcare and clinical research. We report the translations and cultural adaptations of the Asian Cohort for Alzheimer's Disease (ACAD) study materials into Chinese, Korean, and Vietnamese. This translation methodology should be extended to Asian Indians, Filipinos, and other Asian American or Asian Canadian populations.

关键词： Alzheimer's disease Asian cognitive assessment community‐based participatory research cultural adaptation dementia translation

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Nanofiltration of extracellular vesicles from human plasma & their on-chip qualification and quantification with a NanoBioAnalytical platform

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Meta Gene 2018年 17卷 S7-S7页

作者： Obeid Sameh Benoît Le Roy de Boiseaumarie Celine Elie-Caille Wilfrid Boireau Ming Li Chou Thierry Burnouf Pei-Shan Sung Shie-Liang Hsieh Institut FEMTO-ST Univ. Bourgogne Franche Comté CNRS France Graduate Institute of Biomedical Material and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taiwan Institute of Clinical Medicine National Yang Ming University Taipei Taiwan Genomic Research Center Academia Sinica Taiwan Department of Medical Research Taipei Veterans General Hospital Taiwan

One complication of plasma transfusion is non-immune transfusion related acute lung injury (TRALI), which is associated with the formation of neutrophil extracellular traps (NETs) resulting from polymorphonuclear neutrophil (PMN) activation. Activated platelets have recently been shown to trigger NETs formation. We hypothesized that (a) NETs could be promoted by platelet derived microparticles (PMPs) and (b) that 75 nm-nanofiltration of plasma, by removing parts of PMPs, could avoid NETs formation. To better characterize the large spectrum of size and concentration of PMPs in complex media, we combined conventional approaches (Flow Cytometry, TRPS) with an original nanobioanalytical (NBA) platform based on Surface Plasmon Resonance imaging (SPRi) and Atomic Force Microscopy (AFM) techniques. We will demonstrate that this new analytic solution allows: • a label-free follow-up of PMPs capture in real time from various complex media, • a multiplex detection of different PMPs subpopulations, • the determination of the size and morphology of captured PMPs in a range of 20 nm to 1 μm their proteomic studies. We expect that such platform will contribute to (i) a better understanding of the physiological function of Evs subpopulations, (ii) the discovery of specific biomarkers and (iii) to therapeutic follow-up.

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Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

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Nature neuroscience 2020年第1期23卷 152页

作者： Rianne D Stowell Grayson O Sipe Ryan P Dawes Hanna N Batchelor Katheryn A Lordy Brendan S Whitelaw Mark B Stoessel Jean M Bidlack Edward Brown Mriganka Sur Ania K Majewska Department of Neuroscience University of Rochester Medical Center Rochester NY USA. Neuroscience Graduate Program University of Rochester Medical Center Rochester NY USA. Picower Institute for Learning and Memory Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA USA. Department of Pharmacology and Physiology University of Rochester Medical Center Rochester NY USA. Department of Biomedical Engineering University of Rochester Rochester NY USA. Department of Neuroscience University of Rochester Medical Center Rochester NY USA. ania_majewska@urmc.rochester.edu. Center for Visual Science University of Rochester Medical Center Rochester NY USA. ania_majewska@urmc.rochester.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Consistency of Surface Electromyography Assessment at Lower Limb Selected Muscles During Vertical Countermovement

Consistency of Surface Electromyography Assessment at Lower ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Carlos Rodrigues Miguel Correia Joao M. C. S. Abrantes Jurandir Nadal Marco A. Benedetti Rodrigues Centre for Biomedical Engineering Research INESC TEC Porto Portugal INESC TEC FEUP Department of Electrical and Computer Engineering University of Porto Porto Portugal MovLab ULHT PEB UFRJ PPGEE UFPE Graduate Program in Electrical Engineering Federal University of Pernambuco Recife Brazil

Given the difficulty of invasive methods to assess muscle action during natural human movement, surface electromyography (sEMG) has been increasingly used to capture muscle activity in relation to kinesiological analysis of specific tasks. Isolated isometric, concentric and eccentric forms of muscle action have been receiving the most attention for research purposes. Nevertheless natural muscle action frequently involves the use of a preceding eccentric muscle action as a form of potentiation of immediate muscle concentric action, in what is designated as muscle stretch-shortening cycle (SSC). The most frequently applied protocols for the evaluation of SSC on vertical jumps are by virtue of their reproducibility and control of experimental conditions, squat jump (SJ) without countermovement (CM), countermovement jump (CMJ) with long CM and drop jump (DJ) with short CM. The methods used to extract information and relationship of the captured signals also present a high diversity, with the question about the consistency of the methods and obtained results. The objective of this study is to evaluate the consistency of the analysis and results by applying different EMGs signal analysis techniques related to strategic muscle groups of the lower limbs at different countermovement evaluated in vertical jumps. Raw sEMG signals of 5 lower limb muscles of 6 subjects during SJ, CMJ and DJ were rectified, filtered and obtained their envelope, and then correlated (CR) for detection of synergistic, agonist and antagonist activity, applied principal component analysis (PCA) for the detection of uncorrelated components explaining maximum variability and normalized cross-correlation (CCRN) for detection of maximum correlations and time lag. CR of EMG envelopes presented higher coactivities (CoA) in DJ relative to SJ and these CoA superior to CMJ with greater synergy in DJ relative to SJ and CMJ that present several loop cycles corresponding to time lag of activity. CCRN of the EMG e

关键词： Muscles Correlation Electromyography Principal component analysis Eigenvalues and eigenfunctions Electronic mail Radio frequency

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Cognitive priority model for advanced telemedical support in Limited Bandwidth Applications

Cognitive priority model for advanced telemedical support in...

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IEEE Canadian Conference on Electrical and Computer engineering

作者： Thomas E. Doyle David. M. Musson Taralyn Schwering McMaster eHealth Graduate Program Electrical and Computer Engineering School of Biomedical Engineering McMaster University Hamilton Ontario Canada Undergraduate Medical Education Northern Ontario School of Medicine Thunder Bay Ontario Canada Electrical and Computer Engineering McMaster University Hamilton Ontario Canada

Telemedicine offers the ability to provide real-time medical support, education, and care to remote and austere locations under limited bandwidth restrictions. These types of communication channels can easily be overwhelmed and delays or interruptions make communication difficult, if not impossible. These interruptions destroy the temporal orientation of communication resulting in significant cognitive loading. The objective of this research was to lower cognitive load and minimize digital communication bandwidth by developing a priority model from perceptual quality and content focus of telemedical video. H.264/AVC encoding was used to encode two types of medical context with varying bitrates, frame rates, and frame sizes. Telemedical video contexts were room awareness, and medical procedure. Objective quality and subjective quality tests were performed using Structural Similarity (SSIM) and perceptual feedback, respectively. The objective of this research is to develop context specific telemedicine communication models for the highest perceptual quality for available bandwidth for the purpose of increased temporal orientation and decreased cognitive load. Our research presents a method to select the best encoding parameters (maximum bitrate, frame rate and frame size) for the medical context to minimize bandwidth and maintain diagnostic and education quality.

关键词： biomedical Telemetry Telemedicine Telematics Medical Information Systems Medical Services Temporal Orientation Cognitive Load

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