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MA 06.12 Genomic Rearrangements of Lung Adenocarcinomas with Fusion Driver Gene

Journal of Thoracic Oncology 2017年第11期12卷 S1824-S1824页

作者： S. Park J. Lee K. Yi K.H. Kang Y.T. Kim Y.S. Ju Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology Daejeon/KR Korea Institute of Science and Technology Information Daejeon/KR Biomedical Science and Engineering Interdisciplinary Program Korea Advanced Institute of Science and Technology Daejeon/KR Department of Thoracic Surgery Seoul National University Hospital Seoul/KR

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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Balance perturbation leads a stretching reflexion on tibialis anterior muscle 8

Balance perturbation leads a stretching reflexion on tibiali...

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8th International Conference on Bio-Inspired Systems and Signal Processing, BIOSIGNALS 2015

作者： Corrêa, Renata Gonçalves Pinheiro Aguiar, Matheus Lucas Papcke, Caluê Neves, Eduardo Borba Vieira, Agnelo Denis Scheeren, Eduardo Mendonça Pontifícia Universidade Católica Do Paraná Polytecnic School Health Tecnology Graduate Program Rua Imaculada Conceição 1155 Curitiba Brazil Universidade Tecnologica Federal Do Paraná Biomedical Engineering Graduate Program Curitiba Brazil

ISBN: (纸本)9789897580697

Human posture control is a sophisticated process involving the relationship among multiple joints, muscle groups and environment. The aim of this study is to show how the balance perturbation (in posterioranterior direction) leads to a stretching reflexion on the tibialis anterior (TA) muscle. A case study that involved a male participant with 23 years old. To disturb the participant's balance, it has been employed a specially plataform designed with dimensions 1.5 m by 1.5 m with movement of 5 mm of amplitude on a total time of 3 ms along the axis coinciding with participant's anterior-posterior axis. Soleus (SO) and TA electromyography signal (EMG) has been recorded. Perturbation in the equilibrium was delivered in the posterior-anterior direction. The first event observed was the pre-activation of the TA muscle that leads a reduction in the SO muscle activation, due the stretch reflex at TA.

关键词： Muscle

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Nanorobotics in Drug Delivery Systems for Treatment of Cancer： A Review

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材料科学与工程（中英文A版） 2016年第3期6卷 167-180页

作者： Glecia Virgolino da Silva LUZ Post-Graduate Program in Biomedical Engineering Campus Gama-FGA University of Brasilia-UnB Brasilia 72444-240 Brazil Pharmaceutical Technology and Quality Control of Medicines University Center of Distrito Federal-UDF Brasilia 70390-045Brazil University of Brasilia-UnB/ UnB at Gama-FGA Brasilia 72444-240 Brazil Post-Graduate Program in Health Sciences Campus Darcy Ribeiro University of Brasilia-UnB Brasilia 70910-900 Brazil Nanotechnology Laboratory- University of Brasilia at Gama (NANOTEC-FGA/UnB) Brasilia 72444-240 Brazil

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Ultrastructural Imaging of Collagen Fibrils in Mouse Model of Abdominal Aortic Aneurysm

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Microscopy and Microanalysis 2016年第S3期22卷 1196-1197页

作者： Jeffrey R Tonniges Ben Albert Edward Calomeni Chetan Hans Gunjan Agarwal Biophysics Graduate Program The Ohio State University Columbus OH USA Department of Biomedical Engineering The Ohio State University Columbus OH USA Renal Pathology and Electron Microscopy lab Wexner Medical Center Columbus OH USA Center for Cardiovascular Research Nationwide Children’s Hospital Columbus OH USA

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Cell‐Membrane engineering: engineering Cell Surface Function with DNA Origami (Adv. Mater. 46/2017)

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Advanced Materials 2017年第46期29卷

作者： Ehsan Akbari Molly Y. Mollica Christopher R. Lucas Sarah M. Bushman Randy A. Patton Melika Shahhosseini Jonathan W. Song Carlos E. Castro Department of Mechanical and Aerospace Engineering The Ohio State University Columbus OH 43210 USA Department of Biomedical Engineering The Ohio State University Columbus OH 43210 USA Department of Mechanical and Aerospace Engineering The Ohio State University Comprehensive Cancer Center The Ohio State University Columbus OH 43210 USA Department of Mechanical and Aerospace Engineering Biophysics Graduate Program The Ohio State University Columbus OH 43210 USA

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

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Genomics 2020年第2期112卷 1223-1232页

作者： Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Adeline Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda H Dean Hosgood Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Electronic address: jason.wong@nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan. Department of Pathology Queen Mary Hospital The University of Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Saw Swee Hock School of Public Health National University of Singapore Singapore. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc Gaithersburg MD USA Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

关键词： Lung adenocarcinoma Lung cancer Mendelian randomization Pathway analysis Tuberculosis

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Neural stem cells attacked by Zika virus

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细胞研究（英文版） 2016年第7期26卷 753-754页

作者： Ha Nam Nguyen Xu yu Qian Hong jun Song Guo-li Ming Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Biomedical Engineering Graduate Program Johns Hopkins University School of Medicine Baltimore MD 21205 USA Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA The Solomon Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA The Solomon Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore MD 21205 USA

The current outbreak of Zika virus-associated diseases in South America and its threat to spread to other parts of the world has emerged as a global health *** from cell and animal models to understand how Zika virus ... 详细信息

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Corrigendum to "A mixed-effects model approach for the statistical analysis of vocal fold viscoelastic shear properties" [J. Mech. Behav. Biomed. Mater. 75 (2017) 477-485]

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Journal of the mechanical behavior of biomedical materials 2018年 79卷 114页

作者： Chet C Xu Roger W Chan Han Sun Xiaowei Zhan Department of Otolaryngology-Head and Neck Surgery University of Texas Southwestern Medical Center Dallas TX 75390 USA Graduate Program in Biomedical Engineering University of Texas Southwestern Medical Center Dallas TX 75390 USA. Electronic address: che.xu@utsouthwestern.edu. Department of Speech Language Pathology National Taipei University of Nursing and Health Sciences Taipei Taiwan. Department of Quantitative Health Sciences the Cleveland Clinic Foundation Cleveland OH 44195 USA Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland OH 44106 USA. Department of Clinical Science University of Texas Southwestern Medical Center Dallas TX 75390 USA.

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Human Bone Xenografts: from Preclinical Testing for Regenerative Medicine to Modeling of Diseases

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Current Molecular Biology Reports 2016年第3期2卷 158-170页

作者： Mark Seow Khoon Chong Chaolemeng Bao King Pan Ng Jing Lim Jerry Kok Yen Chan Division of Bioengineering School of Chemical and Biomedical Engineering Nanyang Technological University Singapore Singapore Department of Obstetrics and Gynaecology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Cancer and Stem Cell Biology Program Duke-NUS Graduate Medical School Singapore Singapore Department of Reproductive Medicine KK Women’s and Children’s Hospital Singapore Singapore

Xenografting involves the transplantation of human tissue or cells into animal models and is an important tool for regenerative medicine research. Implantation of engineered human bone tissues into animal models, for example, is performed in preclinical evaluations of product safety and efficacy. With the advent of improved experimental methodologies, these models are further being exploited to interrogate molecular mechanisms and physiological interactions in vivo. In parallel to these developments, patient-derived xenograft murine models of cancer are increasingly being studied for various applications in cancer research and therapy; it follows that xenograft models in tissue engineering may be adapted for such approaches. In this review, we first discuss the development of human bone xenograft models to recapitulate physiological states in regenerative medicine. Subsequently, we discuss the use of these techniques for applications in modeling pathological states in skeletal oncology, namely, hematopoietic malignancies, bone metastatic disease, and primary bone malignancy.

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