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Objective detection of Steady State Visual Evoked Responses for different lighting conditions

Journal of Physics: Conference Series 2013年第1期477卷

作者： A M Tannus C J Tierra-Criollo D B Melges Graduate Program in Electrical Engineering – Federal University of Minas Gerais -Av. Antônio Carlos 6627 31270-901 Belo Horizonte MG Brazil Biomedical Engineering Program – Federal University of Rio de Janeiro – Av. Horácio de Macedo 2030 21941-914 Rio de Janeiro RJ Brazil

This work aims at evaluating the performance of two Objective Response Detection (ORD) techniques: the Magnitude-Squared Coherence (MSC) and the Multiple Coherence (MC) for detecting Steady State Visual Evoked Response (SSVEP) for two different lighting conditions (scotopic and photopic). EEG signals were collected (using a wireless headset) from ten volunteers without history of neurological diseases during stimulation with white LED flickering at frequencies of 6, 7, 8, 9, 10 and 11 Hz. The experimental protocol was composed by 13 sessions in a dark room and 13 in a bright one. The frequency order was randomized. The MSC was applied to derivations [P7], [P8], [O1] and [O2], and MC to the combinations of leads [O1-O2], [O1-O2-P7], [O1-O2-P8] and [O1-O2-P7-P8]. Both estimates were calculated using M = 11 epochs. The detection rates for MSC presented an important decrease at photopic condition compared to the scotopic one for all derivations and all frequencies. The employment of MC to [O1-O2-P7-P8] allowed overcoming this limitation, leading to detection percentages of at least 80% for all frequencies (except 9 Hz). These results show that MC is a promising technique for building SSVEP Bran Computer Interfaces (BCI).

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Proceedings of the 3rd IPLeiria's International Health Congress Abstracts

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BMC HEALTH SERVICES RESEARCH 2016年第3期16卷 111-242页

作者： [Anonymous] Health Sciences Research Unit: Nursing Collegue of College of Health Technology of Coimbra Coimbra Portugal Sisters Hospitallers of the Sacred Heart of Jesus Casa de Saúde Rainha Santa Isabel Coimbra Portugal Research Unit for Sport and Physical Activity Faculty of Sport Sciences and Physical Education University of Coimbra Coimbra Portugal Complementary Sciences- INESCC Coimbra Portugal CUF Hospitals Lisbon Portugal Breast Unit Champalimaud Clinical Center Lisbon Portugal Swiss Centre for Medical Simulation & Swiss Association of Simulation in Healthcare Basel Switzerland Basel University Hospital Basel Switzerland HELPO Association Cascais Portugal Centro de Linguística Universidade de Lisboa Lisboa Portugal Centro Superior de Estudios Universitarios La Salle Madrid Spain Universidade da Madeira Funchal Portugal Serviço de Saúde da Região Autónoma da Madeira E.P.E. Funchal Portugal Escola Superior de Enfermagem de Lisboa Lisboa Portugal Instituto Superior Miguel Torga Coimbra Portugal Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo Comportamental Universidade de Coimbra Coimbra Portugal Escola Superior de Saúde de Leiria & Unidade de Investigação em Saúde Instituto Politécnico de Leiria Leiria Portugal National School of Public Health & Centro de Investigação em Saúde Pública Universidade Nova de Lisboa Lisboa Portugal Agrarian Superior School Polytechnic Institute of Viseu Viseu Portugal Laboratory of Microbiology Department of Biological Sciences Faculty of Pharmacy University of Porto Porto Portugal Unit for Multidisciplinary Biomedical Research Institute of Biomedical Sciences Abel Salazar University of Porto Porto Portugal Agrupamento de Centros de Saúde (ACES) Baixo Mondego Figueira da Foz Portugal Universidade de Trás-os-Montes e Alto Douro Vila Real Portugal Centro de Salud La Paz Badajoz España Centro de Salud San Fernando Badajoz España Complejo Hospitalario Universitario de Badajoz Badajoz España Hospital Don Beni

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Objective Response Detection of Multiple Auditory Steady-State Responses: Rice Detector vs Component Synchrony Measure

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Journal of Physics: Conference Series 2013年第1期477卷

作者： J J Silva T Santos C J Tierra-Criollo D B Melges Graduate Program in Electrical Engineering – Federal University of Minas Gerais – Av. Antônio Carlos 6627 31270-901 Belo Horizonte MG Brazil Graduate Program in Neuroscience – Federal University of Minas Gerais – Av. Antônio Carlos 6627 31270-901 Belo Horizonte MG Brazil Biomedical Engineering Program – Federal University of Rio de Janeiro – Av. Horácio de Macedo 2030 21941-914 Rio de Janeiro RJ Brazil

Multiple auditory steady state responses (MASSR) is used to assess the integrity auditory pathways for different frequencies applied simultaneously without significant increases in exam time. Objective Response Detection (ORD) techniques have been employed for hearing screening since it conducts to response identification with statistical basis. This work aims at comparing time and detection rate of two ORD, Rice detector (RD) and Component Synchrony Measure (CSM). The binaural auditory stimulation was applied to 21 normal hearing infants and consisted of four amplitude-modulated (AM) tones presented simultaneously on each ear with the carriers 500, 1000, 2000 and 4000 Hz, and at 50 and 40 dBSPL intensity levels. The CSM presented higher detection rates than RD for all carriers, both intensities and ears (statistical difference, assessed by proportion test with significance level of alfa=0.05, only for 500 Hz in both ears and for 1000 Hz in the left ear). Moreover, detection times were lower for CSM compared to RD (unpaired Wilcoxon rank-sum test with alfa=0.05 indicated statistical difference for 1000 Hz at 50 dBSPL and 2000 Hz at 50 dBSPL both for the left ear). Hence, the CSM could be considered more effective for hearing screening purposes.

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Progressive alterations in biomechanical response of a mouse model of aneurysm

Progressive alterations in biomechanical response of a mouse...

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ASME 2012 Summer Bioengineering Conference, SBC 2012

作者： Haskett, Darren Utzinger, Urs Azhar, Mohamad Geest, Jonathan Vande Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ 85721 United States Department of Biomedical Engineering University of Arizona Tucson AZ 85721 United States BIO5 Institute University of Arizona Tucson AZ 85721 United States Department of Cell Biology and Anatomy University of Arizona Tucson AZ 85721 United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ 85721 United States

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Identification of drowsiness and alertness conditions by means of Spectral F-Test applied to pupillometric signals

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Journal of Physics: Conference Series 2013年第1期477卷

作者： V C G Soares J K S Souza G E Ginani S Pompéia C J Tierra-Criollo D B Melges Graduate Program in Electrical Engineering – Federal University of Minas Gerais – Av. Antônio Carlos 6627 31270-901 Belo Horizonte MG Brazil UNIFESP/ Psychobiology Department Federal University of São Paulo São Paulo Brazil UFRJ/Biomedical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil

The autonomous regulation of pupil size provides an objective physiological measure of alertness level. Pupil diameter decreases and its fluctuations increase during drowsiness. In this work, a statistical based technique in frequency domain, known as Spectral F-Test (SFT), was applied in order to compare the power of pupillometric signals measured in two conditions, wakefulness and sleepiness, from eleven volunteers. SFT was calculated based on Welch Periodograms of time series of pupil diameter (TSPD) signals. The median power for TSPD in two conditions and each volunteer at frequencies bellow 0.8 Hz were compared by means of the paired Wilcoxon signed-rank test. The percentages of volunteers for whom power during drowsiness were statistically higher than power during alertness achieved 100% for several frequencies bellow 0.2 Hz. For frequencies from 0.2 to 0.8 Hz, the percentages presented high variability, fluctuating from 40 to 90%. The Wilcoxon test indicated that median power of TSPD during drowsiness was higher than TSPD during alertness for frequencies bellow 0.2 Hz presented statistical difference. Hence, the SFT showed to be a suitable tool for drowsiness/alertness differentiation that could be applied to sleep studies.

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Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

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Human molecular genetics 2016年第3期25卷 620-9页

作者： Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Yun-Chul Hong Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA wangzha@mail.nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Division of Genome Biology National Cancer Center Hospital Tokyo Japan. Institute of Population Health Sciences. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China. Epidemiology and Prevention Group Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan. Shanghai Pulmonary Hospital Shanghai China. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Preventive Medicine. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Cancer Genome Biology Group Institute of Predictive and Personalized Medicine of Cancer Barcelona Spain. Department of Medical Oncology Japanese Red Cross Medical Center Tokyo Japan. Laboratory for Genotyping Development RIKEN Center for Integrative Medical Sciences Yokohama Japan. Laboratory of Molecular Medicine Human Genome Center Institute of Medical Science University of Tokyo Tokyo Japan. Division of Thoracic Surgery Kinki University School of Medicine

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.

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Exploring Possibilities for Real-Time Muscle Dynamics State Estimation from EMG signals

Exploring Possibilities for Real-Time Muscle Dynamics State ...

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IEEE RAS & EMBS International Conference on biomedical Robotics and Biomechatronics

作者： Luciano L. Menegaldo The Alberto Luiz Coimbra Institute for Graduate Studies and Research in Engineering Biomedical Engineering Program (PEB/COPPE) Universidade Federal do Rio de Janeiro

ISBN: (纸本)9781457711992

Real-time estimation of muscle state (activation, force and length) can be used for visualization of muscle function in neuromuscular rehabilitation and control of wearable assistive and augmenting devices. This paper proposes two formulations for developing linear state estimations of muscle dynamics in isometric contractions: the Luemberger observer and the Kalman filter. One of the main requirements of an estimator for such application is small lag, and a Finite Impulse Response (FIR) pre-filter was used to eliminate part of the high-frequency content of the EMG signal. A run test with human soleus EMG sample was performed. Both Luemberger observer and Kalman filter provided reasonably accurate estimations of the muscle state, compared to usual off-line EMG-driven analysis. In addition, the role of some Kalman filter parameters is analyzed.

关键词： Electromyogram State estimation Kalman filters muscles filter parameters Frequency spectra Time Estimation muscle function signals

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3D prostate histology image reconstruction: Quantifying the impact of tissue deformation and histology section location

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Journal of pathology informatics 2013年第1期4卷 31页

作者： Eli Gibson Mena Gaed José A Gómez Madeleine Moussa Stephen Pautler Joseph L Chin Cathie Crukley Glenn S Bauman Aaron Fenster Aaron D Ward Robarts Research Institute London Canada Graduate Program in Biomedical Engineering London Canada. Lawson Health Research Institute London Canada Department of Pathology The University of Western Ontario London Canada. Department of Urology The University of Western Ontario London Canada. Lawson Health Research Institute London Canada. Department of Oncology The University of Western Ontario London Canada. Graduate Program in Biomedical Engineering London Canada Department of Oncology The University of Western Ontario London Canada Department of Medical Biophysics The University of Western Ontario London Canada.

BACKGROUND:Guidelines for localizing prostate cancer on imaging are ideally informed by registered post-prostatectomy histology. 3D histology reconstruction methods can support this by reintroducing 3D spatial information lost during histology processing. The need to register small, high-grade foci drives a need for high accuracy. Accurate 3D reconstruction method design is impacted by the answers to the following central questions of this work. (1) How does prostate tissue deform during histology processing? (2) What spatial misalignment of the tissue sections is induced by microtome cutting? (3) How does the choice of reconstruction model affect histology reconstruction accuracy? MATERIALS AND METHODS:Histology, paraffin block face and magnetic resonance images were acquired for 18 whole mid-gland tissue slices from six prostates. 7-15 homologous landmarks were identified on each image. Tissue deformation due to histology processing was characterized using the target registration error (TRE) after landmark-based registration under four deformation models (rigid, similarity, affine and thin-plate-spline [TPS]). The misalignment of histology sections from the front faces of tissue slices was quantified using manually identified landmarks. The impact of reconstruction models on the TRE after landmark-based reconstruction was measured under eight reconstruction models comprising one of four deformation models with and without constraining histology images to the tissue slice front faces. RESULTS:Isotropic scaling improved the mean TRE by 0.8-1.0 mm (all results reported as 95% confidence intervals), while skew or TPS deformation improved the mean TRE by <0.1 mm. The mean misalignment was 1.1-1.9(°) (angle) and 0.9-1.3 mm (depth). Using isotropic scaling, the front face constraint raised the mean TRE by 0.6-0.8 mm. CONCLUSIONS:For sub-millimeter accuracy, 3D reconstruction models should not constrain histology images to the tissue slice front faces and should be flexib

关键词： 3D histology reconstruction Correlative histopathology image registration prostate cancer imaging validation

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rTMS as a Treatment of Alzheimer's Disease with and without Comorbidity of Depression: A Review

Neuroscience journal

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Neuroscience journal 2013年第1期2013卷 679389页

作者： Grant Rutherford Rebecca Gole Zahra Moussavi Department of Electrical and Computer Engineering University of Manitoba Winnipeg MB Canada R3T 5V6 Graduate Program in Biomedical Engineering Faculty of Engineering University of Manitoba Winnipeg MB Canada R3T 5V6. Department of Electrical and Computer Engineering University of Manitoba Winnipeg MB Canada R3T 5V6. Graduate Program in Biomedical Engineering Faculty of Engineering University of Manitoba Winnipeg MB Canada R3T 5V6 Riverview Health Center 1 Morley Avenue Winnipeg MB Canada R3L 2P4.

With an ever-increasing population of Alzheimer's disease (AD) patients worldwide, a noninvasive treatment for AD is needed. In this paper, the application of repetitive transcranial magnetic stimulus (rTMS) as a treatment for patients with probable AD is compared to the application of rTMS as a treatment for depression. Comorbidity of depression and dementia is discussed, as well as possible links between the two diseases. The possible confounding antidepressant effects of rTMS on cognitive improvements in AD patients are discussed.

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Investigations of capacitively-coupled EEG electrode for use in brain-computer interface

Investigations of capacitively-coupled EEG electrode for use...

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IEEE International Conference on Systems, Man and Cybernetics

作者： Hyun Jae Baek Hong Ji Lee Yong Gyu Lim Kwang Suk Park Graduate Program in Bioengineering Seoul National University Seoul South Korea Department of Oriental Biomedical Engineering Sangji University Wonju South Korea Department of Biomedical Engineering Seoul National University Seoul South Korea

In this paper, the preliminary investigation for application of capacitive electroencephalogram (EEG) measurement for brain-computer interface (BCI) is described. EEG was obtained by active electrodes that very high input impedance pre-amplifier circuit was mounted on the electrodes. This method enabled EEG measurements through hair without direct contact with scalp and conductive gel applications. The presented electrode was attached to the normal usual baseball cap for nonintrusive daily or long-term use. Subject wore electrode installed baseball cap and EEG signal was measured under experimental BCI paradigms such as alpha wave, steady-state visual evoked potential, P300, auditory steady-state response and motor imagery. The results showed that further studies are still required to apply capacitive sensing methods to clinical neurosciences, however, it can be concluded that steady of the art capacitive electrode technology can be used for engineering applications using current popular BCI paradigms.

关键词： Electrodes Electroencephalography Hair Scalp Brain computer interfaces Impedance

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