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ESICM LIVES 2016: part two

Intensive Care Medicine Experimental 2016年第1期4卷 205-404页

作者： S. Sivakumar F. S. Taccone K. A. Desai C. Lazaridis M. Skarzynski M. Sekhon W. Henderson D. Griesdale L. Chapple A. Deane L. Williams R. Strickland K. Lange D. Heyland M. Chapman M. J. Rowland P. Garry J. Westbrook R. Corkill C. A. Antoniades K. T. Pattinson G. Fatania A. J. Strong R. B. Myers C. M. Jermaine C. S. Robertson C. G. Rusin J. Hofmeijer L. Sondag M. C. Tjepkema-Cloostermans A. Beishuizen F. H. Bosch M. J. A. M. van Putten L. Carteron C. Patet D. Solari M. Oddo M. A. Ali C. Dias R. Almeida A. Vaz-Ferreira J. Silva E. Monteiro A. Cerejo A. P. Rocha A. A. Elsayed A. M. Abougabal B. N. Beshey K. M. Alzahaby S. Pozzebon A. Blandino Ortiz S. Cristallini O. Lheureux A. Brasseur J. L. Vincent J. Creteur M. Hravnak K. Yousef Y. Chang E. Crago R. M. Friedlander S. A. Abdelmonem S. A. Tahon T. A. Helmy H. S. Meligy F. Puig I. Dunn-Siegrist J. Pugin S. Gupta D. Govil S. Srinivasan S. J. Patel J. K. N A. Gupta D. S. Tomar M. Shafi R. Harne D. P. Arora N. Talwar S. Mazumdar E. E. Papakrivou D. Makris E. Manoulakas B. Tsolaki B. Karadodas E. Zakynthinos I. Palacios Garcia A. Diaz Martin V. Sanchez Encinares M. Pachón Ibañez J. Garnacho Montero G. Labrador T. Cebrero Cangueiro V. Poulose J. Koh J. W. Kam H. Yeter A. Kara O. Aktepe A. Topeli I. Tsolakoglou G. Intas P. Stergiannis A. A. Kolaros E. Chalari E. Athanasiadou A. Martika G. Fildisis V. Faivre C. Mengelle B. Favier D. Payen A. Poppe M. S. Winkler E. Mudersbach J. Schreiber M. L. Wruck E. Schwedhelm S. Kluge C. Zöllner T. Tavladaki A. M. Spanaki H. Dimitriou E. Kondili C. Choulaki E. Meleti D. Kafetzopoulos D. Georgopoulos G. Briassoulis A. García-de la Torre M. V. de la Torre-Prados T. Tsvetanova-Spasova P. Nuevo-Ortega C. Rueda-Molina A. Fernández-Porcel E. Camara-Sola L. Salido-Díaz A. García-Alcántara D. E. Meleti B. Suberviola J. Riera L. Rellan M. Sanchez J. C. Robles E. Lopez R. Vicente E. Miñambres M. Santibañez M. Le Guen J. Moore N. Mason M. Windpassinger O. Plattner E. Mascha D. I. Sessler Outcomes Research U. Melia J. Fontanet J. P. van den Berg M. Baylor College of Medicine Neurology/Neurocritical Care Houston USA Erasmus Hospital Intensive Care Medicine Brussels Belgium Centre Hospitalier Régional Orléans Réaimation Médicale Orléans France University of British Columbia Vancouver Canada University of Adelaide Discipline of Acute Care Medicine Adelaide Australia Royal Adelaide Hospital Intensive Care Adelaide Australia Griffith University Menzies Health Institute of Queensland Gold Coast Australia University of Adelaide Discipline of Medicine Adelaide Australia Kingston General Hospital Clinical Evaluation Research Unit Kingston Canada University of Oxford Nuffield Department of Clinical Neurosciences Oxford UK Oxford University Hospitals NHS Foundation Trust Neurosciences Intensive Care Unit Oxford UK King’s College Hospital Department of Neurosurgery London UK King’ College London Institute of Psychiatry Psychology and Neuroscience Department of Clinical Neuroscience London UK Rice University Computer Science Houston USA Baylor College of Medicine Neurosurgery Houston USA Baylor College of Medicine Pediatric Cardiology Houston USA University of Twente Clinical Neurophysiology Enschede Netherlands Rijnstate Hospital Neurology Arnhem Netherlands Medical Spectrum Twente Clinical Neurophysiology Enschede Netherlands Medical Spectrum Twente Intensive Care Enschede Netherlands Rijnstate Hospital Intensive Care Arnhem Netherlands CHUV Department of Intensive Care Medicine Neuroscience Critical Care Research Group Lausanne Switzerland Aga Khan University Hospital Anaesthesiology Karachi Pakistan Centro Hospitalar São João Intensive Care Porto Portugal Faculty of Medicine University of Porto Medicine Porto Portugal Faculdade de Ciências Universidade do Porto Departamento de Matemática Porto Portugal Centro de Matemática Universidade do Porto Porto Portugal The Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine Zaragoza Spain Centro Hospitalar

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A Survival Prediction Model of Rats in Hemorrhagic Shock Using the Random Forest Classifier

A Survival Prediction Model of Rats in Hemorrhagic Shock Usi...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Joon Yul Choi Sung Kean Kim Wan Hyung Lee Tae Keun Yoo Deok Won Kim the Brain Korea 21 Project for Medical Science Yonsei University Seoul Korea the Graduate Program in Biomedical Engineering Yonsei University Seoul Korea Yonsei University College of Medicine Seoul Korea is a Professor at Dept. of Medical Engineering Yonsei University College of Medicine Seoul Korea

ISBN: (纸本)9781457717871

Hemorrhagic shock is the cause of one third of deaths resulting from injury in the world. Although many studies have tried to diagnose hemorrhagic shock early and accurately, such attempts were inconclusive due to compensatory mechanisms of humans. The objective of this study was to construct a survival prediction model of rats in hemorrhagic shock using a random forest (RF) model, which is a newly emerged classifier acknowledged for its performance. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), lactate concentration (LC), and perfusion (PF) measured in rats were used as input variables for the RF model and its performance was compared with that of a logistic regression (LR) model. Before constructing the models, we performed a 5-fold cross validation for RF variable selection and forward stepwise variable selection for the LR model to see which variables are important for the models. For the LR model, sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (ROC-AUC) were 1, 0.89, 0.94, and 0.98, respectively. For the RF models, sensitivity, specificity, accuracy, and AUC were 0.96, 1, 0.98, and 0.99, respectively. In conclusion, the RF model was superior to the LR model for survival prediction in the rat model.

关键词： A Survival Prediction the Random Forest Classifier Heart rate

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Poster abstracts

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Sleep and Biological Rhythms 2016年第1期5卷 A1-A189页

作者： J. Ferrie M. Shipley F. Cappuccio E. Brunner M. Miller M. Kumari M. Marmot A. Coenen J. L. Castillo F. Araya G. Bustamante L. Montecino C. Torres S. Oporto J. Gronli E. Fiske R. Murison B. Bjorvatn E. Sorensen R. Ursin C. M. Portas S. Rajaraman A. Gribok N. Wesensten T. Balkin J. Reifman N. Dursunoglu S. Ozkurt S. Baser O. Delen S. Sarikaya P. Sadler P. Mitchell D. Françon M. Decobert B. Herve A. Richard G. Griebel P. Avenet B. Scatton G. L. Fur D. Eckert A. Jordan A. Wellman S. Smith A. Malhotra D. White D. Bruck I. Thomas A. Kritikos W. Oertel K. Stiasny-Kolster D. Garcia-Borreguero W. Poewe B. Hoegl R. Kohnen E. Schollmayer J. Keffel C. Trenkwalder A. Valle S. Roizenblatt F. Fregni P. Boggio S. Tufik K. Ward L. Robertson L. Palmer P. Eastwood D. Hillman J. Lee S. Mukherjee V. de Padova G. Barbato G. Ficca I. Zilli P. Salzarulo M. Veldi T. Hion V. Vasar M. Kull L. Nowak J. Davis Y. Latzer O. Tzischinsky S. Crowley M. Carskadon M. Anca-Herschkovitsch D. Frey J. Ortega C. Wiseman C. Farley K. Wright A. Campbell A. Neill K. Spiegel R. Leproult E. Tasali N. Scherberg E. van Cauter A. T. Noradina N. A. Karim I. Norlinah A. A. Raymond R. Sahathevan B. Hamidon E. Werth R. Poryazova R. Khatami C. Bassetti R. G. Beran L. Ainley G. Holand J. Duncan H. Kinney B. Davis B. Hood S. Frey C. Schmidt M. Hofstetter P. Peigneux C. Cajochen W.-P. Hu J.-D. Li C. Zhang L. Boehmer J. Siegel Q.-Y. Zhou Y. Sagawa H. Kondo T. Takemura H. Kanayama Y. Kaneko M. Sato T. Kanbayashi Y. Hishikawa T. Shimizu A. Viola L. James L. Schlangen D.-J. Dijk R. Andretic Y.-C. Kim K.-A. Han F. Jones R. Greenspan L. Sanford L. Yang X. Tang K. Dieter E. Uta H. Sven M. Richard N. Oyane S. Pallesen F. Holsten Y. Inoue M. Fujita N. Emura K. Kuroda N. Uchimura A. Johnston J. Astbury G. Kennedy K. Hoedlmoser M. Schabus T. Pecherstorfer S. Moser G. Gruber P. Anderer W. Klimesch N. Naidoo M. Ferber A. Pack D. Neu O. Mairesse G. Hoffmann A. Dris L. Lambrecht P. Linkowski P. Verbanck O. Le Bon N. Matsuura M. Yamao N. Adachi R. Aritomi Y. Komada H. Tanaka S. Shirak University College London London UK University College London London USA Warwick Medical School London UK Warwick Medical School Coventry USA Radboud University Nijmegen Nijmegen Netherlands Department of Neurology University of Chile Santiago Chile Neurology Service Hospital del Salvador Santiago Chile Family Health Center Juan Pablo II Santiago Chile Department of Biomedicine Section on Physiology Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care University of Bergen Bergen Norway Norwegian Competence Center for Sleep Disorders Haukeland University Hospital Bergen Norway Department of Child and Adolescent Psychiatry Haukeland University Hospital Univeristy of Bergen Bergen Norway Department of Biomedicine University of Bergen Bergen Norway US Army Medical Research and Materiel Command Fort Detrick Frederick USA Walter Reed Army Institute of Research Silver Spring USA Department of Behavioral Biology Walter Reed Army Institute of Research Silver Spring USA Faculty Department of Pulmonology Pamukkale University Medical Denizli Turkey University of Ballarat Ballarat Australia Sanofi-Aventis Recherche et Developpement Paris France Brigham and Women’s Hospital Harvard Medical School Boston USA The University of Queensland Adelaide Australia School of Psychology University of Queensland Brisbane Australia The University of Queensland Brisbane Australia Victoria University Melbourne Australia Department of Psychology Victoria University Melbourne Australia School of Psychology Victoria University Melbourne Australia Philips-Universität Marburg Germany Philips-Universitaet-Marburg Marburg Germany Instituto de Investigaciones del Sueno Madrid Spain Universitätsklinik für Neurologie Innsbruck Austria Universitaetsklinik fuer Neurologie Innsbruck Austria IMEREM GmbH Nuernberg Germany Schwarz Pharma AG Monheim Germany

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Investigation of Four Phantoms for PET Normalization

Investigation of Four Phantoms for PET Normalization

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IEEE Nuclear Science Symposium and Medical Imaging Conference

作者： Leith J. Rankine Joshua M. Wilson Timothy G. Turkington Duke University Medical Physics Graduate Program Durham NC USA Department of Radiology Duke University Medical Center Durham NC USA Department of Radiology Duke University Medical Center and Department of Biomedical Engineering Duke University Durham NC USA

Normalization in Positron Emission Tomography (PET) is essential to correct for sensitivity variation across detector elements and produce uniform images. Currently, the standard normalization protocol for General Electric (GE) systems requires a 20 minute scan of a 20 cm diameter cylindrical phantom filled with 2 mCi of ~(18)F Fluorodeoxyglucose (FDG). This process calculates the single detector efficiency factors (e) from the component based normalization factors (NF). We have investigated the feasibility of using smaller phantoms for normalization, including sensitivity to positioning and radioactivity concentration. Four new test phantoms were used for normalization on a GE Discovery 690 PET/CT scanner. The test phantoms included 4.5 cm, 7.5 cm and 10cm diameter cylinders, and a 16-20 cm diameter cylindrical shell. Normalization scans were also taken using the 7.5 cm and 10 cm cylinder phantoms over a range of FDG activities and at transaxially off-center positions. Image quality was assessed by reconstructing a 4 hr high count, uniform activity image quality (IQ) phantom scan using each normalization data set. All test phantoms produced similarly uniform reconstructions of the IQ phantom scan. Upon examining subtractions from the standard, high frequency ring artifacts with ±1% peak intensity were present in images reconstructed using the 4.5cm, 7.5cm, and 10cm normalization phantoms. FFT analysis quantified the spatial period of ring artifacts as T = 2.15 ± 0.1 cm, one half of the detector block width of the GE 690 system. Simulation confirmed that ring artifacts result from periodic detector sensitivity decrease, which points to incident photo obliquity being the cause of said artifact. ROIs across anterior/posterior direction of the central slice were used to quantify low frequency uniformity. Low frequency non-uniformities were found to be produced by off-center normalization phantom positioning, as expected. In addition, an 8 minute Hoffman brain phantom s

关键词： PET GE FDG

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EHS subjects do not perceive RF EMF emitted from smart phones better than non-EHS subjects *

EHS subjects do not perceive RF EMF emitted from smart phone...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Min Kyung Kwon Sung Kean Kim Jeong Mo Koo Joon Yul Choi Deok Won Kim Brain Korea 21 Project for Medical Science Yonsei University Seoul Korea Graduate Program in Biomedical Engineering Yonsei University Seoul Korea Brain Korea 21 Project for Medical Science Yonsei University Seoul Korea Professor at Dept. of Medical Engineering Yonsei University College of Medicine Seoul Korea

ISBN: (纸本)9781424441198

As the use of smart phones increases, social concerns have arisen concerning the possible effects of radio frequency-electromagnetic fields (RF-EMFs) emitted from wideband code division multiple access (WCDMA) mobile phones on human health. The number of people with self-reported electromagnetic hypersensitivity (EHS) who complain of various subjective symptoms, such as headache, insomnia, etc., has also recently increased. However, it is unclear whether EHS subjects can detect RF-EMFs exposure or not. In this double-blind study, two volunteer groups of 17 EHS and 20 non-EHS subjects were investigated in regards to their perception of RF-EMFs with real and sham exposure sessions. Experiments were conducted using a WCDMA module inside a dummy phone with an average power of 24 dBm at 1950 MHz and a specific absorption rate of 1.57 W/kg using a dummy headphone for 32 min. In conclusion, there was no indication that EHS subjects perceive RF-EMFs better than non-EHS subjects.

关键词： increases indication concerning

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Nuclear Resonance Fluorescence (NRF) in GEANT4: Development, Validation, and Testing

Nuclear Resonance Fluorescence (NRF) in GEANT4: Development,...

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IEEE Nuclear Science Symposium and Medical Imaging Conference

作者： Manu N. Lakshmanan Brian P. Harrawood Greeshma A. Agasthya Gencho Rusev Anuj J. Kapadia Departments of Biomedical Engineering and Radiology Duke University Department of Radiology Duke University Durham NC USA Chemistry Division Los Alamos National Laboratory Los Alamos NM USA Department of Radiology and the Medical Physics Graduate Program Duke University Durham NC USA

ISBN: (纸本)9781467320283

Despite its utility and applicability, the ability to simulate the NRF technique is not currently included in GEANT4. Here we describe the development, validation and testing of NRF in GEANT4 for 10 separate isotopes. An NRF class named G4NRF was developed to handle NRF physics. Validation of the simulation was performed by benchmarking it against experimental measurements for measured counts from gamma-ray scattering in water and metallic samples. The validation results show agreement between the simulation and experimental spectra for the appearance of the NRF peak. We have begun applying the NRF simulation for medical research, and we are seeking to make the NRF physics code available to the GEANT4 community in a future release.

关键词： GEANT4 NRF Testing

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Cardiorespiratory fitness level correlates inversely with excess post-exercise oxygen consumption after aerobic-type interval training

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BMC Research Notes 2012年第1期5卷 1-4页

作者： Matsuo, Tomoaki Ohkawara, Kazunori Seino, Satoshi Shimojo, Nobutake Yamada, Shin Ohshima, Hiroshi Tanaka, Kiyoji Mukai, Chiaki Space Biomedical Research Office Japan Aerospace Exploration Agency (JAXA) Tsukuba Ibaraki 305-8505 2-1-1 Sengen Japan Faculty of Informatics and Engineering University of Electro-Communications Chofu Tokyo 182-8585 1-5-1 Chofugaoka Japan Health Promotion and Exercise Program National Institute of Health and Nutrition Shinjuku Tokyo 162-8636 1-23-1 Toyama Japan Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Ibaraki 305-8574 1-1-1 Tennodai Japan

Background: The purpose of this study was to reveal any association between cardiorespiratory fitness level and excess post-exercise oxygen consumption (EPOC) using three cycling protocols with varying degrees of exercise intensity, i.e., sprint interval training (SIT), high-intensity interval aerobic training (HIAT), and continuous aerobic training (CAT). Findings. Ten healthy men, aged 20 to 31 years, attended a cross-over experiment and completed three exercise sessions: SIT consisting of 7 sets of 30-s cycling at 120% VO₂ with a 15-s rest between sets;HIAT consisting of 3 sets of 3-min cycling at 80∼90% VO₂ with a 2-min active rest at 50% VO₂ between sets;and CAT consisting of 40 min of cycling at 60∼65% VO₂. During each session, resting VO₂, exercise VO₂, and a 180-min post-exercise VO₂ were measured. The net exercise VO ₂ during the SIT, HIAT, and CAT averaged 14.7 ± 1.5, 31.8 ± 4.1, and 71.1 ± 10.0 L, and the EPOCs averaged 6.8 ± 4.0, 4.5 ± 3.3, and 2.9 ± 2.8 L, respectively. The EPOC with SIT was greater than with CAT (P < 0.01) and HIAT (P = 0.12). Correlation coefficients obtained between subjects' VO₂ and the ratio of EPOC to net exercise VO₂ for SIT, HIAT, and CAT were -0.61 (P = 0.06), -0.79 (P < 0.01), and -0.42 (P = 0.23), respectively. Conclusions: Our data suggest that cardiorespiratory fitness level correlates negatively with the magnitude of EPOC, especially when performing aerobic-type interval training. © 2012 Matsuo et al.;licensee BioMed Central Ltd.

关键词： Aerobic fitness Cycling Energy expenditure Exercise physiology Maximal oxygen consumption

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Bioengineering and technoscience art: Electromyography and signal processing for synaesthesia In-activity muscles and data visualization

Bioengineering and technoscience art: Electromyography and s...

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Pan American Health Care Exchanges, PAHCE 2011 - Conference, Workshops, and Exhibits. Cooperation / Linkages: An Independent Forum for Patient Care and Technology Support

作者： Domingues, D.G. Miosso, C.J. Paredes, A.O. Rocha, A.F. LART - Laboratory of Art and Technoscience Graduate Program in Biomedical Engineering University of Brasilia at Gama - FGA/UnB Gama Distrito Federal Brazil

ISBN: (纸本)9781612849164

At the convergence of advanced biomedical scientific research in contemporary art with technoscience collaborative practices, as well as with transdisciplinar issues regarding the human condition and the reinvented life, we propose a biocybrid system using electromyography and body signals for the new perceptive, cognitive and technological expansion and the sensorial domain of synesthesia. The electrical potentials and introspective mapping and tracing of body activities in electromyography translated into sonic landscapes and data visualization by using electrical signals generated by in-activity muscles and collected by specific instrumentation equipment are widely used in biomedical engineering and medicine. The system entails new ways of deciphering human ways of acting, by using bodily muscles in microscales, by allowing the perception and communication for generating sound patterns and data visualization landscapes that dynamically change according to several properties extracted from electromyographic (EMG) signals. We also intend future application of our prototype for industrial technological innovations and affective interfaces for medice, health and fitness, art and neuroscience and other domain. © 2011 IEEE.

关键词： Biofeedback

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Module for the acquisition and processing of biological signals related to the emotional state

Module for the acquisition and processing of biological sign...

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Pan American Health Care Exchanges, PAHCE 2011 - Conference, Workshops, and Exhibits. Cooperation / Linkages: An Independent Forum for Patient Care and Technology Support

作者： Domingues, D.G. Miosso, C.J. Paredes, A.E. Rocha, A.F. LART - Laboratory of Art and Technoscience Graduate Program in Biomedical Engineering University of Brasilia at Gama - FGA/UnB Gama Distrito Federal Brazil

ISBN: (纸本)9781612849164

Medical, artistic and social applications of biomedical signals benefit from the possibility of measuring a person's emotional state, and of creating, through biofeedback techniques, a personal dynamic interaction with the environment. This paper describes a wearable microsensor module used to acquire and preprocess biological signals that are directly related to one's emotional state in daily activities. The main circuit includes a skin galvanic sensor, a breathing sensor, and an electrocardiograph with three electrodes. The acquired signals are treated by independent instrumentation amplifiers and digitized by a dedicated microcontroller at an acquisition/preprocessing board. The module and the enhanced application for Networked Communications in biomedical engineering and ubiquitous computing reinvent the sense of presence in the physical world when wearing a BWAS Biocybrid Wearable Art System. Ontological levels of creative reality and phenomenological framework using embedded systems and the ways of using hardware and software are discussed. The results intend future industry developments of devices to enhance and to supplement the human perceptive and affective human condition. The identification and interpretation of appropriate models for art, communication, aesthetic, design, fashion, health, personal security or other applications are challenges for insightful discussions of the role of engineers, physiologists, artists, educators, social scientists, as well as of ethnographic methods and practices. © 2011 IEEE.

关键词： Electrocardiograms

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Quantitative measurements of pressure dependent laminar cribrosa microstructure in human eyes

Quantitative measurements of pressure dependent laminar crib...

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ASME 2011 Summer Bioengineering Conference, SBC 2011

作者： Yan, Dongmei Keyes, Joseph T. Vande Geest, Jonathan P. Aerospace and Mechanical Engineering University of Arizona United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona United States Biomedical Engineering University of Arizona United States BIO5 Institute University of Arizona United States

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