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ASME 2010 Summer Bioengineering Conference, SBC 2010

作者： Keyes, Joseph T. Borowicz, Stacy Utzinger, Urs Simon, Bruce Vande Geest, Jonathan P. Graduate Interdisciplinary Program in Biomedical Engineering University of Arizona Tucson AZ United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ United States BIO5 Institute for Biocollaborative Research University of Arizona Tucson AZ United States Department of Biomedical Engineering University of Arizona Tucson AZ United States

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A galerkin-type finite element solution for simulation of mass diffusion in the application of tissue engineering: Heterogeneous and non-porous media

A galerkin-type finite element solution for simulation of ma...

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作者： Mohammadi, H. Mequanint, K. Bahramian, F. Biomedical Engineering Graduate Program Faculty of Engineering University of Western Ontario London ON N6A 5B9 Canada Department of Chemical and Biochemical Engineering University of Western Ontario London ON Canada Department of Mechanical and Materials Engineering University of Western Ontario London Canada

This study is an effort to produce a generic and comprehensive solution to the simulation of mass diffusion through a multiphasic and heterogeneous material model. A Galerkin-type finite element formulation is developed to solve Fick's equation for steady-state and time-dependent analysis. The effect of the interface in modelling of a liquid-solid medium is presented in this work. To show the robustness of the proposed approach, the gas exchange (oxygen and carbon dioxide) process through the capillary network between the alveolar membrane and red blood cells has been analysed and then validated with experimental data. The current work is a significant asset to modelling the diffusion of oxygen between cells and scaffolds in tissue engineering or tissue regeneration/repair studies. It is one step towards the development of high-order elements for application of the simulation of mass transfer through a multiphasic and porous model with varying degrees of interconnectivity and pore size for tissue engineering applications.

关键词： Finite element method

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Investigating engineering students' mathematical modeling abilities in capstone design

Investigating engineering students' mathematical modeling ab...

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2010 ASEE Annual Conference and Exposition

作者： Cole, Jennifer Linsenmeier, Robert McKenna, Ann Glucksberg, Matthew Department of Chemical and Biological Engineering Robert R. McCormick School of Engineering and Applied Science Northwestern University United States Department of Biomedical Engineering Inderdepartmental Neuroscience Graduate Program Northwestern University United States Department of Mechanical Engineering School of Education and Social Policy Northwestern University United States Department of Biomedical Engineering Robert R. McCormick School of Engineering and Applied Science Northwestern University United States

engineering capstone design is a culminating experience that is intended to provide an opportunity for students to apply their previous engineering knowledge to develop solutions to open-ended problems. Capstone design problems are often analytically complex, and their solutions integrate several disciplinary fundamentals, as well as more general design process knowledge. Often, the expectation is that a thorough or rigorous solution to a capstone level problem would include some type of computational or mathematical analysis appropriate to that discipline. However, engineering students often struggle in recognizing when and how disciplinary knowledge (e.g. mathematical analysis inherent in many engineering fundamentals) applies to their particular design solutions. This paper describes the strategy for and initial results of a study exploring how students use mathematical reasoning when developing design solutions. Specifically, we want to understand where students struggle in the development and implementation of a mathematical model. We conducted our study in a biomedical capstone (senior) design course. We presented students with a scenario based on a design problem in using phototherapy to treat jaundice, and asked specific questions relating to mathematical modeling in the solution to this problem. We developed the scenario and corresponding assignments based on previous work that identified six steps for what mathematical modeling should include. We staged the activities over a four-week period such that students addressed two of these steps at each time interval, or assignment stage. This report analyzes results from the first two activities, which focused on identifying the real-world phenomenon and simplifying or idealizing it. We found that in an open-ended statement of the problem, no students proposed using a mathematical model to assist in designing the device. When we specifically asked for a mathematical model in a second activity, only five students

关键词： Students

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A robust approach toward recognizing valid arterial-blood-pressure pulses

A robust approach toward recognizing valid arterial-blood-pr...

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作者： Asgari, Shadnaz Bergsneider, Marvin Hu, Xiao Neural Systems and Dynamics Laboratory Department of Neurosurgery University of California Los Angeles CA 90024 United States Biomedical Engineering Graduate Program Henry Samueli School of Engineering and Applied Science University of California Los Angeles CA 90024 United States

We propose a projection method based on singular value decomposition (SVD) to validate arterial blood pressure (ABP) signal in order to avoid artifacts and noise in subsequent processing. The projection has been done on 567 validated ABP beats collected from 51 patients hospitalized in University of California, Los Angeles Medical Center. Then, we compare the performance of the proposed projection method with that of a previously developed algorithm, signal abnormality index (SAI), which is a value- and trend-based approach, and has shown to be effective in cleaning the ABP waveforms. The testing dataset consists of 1336 ten-second ABP segments (18472 ABP beats) of both valid and invalid pulses selected randomly from multiparameter intelligent monitoring for intensive care II database. The proposed projection approach that validates the signal based on the shape of the waveform achieves a true positive rate (TPR) of 99.06%, 5.43% higher than that of the SAI, and a false positive rate (FPR) of 7.69%, 17.38% lower than that of SAI. Integration of some of the SAI-value-based abnormality conditions to the validation process of SVD-based method can further improve the performance by reducing the FPR to 3.92%, while keeping the TPR at the high rate of 99.05%. © 2009 IEEE.

关键词： Singular value decomposition

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Nonconstrained sleep monitoring system and algorithms using air-mattress with balancing tube method

Nonconstrained sleep monitoring system and algorithms using ...

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作者： Shin, Jae Hyuk Chee, Young Joon Jeong, Do-Un Park, Kwang Suk Interdisciplinary Program on Biomedical Engineering Seoul National University Graduate School Chongno-Ku Seoul 110-799 Korea Republic of Department of Biomedical Engineering Ulsan University Ulsan 680-190 Korea Republic of Department of Neuropsychiatry Clinical Research Institute Seoul National University College of Medicine and Hospital Chongno-Ku Seoul 110-799 Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Chongno-Ku Seoul 110-799 Korea Republic of

We evaluated the performance of a bed-type sensor system using the air-mattress with balancing tube (AMBT) method to noninvasively monitor the signals of heartbeat, respiration, and events of snoring, sleep apnea and body movement of subject on the system. The proposed system consists of multiple cylindrical air cells, two sensor cells and 18 support cells, and the small physiological signals were measured by the changes in pressure difference between the sensor cells, and the dc component was removed by balancing tube that is connecting the sensor cells. Using newly developed AMBT method, heartbeat, respiration, snoring, and body movement signals were clearly measured. For the concept of a home healthcare system, two automatic processing algorithms were developed: one is to estimate the mean heart and respiration rates for every 30 s, and another one is to detect the snoring, sleep apnea, and body movement events from the measured signals. In the beat-to-beat heart rate and breath-by-breath respiration rate analyses, the correlation coefficients of the heart and respiration rates from the proposed AMBT method compared with reference methods, electrocardiogram, and respiration effort signal from piezoelectric belt, were 0.98 (p

关键词： Electrocardiograms

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WE-G-220-03: Evaluating Image-Similarity Metrics to Detect Prostate Motion during 3D TRUS-Guided Prostate Biopsy

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Medical Physics 2011年第6PART34期38卷 3838-3838页

作者： T De Silva A Fenster J Samarabandu A Ward Robarts Research Institute The University of Western Ontario London ON CA Imaging Research Laboratory Baines Centre for Translational Cancer Research London ON CA Department of Medical Biophysics The University of Ontario London ON CA Department of Electrical Engineering The University of Western Ontario London ON CA Graduate Program in Biomedical Engineering The University of Western Ontario London ON CA

Purpose: For 3D transrectal ultrasound (TRUS) guided prostate biopsy, we evaluate the utility of image-similarity metrics for comparing real-time 2D- TRUS video frames to pre-acquired 3D-TRUS images in order to detect misalignment due to prostate motion and deformation. Methods: The experiments were conducted on retrospective data of 3D TRUS images from 3 subjects at the start of the biopsy procedure using a mechanically assisted 3D TRUS-guided biopsy system. For each subject, 2D TRUS images were acquired immediately prior to biopsy needle insertion. In this work, simulation and real human studies were performed to explore the utility of two image similarity metrics (normalized cross correlation and mutual information) for the detection of prostate motion during the biopsy procedure. Rigid prostate motion was simulated by translating the 3D volume in the direction orthogonal to the ground truth image, and by rotating the 3D volume around the long axis of the TRUS probe. We calculated similarity metrics for each of these simulated motion images and its corresponding ground truth image. In the human study, we performed preliminary testing of a 2D-to-3D rigid intensity-based registration method and measured its error by calculating its target registration error (TRE), based on identified anatomically homologous intrinsic fiducial pairs. Results: The registration gave an overall TRE of 2.1 mm, and both the mutual information and normalized cross correlation metrics have a convex shape near the optimal plane. Conclusions: The convex metric profiles encourage the use of intensity-based registration to compensate for motion and deformation of the prostate during TRUS-guided biopsy. The gradient of the mutual information curves are generally higher, making this metric more sensitive to the detection of small misalignments. The normalized cross correlation has a higher capture range, making it more suitable to be used in an image registration where the initialization may be

关键词： Ultrasonography Medical imaging Testing procedures Image registration

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Abstracts Of Shellfish Technical Papers Presented at the joint meeting of the Northeast Aquaculture Conference and Exposition Milford Aquaculture Seminar and the International Conference on Shellfish Restoration Groton, Connecticut December 12–15, 2012

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Journal of Shellfish Research 2013年第2期32卷 571-612页

作者： Walter Blogoslawski Christopher Davis Dorothy Leonard Lisa Milke Steven Allen Peter Bergstrom A.C. Carpenter Mark Luckenbach Kennedy Paynter Angela Sowers Eric Weissberger James Wesson Stephanie Westby Steven Allen Stephanie Westby Claire O'Neil Angela Sowers Eric Weisberrger Oliver Bender Peter Boyce Gabriel Betty Mark Borrelli Anamarija Frankic Curtis Felix Jennifer Wilson Peter Boyce Oliver Bender Suzanne Bricker Tessa Getchis Cary Chadwick Julie Rose Cori Rose Kelsey Brockett Jessica Peterman David Bushek Daphne Munroe Eric Powell Lisa Calvo Barney Hollinger William Riggin William Shadel Jenny Paterno Ryan Carnegie David Bushek Carole Cyr Lisandre G. Solomon Francoise Bourque Tyler Carrier Stephen Eddy Sarah Redmond James Cervino Rand Weeks Jason Shorr Carmen Lin Dajana Gjoza Thomas J. Goreau Erik Chapman Derrick Chelikowsky Diane Kapareiko Dorothy Jefferess Gary Wikfors Carmela Cuomo Joseph Choromanski Sheila Stiles Dorothy Jeffress Haley Ladeau Loren Coen Boze Hancock Lesley Baggett Sean Powers Rob Brumbaugh Summer Morlock Bryan DeAngelis Anne Cohen Daniel McCorkle Gail Schwietermann Kathryn Rose Dave Conley SaiGiridhar Dasika April Croxton Soren Dahl Debra Barnes Bassem Allam Jonathan Davis Brian Allen Betsy Peabody Jonathan Davis Julie Davis William Walton Donatella Del Piero Michael Devin Molly Flanagan Paul Rawson Chauncey Devin Dana Morse Mark S. Dixon Genevieve Bernatchez Kelsey Boeff Eve Galimany Yaqin Li Aynur Lok Shannon L. Meseck Marguerite Petit Sean Dixon Sam Lee Dennis O'Connor Kelly Drake Shelley Edmundson Elizabeth Fairchild Melissa Evans Allison Fitzgerald Chester Zarnoch William Wallace Amy Fitzpatrick Gef Flimlin Sandra Macfarlane Gef Flimlin Thomas Foca David Bushek Timothy Visel Walter Blogoslawski Deborah A. Bouchard Joseph Buttner John Ewart Ann Faulds George E. Flimlin Doris Hicks Craig Hollingsworth Andrew Lazur Dale Leavitt Dennis McIntosh Dana L. Morse Tom Rippen Gregg Rivara Roxanna Smolowitz Dan Terlizzi Don Webster Michael Chambers Diane C. Murphy Robert Pomeroy Josh Reitsma Mic U.S. Department of Commerce National Oceanic and Atmospheric Administration National Marine Fisheries Service Northeast Fisheries Science Center Milford Laboratory 212 Rogers Avenue Milford CT 06460 Maine Aquaculture Innovation Center 5717 Corbett Hall Room 436 Orono ME 04469 Ocean Equities LLC 776 Rolling View Drive Annapolis MD 21409. Oyster Recovery Partnership 1805A Virginia St Annapolis MD 21401 NOAA Chesapeake Bay Office 410 Severn Ave Suite 207-A Annapolis MD 21403 Potomac River Fisheries Commission 222 Taylor St Colonial Beach VA 22443 Virginia Institute of Marine Science Eastern Shore Laboratory PO Box 350 Wachapreague VA 23480 1213 HJ Patterson Hall University of Maryland College Park MD 20742 U. S. Army Corps of Engineers Baltimore District P.O. Box 1715 Baltimore MD 21203 Maryland Department of Natural Resources 580 Taylor Ave Annapolis MD 21401 Virginia Marine Resources Commission 2600 Washington Ave Newport News VA 23607 NOAA Restoration Center 410 Severn Ave Annapolis MD 21403. Oyster Recovery Partnership 1805A Virginia St Annpolis MD 21401 National Oceanographic and Atmospheric Administration 410 Severn Ave Suite 107-A Annapolis MD 21403 USA Army Corps of Engineers 10 South Howard St Baltimore MD 21201 Maryland Department of Natural Resources 580 Taylor Ave Tawes State Office Building Annapolis MD 21401. Maria Mitchell Association 4 Vestal St Nantucket MA 02554 Maria Mitchell Association 65 Meadowview Drive Nantucket MA 02554. University of Rhode Island 620 Main St. Hopkinton RI 02832. Provincetown Center for Coastal Studies 5 Holway Avenue Provincetown MA 02657 University of Massachusetts Boston 100 Morrissey Blvd Boston Massachusetts Boston MA Town of Wellfleet 300 Main Street Wellfleet Massachusetts MA 02667. Maria Mitchell Association 65 Meadowview Dr Nantucket MA 02554. NOAA National Center for Coastal Ocean Science 1305 East West Highway Room 8110 Silver Spring MD 20910 Connecticut Sea Grant University o

It was with great excitement that we planned the combined meetings of Northeast Aquaculture Conference and Exposition (NACE) and the International Conference on Shellfish Restoration (ICSR) with the 33rd Milford Aquaculture Seminar (MAS). Bringing these different but complementary audiences together resulted in a meeting that combined many different aspects of fisheries restoration and aquaculture under one *** hundred attendees including government representatives, research scientists, industry, and academia at both the university and vocational high school levels attended this event. The meeting commenced on Wednesday December 12th 2012, with over eighty people attending seven field trips to area aquaculture farms and research facilities. The formal program began on Thursday, December 13th with a plenary session including invited speakers Eric Schwabb, Acting Assistant Secretary for Conservation and Management at NOAA; Sebastian Belle, Executive Director of the Maine Aquaculture Association and Boze Hancock from the Nature Conservancy, who discussed the role of aquaculture in fisheries restoration. John Bullard, the Northeast Regional Administrator of NOAA Fisheries Service, addressed the group during the luncheon the following day. The technical papers and workshops presented were divided into 35 sessions over three days of the meeting and included topics such as the history of aquaculture, aquaculture hatchery innovations, siting and planning issues, risk management, aquaculture business management, ocean acidification, climate change, as well as aquaculture disease issues and potential remedies. Having persons present who have experienced problems and successes, along with those in manufacturing and government responsible for addressing concerns and sharing best practices, was invaluable. Discussions among this cross-section of persons who represent different aspects of aquaculture were as important as the well-presented and interesting formal papers

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Platinum Concave Nanocubes with High‐Index Facets and Their Enhanced Activity for Oxygen Reduction Reaction†

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Angewandte Chemie 2011年第12期123卷

作者： Taekyung Yu Do Youb Kim Hui Zhang Younan Xia Department of Biomedical Engineering Washington University Saint Louis MO 63130 (USA) Department of Chemical and Biomolecular Engineering (BK21 graduate program) Korea Advanced Institute of Science and Technology (KAIST) 335 Gwahangro Yuseong‐gu Daejeon 305‐701 (Korea) State Key Laboratory of Silicon Materials and Department of Materials Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 (People's Republic of China)

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Effects of positive airway pressure on heart rate variability and baroreflex sensitivity in healthy subjects

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Autonomic Neuroscience: Basic and Clinical 2011年第1期163卷 42-42页

作者： Gonçalves, T.R. Barros, R.B.M. Nunes, M.V.L. Farinatti, P.T.V. Giannella Neto, A. Soares, P.P. Fluminense Federal University Laboratory Experimental and Applied Exercise Physiology Brazil Rio de Janeiro Federal University Biomedical Engineering Program Brazil Physical Activity and Health Promotion Laboratory (LABSAU) Physical Education and Sports Institute State University of Rio de Janeiro Rio de Janeiro Brazil - Graduate Program in Physical Activity Sciences of the Salgado de Oliveira University Rio de Janeiro Brazil

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The effects of angiotensin ii infusion on the mechanical response and microstructural organization of mouse aorta

The effects of angiotensin ii infusion on the mechanical res...

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ASME 2010 Summer Bioengineering Conference, SBC 2010

作者： Haskett, Darren Fouts, Marie Utzinger, Urs Larson, Doug Azhar, Mohamad Geest, Jonathan Vande Biomedical Engineering Graduate Interdisciplinary Program University of Arizona United States BIO5 Institute for Collaborative Bioresearch University of Arizona Tucson AZ United States Department of Medical Pharmacology College of Medicine University of Arizona United States Department of Surgery Sarver Heart Center University of Arizona Tucson AZ United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ United States Department of Biomedical Engineering University of Arizona Tucson AZ United States

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