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Correction: How Can Artificial Intelligence Make Medicine More Preemptive?

Journal of medical Internet research 2020年第8期22卷 e23645页

作者： Usman Iqbal Leo Anthony Celi Yu-Chuan Jack Li Master Program in Global Health & Development PhD Program in Global Health & Health Security College of Public Health Taipei Medical University Taipei Taiwan. International Center for Health Information Technology Taipei Medical University Taipei Taiwan. Laboratory for Computational Physiology Massachusetts Institute of Technology Cambridge MA United States. Division of Pulmonary Critical Care and Sleep Medicine Beth Israel Deaconess Medical Center Boston MA United States. Department of Biostatistics Harvard TH Chan School of Public Health Harvard University Boston MA United States. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Dermatology Taipei Municipal Wan-Fang Hospital Taipei Taiwan. International Medical Informatics Association Geneva Switzerland.

[This corrects the article DOI: .].

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Correction: A COVID-19 Pandemic Artificial Intelligence-Based System With Deep Learning Forecasting and Automatic Statistical Data Acquisition: Development and Implementation Study

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Journal of medical Internet research 2021年第7期23卷 e31085页

作者： Cheng-Sheng Yu Shy-Shin Chang Tzu-Hao Chang Jenny L Wu Yu-Jiun Lin Hsiung-Fei Chien Ray-Jade Chen Department of Family Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Family Medicine Taipei Medical University Hospital Taipei Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan. Clinical Big Data Research Center Taipei Medical University Hospital Taipei Taiwan. Division of Plastic Surgery Department of Surgery Taipei Medical University Hospital and School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Division of General Surgery Department of Surgery Taipei Medical University Hospital Taipei Taiwan.

[This corrects the article DOI: 10.2196/27806.].

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Correction to: binomialRF: interpretable combinatoric efficiency of random forests to identify biomarker interactions

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BMC bioinformatics 2020年第1期21卷 495页

作者： Samir Rachid Zaim Colleen Kenost Joanne Berghout Wesley Chiu Liam Wilson Hao Helen Zhang Yves A Lussier Center for Biomedical Informatics and Biostatistics University of Arizona Health Sciences 1230 N. Cherry Ave Tucson AZ 85721 USA. The Graduate Interdisciplinary Program in Statistics The University of Arizona 617 N. Santa Rita Ave Tucson AZ 85721 USA. College of Medicine Tucson 1501 N. Campbell Ave Tucson AZ 85721 USA. Center for Biomedical Informatics and Biostatistics University of Arizona Health Sciences 1230 N. Cherry Ave Tucson AZ 85721 USA. hzhang@math.arizona.edu. The Graduate Interdisciplinary Program in Statistics The University of Arizona 617 N. Santa Rita Ave Tucson AZ 85721 USA. hzhang@math.arizona.edu. Department of Mathematics College of Sciences The University of Arizona 617 N. Santa Rita Ave Tucson AZ 85721 USA. hzhang@math.arizona.edu. Center for Biomedical Informatics and Biostatistics University of Arizona Health Sciences 1230 N. Cherry Ave Tucson AZ 85721 USA. Lussier.Y@***. The Graduate Interdisciplinary Program in Statistics The University of Arizona 617 N. Santa Rita Ave Tucson AZ 85721 USA. Lussier.Y@***. College of Medicine Tucson 1501 N. Campbell Ave Tucson AZ 85721 USA. Lussier.Y@***. The Center for Applied Genetic and Genomic Medicine 1295 N. Martin Tucson AZ 85721 USA. Lussier.Y@***. The University of Arizona Cancer Center 3838 N. Campbell Ave Tucson AZ 85721 USA. Lussier.Y@***. The University of Arizona BIO5 Institute 1657 E. Helen Street Tucson AZ 85721 USA. Lussier.Y@***.

An amendment to this paper has been published and can be accessed via the original article.

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Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma (vol 33, pg 2429, 2019)

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LEUKEMIA 2020年第5期34卷 1485-1485页

作者： Harrington, Colleen T. Sotillo, Elena Robert, Aude Hayer, Katharina E. Bogusz, Agata M. Psathas, James Yu, Duonan Taylor, Deanne Dang, Chi V. Klein, Peter S. Hogarty, Michael D. Geoerger, Birgit El-Deiry, Wafik S. Wiels, Joelle Thomas-Tikhonenko, Andrei Division of Cancer Pathobiology Children’s Hospital of Philadelphia Philadelphia USA Cell & Molecular Biology Graduate Group Perelman School of Medicine at the University of Pennsylvania Philadelphia USA Stanford Cancer Institute Stanford USA CNRS UMR 8126 Univ Paris-Sud - Université Paris-Saclay Institut Gustave Roussy Villejuif France Department of Biomedical and Health Informatics Children’s Hospital of Philadelphia Philadelphia USA Department of Pathology and Laboratory Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia USA The Janssen Pharmaceutical Companies of Johnson & Johnson Malvern USA Noncoding RNA Center Yangzhou University Yangzhou China Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania Philadelphia USA Molecular and Cellular Oncogenesis Program The Wistar Institute Philadelphia USA Department of Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia USA Division of Oncology Children’s Hospital of Philadelphia Philadelphia USA CNRS UMR 8203 Univ Paris-Sud - Université Paris-Saclay Institut Gustave Roussy Villejuif France Department of Pediatric and Adolescent Oncology Univ Paris-Sud - Université Paris-Saclay Institut Gustave Roussy Villejuif France Department of Pathology and Laboratory Medicine Brown University Medical School Providence USA

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

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四川生理科学杂志 2022年第7期44卷 1246-1246页

作者： Michael Worobey Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ 85721 USA Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA 92037 USA W. Harry Feinstone Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA Department of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA Department of Human Genetics University of Utah School of Medicine Salt Lake City UT 84112 USA Vaccine and Infectious Disease Organization University of Saskatchewan Saskatoon SK S7N 5E3 Canada Center for Global Health Science and Security Georgetown University Washington DC 20057 USA Department of Zoology University of Oxford Oxford OX1 3SZ UK Wildlife Conservation Research Unit Department of Zoology The Recanati-Kaplan Centre University of Oxford Oxford OX13 5QL UK Pandemic and Disaster Preparedness Centre Erasmus University Medical Center 3015 CE Rotterdam Netherlands Department of Viroscience Erasmus University Medical Center 3015 CE Rotterdam Netherlands Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles CA 90095 USA Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA Department of Medicine University of California San Diego La Jolla CA 92093 USA Department of Microbiology Immunology and Transplantation Rega Institute for Medical Research KU Leuven 3000 Leuven Belgium Global Virus Network (GVN) Baltimore MD 21201 USA MRC-University of Glasgow Center for Virus Research Glasgow G61 1QH UK Tulane University School of Medicine Department of Microbiology and Immu

Understanding how severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in 2019 is critical to preventing zoonotic outbreaks before they become the next *** Huanan Seafood Wholesale Market in Wuhan,China,was identified as a likely source of cases in early reports but later this conclusion became *** show the earliest known COVID-19 cases from December 2019,including those without reported direct links,were geographically centered on this *** report that live SARS-CoV-2 susceptible mammals were sold at the market in late 2019 and,within the market,SARS-CoV-2-positive environmental samples were spatially associated with vendors selling live mammals.

关键词： Market likely Wuhan

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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Geographic and age variations in mutational processes in colorectal cancer

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Nature 2025年 1-11页

作者： Marcos Díaz-Gay Mariya Kazachkova Ammal Abbasi Christopher D. Steele Raviteja Vangara Erik N. Bergstrom Azhar Khandekar Burçak Otlu Ludmil B. Alexandrov Wellington dos Santos Sergey Senkin Behnoush Abedi-Ardekani Ana Carolina de Carvalho Thomas Cattiaux Ricardo Cortez Cardoso Penha Valérie Gaborieau Priscilia Chopard Sandra Perdomo Paul Brennan Sarah Moody Jingwei Wang Stephen Fitzgerald Saamin Cheema Calli Latimer Jon W. Teague Laura Humphreys Michael R. Stratton Christine Carreira Anush Mukeriya David Zaridze Riley Cox Monique Albert Larry Phouthavongsy Steven Gallinger Reza Malekzadeh Ahmadreza Niavarani Marko Miladinov Katarina Erić Sasa Milosavljevic Suleeporn Sangrajrang Maria Paula Curado Samuel Aguiar Rui Manuel Reis Monise Tadin Reis Luis Gustavo Romagnolo Denise Peixoto Guimarães Ivana Holcatova Jaroslav Kalvach Carlos Alberto Vaccaro Tamara Alejandra Piñero Beata Świątkowska Jolanta Lissowska Katarzyna Roszkowska-Purska Antonio Huertas-Salgado Tatsuhiro Shibata Satoshi Shiba Surasak Sangkhathat Taned Chitapanarux Gholamreza Roshandel Patricia Ashton-Prolla Daniel C. Damin Francine Hehn de Oliveira Trevor D. Lawley Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA Department of Bioengineering University of California San Diego La Jolla CA USA Moores Cancer Center University of California San Diego La Jolla CA USA Digital Genomics Group Structural Biology Program Spanish National Cancer Research Center (CNIO) Madrid Spain Biomedical Sciences Graduate Program University of California San Diego La Jolla CA USA Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Health Informatics Graduate School of Informatics Middle East Technical University Ankara Turkey Sanford Stem Cell Institute University of California San Diego La Jolla CA USA Genomic Epidemiology Branch International Agency for Research on Cancer (IARC/WHO) Lyon France Cancer Ageing and Somatic Mutation Wellcome Sanger Institute Cambridge UK Evidence Synthesis and Classification Branch International Agency for Research on Cancer (IARC/WHO) Lyon France Clinical Epidemiology N. N. Blokhin National Medical Research Centre of Oncology Moscow Russia Ontario Tumour Bank Ontario Institute for Cancer Research Toronto Ontario Canada Centre for Biodiversity Genomics University of Guelph Guelph Ontario Canada Lunenfeld-Tanenbaum Research Institute Sinai Health System Toronto Ontario Canada Digestive Oncology Research Center Digestive Disease Research Institute Tehran University of Medical Sciences Tehran Iran Clinic for Digestive Surgery—First Surgical Clinic University Clinical Centre of Serbia Belgrade Serbia Department of Pathology University Clinical Centre of Serbia Belgrade Serbia International Organization for Cancer Prevention and Research Belgrade Serbia National Cancer Institute Bangkok Thailand Department of Epidemiology A. C. Camargo Cancer Center Sao Paulo Brazil Colon Cancer Reference Center A. C. Camargo Cancer Center Sao Paulo Brazil Molecular Oncology Research Center Barretos Cancer Hospital

Incidence rates of colorectal cancer vary geographically and have changed over time1. Notably, in the past two decades, the incidence of early-onset colorectal cancer, which affects individuals below 50 years of age, has doubled in many countries2,3,4,5. The reasons for this increase are unknown. Here we investigate whether mutational processes contribute to geographic and age-related differences by examining 981 colorectal cancer genomes from 11 countries. No major differences were found in microsatellite-unstable cancers, but variations in mutation burden and signatures were observed in the 802 microsatellite-stable cases. Multiple signatures, most with unknown aetiologies, exhibited varying prevalence in Argentina, Brazil, Colombia, Russia and Thailand, indicating geographically diverse levels of mutagenic exposure. Signatures SBS88 and ID18, caused by the bacteria-produced mutagen colibactin6,7, had higher mutation loads in countries with higher colorectal cancer incidence rates. SBS88 and ID18 were also enriched in early-onset colorectal cancers, being 3.3 times more common in individuals who were diagnosed before 40 years of age than in those over 70 years of age, and were imprinted early during colorectal cancer development. Colibactin exposure was further linked toAPCdriver mutations, with ID18 being responsible for about 25% ofAPCdriver indels in colibactin-positive cases. This study reveals geographic and age-related variations in colorectal cancer mutational processes, and suggests that mutagenic exposure to colibactin-producing bacteria in early life may contribute to the increasing incidence of early-onset colorectal cancer.

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Validation of MRI-VLFF for the non-invasive measurement of steatosis in children

GastroHep

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GastroHep 2020年第4期2卷

作者： Miriam B. Vos Eduardo Castillo-Leon Jack Knight-Scott Rebecca Cleeton Alvin Jay Freeman Jennifer K. Frediani Albert Hernandez Stephen F. Simoneaux Jun Kong Alton Brad Farris Michael J House Tim St. Pierre Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Emory University Atlanta GA USA Children's Healthcare of Atlanta Atlanta GA USA Nutrition and Health Sciences Program Laney Graduate School Emory University Atlanta GA USA Department of Radiology Children's Healthcare of Atlanta Atlanta GA USA Department of Computer Science and Biomedical Informatics Emory University Atlanta GA USA Department of Mathematics and Statistics and Computer Science Georgia State University Atlanta GA USA Department of Pathology and Laboratory Medicine Emory University Atlanta GA USA School of Physics Mathematics and Computing The University of Western Australia Crawley WA Australia Resonance Health Ltd Claremont WA Australia

Background & Aims Magnetic resonance-based steatosis measurement of the liver has become the non-invasive gold standard; however very few diagnostic thresholds have been independently validated and none in children. This study was designed to validate diagnostic thresholds, assess repeatability and the relationship to histology of a proprietary MRI volumetric liver fat fraction (VLFF) method (HepaFat-Scan ® ) and magnetic resonance spectroscopy (MRS) proton density fat fraction (PDFF) method. Methods This cross-sectional study assesses the diagnostic accuracy of MRI-VLFF and MRS-PDFF of 50 children who had a clinically indicated liver biopsy. Twenty-five children were randomly selected for intra-examination repeatability. The positive pixel count (PPC) algorithm was used to quantify the area of fat vesicles in the histology. The area under the receiver operating characteristic curve (AUROC) was used to assess the diagnostic accuracy. Bland-Altman plots were used to compare the methods and examine the repeatability. Results The MRI-VLFF ranged from 0.3% to 35.4% and the MRS-PDFF ranged from 0.5% to 36.9%. Based on histopathological analysis, the diagnostic accuracy of MRI-VLFF for steatosis detection (grade 0 vs 1-3) showed an AUROC of 0.95 (95% confidence interval [CI]: 0.89-1.00), whereas MRI-PDFF classified grade 0 vs 1-3 showed an AUROC of 0.96 (95% CI: 0.91-1.00). The repeatability coefficients were 1.8 (±0.5) % for MRI-VLFF and 2.1 (±0.6) % for MRS-PDFF. There was no bias between MRI-VLFF and PPC steatosis. To allow direct comparison, MRS-PDFF was converted to MRS-VLFF. Small, but significant biases were measured between PPC steatosis and MRS-VLFF (−1.38%) and between MRI-VLFF and MRS-VLFF (−1.39%). Conclusions Both MRI-VLFF and MRS-PDFF accurately estimated hepatic steatosis in children with excellent agreement with the histological assessment.

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