检索结果-内蒙古大学图书馆

Author Correction: Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease

Nature communications 2023年第1期14卷 4370页

作者： Matteo D'Antonio Jennifer P Nguyen Timothy D Arthur Hiroko Matsui Agnieszka D'Antonio-Chronowska Kelly A Frazer Department of Pediatrics University of California San Diego La Jolla CA 92093 USA. madantonio@ucsd.edu. Division of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA. madantonio@ucsd.edu. Institute of Genomic Medicine University of California San Diego 9500 Gilman Dr La Jolla CA 92093 USA. madantonio@ucsd.edu. Division of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA. Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA. Biomedical Sciences Graduate Program University of California San Diego La Jolla CA 92093 USA. Institute of Genomic Medicine University of California San Diego 9500 Gilman Dr La Jolla CA 92093 USA. Department of Pediatrics University of California San Diego La Jolla CA 92093 USA. Department of Pediatrics University of California San Diego La Jolla CA 92093 USA. kafrazer@health.ucsd.edu. Institute of Genomic Medicine University of California San Diego 9500 Gilman Dr La Jolla CA 92093 USA. kafrazer@health.ucsd.edu.

来源：评论

学校读者我要写书评

暂无评论

Clinical use of current polygenic risk scores may exacerbate health disparities (vol 51, pg 584, 2019)

引用

NATURE GENETICS 2021年第5期53卷 763-763页

作者： Martin, Alicia R. Kanai, Masahiro Kamatani, Yoichiro Okada, Yukinori Neale, Benjamin M. Daly, Mark J. Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA USA Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan Institute for Molecular Medicine Finland (FIMM) University of Helsinki Helsinki Finland Kyoto–McGill International Collaborative School in Genomic Medicine Kyoto University Graduate School of Medicine Kyoto Japan Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan Laboratory of Statistical Immunology Immunology Frontier Research Center (WPI-IFReC) Osaka University Suita Japan

来源：评论

学校读者我要写书评

暂无评论

Establishment of a protocol for rapidly expanding Epstein-Barr-virus-specific cytotoxic T cells with enhanced cytotoxicity

引用

BMC cancer 2024年第1期24卷 980页

作者： Chih-Hao Fang Ya Fang Cheng Shian-Ren Lin Wan-Yu Lai Li-Ren Liao Yen-Ling Chiu Jan-Mou Lee FullHope Biomedical Co. Ltd. 10F. No. 10 Ln. 609 Sec. 5 Chongxin Rd. Sanchong Dist. New Taipei City 241405 Taiwan. Department of Otolaryngology Far Eastern Memorial Hospital New Taipei City 220216 Taiwan. Division of Nephrology Department of Medicine Far Eastern Memorial Hospital New Taipei City 220216 Taiwan. yenling.chiu@***. Department of Medical Research Far Eastern Memorial Hospital No. 121 Sec. 2 Nanya S. Rd. Banqiao Dist. New Taipei City 220216 Taiwan. yenling.chiu@***. Graduate Institute of Medicine and Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan 320315 Taiwan. yenling.chiu@***. Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei 100233 Taiwan. yenling.chiu@***. FullHope Biomedical Co. Ltd. 10F. No. 10 Ln. 609 Sec. 5 Chongxin Rd. Sanchong Dist. New Taipei City 241405 Taiwan. billlee@fhb.com.tw.

BACKGROUND:Lytic Epstein-Barr virus (EBV) infection plays a major role in the pathogenesis of nasopharyngeal carcinoma (NPC). For patients with recurrent or metastatic NPC and resistant to conventional therapies, adoptive cell therapy using EBV-specific cytotoxic T cells (EBV-CTLs) is a promising option. However, the long production period (around 3 to 4 weeks) and low EBV-CTL purity (approximately 40% of total CD8 T cells) in the cell product limits the application of EBV-CTLs in clinics. Thus, this study aimed to establish a protocol for the rapid production of EBV-CTLs. METHODS:By culturing peripheral blood mononuclear cells (PBMCs) from EBV-seropositive donors with EBV-specific peptides and interleukin (IL)-2, IL-15, and interferon α (IFN-α) for 9 days, we identified that IL-15 can enhance IL-2-mediated CTL activation and significantly increase the yield of CTLs. RESULTS:When IFN-α was used in IL-2/IL-15-mediated CTL production from days 0 to 6, the productivity of EBV-CTLs and EBV-specific cytotoxicity significantly were reinforced relative to EBV-CTLs from IL-2/IL-15 treatment. Additionally, IFN-α-induced production improvement of virus-specific CTLs was not only the case for EBV-CTLs but also for cytomegalovirus-specific CTLs. CONCLUSION:We established a novel protocol to rapidly expand highly pure EBV-CTLs from PBMCs, which can produce EBV-CTLs in 9 days and does not require feeder cells during cultivation.

关键词： Adoptive cell therapy Cytotoxic T lymphocytes Epstein Barr virus Immunotherapy Nasopharyngeal carcinoma

来源：评论

学校读者我要写书评

暂无评论

GestaltMML: Enhancing Rare Genetic Disease Diagnosis through Multimodal Machine Learning Combining Facial Images and Clinical Texts

arXiv

引用

arXiv 2023年

作者： Wu, Da Yang, Jingye Liu, Cong Hsieh, Tzung-Chien Marchi, Elaine Blair, Justin Krawitz, Peter Weng, Chunhua Chung, Wendy Lyon, Gholson J. Krantz, Ian D. Kalish, Jennifer M. Wang, Kai Raymond G. Perelman Center for Cellular and Molecular Therapeutics Children's Hospital of Philadelphia PhiladelphiaPA19104 United States Department of Biomedical Informatics Columbia University Irving Medical Center New YorkNY10032 United States Institute for Genomic Statistics and Bioinformatics University Hospital Bonn Rheinische Friedrich-Wilhelms-Universität Bonn Bonn Germany Department of Human Genetics New York State Institute for Basic Research in Developmental Disabilities Staten IslandNY United States Division of Human Genetics Children's Hospital of Philadelphia PhiladelphiaPA19104 United States Department of Pediatrics Boston Children’s Hospital Harvard Medical School BostonMA United States Biology PhD Program The Graduate Center The City University of New York New York United States Department of Genetics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Pediatrics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States

Individuals with suspected rare genetic disorders often undergo multiple clinical evaluations, imaging studies, laboratory tests and genetic tests, to find a possible answer over a prolonged period of time. Addressing this "diagnostic odyssey" thus has substantial clinical, psychosocial, and economic benefits. Many rare genetic diseases have distinctive facial features, which can be used by artificial intelligence algorithms to facilitate clinical diagnosis, in prioritizing candidate diseases to be further examined by lab tests or genetic assays, or in helping the phenotype-driven reinterpretation of genome/exome sequencing data. Existing methods using frontal facial photos were built on conventional Convolutional Neural Networks (CNNs), rely exclusively on facial images, and cannot capture non-facial phenotypic traits and demographic information essential for guiding accurate diagnoses. Here we introduce GestaltMML, a multimodal machine learning (MML) approach solely based on the Transformer architecture. It integrates facial images, demographic information (age, sex, ethnicity), and clinical notes (optionally, a list of Human Phenotype Ontology terms) to improve prediction accuracy. Furthermore, we also evaluated GestaltMML on a diverse range of datasets, including 528 diseases from the GestaltMatcher Database, several in-house datasets of Beckwith-Wiedemann syndrome (BWS, over-growth syndrome with distinct facial features), Sotos syndrome (overgrowth syndrome with overlapping features with BWS), NAA10-related neurodevelopmental syndrome, Cornelia de Lange syndrome (multiple malformation syndrome), and KBG syndrome (multiple malformation syndrome). Our results suggest that GestaltMML effectively incorporates multiple modalities of data, greatly narrowing candidate genetic diagnoses of rare diseases and may facilitate the reinterpretation of genome/exome sequencing data. © 2023, CC BY.

关键词： Diseases

来源：评论

学校读者我要写书评

暂无评论

Real world fracture prediction of fracture risk assessment tool (FRAX), osteoporosis self-assessment tool for Asians (OSTA) and one-minute osteoporosis risk test: An 11-year longitudinal study

引用

Bone Reports 2024年 20卷 101742页

作者： Sheng, Yueh-Hsuan Wu, Tai-Yin Liaw, Chen-Kun Hsiao, Sheng-Huang Kuo, Kuan-Liang Tsai, Ching-Yao Department of Family Medicine Taipei City Hospital Renai Branch No. 10 Sec. 4 Renai Rd. Daan Dist. Taipei City Taiwan Department of Family Medicine Taipei City Hospital Zhongxing Branch No. 145 Zhengzhou Rd. Datong Dist. Taipei City Taiwan Institute of Epidemiology and Preventive Medicine National Taiwan University No. 17 Xuzhou Rd. Zhongzheng Dist. Taipei City Taiwan Department of Health and Welfare University of Taipei No. 101 Sec. 2 Zhongcheng Rd. Shilin Dist Taipei City Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University No. 250 Wuxing St. Xinyi Dist. Taipei City Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University No. 291 Zhongzheng Rd. Zhonghe Dist. New Taipei City Taiwan Research Center of Biomedical Device College of Biomedical Engineering Graduate Institute of Biomedical Optomechatronics Taipei Medical University No. 250 Wuxing St. Xinyi Dist. Taipei City Taiwan TMU Biodesign Center Taipei Medical University No. 250 Wuxing St. Xinyi Dist. Taipei City Taiwan Department of Neurosurgery Taipei City Hospital Renai Branch No. 10 Sec. 4 Ren'ai Rd. Da'an Dist. Taipei City Taiwan Department of Psychology National Chengchi University No. 64 Sec. 2 Zhinan Rd. Wenshan Dist. Taipei City Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University No. 155 Sec. 2 Linong St. Beitou Dist. Taipei City Taiwan The Bachelor's Program in Medical Informatics and Innovative Applications Fu Jen University No. 510 Zhongzheng Rd. Xinzhuang Dist. New Taipei City Taiwan Department of Ophthalmology Taipei City Hospital No. 145 Zhengzhou Rd. Datong Dist. Taipei City Taiwan Institute of Public Health National Yang Ming Chiao Tung University No. 155 Sec. 2 Linong St. Beitou Dist. Taipei City Taiwan Department of Business Administration Fu Jen Catholic University No. 510 Zhongzheng Rd. Xinzhuang Dist. New Taipei City Taiwan

Introduction: Fractures affect people's quality of life especially in the elders. One of the most important risk factors is osteoporosis. There are many screening tools to predict osteoporosis and fractures. We aimed to compare the predictive validity of three commonly used screening tools: fracture risk assessment tool (FRAX), osteoporosis self-assessment tool for Asians (OSTA) and one-minute osteoporosis risk test. Among them, OSTA and one-minute osteoporosis risk test were originally developed to predict osteoporosis risks and FRAX was to predict fracture risks. Methods: This is an 11-year longitudinal study. We enrolled 708 senior people from health examinees in Taiwan in 2010. A standardized questionnaire and blood tests were provided. Annual telephone interview was conducted to assess the real fracture status. We calculated risk scores of FRAX, OSTA, and one-minute osteoporosis risk test and compared with real-world fracture records. Results: The mean age of the participants were 74.9 (SD 6.4). There were 356 (50.3 %) men. From 2010 to 2020, a total of 105 (14.8 %) persons suffered from fractures. Compared to people without fractures, people with fractures had higher FRAX major osteoporotic fracture risk scores (14.0 % ± 7.6 % vs.11.3 % ± 5.7 %), higher hip fracture risk scores, and higher OSTA risk (5.9 % ± 1.4 % vs. 5.3 % ± 1.3 %). Cox regression analysis showed that hazard ratios for fracture of high FRAX risk was 1.53 (95 % confidence interval (CI) 1.05–2.21), and for high OSTA risk was 1.37 (95 % CI 1.04–1.82). Conclusions: Only OSTA and FRAX scores were satisfactory in predicting 10-year fractures. © 2024

关键词： Fracture risk assessment tool (FRAX) Fractures One-minute osteoporosis risk test Osteoporosis self-assessment tool for Asians (OSTA)

来源：评论

学校读者我要写书评

暂无评论

AAV-mediated silencing of Sox4 leads to long-term amelioration of liver phenotypes in mouse models of Alagille syndrome

引用

Gastroenterology 2025年

作者： Duncan Fox Jun Xie Jennifer L Burwinkel Josh M Adams Kashish Chetal Marzieh Keivandarian Yaniv Faingelernt Sanjay Subramanian Mario F Lopez Anna L Peters Nathan Salomonis Neda Zarrin-Khameh Guangping Gao Stacey S Huppert Hamed Jafar-Nejad Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas Genetics and Genomics Graduate Program Baylor College of Medicine Houston Texas. Department of Genetic and Cellular Medicine UMass Chan Medical School Worcester Massachusetts Horae Gene Therapy Center UMass Chan Medical School Worcester Massachusetts Department of Microbiology UMass Chan Medical School Worcester Massachusetts Viral Vector Core UMass Chan Medical School Worcester Massachusetts. Division of Gastroenterology Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio. Program in Developmental Biology Baylor College of Medicine Houston Texas. Division of Biomedical Informatics Cincinnati Children's Hospital Medical Center Cincinnati Ohio Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio. Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas. Division of Gastroenterology Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio Department of Pathology and Immunology Baylor College of Medicine and Ben Taub Hospital Houston Texas. Genetics and Genomics Graduate Program Baylor College of Medicine Houston Texas Program in Developmental Biology Baylor College of Medicine Houston Texas. Electronic address: hamedj@bcm.edu.

BACKGROUND & AIMS:In patients with Alagille syndrome (ALGS), bile duct paucity often leads to severe cholestatic phenotypes for which liver transplantation remains the only definitive treatment. No FDA-approved mechanism-based strategies exist to enhance biliary development in ALGS or other diseases with bile duct paucity. We aimed to identify a therapeutic target to address this unmet need. METHODS:Preclinical ALGS mouse models lacking one copy of Jag1 with or without conditional deletion of one or both copies of Sox9 were used. Sox4 levels were reduced genetically or with adeno-associated virus 8 (AAV8) vectors driving a Sox4-silencing sequence. Liver histology, biliary tree ink injection, serum chemistry, RNAscope (on mouse and human livers), mouse liver single-cell RNA-sequencing (scRNA-Seq), and reanalysis of published human liver bulk RNA-Seq were performed. RESULTS:Conditional removal of one copy of Sox4 in mouse liver significantly improved the ALGS liver phenotypes in a Sox9-dependent manner. An increase in Sox4/SOX4 expression in early postnatal Jag1-heterozygous mouse livers and ALGS patient livers was observed. scRNA-Seq revealed the appearance of an intermediate hepatobiliary cluster co-expressing Sox4 and Sox9 in Jag1-heterozygous livers. AAV8-mediated Sox4 knockdown, ubiquitously or driven by the hepatocyte-specific TBG promoter, led to long-term improvement of ALGS liver phenotypes upon injection at postnatal day 1 (P1). AAV8 injection at P15-after the appearance of liver necrosis-led to the incorporation of some transduced cells into bile ducts and phenotypic improvement. CONCLUSIONS:Preclinical studies provide proof of principle for postnatal AAV-mediated Sox4 knockdown in TBG cells as a therapeutic approach for ALGS liver disease.

关键词： Gene therapy JAG1 Notch signaling cholestasis

来源：评论

学校读者我要写书评

暂无评论

Mixture-of-experts variational autoencoder for clustering and generating from similarity-based representations

arXiv

引用

arXiv 2019年

作者： Kopf, Andreas Fortuin, Vincent Somnath, Vignesh Ram Claassen, Manfred Institute of Molecular Systems Biology Department of Biology ETH Zürich Switzerland Biomedical Informatics Group Department of Computer Science ETH Zürich Switzerland Switzerland Life Science Graduate School Zurich PhD Program Systems Biology Switzerland

Clustering high-dimensional data, such as images or biological measurements, is a long-standing problem and has been studied extensively. Recently, Deep Clustering gained popularity due to the non-linearity of neural networks, which allows for flexibility in fitting the specific peculiarities of complex data. Here we introduce the Mixture-of-Experts Similarity Variational Autoencoder (MoE-Sim-VAE), a novel generative clustering model. The model can learn multi-modal distributions of high-dimensional data and use these to generate realistic data with high efficacy and efficiency. MoE-Sim-VAE is based on a Variational Autoencoder (VAE), where the decoder consists of a Mixture-of-Experts (MoE) architecture. This specific architecture allows for various modes of the data to be automatically learned by means of the experts. Additionally, we encourage the latent representation of our model to follow a Gaussian mixture distribution and to accurately represent the similarities between the data points. We assess the performance of our model on synthetic data, the MNIST benchmark data set, and a challenging real-world task of defining cell subpopulations from mass cytometry (CyTOF) measurements on hundreds of different datasets. MoE-Sim-VAE exhibits superior clustering performance on all these tasks in comparison to the baselines and we show that the MoE architecture in the decoder reduces the computational cost of sampling specific data modes with high fidelity. Copyright © 2019, The Authors. All rights reserved.

关键词： Clustering algorithms

来源：评论

学校读者我要写书评

暂无评论

Mapping of human monoclonal antibody responses to XBB.1.5 COVID-19 monovalent vaccines: a B cell analysis

The Lancet. Microbe

引用

The Lancet. Microbe 2025年 101103页

作者： Raianna F Fantin Jordan J Clark Hallie Cohn Deepika Jaiswal Bailey Bozarth Vishal Rao Alesandro Civljak Igor Lobo Jessica R Nardulli Komal Srivastava Jeremy S Yong Robert Andreata-Santos Kaitlyn Bushfield Edward S Lee Gagandeep Singh Steven H Kleinstein Florian Krammer Viviana Simon Goran Bajic Camila H Coelho Department of Microbiology Icahn School of Medicine at Mount Sinai New York NY USA Center for Vaccine Research and Pandemic Preparedness Icahn School of Medicine at Mount Sinai New York NY USA. Department of Microbiology Icahn School of Medicine at Mount Sinai New York NY USA. Center for Vaccine Research and Pandemic Preparedness Icahn School of Medicine at Mount Sinai New York NY USA Graduate School of Biomedical Sciences Icahn School of Medicine at Mount Sinai New York NY USA. Retrovirology Laboratory Department of Microbiology Immunology and Parasitology Paulista School of Medicine Federal University of São Paulo São Paulo Brazil. Department of Laboratory Medicine Yale School of Medicine New Haven CT USA Department of Pathology Yale School of Medicine New Haven CT USA. Department of Pathology Yale School of Medicine New Haven CT USA Program in Computational Biology and Biomedical Informatics Yale University New Haven CT USA Department of Immunobiology Yale School of Medicine New Haven CT USA Department of Biomedical Informatics and Data Science Yale School of Medicine New Haven CT USA. Department of Pathology Molecular and Cell-Based Medicine Icahn School of Medicine at Mount Sinai New York NY USA Ignaz Semmelweis Institute Interuniversity Institute for Infection Research Medical University of Vienna Vienna Austria. The Global Health and Emerging Pathogens Institute Icahn School of Medicine at Mount Sinai New York NY USA Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Program in Computational Biology and Biomedical Informatics Yale University New Haven CT USA. Electronic address: goran.bajic@mssm.edu. Precision Immunology Institute Icahn School of Medicine at Mount Sinai New York NY USA. Electronic address: camila.coelho@mssm.edu.

BACKGROUND:The rapid emergence of highly transmissible and immune-evasive SARS-CoV-2 variants has required the reformulation of COVID-19 vaccines to target these evolving threats. Although previous infections and booster vaccinations can boost variant neutralisation, it remains uncertain whether monovalent vaccines-delivered via mRNA or protein-based platforms-can trigger novel B-cell responses specific to omicron XBB.1.5 variants. We sought to address this uncertainty by characterising the antibody repertoire of individuals receiving a monovalent booster vaccine. METHODS:In this observational study, we analysed the genetic antibody repertoire of 603 individual plasmablasts from five individuals (recruited at the Icahn School of Medicine at Mount Sinai, New York, NY, USA, from STUDY-16-01215/IRB-16-00971 and STUDY-20-00442/IRB-20-03374) vaccinated with a monovalent XBB.1.5 vaccine, either through mRNA (Moderna or Pfizer-BioNTech; participants 1, 2, and 3) or adjuvanted protein (Novavax; participants 4 and 5) platforms. Before XBB.1.5 booster vaccination, all participants received mRNA-based priming and booster vaccine with ancestral SARS-CoV-2 and four of the five participants had a breakthrough omicron variant infection. We expressed 100 human monoclonal antibodies (mAbs; 50 from participants 1, 2, and 3, and 50 from participants 4 and 5) and evaluated their binding and neutralisation against various SARS-CoV-2 variants, including JN.1. We then selected four mAbs for in-vivo protection experiments by passive immunisation and viral challenge, and cryo-electron microscopy with two selected mAbs complexed with the XBB.1.5 spike (S) protein to determine their structures and binding interactions. FINDINGS:Between October and November, 2023, we enrolled three male and two female participants (mean age 46 years) all of whom were White. We identified 21 binding mAbs and tested their neutralisation capacity against ancestral SARS-CoV-2, XBB.1.5, and JN.1. From the six neutr

关键词：

来源：评论

学校读者我要写书评

暂无评论

Percutaneous Coronary Intervention With a Drug-Eluting Stent Versus Coronary Artery Bypass Grafting in Patients Receiving Dialysis: A National Study From Taiwan

引用

Kidney medicine 2024年第2期6卷 100768页

作者： Szu-Yu Pan Ju-Yeh Yang Nai-Chi Teng Yun-Yi Chen Shi-Heng Wang Chien-Lin Lee Kang-Lung Chen Yen-Ling Chiu Shih-Ping Hsu Yu-Sen Peng Yung-Ming Chen Shuei-Liong Lin Likwang Chen Department of Integrated Diagnostics and Therapeutics National Taiwan University Hospital Taipei Taiwan. Division of Nephrology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan. Division of Nephrology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan. Institute of Health Policy and Management College of Public Health National Taiwan University Taipei Taiwan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Research Shin-Kong Wu Ho-Su Memorial Hospital Taipei Taiwan. Institute of Hospital and Health Care Administration National Yang Ming Chiao Tung University Taipei Taiwan. National Center for Geriatrics and Welfare Research National Health Research Institutes Yunlin Taiwan. Department of Cardiology Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Cardiovascular Surgery Far Eastern Memorial Hospital New Taipei City Taiwan. Graduate Program in Biomedical Informatics Department of Computer Science and Engineering College of Informatics Yuan Ze University Taoyuan Taiwan. Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan. Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan.

Rationale & Objective:We aimed to study the comparative effectiveness of percutaneous coronary intervention with drug-eluting stent and coronary artery bypass grafting in patients receiving dialysis. Study Design:This was a retrospective observational cohort study. Setting & Participants:This population-based study identified patients receiving dialysis hospitalized for coronary revascularization between January 1, 2009 and December 31, 2015, in the Taiwan National Health Insurance Research Database. Exposures:Patients received percutaneous coronary intervention with drug-eluting stent versus coronary artery bypass grafting. Outcomes:The study outcomes were all-cause mortality, in-hospital mortality, and repeat revascularization. Analytical Approach:Propensity scores were used to match patients. Cox proportional hazards models and logistic regression models were constructed to examine associations between revascularization strategies and mortality. Interval Cox models were fitted to estimate time-varying hazards during different periods. Results:A total of 1,840 propensity score-matched patients receiving dialysis were analyzed. Coronary artery bypass grafting was associated with higher in-hospital mortality (coronary artery bypass grafting vs percutaneous coronary intervention with drug-eluting stent; crude mortality rate 12.5% vs 3.3%; adjusted OR, 5.22; 95% CI, 3.42-7.97; < 0.001) and longer hospitalization duration (median [IQR], 20 [14-30] days vs 3 [2-8] days; < 0.001). After discharge, repeat revascularization, acute coronary syndrome, and repeat hospitalization all occurred more frequently in the percutaneous coronary intervention with drug-eluting stent group. Importantly, with a median follow-up of 2.8 years, coronary artery bypass grafting was significantly associated with a higher risk of all-cause overall mortality (adjusted HR, 1.19; 95% CI, 1.05-1.35; = 0.006) in the multivariable Cox proportional hazard model. Sensitivity and subgroup analyses yie

关键词： Coronary artery bypass grafting coronary revascularization dialysis drug-eluting stent end-stage kidney disease mortality percutaneous coronary intervention survival

来源：评论

学校读者我要写书评

暂无评论

Author Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma

引用

Nature 2024年第8006期628卷 E1页

作者： Guangchun Han Ansam Sinjab Zahraa Rahal Anne M Lynch Warapen Treekitkarnmongkol Yuejiang Liu Alejandra G Serrano Jiping Feng Ke Liang Khaja Khan Wei Lu Sharia D Hernandez Yunhe Liu Xuanye Cao Enyu Dai Guangsheng Pei Jian Hu Camille Abaya Lorena I Gomez-Bolanos Fuduan Peng Minyue Chen Edwin R Parra Tina Cascone Boris Sepesi Seyed Javad Moghaddam Paul Scheet Marcelo V Negrao John V Heymach Mingyao Li Steven M Dubinett Christopher S Stevenson Avrum E Spira Junya Fujimoto Luisa M Solis Ignacio I Wistuba Jichao Chen Linghua Wang Humam Kadara Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Graduate Program in Developmental Biology Baylor College of Medicine Houston TX USA. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. Department of Biostatistics Epidemiology and Informatics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Thoracic Head and Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cardiovascular and Thoracic Surgery The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Medicine The University of California Los Angeles Los Angeles CA USA. Lung Cancer Initiative at Johnson & Johnson Boston MA USA. Section of Computational Biomedicine School of Medicine Boston University Boston MA USA. Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. JChen16@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. JChen16@***. Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. lwang22@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. lwang22@***. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX USA. hkadara@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. hkadara@***.

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：