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3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering

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ACS Applied Materials and Interfaces 2025年第20期17卷 29455-29468页

作者： Chen, Chieh-Ying Hope Gadia Moreno, Ruaina Lily Wang, Po-Yao Nguyen, Thanh Sang Wu, Jia-Lin Chen, Kuan-Hao Chen, Chih-Hwa Lin, Chia-Ying Wong, Pei-Chun Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Trauma Hue Central Hospital Hue530000 Viet Nam Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Orthopedics Research Center Taipei Medical University Hospital Taipei11031 Taiwan Centers for Regional Anesthesia and Pain Medicine Wan Fang Hospital Taipei Medical University Taipei11096 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei23561 Taiwan Convergent Bioscience and Technology Institute Department of Biomedical Engineering and Informatics Indiana University IndianapolisIN46202 United States

Three-dimensional (3D) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise and customizable solutions for bone tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties for temperature-controlled bone regeneration. The AuPB-PCL scaffolds demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, and improved osteogenic potential. Photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, and mineralization. Notably, mild hyperthermia (39-41 °C) induced by laser irradiation optimized osteogenesis, while excessive temperatures (≥42.5 °C) impaired cellular function due to mitochondrial stress and oxidative damage. These findings highlight the potential of AuPB-PCL scaffolds for controlled photothermal bone regeneration, offering a promising strategy for precise, completely noninvasive stimulation of bone repair. © 2025 The Authors. Published by American Chemical Society.

关键词： Fiber bonding

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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Enhanced Performance and Data Privacy in Lung Nodule Classification via Federated Deep Learning Approach 24

Enhanced Performance and Data Privacy in Lung Nodule Classif...

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2024 7th International Conference on Healthcare Service Management, ICHSM 2024

作者： Nguyen, Duc-Khanh Li, Ai-Hsien Adam Lai, Yen-Jun Chiu, Yen-Ling Phan, Dinh-Van Chien, Ting-Ying Chan, Chien-Lung Department of Information Management Yuan Ze University Taoyuan Taiwan Department of Statistics and Informatics University of Economics The University of Danang Danang Viet Nam Division of Cardiology Far Eastern Memorial Hospital New Taipei Taiwan Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan Taiwan Department of Radiology Far Eastern Memorial Hospital New Taipei Taiwan Graduate Institute of Medicine and Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan Taiwan Department of Medical Research Far Eastern Memorial Hospital New Taipei Taiwan Department of Computer Science and Engineering Yuan Ze University Taoyuan Taiwan ZDT Group- YZU Joint Research and Development Center for Big Data Taoyuan Taiwan Yuan Ze University Taoyuan Taiwan

ISBN: (纸本)9798400710162

This study explores the feasibility of deep learning for classifying nodule neoplasms, analyzing their performance on two openly available datasets, LUNGx SPIE, and LIDC-IDRI. These datasets offer valuable diversity in image quantity, quality, and malignancy annotation methodologies, posing a real-world challenge for effective model development. To handle the disparities in these diverse datasets, we aim to develop a robust classification model trained using federated learning. This decentralized approach allows model training across datasets without sharing patient data, preserving privacy and overcoming data fragmentation. Our experiments demonstrate that federated learning enables the development of a robust and superior deep learning model compared to individual models trained on limited data. This combination of deep learning, and federated learning holds immense promise for nodule neoplasm classification and can significantly improve patient care and outcomes. © 2024 Copyright held by the owner/author(s).

关键词： Federated learning

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Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies

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Journal of biomedical Science 2025年第1期32卷 1-17页

作者： Thio, Christina Li-Ping Shao, Jheng-Syuan Luo, Chia-Hui Chang, Ya-Jen Institute of Biomedical Sciences Academia Sinica No. 128 Academia Road Section 2 Nankang Taipei City 115 Taiwan Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei City 115 Taiwan Institute of Translational Medicine and New Drug Development China Medical University Taichung City 404 Taiwan

Asthma is a chronic inflammatory lung disease driven by a complex interplay between innate and adaptive immune components. Among these, innate lymphoid cells (ILCs) and innate-like lymphocytes have emerged as crucial players in shaping the disease phenotype. Within the ILC family, group 2 ILCs (ILC2s), in particular, contribute significantly to type 2 inflammation through their rapid production of cytokines such as IL-5 and IL-13, promoting airway eosinophilia and airway hyperreactivity. On the other hand, innate-like lymphocytes such as invariant natural killer T (iNKT) cells can play either pathogenic or protective roles in asthma, depending on the stimuli and lung microenvironment. Regulatory mechanisms, including cytokine signaling, metabolic and dietary cues, and interactions with other immune cells, play critical roles in modulating their functions. In this review, we highlight current findings on the role of ILCs and innate-like lymphocytes in asthma development and pathogenesis. We also examine the underlying mechanisms regulating their function and their interplay with other immune cells. Finally, we explore current therapies targeting these cells and their effector cytokines for asthma management. © The Author(s) 2025.

关键词： Asthma ILCs Immune regulation Innate-like lymphocytes Therapeutic targets

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Association of computed variables with anthropometric indices in north indian children exposed to Bisphenol-A and heavy metals

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Discover Epidemics 2025年第1期2卷 1-17页

作者： Malik, Vivek Singh Attri, Savita Verma Dayal, Devi Ravindra, Khaiwal Department of Community Medicine and School of Public Health Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India Department of Pediatrics Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India Department of Telemedicine and Biomedical Informatics All India Institute of Medical Sciences (AIIMS) Rishikesh India

Obesity and underweight-associated environmental risk factors pose significant health challenges for the public, especially among children at an early stage of life. This study evaluates the association and potential role of combined exposure to Bisphenol-A (BPA) and heavy metals with anthropometric indices among North Indian children. This study also demonstrates the possibility of reverse causality, where obesity or underweight may result from BPA and heavy metals exposure among children. A total of 301 children were enrolled, grouped into obese, non-obese, and underweight. Urinary BPA and blood heavy metal levels were measured using LC–MS/MS and ICP-MS. Both quantitative variables, BPA and metals, were combined using the computed feature of SPSS, followed by linear regression analysis to identify the association with anthropometric indices (height, weight, BMI, waist and hip circumference, waist-to-stature ratio, and waist-to-hip ratio). A positive association was found among obese children for computed variables of combined exposure to BPA*Zn (WB) and a negative association with BPA*Fe (WB) for weight, height, and BMI. Similarly, a positive association was observed among underweight children for the computed variable of BPA*U (WB) with weight, height, and BMI. Significant negative associations were also observed for the BPA*Mg (WB) and BPA*Hg (WB) with WHR among obese and BPA*Cu (WB) with weight and BPA*Hg (WB) with WHR among underweight children. This study found a positive association for BPA*Se (WB) and BPA*Cd (S) with WC and WHR, respectively, among non-obese children. Our analysis suggests that BPA, combined with metals, is associated with both obesity and underweight. Both BPA and heavy metals are endocrine disruptive pollutants that may affect the metabolic pathways by substituting vital metals and inducing oxidative stress. This extends the scope for future research to address obesity and underweight among children. However, these results should be inter

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Effects of stepping practice and functional electrical stmulation on neuromotor excitability in able bodied young adults

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Experimental Brain Research 2025年第6期243卷 1-11页

作者： Spencer, Jacob Aloba, Fisayo K. Slusarenko, Alexandra Leone, Taylor Patel, Jay Eyvazzadeh, Lily Lynch, Anna-Lee Borich, Michael R. Kesar, Trisha M. Division of Physical Therapy Department of Rehabilitation Medicine Emory University Atlanta GA United States School of Biological Sciences Georgia Institute of Technology Atlanta GA United States Neuroscience Graduate Program Graduate Division of Biological and Biomedical Sciences Emory University Atlanta GA United States Neuroscience and Behavioral Biology Undergraduate Program College of Arts and Sciences Emory University Atlanta GA United States Emory Rehabilitation Hospital 1441 Clifton Rd NE Room RG44 Atlanta 30322 GA United States

The neural processes underlying gait retraining interventions that combine stepping practice with electrical stimulation are poorly understood. The purpose of this study was to compare acute changes in corticomotor excitability measured by motor evoked potential (MEP) amplitude, monosynaptic stretch reflex excitability measured by H/M ratio, and propulsive force generation during gait measured by anterior ground reaction forces (AGRF), induced by 30-minutes of fast walking (Fast) and 30-minutes of fast walking with functional electrical stimulation of the ankle plantarflexors and dorsiflexors (FastFES) in 14 able-bodied young adults. Our results showed that FastFES, but not Fast elicited a significant acute decrease in tibialis anterior MEP amplitude (p =.01). Furthermore, the practice-induced acute decrease in tibialis anterior MEP amplitudes was significantly larger for FastFES than Fast (p =.04). FastFES also elicited a statistically significant increase in the AGRF in the tested limb (p =.01), which was significantly larger than the change induced by Fast (p =.04). Additionally, baseline soleus MEP amplitude was positively correlated with within-session change in AGRF (p =.04, r² = 0.16). Acute decrease in tibialis anterior MEP amplitude for the FastFES condition relative to the Fast condition may be caused by fatigue, while the greater increase in AGRF for the FastFES condition signify that stepping practice facilitated alterations of gait patterns. More research is needed to confirm neural mechanisms and investigate the acute as well as long-term effects of Fast and FastFES on clinical populations. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.

关键词： Corticospinal tract Functional electrical stimulation Gait training Neuroplasticity Walking exercise

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Age-Associated Perinexal Narrowing Masks Consequences of Sodium Channel Gain of Function in Guinea Pig Hearts

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JACC: Clinical Electrophysiology 2025年第5期11卷 919-930页

作者： Wu, Xiaobo King, David Ryan Hoeker, Gregory S. Wan, Xiaoping Deschenes, Isabelle Johnstone, Scott R. Gourdie, Robert G. Weinberg, Seth H. Poelzing, Steven Translational Biology Medicine and Health Graduate Program Virginia Polytechnic Institute and State University Roanoke VA United States Center for Vascular and Heart Research Fralin Biomedical Research Institute at Virginia Tech Carilion Roanoke VA United States Frick Center for Heart Failure and Arrhythmia Dorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Wexner Medical Center Columbus OH United States Department of Biomedical Engineering and Mechanics Virginia Polytechnic Institute and State University Blacksburg VA United States Department of Biomedical Engineering Davis Heart and Lung Research Institute The Ohio State University Columbus OH United States

Background: Voltage-gated sodium channel gain of function (NavGOF) is associated with an elevated risk for cardiac arrhythmia. Recent studies have demonstrated that NavGOF can be exacerbated by widening the sodium cha... 详细信息

Background: Voltage-gated sodium channel gain of function (Na_vGOF) is associated with an elevated risk for cardiac arrhythmia. Recent studies have demonstrated that Na_vGOF can be exacerbated by widening the sodium channel–rich perinexus next to gap junction plaques. Clinically, the incidence of Na_vGOF-related cardiac events increases with advancing age. However, the impact of aging on perinexal changes and contribution to age-related risk for arrhythmias in Na_vGOF remains unclear. Objectives: The aim of this study was to test the hypothesis that age-related increase in arrhythmogenic risk is associated with perinexal remodeling in a model of Na_vGOF. Methods: Na_vGOF was pharmacologically induced in isolated adult (3 months, n = 17) and aged (15 months, n = 19) guinea pig hearts. Epicardial action potentials were optically mapped, and age-associated perinexal remodeling was measured with transmission electron microscopy. Results: Na_vGOF electrical phenotypes were comparable between adult and aged hearts despite their exacerbation after perinexal widening. The similarity in these phenotypes may be masked by the narrower perinexus with aging. Furthermore, perinexal widening led to a high incidence of arrhythmias in aged Na_vGOF hearts, whereas no arrhythmias were induced in adult Na_vGOF hearts. This increased incidence of arrhythmias in aged Na_vGOF hearts following perinexal widening may be associated with the increased dispersions of epicardial action potential duration and transmural repolarization. Conclusions: Perinexal widening exacerbates arrhythmogenic propensity with age, primarily by heterogeneously increasing action potential duration, whereas perinexal narrowing appears to be adaptive and cardio protective in the context of Na_vGOF. © 2025

关键词： aging APD dispersion arrhythmia GOF perinexus sodium channel

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Cytocompatible and antibacterial Fe-, Cu- and Zn-substituted calcium hydroxyapatite materials for skin applications

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Ceramics International 2025年第9期51卷 11286-11296页

作者： Lukaviciute, L. Lukowiak, A. Stankeviciute, Z. Junka, A. Mortimer, M. Zarkov, A. Yang, J.-C. Ganceviciene, R. Kareiva, A. Faculty of Chemistry and Geosciences Vilnius University Naugarduko st. 24 Vilnius03225 Lithuania Institute of Low Temperature and Structure Research Polish Academy of Sciences Okolna 2 Wroclaw50422 Poland Department of Pharmaceutical Microbiology and Parasitology Wroclaw Medical University Borowska 211A Wroclaw50556 Poland Laboratory of Environmental Toxicology National Institute of Chemical Physics and Biophysics Akadeemia tee 23 Tallinn12618 Estonia Graduate Institute of Nanomedicine and Medical Engineering International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Research Center of Biomedical Device Research Center of Digital Oral Science and Technology Taipei Medical University Taiwan Faculty of Medicine Vilnius University M.K. Ciurlionio st. 21 Vilnius03101 Lithuania

Calcium hydroxyapatite (C10(PO4)6(OH)2;CHAp) and metal-substituted samples (Fe:CHAp, Cu:CHAp, and Zn:CHAp) were synthesized using a recently developed method. This method involved the wet precipitation of amorphous calcium phosphate (ACP), followed by solid-state reaction synthesis of α-tricalcium phosphate (α-TCP), and finally hydrothermal synthesis of CHAp. The effect of Fe3+, Cu2+, and Zn2+ substitution on the phase purity and antimicrobial properties of CHAp are summarized in this study. Notably, it highlights the phase purity of CHAp and Zn:CHAp (in the presence of Fe3+ and Cu2+ ions, the α- and β-TCP phases have formed) as well as the antimicrobial activity of Zn:CHAp and Cu:CHAp against Staphylococcus aureus and Candida albicans. The synthesized nanosized CHAp, Fe:CHAp, Cu:CHAp, and Zn:CHAp samples were used as additives in the preparation of skin creams. In vitro biological studies of the resulting skin creams demonstrated their antimicrobial activity against Pseudomonas aeruginosa, and showed a reduction in osteoblasts cells viability of in the range of 20–40 %. The addition of zinc enhances antimicrobial efficacy but reduces biocompatibility, while copper maintains both high antimicrobial activity and biocompatibility, making it more suitable for the development of medical or cosmetic materials. Dermal creams containing CHAp with copper and iron ions also show significant antimicrobial activity while preserving good cell viability. These results highlight the importance of optimizing the balance between antimicrobial effectiveness and biocompatibility in these materials. © 2024

关键词： Biocompatibility

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SwiftMedSAM: An Ultra-lightweight Prompt-Based Universal Medical Image Segmentation Model for Highly Constrained Environments

SwiftMedSAM: An Ultra-lightweight Prompt-Based Universal Med...

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International Challenge on Segment Anything in Medical Images on Laptop held in conjunction with the IEEE/CVF Conference on Computer Vision and Pattern Recognition, CVPR 2024

作者： Kong, Youngbin Kim, Kwangtai Jeong, Seoi Lee, Kyu Eun Kong, Hyoun-Joong Interdisciplinary Program in Bioengineering Graduate School Seoul National University Seoul Korea Republic of Department of Transdisciplinary Medicine Seoul National University Hospital Seoul Korea Republic of Department of Surgery Seoul National University Hospital and College of Medicine Seoul Korea Republic of Department of Medicine Seoul National University College of Medicine Seoul Korea Republic of Innovative Medical Technology Research Institute Seoul National University Hospital Seoul Korea Republic of Interdisciplinary Program of Medical Informatics Seoul National University College of Medicine Seoul Korea Republic of

ISBN: (纸本)9783031818530

Medical image segmentation is a crucial step for accurate diagnosis and treatment planning, as it provides quantitative information about anatomical structures and pathological lesions in various clinical scenarios. However, the existing methodologies have limitations in terms of their generalizability and computational efficiency. In this study, we propose SwiftMedSAM, an ultra-lightweight prompt-based general model, to enable efficient medical image segmentation even in resource-constrained environments. Based on LiteMedSAM, we significantly reduced the model size and computational complexity through the hyperparameter optimization of the image encoder and mask decoder components. SwiftMedSAM showed remarkable performance across various imaging modalities enabling real-time inference in resource-limited computing environments. It achieved a validation score of 0.75 demonstrating that SwiftMedSAM outperformed the existing methodologies in terms of the trade-off between accuracy and efficiency. Owing to its unprecedented generalizability and low computational cost, SwiftMedSAM is expected to enable high-quality medical image analysis in resource-constrained settings, thereby contributing to advancements in precision medicine and telemedicine. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Medical imaging

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Non-variable RNA deletion using the CRISPR-Cas9 technique demonstrated improved outcomes in human intestine single-cell RNA sequencing data, even at half sequencing depths

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Genomics and informatics 2025年第1期23卷 1-11页

作者： Kim, Dong Jun Joh, Christine Suh Yun Jeong, So Young Kim, Yong Jun Koh, Seong Joon Kim, Hyun Je Department of Biomedical Sciences Seoul National University Graduate School Seoul 03080 South Korea Department of Microbiology and Immunology Seoul National University College of Medicine Seoul 03080 South Korea Cancer Research Institute Seoul National University College of Medicine Seoul 03080 South Korea Genomic Medicine Institute Seoul National University College of Medicine Seoul 03080 South Korea Interdisciplinary Program in Artificial Intelligence (IPAI) Seoul National University Seoul 08826 South Korea Department of Internal Medicine and Liver Research Institute Medical Research Center Seoul National University College of Medicine Seoul 03080 South Korea

In single-cell RNA sequencing (scRNA-seq) data, issues related to the high expression of non-variable RNAs often arise due to organ traits or sample quality. Computational methods, such as SoupX (Young (Gigascience 9:giaa151, 2020)), have been used to solve this problem but it may remove biologically relevant data. This study presents a clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9-based method that selectively removes non-variable RNAs. We applied this approach to scRNA-seq data from human intestinal tissues of 17 patients. By targeting non-variable genes, including ribosomal and mitochondrial RNAs, CRISPR-Cas9 treatment effectively reduced their expression, outperforming computational methods in both the number and extent of gene removal. The CRISPR-Cas9 treated samples, sequenced at half the depth compared to untreated samples, maintained comparable sequencing quality, and saturation, demonstrating that this approach can reduce sequencing costs while preserving data quality. Cell type composition and gene expression patterns remained consistent between treated and original datasets, with no unintended gene deletions. Overall, our findings suggest that the CRISPR-Cas9-based method offers a cost-effective solution for improving scRNA-seq data quality, particularly for tissues with high levels of non-variable RNAs, without compromising biological integrity. © The Author(s) 2025.

关键词： CRISPR-Cas9 Non-variable RNA Single cell RNA sequencing

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