Cardiac rehabilitation protocols applied during the inhospital phase(phaseⅠ)are subjective and their results are contested when evaluated considering what should be the three basic principles of exercise prescription...
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Cardiac rehabilitation protocols applied during the inhospital phase(phaseⅠ)are subjective and their results are contested when evaluated considering what should be the three basic principles of exercise prescription:specificity,overload and *** this review,we focus on the problems associated with the models of exercise prescription applied at this early stage in-hospital and adopted today,especially the lack of clinical studies demonstrating its ***,we present the concept of"periodization"as a useful tool in the search for better results.
The filamentous fungus Moniliophthora perniciosa (Stahel) Aime & Phillips-Mora is a hemibiotrophic Basidiomycota that causes witches' broom disease of cocoa (Theobroma cacao L.). This disease has resulted in a...
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ISBN:
(纸本)9781615677153
The filamentous fungus Moniliophthora perniciosa (Stahel) Aime & Phillips-Mora is a hemibiotrophic Basidiomycota that causes witches' broom disease of cocoa (Theobroma cacao L.). This disease has resulted in a severe decrease in the Brazilian cocoa production, which changed the position of Brazil in the market from the second largest cocoa exporter to a cocoa importer. Fungal mitochondrial plasmids are usually invertrons encoding DNA and RNA polymerases. Plasmid insertion into host mitochondrial genomes are probably associated to modifications in host generation time, which can be involved in fungal aging. This association suggests activity of polymerases, and these can be used as new targets for drugs against mitochondrial activity of fungi, more specifically against witches' broom disease. DNA and RNA polymerases of M. perniciosa mitochondrial plasmid were completely sequenced and their models were built by Comparative Modeling approach using Swiss-PdbViewer. The DNA and RNA polymerases models were refined by a set of Molecular Mechanics (MM) and Molecular Dynamics (MD) simulation in water. The resultant models were evaluated by Procheck 3.0 and ANOLEA. Ramachandran plots showed 97% and 98% of residues in favorable region for DNA and RNA polymerases, respectively. Potential Energy plots showed, in general, that all atoms of sidechain had favorable thermodynamic values for both proteins. This study can contribute for the development of new alternatives for controlling the fungal agent of witches' broom disease.
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