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A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy

Light(Science & Applications) 2025年第1期14卷 153-166页

作者： Zhichao Wang Yuqi Tang Quan Li Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast UniversityNanjing211189China Materials Science Graduate Program Kent State UniversityKentOH44242USA

The microenvironment of immunosuppression and low immunogenicity of tumor cells has led to unsatisfactory therapeutic effects of the currently developed *** cell death,such as pyroptosis and ferroptosis,can efficiently boost antitumor ***,the exploration of nanoplatform for dual function inducers and combined immune activators that simultaneously trigger pyroptosis and ferroptosis remains ***,a multifunctional pH-responsive theranostic nanoplatform(M@P)is designed and constructed by self-assembly of aggregation-induced emission photosensitizer MTCN-3 and immunoadjuvant Poly(l:C),which are further encapsulated in amphiphilic *** nanoplatform is found to have the characteristics of cancer cell targeting,pH response,near-infrared fluorescence imaging,and lysosome ***,after targeting lysosomes,M@P can cause lysosome dysfunction through the generation of reactive oxygen species and heat under light irradiation,triggering pyroptosis and ferroptosis of tumor cells,achieving immunogenic cell death,and further enhancing immunotherapy through the combined effect with the immunoadjuvant Poly(I:C).The anti-tumor immunotherapy effect of M@P has been further demonstrated in in vivo antitumor experiment of 4T1 tumor-bearing mouse model with poor *** research would provide an impetus as well as a novel strategy for dual function inducers and combined immune activators enhanced photoimmunotherapy.

关键词： immunotherapy cancer aggregation

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TaxDiff: taxonomic-guided diffusion model for protein sequence generation

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Science China(Information Sciences) 2025年第4期68卷 385-386页

作者： Zongying LIN Hao LI Liuzhenghao LV Yu WANG Bin LIN Junwu ZHANG Zijun CHEN Calvin Yu-Chian CHEN Li YUAN Yonghong TIAN School of Electronic and Computer Engineering Peking University AI for Science (AI4S)-Preferred Program Peking University Shenzhen Graduate School Peng Cheng Laboratory School of Chemical Biology and Biotechnology Peking University

Protein design aims to generate protein variants with targeted biological functions, which is significant in multiple biological areas, including enzyme reaction catalysis, vaccine design, and fluorescence intensity. Protein design contains two paradigms: sequence generation and structure generation. Recently, EvoDiff [1] proposed a universal designing paradigm, combining structure and sequence generation using the diffusion framework, which improves the protein design efficiency.

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Production and characterization of polymeric nanocomposite foams based on starch and cellulose nanofibers from oil palm mesocarp fiber

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Applied Nanoscience (Switzerland) 2025年第2期15卷 1-11页

作者： Souza, Mariana Costa Gonçalves, Ana Paula Bispo da Silva Oliveira, Emanoel Igor dos Santos, Juscivaldo Passos Lazzari, Lídia Kunz Zattera, Ademir José José, Nadia Mamede Chemical Engineering Graduate Program Polytechnic School Federal University of Bahia Bahia Salvador Brazil Department of Education Federal Institute of Education Science and Technology Feira de Santana Bahia Brazil Postgraduate Program in Process Engineering and Technologies University of Caxias Do Sul Rio Grande Do Sul Caxias Do Sul Brazil

The demand for sustainable and eco-friendly materials has promoted studies over the years to explore different polymeric materials that meet requirements such as biodegradability and sustainability. In this context, biopolymer materials based on cellulose nanoparticles and starch from different botanical sources have been investigated, aiming to achieve satisfactory performance. The present study aims to develop and characterize cassava starch foams based on density, scanning electron microscopy (SEM), and three-point flexure tests, and to evaluate the effect of cellulose nanofibers obtained from palm mesocarp fibers using the ultrafine friction grinding method after different processing times, characterized by X-ray diffractometry (XRD), microscopy, and chemical composition, as a reinforcing filler. The chemical composition and scanning electron microscopy revealed the effectiveness of the cellulose isolation process, with the analysis of the chemical composition revealing a cellulose content of 55.70% in the fibers after pulping and bleaching, in addition to changes in the visual characteristics of the material after the process aimed at isolating the cellulose. After grinding, XRD showed an increase in crystallinity (76.1% at the maximum grinding time), along with typical microscopy images of cellulose nanofibers. The analysis of the obtained nanocomposites provided insights into the role of these nanostructures in the thermo-expanded starch matrix, indicating that the nanofibers promoted changes such as an increase in mechanical properties and crystallinity, which contributed to improving overall mechanical performance. A 67.48% increase in flexural strength was achieved for the formulation with cellulose nanofibers that underwent 150 min of grinding, without causing major variations in density. © King Abdulaziz City for Science and Technology 2025.

关键词： Starch

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Multi-Scale Analysis Combined Operando Elemental/Spectroscopic Measurement Techniques in Oxide-Type All-Solid-State Na Batteries

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Energy & Environmental Materials 2025年第2期8卷 38-47页

作者： Koji Hiraoka Kazuo Yamamoto Takeshi Kobayashi Tetsuo Sakamoto Shiro Seki Graduate School of Engineering Applied Chemistry and Chemical Engineering Program Kogakuin University Nanostructures Research Laboratory Japan Fine Ceramics Center Energy Transformation Research Laboratory Central Research Institute of Electric Power Industry Graduate School of Engineering Electrical Engineering and Electronics Program Kogakuin University

Understanding the charge/discharge mechanism of batteries plays an important role in the development of high-performance systems,but extremely complicated reactions are *** these complex phenomena are also bottlenecks for the establishment of all-sol id-state batteries(ASSB),we conducted multi-scale analysis using combined multi-measurement techniques,to directly observe charge/discharge reactions at hierarchical scales for the oxide-type ASSB using Na as the carrier *** particular,all of measurement techniques are applied to cross-section ASSB in the same cell,to complementarily evaluate the elemental distributions and structural *** Operando scanning electron microscopy-energy-dispersive X-ray spectroscopy,the Na concentration in the electrode layers changes on the micrometer scale under charge/discharge reactions in the first ***,Operando Raman spectroscopy reveal changes in the bonding states at the atomic scale in the active material,including changes in reversible structural *** cycling the ASSB,the elemental distributions are clearly observed along with the particle shapes and can reveal the Na migration mechanism at the nanometer scale,by time-of-flight secondary ion mass ***,this study can provide a fundamental and comprehensive understanding of the charge/discharge mechanism by observing reaction processes at multiple scales.

关键词： Operando oxide-type all-solid-state battery Raman SEM-EDS sodium battery TOF-SIMS

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Collaborative actuation of liquid crystal elastomer unit cells as a function design platform

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Science China Materials 2025年第1期68卷 236-243页

作者： Jinyu Wang Hari Krishna Bisoyi Yinliang Huang Yiyi Xu Xinfang Zhang Ben Fan Tao Yang Zhiyang Liu Shuai Huang Quan Li Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Materials Science Graduate Program Kent State UniversityKentOH 44242US

As future soft robotic devices necessitate a level of complexity surpassing current standards,a new design approach is needed that integrates multiple systems necessary to synchronize the motions of soft actuators and the response of signals,thereby enhancing the intelligence of flexible ***,we propose a liquid crystal elastomer unit cell-based platform that organizes the cells in a group to create expandable *** unit cell behaves like a flexible module that can expand biaxially into a specific,stable,and controllable *** the unit cells in different manners results in an adaptable soft grasper,a half-adder for information processing,and a tunable phononic *** implies a high level of reconfigurability and scalability in both structures and functions by elegantly reassembling the unit *** design strategy has the potential to integrate multiple functions that traditional soft actuators cannot accommodate,providing a platform for developing intelligent soft robotics.

关键词： liquid crystal elastomer light-responsive material smart material soft actuator

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Current advances in bioethanol synthesis from lignocellulosic biomass: sustainable methods, technological developments, and challenges

Journal of Umm Al-Qura University for Applied Sciences

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Journal of Umm Al-Qura University for Applied Sciences 2025年 1-18页

作者： Novia, Novia Melwita, Elda Jannah, Asyeni Miftahul Selpiana, Selpiana Yandriani, Yandriani Afrah, Bazlina Dawami Rendana, Muhammad Department of Chemical Engineering Faculty of Engineering Universitas Sriwijaya Jl. Raya Palembang-Prabumulih KM 32 Inderalaya Sumatera Selatan Ogan Ilir 30662 Indonesia Master Program of Environmental Management Graduate School Universitas Sriwijaya Jl. Padang Selasa 524 Bukit Besar Sumatera Selatan Palembang 30139 Indonesia Doctoral Program Faculty of Engineering Universitas Sriwijaya South Sumatra Palembang 30139 Indonesia

Bioethanol production from lignocellulosic biomass has become an economical and environmentally friendly substitute to current petroleum-based fuels. This is due to its ability to decrease carbon dioxide emissions and make use of plentiful natural resources. Current advances in this area concentrate on improving the effectiveness and expandability of the conversion procedures by using inventive pretreatment approaches, enhanced enzyme compositions, and refined fermentation technologies. Consolidated bioprocessing (CBP) and utilizing genetically modified microbes have expedited the decomposition of intricate biomass complexes and enhanced overall productivity. Furthermore, process intensification developments, such as the adoption of hybrid reactors and continuous production systems, have considerably decreased production expenses and energy usage. Nevertheless, there are still obstacles to overcome, including the raw materials inconsistency, the demand for efficient recovery and purifying techniques, and the financial viability of extensive processes. This study examines the latest developments in bioethanol production from lignocellulosic biomass. It focuses on ecological approaches, technical advancements, and the main obstacles that need to be overcome to exploit its promise as a biofuel fully. This review primarily focused on outcomes documented in the last five years from 2019 to 2024. The first segment of this work focuses on the second-generation bioethanol production process, which includes: the properties and composition of lignocellulosic biomass, pretreatment, enzymatic saccharification, and fermentation. The subsequent portion of this paper examines a techno-economic analysis, the obstacles and the prospective technology outlook. It finishes by discussing findings from research fields that haven't been investigated yet, besides the obstacles faced in bioethanol manufacturing methods. © The Author(s) 2025.

关键词： Bioethanol Enzymatic hydrolysis Fermentation Lignocellulosic biomass Pretreatment

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Inner-sphere adsorption of orthophosphates on amorphous aluminum hydroxide: The Laplace transform solution to a kinetic model involving first-order Taylor approximations to the Langmuir isotherm

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Separation and Purification Technology 2025年 369卷

作者： Nishimura, Thiago de Barros, Ivan Ricardo Benincá, Cristina Zanoelo, Everton Fernando Federal University of Paraná Graduate Program in Chemical Engineering PR Curitiba Brazil Federal University of Rio Grande Graduate Program in Technological and Environmental Chemistry Santo Antônio da Patrulha RS Brazil

The kinetics of interaction between orthophosphates and Al(OH)3 is of importance to remove phosphorus from wastewater and to understand its mobility and bioavailability in soils. In this study, the kinetics of adsorption of orthophosphates on amorphous Al(OH)3 was examined in an agitated vessel containing an aqueous solution with initial adsorbate concentrations (C0) ranging from ∼3 to 92 mg L−1, at ∼25 °C and pH ∼ 6.9. The soluble orthophosphates were rapidly adsorbed by inner-sphere complexation, but the adsorption capacity was limited to ∼13 mg of phosphorus per g of Al(OH)3. The yield of removal of adsorbing species from the liquid changed from ∼5 to 73 %. A novel reliable adsorption kinetic model was proposed by an original analytical solution of a system of differential equations from adsorbate balances. This solution by using Laplace transform was possible because a valid, robust and simplified procedure was suggested to describe the Langmuir isotherm by first-order Taylor approximations (R2 ∼ 0.93). By contrast to the usual kinetic modeling approaches for liquid–solid adsorption, the current model involves an effective adsorption rate constant (kCA = 3.840 × 10−4 L s−1) considered to be independent of C0. The rates of adsorbate transport from the bulk liquid to the internal adsorbent surface were supposed to be much slower than that of orthophosphates adsorption. ICP spectroscopy, XRD, SEM, EDX spectroscopy and gas adsorption analyses confirm that phosphorous was adsorbed on mesoporous amorphous Al(OH)3 with average pore size of 263 Å and specific surface area of ∼100 m2 g−1. A large independent set of adsorption data for P on Al(OH)3 was used to explain and validate the results. © 2025 Elsevier B.V.

关键词： Aluminum hydroxide

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The revolution of type I organic photosensitizers: current strategies and future directions

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Science Bulletin 2025年第8期70卷 1203-1206页

作者： Yang, Mengyao Zhou, Luyan Zhao, Yuan-Yuan Swamy, Kunemadihalli Mathada Kotraiah Chen, Aibing Yoon, Juyoung College of Chemical and Pharmaceutical Engineering Hebei University of Science and Technology Shijiazhuang050018 China Department of Chemistry and Nanoscience Ewha Womans University Seoul03760 Korea People's Democratic Rep Graduate Program in Innovative Biomaterials Convergence Ewha Womans University Seoul03760 Korea People's Democratic Rep

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3d Fluid-Particle Interaction Dynamics and Filtration Performance of Realistic Fibrous Filters Using Deep Learning and X-Ray Computed Tomography Images

SSRN

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SSRN 2025年

作者： Hada, Kodai Shirzadi, Mohammadreza Fukasawa, Tomonori Fukui, Kunihiro Ishigami, Toru Chemical Engineering Program Graduate School of Advanced Science and Engineering Hiroshima University 1-4-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8527 Japan

This paper presents a framework for analyzing the filtration performance and fluid–particle interaction inside fibrous filters using high-resolution computational fluid dynamics (CFD), deep learning convolutional neural networks (DCNNs), and X-ray computed tomography (CT) images of realistic filter microstructures. X-ray CT images of ten filter microstructures were obtained using an advanced image processing technique, and a high-resolution three-dimensional (3D) CFD model was used to predict the distribution of velocity and pressure around filter microstructures to create a database. A 3D flow surrogate model was then trained using ground-truth CFD data based on two different DCNN models with UNet and MSNet architectures. The 3D flow surrogate model was coupled with a particle model based on the discrete phase model (DPM) to calculate the filter performance in terms of the filter pressure drop, collection efficiency, and quality factor. The accuracies of UNet-DPM and MSNet-DPM were evaluated in detail. It was shown that the 3D flow surrogate model could accurately predict the distribution of flow parameters (velocity and pressure) for different microstructures with a computational speed three orders of magnitude faster than that of the CFD model. The generalizability of the models was evaluated in detail. It was found that the coupled 3D flow surrogate models could predict the particle dynamics around the fiber with some overestimations in the prediction of the collection efficiency and quality factor. Overall, UNet-DPM showed better generalization performance. The developed framework was shown to be a useful machine learning-based tool for the prediction of realistic filters in a simple manner using only a few X-ray CT images, which makes it feasible for industrial applications for design and optimization purposes. © 2025, The Authors. All rights reserved.

关键词： Computational fluid dynamics

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Basal and Edge Plane Activity of Two-Dimensional Dirac Semimetal Nite2 for Hydrogen Evolution Reaction

SSRN

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SSRN 2025年

作者： Cho, Suyeon Jeong, Seung Weon Kim, Jeong Hyo Lee, Seungyeon Yang, Heejun Lee, Sangheon Division of Chemical Engineering and Materials Science Graduate Program in System Health Science and Engineering Ewha Womans University Seoul03760 Korea Republic of Daejeon34141 Korea Republic of

. Nickel ditelluride (NiTe2), one of group-10 transition metal dichalcogenides, has shown intriguing surface states originating from its topological semi-metallicity. Here, we demonstrate abnormal catalytic activities at the NiTe2 surface for hydrogen evolution reaction (HER). We investigate the differences in catalytic activities at the basal and edge planes of NiTe2 using a micro-sized electrochemical reactor. The basal plane is found to be more active than the edge plane, resulting in a current density at the basal plane of NiTe2 exceeding 800 mA/cm2 with a small overpotential of -0.162 V. We conduct ab initio calculations to estimate the intrinsic catalytic activities of HER on the basal and edge planes of NiTe2. Interestingly, our calculation results suggest that the active sites at the edge plane are electrochemically more active than those at the basal plane. The discrepancy between the experimental measurements and theoretical predictions for the crystal-orientation-dependent HER activity highlights that the specialty of a topological semimetal plays a vital role in determining the HER rate for NiTe2 nanoparticle catalysts © 2025, The Authors. All rights reserved.

关键词： Hydrogen evolution reaction

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