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Efficient production of cell-encapsulated microgels using flicking technique

Journal of Drug Delivery Science and Technology 2025年 108卷

作者： Torabi-Rahvar, Parisa Noohi, Parisa Abdekhodaie, Mohammad J. Shafiee, Mohammad A. Department of Chemical Engineering Sharif University of Technology Tehran Iran Tissue Engineering for Orthopaedic & Mechanobiology Bone & Joint Program Department for BioMedical Research (DBMR) Medical Faculty University of Bern Bern Switzerland Environmental and Applied Science Management Yeates School of Graduate Studies Toronto Metropolitan University Toronto Canada Division of General Internal Medicine Department of Medicine University of Toronto Toronto Canada

In this study, a simple flicking-base method was developed for the mass production of uniform alginate microgels. A comprehensive investigation was conducted to determine the relationship between the microencapsulation parameters and the size as well as the sphericity of the microgels. Fractional factorial design (FFD) was employed to determine the main factors affecting microgel size, identifying flow rate, alginate concentration, and motor speed as the most influential. Furthermore, the simultaneous effect of these critical factors on microgel size and sphericity was modeled using central composite design (CCD). The resulting quadratic empirical models offered insights into the jet break process in flicking-based microencapsulation and enabled the selection of factors and their levels to generate appropriately sized and shaped alginate microgels. Spherical microgels with a minimum size of 528 ± 20 μm were obtained at a flow rate of 5.8 ml/h, alginate concentration of 2 %, and motor speed of 17.1 Hz. Human mesenchymal stem cells were successfully encapsulated in the microgels with high cell viability exceeding 90 %. This study highlights the flicking method as a promising technique for efficiently producing uniform cell-encapsulated alginate microgels. The simplicity and cost-effectiveness of this method make it an available option for practical laboratory research, enabling the efficient preparation of microgels with adjustable size and shape. Furthermore, this microencapsulation approach has potential applications in tissue engineering, pharmaceutical disease models, cell-based transplantation, and regenerative medicine. © 2025

关键词： Alginate Cell microencapsulation Flicking technique Microgels Response surface methodology

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Advanced landfill leachate treatment: Sequential electrocoagulation and electrooxidation system for efficient remediation

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Journal of Water Process engineering 2025年 74卷

作者： Justen, Nicóli Borba, Fernando H. Mayer, Ildemar Seibert, Daiana Inticher, Jonas J. Ferreira Piazzi Fuhr, Ana C. Carissimi, Elvis Leichtweis, Jandira Postgraduate Program of Environment and Sustainable Technologies Federal University of Fronteira Sul Av. Jacob Reinaldo Haupenthal 1580 RS Cerro Largo 97900-000 Brazil Postgraduate Program of Chemical Engineering West Paraná State University Rua da Faculdade 645 Jd. Santa Maria PR Toledo 85903-000 Brazil Materials Science and Engineering Graduate Program Federal University of Pelotas 1 Gomes Carneiro St. RS Pelotas 96010-610 Brazil Department of Sanitation and Environmental Engineering Federal University of Santa Maria Av. Roraima 1000 RS Santa Maria 97105-000 Brazil

The treatment of concentrated landfill leachate generated by nanofiltration and reverse osmosis processes represents a significant challenge. This concentrate is characterized by high concentrations of heavy metals, contaminants of emerging concern, dissolved salts, and organic compounds. In this study, a novel advanced treatment system integrating an Electrocoagulation Reactor with a subsequent electrooxidation process was proposed. Two anode/cathode arrangements were evaluated: electrocoagulation followed by electrooxidation with “boron-doped diamond” and steel electrodes, and electrocoagulation followed by electrooxidation with “boron-doped diamond” and aluminum electrodes, focusing on their effectiveness in degrading contaminants and improving the quality of the treated concentrated landfill leachate. In order to monitor the efficiency of the electrocoagulation process and integrated systems, the degradation of the physicochemical parameters of absorbance at 254 nm, total organic carbon, and turbidity were investigated. Within the best performance, acute toxicity indices (Artemia salina - LC50) were determined and possible degradation and/or formation of contaminants of emerging concern were identified by gas chromatography–mass spectrometry (GC–MS). The results indicated the mineralization of 73 % of total organic carbon and 25 % of total nitrogen, an increase in the biodegradability fraction (BOD5/COD) of the concentrated landfill leachate from 0.18 to 0.35, as well as a significant reduction in toxicity (LC50 of 54.4 %), demonstrated by Artemia salina bioassays. The reduction in toxic potential was also observed in the by-product analysis by GC–MS, which indicated the removal of emerging contaminants such as benzene, 2-(2-methoxy-1-propenyl)-1,3,5-trimethylbenzene, benzothiazole, 2-(methylthio) and phenol, 2,2′-methylenebis[6-(1,1-dimethylethyl)-4-methyl-. These findings highlight that the integration of the electrocoagulation process with electrooxidation us

关键词： Concentrated landfill leachate Contaminants of emerging concern Electrocoagulation Electrooxidation

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Valorization of the agro-industrial by-products of bacupari(Garcinia brasiliensis(Mart.))through production of flour with bioactive properties

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Food Bioscience 2022年第1期45卷 377-385页

作者： Anely Maciel de Melo Rafaela Cristina Turola Barbi Bruno Patrício Costa Mˆonica Ikeda Danielle Carpine Rosemary Hoffmann Ribani Food Engineering Graduate Program Federal University of ParanaDepartment of Chemical Engineering81531-990CuritibaPRBrazil

Brazil has a wide variety of fruits that remain insufficiently *** encourage the use of one such fruit,the bacupari((Garcinia brasiliensis(Mart.)),the current study produced flours from its by-products(the peel and seed)at two maturation stages and subsequently evaluated their proximate composition,physical,antioxidant,bioactive,microstructural and thermal *** results revealed that the flours have a high in fiber content(>15%)and are a potential source of protein(>5%).Seed flour has an energy value similar to that of wheat flour and other conventional *** flour micrographs indicate the presence of starch,a fact confirmed by viscosity *** flours contain phenolic compounds and exhibit antioxidant activity,especially the unripe peel *** the compounds identified by chromatography,those present in the greatest concentrations were quinine(≅111μg/g),p-coumaric acid(≅25μg/g),m-coumaric acid(≅15μg/g),and formononetin(≅21μg/g),all of which are known to have several human health *** flour crystallinity diminished as the fruit *** flour exhibited similar thermal transitions but less thermal stability than seed *** summary,this study revealed that flours produced from the peel and seeds of bacupari,which are generated in large quantities as agro-industrial by-products,can be used as alternative ingredients in various sectors of the food industry.

关键词： Antioxidant activity Bacupari fruit Seed Peel Phenolic compounds

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Chitosan-geopolymer composites: A synergistic approach to sustainable and functional materials

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Ceramics International 2025年

作者： Angelo Oliveira Silva Paolo Colombo Dachamir Hotza Graduate Program in Chemical Engineering Federal University of Santa Catarina 88040-900 Florianópolis SC Brazil Department of Industrial Engineering University of Padova 35131 Padova Italy

The combination of chitosan, a natural biopolymer, with geopolymers, a class of inorganic materials, represents a promising strategy to develop sustainable and high-performance composites for various applications. This review explores the current state of research on chitosan-geopolymer composites, focusing on two primary methods of incorporation: pre-geopolymerization and post-geopolymerization. Key findings highlight how chitosan addition impacts the properties of geopolymers, with potential applications in civil construction materials and environmental remediation. The review also discusses the challenges of process optimization, scalability, and long-term performance, identifying future research directions to enhance the effectiveness of these materials. This work aims to provide a comprehensive overview for researchers and engineers interested in the development and application of innovative, eco-friendly materials.

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BPS2025 - Altering terminal locations to modify the MS2 VLP with circular permutation

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Biophysical Journal 2025年第3期124卷 229a-229a页

作者： Shiqi Liang Danielle Tullman-Ercek Interdesciplinary Biological Sciences Graduate Program Northwestern University Evanston IL USA Department of Chemical and Biological Engineering Northwestern University Evanston IL USA

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Role of the Ionomer in Supporting Electrolyte-Fed Anion Exchange Membrane Water Electrolyzers

ACS electrochemistry

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ACS electrochemistry 2025年第2期1卷 239-248页

作者： Emily K Volk Arielle L Clauser Melissa E Kreider Diego D Soetrisno Sunilkumar Khandavalli Joshua D Sugar Stephanie Kwon Shaun M Alia Advanced Energy Systems Graduate Program Colorado School of Mines Golden Colorado 80401 United States. Sandia National Laboratories Livermore California 94550 United States. Chemistry and Nanoscience Center National Renewable Energy Laboratory Golden Colorado 80401 United States. Materials Science Center National Renewable Energy Laboratory Golden Colorado 80401 United States. Department of Chemical and Biological Engineering Colorado School of Mines Golden Colorado 80401 United States.

While anion exchange membrane water electrolyzers (AEMWEs) have achieved significant performance advances in recent decades, overpotentials remain high relative to their proton exchange membrane water electrolyzer (PEMWE) counterparts, requiring AEMWE-specific catalyst layer design strategies to further advance this technology. In this work, the role of the ionomer in catalyst layer structure and quality, catalyst layer stability, and ion conduction for supporting electrolyte-fed AEMWEs is assessed for catalyst layers composed of NiFeO and PiperION TP85 from Versogen at variable ionomer contents (0-30 wt %) for tests up to 200 h. The results reveal that, for supporting electrolyte-fed AEM devices, the ionomer is not required for ion conduction through the catalyst layer. Instead, the ionomer is found to play a critical role in catalyst layer structure and stability, where intermediate ionomer contents lead to the lowest overpotentials, highest effective surface areas, and lowest catalyst layer resistances. Catalyst layer stability is found to be a function of both catalyst adhesion and ionomer loss. These results show that an ionomer may be selected which is not of the same chemistry as the anion exchange membrane, mitigating ionomer stability concerns throughout the catalyst layer and offering a pathway towards highly active and stable AEMWEs.

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Customizable flame-spheroidized submicron glass particles with controlled CaO–Al2O3–SiO2 compositions

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Journal of the American Ceramic Society 2025年

作者： Nguyen, Tue Tri Hirano, Tomoyuki Fusatani, Kodai Pham, Tung Van Mizutani, Kazuki Katou, Takahisa Ogi, Takashi Chemical Engineering Program Department of Advanced Science and Engineering Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima Higashihiroshima Japan Takara Standard Co. Ltd. Osaka Osaka Japan

Glass particles are extensively utilized in electronic device substrates, conductive pastes for batteries, and various sealing and bonding applications due to their tunable material properties, such as refractive index, thermal conductivity, and high-frequency characteristics. With the miniaturization of electronic components driven by advancements in data communication and device performance, there is a growing demand for glass particles with controlled size, shape, and composition to densely fill fine spaces. Traditional methods producing particles of 10.0–20.0 µm are inadequate as size reduction becomes critical. Although crushing glass to about 1.0 µm is a common approach, it is time-consuming, energy-intensive, and lacks control over particle size and shape. In this study, we aimed to synthesize spherical CaO–Al2O3–SiO2 glass particles within the submicron range (0.1–1.0 µm) with precisely controlled chemical compositions using a flame process. We evaluated the effects of precursor concentration, reactor temperature, and residence time on the glass particle properties and the formation mechanisms for each condition. The results confirmed successful submicron-size control and spheroidization and precise compositions, demonstrating the significant potential of flame method in producing tailored glass particles for advanced electronic applications. © 2025 The Author(s). Journal of the American Ceramic Society published by Wiley Periodicals LLC on behalf of American Ceramic Society.

关键词： Glass bonding

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Bioaccessibility of iron, zinc, and copper from edible insects available on the European market

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Applied Food Research 2025年第1期5卷

作者： da Costa, M.A.J. Lopes Angaïts, A. Bierła, K. de Gois, J.S. Szpunar, J. Graduate Program in Chemical Engineering Rio de Janeiro State University Rua Sāo Francisco Xavier 524 – Maracanā RJ Rio de Janeiro 20550-013 Brazil CNRS Institute of Analytical and Physical Chemistry for the Environment and Materials (IPREM) Université de Pau Hélioparc 2 Av. Pr. Angot Pau 64053 France

Consumption of insects contributes increasingly to sustainable nutrition in the context of global food security. This study investigates the total content and bioaccessibility of essential trace elements Fe, Zn, and Cu in various edible insects. Samples of, among others, mealworms (Tenebrio molitor), silkworms (Bombyx mori), sago worms (Rhynchophorus ferrugineus), crickets (Gryllus bimaculatus), black scorpions (Heterometrus longimanus), and weaver ants (Oecophylla smaragdina) were analysed. Inductively coupled plasma mass spectrometry (ICP-MS) determined significant variability in metal content among different insect species, with an overall content higher than in meat. Bioaccessibility studies were conducted using pepsin, pancreatin and bile salts, to simulate gastrointestinal digestion conditions, as is standard in such studies. The bioaccessibility of Fe, Zn, and Cu ranged from 45 % to 65 % and was generally higher in mealworms than in Orthoptera species. Size exclusion chromatography (SEC-ICP-MS) provided insight into the molecular forms of Fe, Zn, and Cu during gastric and intestinal digestion. Intense peaks in the elution range of low molecular mass compounds were observed in the intestinal digests, suggesting complexation of the metal ions with organic ligands. The study highlights the nutritional potential of edible insects as a rich source of essential elements, such as Fe, Zn, and Cu. © 2025

关键词： Essential elements Gastrointestinal digestion ICP-MS SEC Sustainable food sources

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Amplification of enzymatic and microbial fuel cells using organic electrochemical transistors

Device

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Device 2025年

作者： Saxena, Ravindra Zhang, Xu Cai, Rong Suggs, Olivia Bruggeman, Chase Hickey, David P. Ajo-Franklin, Caroline M. Verduzco, Rafael Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston 77005 TX United States Department of Biosciences Rice University Houston 77005 TX United States Department of Chemical Engineering and Materials Science Michigan State University East Lansing 48824 MI United States Department of Bioengineering Rice University Houston 77005 TX United States Department of Chemical and Biomolecular Engineering Rice University Houston 77005 TX United States Rice Advanced Materials Institute Rice University Houston 77005 TX United States

Organic electrochemical transistors (OECTs) are thin-film devices operated in aqueous and biological environments for sensing chemicals and biomolecules. However, most sensor configurations involve introducing the target biomolecule directly in the OECT device. This has drawbacks because it may not be possible to have an electrolyte compatible with the target biomolecule or an environment optimal for the OECT. Here, we demonstrate a general and modular approach to building electrochemical sensors by coupling OECTs electronically with either an enzymatic fuel cell (EFC) or microbial fuel cell (MFC). We demonstrate that this modular approach can amplify currents by three orders of magnitude and enhance the signal-to-noise ratio. We also show that the power generated by the fuel cell can help tune the sensor's response for different applications. This work demonstrates a simple and versatile approach for amplifying currents from MFCs and EFCs useful for the development of bioelectronic sensors. © 2025 The Authors

关键词： amplification biosensors DTI-3: Develop electro-active bacteria enzymatic fuel cells microbial fuel cells organic electrochemical transistors power

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Rheological and stability analysis of cement pastes incorporating silica-based wastes

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Particuology 2024年第6期89卷 144-152页

作者： Julia da Rosa Martins Janaíde Cavalcante Rocha Dachamir Hotza Luciano Senff Graduate Program in Materials Science and Engineering(PPGMAT) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Civil Engineering(PPGEC) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Chemical Engineering(POSENQ) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Department of Mobility Engineering Federal University of Santa Catarina(UFSC)Joinville89219-600SCBrazil

This study investigates the influence of waste characteristics,especially zeta potential,on the properties of cement pastes and *** focus is to evaluate the impact of the zeta potential of cement particles and waste materials on the sedimentation speed,rheology,and hardening time of stabilized cement *** Cement II F 40,retarder additive,silica,and fly ash were used in the *** pastes were prepared,and during the stabilization period,their rheological properties and pH were *** zeta potential and sedimentation speed of the cement and waste particles were measured at the pH that the pastes presented during the entire stabilization *** the stabilization period,the pastes were subjected to the hardening time *** zeta potential analyses revealed diverse values for the different powder types,with the cement particles exhibiting a zeta potential of−3.0 mV,the silica particles exhibiting−10.5 mV,and the fly ash particles exhibiting−20.3 *** influence of the high zeta potential modulus was observed on the sedimentation speed,with the solution containing fly ash exhibiting a speed of 40.01μm/s,whereas the solution containing only cement exhibited a speed of 99.38μm/*** the pastes,the results indicate that the presence of fly ash particles with a significantly negative zeta potential led to a 16%reduction in hardening time compared to particles with a lower modulus of zeta *** tests showed that the inclusion of fly ash particles prevented the formation of *** the zeta potential influenced agglomerate formation and hardening time,it was found to have no effect on yield stress or viscosity.

关键词： Wastes Zeta potential Setting time Rheometry

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