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检索条件"机构=Graduate Program in Computational Biology & Bioinformatics"
136 条 记 录,以下是41-50 订阅
排序:
Functional annotation of chemical libraries across diverse biological processes (vol 13, pg 982, 2017)
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NATURE CHEMICAL biology 2017年 第12期13卷 1286-1286页
作者: Piotrowski, Jeff S. Li, Sheena C. Deshpande, Raamesh Simpkins, Scott W. Nelson, Justin Yashiroda, Yoko Barber, Jacqueline M. Safizadeh, Hamid Wilson, Erin Okada, Hiroki Gebre, Abraham A. Kubo, Karen Torres, Nikko P. LeBlanc, Marissa A. Andrusiak, Kerry Okamoto, Reika Yoshimura, Mami DeRango-Adem, Eva van Leeuwen, Jolanda Shirahige, Katsuhiko Baryshnikova, Anastasia Brown, Grant W. Hirano, Hiroyuki Costanzo, Michael Andrews, Brenda Ohya, Yoshikazu Osada, Hiroyuki Yoshida, Minoru Myers, Chad L. Boone, Charles RIKEN Center for Sustainable Resource Science Wako Saitama Japan Department of Computer Science and Engineering University of Minnesota-Twin Cities Minneapolis Minnesota USA Bioinformatics and Computational Biology Program University of Minnesota-Twin Cities Minneapolis Minnesota USA Department of Electrical and Computer Engineering University of Minnesota-Twin Cities Minneapolis Minnesota USA Department of Integrated Biosciences Graduate School of Frontier Sciences University of Tokyo Kashiwa Chiba Japan Donnelly Centre University of Toronto Toronto Ontario Canada Institute of Molecular and Cellular Biosciences Center for Epigenetic Disease University of Tokyo Bunkyo-ku Tokyo Japan Lewis-Sigler Institute for Integrative Genomics Princeton University Princeton New Jersey USA Department of Biochemistry University of Toronto Toronto Ontario Canada.
Chemical-genetic approaches offer the potential for unbiased functional annotation of chemical libraries. Mutations can alter the response of cells in the presence of a compound, revealing chemical-genetic interaction... 详细信息
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Integration of Protein Structure and Population-Scale DNA Sequence Data for Disease Gene Discovery and Variant Interpretation
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Biomedical Data Science 1000年 第1期5卷 141-161页
作者: Bian Li Bowen Jin John A. Capra William S. Bush 1Department of Biological Sciences and Center for Structural Biology Vanderbilt University Nashville Tennessee USA 2Graduate Program in Systems Biology and Bioinformatics Department of Nutrition School of Medicine Case Western Reserve University Cleveland Ohio USA 3Bakar Computational Health Sciences Institute and Department of Epidemiology and Biostatistics University of California San Francisco California USA email: tony@*** 4Cleveland Institute for Computational Biology Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA email: wsb36@case.edu
The experimental and computational techniques for capturing information about protein structures and genetic variation within the human genome have advanced dramatically in the past 20 years, generating extensive new ... 详细信息
来源: 评论
Evolution at the edge of expanding populations
arXiv
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arXiv 2017年
作者: Deforet, Maxime Carmona-Fontaine, Carlos Korolev, Kirill S. Xavier, Joao B. Sorbonne Université Centre National de la Recherche Rcientifique Laboratoire Jean Perrin LJP Paris75005 France Center for Genomics and Systems Biology Department of Biology New York University New York CityNY10003 United States Department of Physics Graduate Program in Bioinformatics Boston University BostonMA02215 Program in Computational Biology Memorial Sloan-Kettering Cancer Center New York CityNY10065 United States
Predicting evolution of expanding populations is critical to control biological threats such as invasive species and cancer metastasis. Expansion is primarily driven by reproduction and dispersal, but nature abounds w... 详细信息
来源: 评论
STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity
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Nature 2025年 1-10页
作者: Jiajia Zhou Kole Tison Michael Pitter Linda Vatan Peng Liao Jiali Yu Heng Lin Shuang Wei Xue Gao Sara Grove Ilona Kryczek Weiping Zou Long Jiang Michael D. Green Marcin Cieslik Haibin Zhou Longchuan Bai Ranjan Kumar Acharyya Donna McEachern Hoda Metwally Yu Wang Shaomeng Wang Jae Eun Choi Abhijit Parolia Arul M. Chinnaiyan Jian-Xin Lin Warren J. Leonard Department of Surgery University of Michigan Medical School Ann Arbor MI USA Center of Excellence for Cancer Immunology and Immunotherapy University of Michigan Rogel Cancer Center Ann Arbor MI USA Graduate Program in Immunology University of Michigan Ann Arbor MI USA Department of Computational Medicine and Bioinformatics University of Michigan Medical School Ann Arbor MI USA Department of Pathology University of Michigan Medical School Ann Arbor MI USA University of Michigan Rogel Cancer Center University of Michigan Ann Arbor MI USA Graduate Program in Cancer Biology University of Michigan Ann Arbor MI USA Department of Radiation Oncology University of Michigan Medical School Ann Arbor MI USA Michigan Center for Translational Pathology University of Michigan Medical School Ann Arbor MI USA Division of Hematology and Oncology Department of Internal Medicine University of Michigan Medical School Ann Arbor MI USA Department of Pharmacology University of Michigan Medical School Ann Arbor MI USA Department of Medicinal Chemistry College of Pharmacy University of Michigan Ann Arbor MI USA Howard Hughes Medical Institute University of Michigan Medical School Ann Arbor MI USA Laboratory of Molecular Immunology and the Immunology Center National Heart Lung and Blood Institute National Institutes of Health Bethesda MD USA
Immune checkpoint blockade (ICB) has transformed cancer therapy1,2. The efficacy of immunotherapy depends on dendritic cell-mediated tumour antigen presentation, T cell priming and activation3,4. However, the relation...
来源: 评论
A Bayesian model for SNP discovery based on next-generation sequencing data
A Bayesian model for SNP discovery based on next-generation ...
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IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)
作者: Yanxun Xu Xiaofeng Zheng Yuan Yuan Marcos R Estecio Jean-Pierre Issa Yuan Ji Shoudan Liang Department of Statistics Rice University Houston TX USA Department of Bioinformatics and Computational Biology University of Texas M.D. Anderson Cancer Center Houston TX USA Graduate Program in Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine Houston TX USA Department of Biochemistry and Molecular Biology University of Texas M.D. Anderson Cancer Center Houston TX USA Fels Institute for Cancer Research and Molecular Biology Temple University Philadelphia PA USA CCRI NorthShore University HealthSystem Chicago IL USA
A single-nucleotide polymorphism (SNP) is a single base change in the DNA sequence and is the most common polymorphism. Since some SNPs have a major influence on disease susceptibility, detecting SNPs plays an importa... 详细信息
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Large-scale analysis of human heavy chain V(D)J recombination patterns
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Immunome Research 2008年 第1期4卷 3-3页
作者: Volpe, Joseph M Kepler, Thomas B Center for Computational Immunology Duke University Durham NC United States Department of Immunology Duke Univeristy Medical Center Durham NC United States Department of Biostatistics and Bioinformatics Duke Univeristy Medical Center Durham NC United States Institute of Statistics and Decision Sciences Duke Univeristy Durham NC United States Computational Biology and Bioinformatics Graduate Program Institute for Genome Sciences and Policy Duke Univeristy Durham NC United States
Background. The processes involved in the somatic assembly of antigen receptor genes are unique to the immune system and are driven largely by random events. Subtle biases, however, may exist and provide clues to the ...
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Void distributions reveal structural link between jammed packings and protein cores
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Physical Review E 2019年 第2期99卷 022416-022416页
作者: John D. Treado Zhe Mei Lynne Regan Corey S. O'Hern Department of Mechanical Engineering & Materials Science Yale University New Haven Connecticut 06520 USA Integrated Graduate Program in Physical & Engineering Biology Yale University New Haven Connecticut 06520 USA Department of Chemistry Yale University New Haven Connecticut 06520 USA Department of Molecular Biophysics & Biochemistry Yale University New Haven Connecticut 06520 USA Department of Physics Yale University New Haven Connecticut 06520 USA Department of Applied Physics Yale University New Haven Connecticut 06520 USA Program in Computational Biology and Bioinformatics Yale University New Haven Connecticut 06520 USA
Dense packing of hydrophobic residues in the cores of globular proteins determines their stability. Recently, we have shown that protein cores possess packing fraction ϕ≈0.56, which is the same as dense, random packi... 详细信息
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Core packing of well-defined x-ray and NMR structures is the same
arXiv
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arXiv 2022年
作者: Grigas, Alex T. Liu, Zhuoyi Regan, Lynne O’Hern, Corey S. Graduate Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Institute of Quantitative Biology Biochemistry and Biotechnology Centre for Synthetic and Systems Biology School of Biological Sciences University of Edinburgh United Kingdom Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States
Numerous studies have investigated the differences and similarities between protein structures determined by solution NMR spectroscopy and those determined by x-ray crystallography. A fundamental question is whether a... 详细信息
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Inhibition of topoisomerase IIα and induction of DNA damage in cholangiocarcinoma cells by altholactone and its halogenated benzoate derivatives
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Biomedicine and Pharmacotherapy 2020年 127卷 110149-110149页
作者: Kitdumrongthum, Sarunya Reabroi, Somrudee Suksen, Kanoknetr Tuchinda, Patoomratana Munyoo, Bamroong Mahalapbutr, Panupong Rungrotmongkol, Thanyada Ounjai, Puey Chairoungdua, Arthit Toxicology Graduate Program Faculty of Science Mahidol University Bangkok Thailand Excellent Center for Drug Discovery (ECDD) Mahidol University Bangkok Thailand Department of Pharmacology Faculty of Science Mahidol University Bangkok Thailand Department of Physiology Faculty of Science Mahidol University Bangkok Thailand Department of Chemistry Faculty of Science Mahidol University Bangkok Thailand Structural and Computational Biology Research Unit Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok Thailand Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Bangkok Thailand Department of Biology Faculty of Science Mahidol University Bangkok Thailand
Topoisomerase IIα enzyme (Topo IIα) plays a critical function in DNA replication process and is considered to be a promising target of anti-cancer drugs. In the present study, we reported that the altholactone deriv... 详细信息
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Characterizing the mechanical response of metallic glasses to uniaxial tension using a spring network model
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Physical Review Materials 2023年 第7期7卷 073605-073605页
作者: Aya Nawano Weiwei Jin Jan Schroers Mark D. Shattuck Corey S. O'Hern Department of Mechanical Engineering and Materials Science Yale University New Haven Connecticut 06520 USA Benjamin Levich Institute and Physics Department The City College of New York New York New York 10031 USA Department of Physics Yale University New Haven Connecticut 06520 USA Department of Applied Physics Yale University New Haven Connecticut 06520 USA Graduate Program in Computational Biology and Bioinformatics Yale University New Haven Connecticut 06520 USA
A coarse-grained spring network model is proposed for the prediction of the mechanical response of metallic glasses as a function of the microstructure prior to loading. This model describes the mechanical response of... 详细信息
来源: 评论