检索结果-内蒙古大学图书馆

Publisher Correction: Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment

Nature cancer

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Nature cancer 2023年第4期4卷 582页

作者： Sayali Onkar Jian Cui Jian Zou Carly Cardello Anthony R Cillo Mostofa Rafid Uddin April Sagan Marion Joy Hatice U Osmanbeyoglu Katherine L Pogue-Geile Priscilla F McAuliffe Peter C Lucas George C Tseng Adrian V Lee Tullia C Bruno Steffi Oesterreich Dario A A Vignali Department of Immunology University of Pittsburgh School of Medicine Pittsburgh PA USA. Tumor Microenvironment Center UPMC Hillman Cancer Center Pittsburgh PA USA. Graduate Program in Microbiology and Immunology University of Pittsburgh School of Medicine Pittsburgh PA USA. Department of Biostatistics University of Pittsburgh Pittsburgh PA USA. Computational Biology Department Carnegie Mellon University Pittsburgh PA USA. Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology Pittsburgh PA USA. Department of Biomedical Informatics University of Pittsburgh Pittsburgh PA USA. UPMC Hillman Cancer Center Pittsburgh PA USA. NSABP Foundation Pittsburgh PA USA. Department of Bioengineering University of Pittsburgh Pittsburgh PA USA. Section of Breast Surgery Division of Surgical Oncology Department of Surgery University of Pittsburgh College of Medicine Magee Women's Hospital of UPMC Pittsburgh PA USA. Women's Cancer Research Center UPMC Hillman Cancer Center Magee-Womens Research Institute University of Pittsburgh Pittsburgh PA USA. Department of Pathology University of Pittsburgh Pittsburgh PA USA. Cancer Biology Program UPMC Hillman Cancer Center Pittsburgh PA USA. Department of Pharmacology and Chemical Biology University of Pittsburgh Pittsburgh PA USA. Cancer Immunology and Immunotherapy Program UPMC Hillman Cancer Center Pittsburgh PA USA. Women's Cancer Research Center UPMC Hillman Cancer Center Magee-Womens Research Institute University of Pittsburgh Pittsburgh PA USA. oesterreichs@upmc.edu. Cancer Biology Program UPMC Hillman Cancer Center Pittsburgh PA USA. oesterreichs@upmc.edu. Department of Pharmacology and Chemical Biology University of Pittsburgh Pittsburgh PA USA. oesterreichs@upmc.edu. Department of Immunology University of Pittsburgh School of Medicine Pittsburgh PA USA. dvignali@pitt.edu. Tumor Microenvironment Center UPMC Hillman Cancer Center Pittsburgh PA USA. dvignali@pi

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Erratum for Wang et al., "Clinically Applicable System for Rapidly Predicting Enterococcus faecium Susceptibility to Vancomycin"

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Microbiology spectrum 2022年第1期10卷 e0261021页

作者： Hsin-Yao Wang Chia-Ru Chung Chao-Jung Chen Ko-Pei Lu Yi-Ju Tseng Tzu-Hao Chang Min-Hsien Wu Wan-Ting Huang Ting-Wei Lin Tsui-Ping Liu Tzong-Yi Lee Jorng-Tzong Horng Jang-Jih Lu Department of Laboratory Medicine Chang Gung Memorial Hospitalgrid.413801.f at Linkou Taoyuan City Taiwan. Ph.D. Program in Biomedical Engineering Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Computer Science and Information Engineering National Central Universitygrid.37589.30 Taoyuan City Taiwan. Graduate Institute of Integrated Medicine China Medical Universitygrid.254145.3 Taichung Taiwan. Proteomics Core Laboratory China Medical Universitygrid.254145.3 Hospital Taichung Taiwan. Graduate Program in Biomedical Information Yuan-Ze University Taoyuan City Taiwan. Department of Information Management Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Graduate Institute of Biomedical Informatics Taipei Medical University Taipei City Taiwan. Clinical Big Data Research Center Taipei Medical University Hospital Taipei City Taiwan. Graduate Institute of Biomedical Engineering Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Division of Haematology/Oncology Department of Internal Medicine Chang Gung Memorial Hospitalgrid.413801.f at Linkou Taoyuan City Taiwan. Biosensor Group Biomedical Engineering Research Center Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Pathology Kaohsiung Chang Gung Memorial Hospitalgrid.413801.f and Chang Gung University College of Medicine Kaohsiung Taiwan. School of Life and Health Sciences The Chinese University of Hong Kong Shenzhen China. Warshel Institute for Computational Biology The Chinese University of Hong Kong Shenzhen China. Department of Bioinformatics and Medical Engineering Asia University Taichung City Taiwan. School of Medicine Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Medical Biotechnology and Laboratory Science Chang Gung Universitygrid.145695.a Taoyuan City Taiwan.

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Spatial proteomics in three-dimensional intact specimens

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四川生理科学杂志 2022年第12期44卷 2202-2202页

作者： Harsharan Singh Bhatia Insititute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Zentrum München 85764 Neuherberg Germany Institute for Stroke and Dementia Research Klinikum der Universität München Ludwig-Maximilians University Munich 81377 Munich Germany Department for Proteomics and Signal Transduction Max Planck Institute of Biochemistry 82152 Martinsried Germany Boehringer Ingelheim Pharma GmbH & Co. KG Drug Discovery Sciences Birkendorfer Str. 65 D-88400 Biberach Riss Germany Graduate School of Neuroscience (GSN) 82152 Munich Germany Munich Cluster for Systems Neurology (SyNergy) 81377 Munich Germany Center for Translational Cancer Research (TranslaTUM) of the TUM 81675 Munich Germany Image-Based Biomedical Modeling Department of Informatics Technical University of Munich 85748 Garching Germany Helmholtz AI Helmholtz Zentrum München 85764 Neuherberg Germany Biomedical Image Analysis Group Department of Computing Imperial College London London SW7 2AZ UK Department for Quantitative Biomedicine University of Zurich 8006 Zurich Switzerland Department of Neuroradiology Klinikum rechts der Isar 81675 Munich Germany Munich Medical Research School (MMRS) 80336 Munich Germany Institute for Diabetes and Cancer Helmholz Zentrum München 85764 Neuherberg Germany Institute for Diabetes and Obesity Helmholz Zentrum München 85764 Neuherberg Germany German Center for Diabetes Research Helmholz Zentrum München 85764 Neuherberg Germany German Center for Neurodegenerative Diseases (DZNE) 81377 Munich Germany Neuroproteomics School of Medicine Klinikum Rechts der Isar Technical University of Munich 81675 Munich Germany Institute of Anatomy University of Leipzig 04109 Leipzig Germany Institute of Computational Biology Helmholz Zentrum München 85764 Neuherberg Germany TUM School of Life Sciences Weihenstephan Technical University of Munich 85354 Freising Germany Department of Mathematics Technical University of Munich 85748 Garching Germany NNF Center for Protein Res

Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological ***,methods for molecular analysis of large biological specimens imaged in 3D are ***,we p... 详细信息

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26th Annual computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Dense sampling of bird diversity increases power of comparative genomics (vol 587, pg 252, 2020)

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NATURE 2021年第7856期592卷 E24-E24页

作者： Feng, Shaohong Stiller, Josefin Deng, Yuan Armstrong, Joel Fang, Qi Reeve, Andrew Hart Xie, Duo Chen, Guangji Guo, Chunxue Faircloth, Brant C. Petersen, Bent Wang, Zongji Zhou, Qi Diekhans, Mark Chen, Wanjun Andreu-Sanchez, Sergio Margaryan, Ashot Howard, Jason Travis Parent, Carole Pacheco, George Sinding, Mikkel-Holger S. Puetz, Lara Cavill, Emily Ribeiro, Angela M. Eckhart, Leopold Fjeldsa, Jon Hosner, Peter A. Brumfield, Robb T. Christidis, Les Bertelsen, Mads F. Sicheritz-Ponten, Thomas Tietze, Dieter Thomas Robertson, Bruce C. Song, Gang Borgia, Gerald Claramunt, Santiago Lovette, Irby J. Cowen, Saul J. Njoroge, Peter Dumbacher, John Philip Ryder, Oliver A. Fuchs, Jerome Bunce, Michael Burt, David W. Cracraft, Joel Meng, Guanliang Hackett, Shannon J. Ryan, Peter G. Jonsson, Knud Andreas Jamieson, Ian G. da Fonseca, Rute R. Braun, Edward L. Houde, Peter Mirarab, Siavash Suh, Alexander Hansson, Bengt Ponnikas, Suvi Sigeman, Hanna Stervander, Martin Frandsen, Paul B. van der Zwan, Henriette van der Sluis, Rencia Visser, Carina Balakrishnan, Christopher N. Clark, Andrew G. Fitzpatrick, John W. Bowman, Reed Chen, Nancy Cloutier, Alison Sackton, Timothy B. Edwards, Scott V. Foote, Dustin J. Shakya, Subir B. Sheldon, Frederick H. Vignal, Alain Soares, Andre E. R. Shapiro, Beth Gonzalez-Solis, Jacob Ferrer-Obiol, Joan Rozas, Julio Riutort, Marta Tigano, Anna Friesen, Vicki Dalen, Love Urrutia, Araxi O. Szekely, Tamas Liu, Yang Campana, Michael G. Corvelo, Andre Fleischer, Robert C. Rutherford, Kim M. Gemmell, Neil J. Dussex, Nicolas Mouritsen, Henrik Thiele, Nadine Delmore, Kira Liedvogel, Miriam Franke, Andre Hoeppner, Marc P. Krone, Oliver Fudickar, Adam M. Mila, Borja Ketterson, Ellen D. Fidler, Andrew Eric Friis, Guillermo Parody-Merino, Angela M. Battley, Phil F. Cox, Murray P. Lima, Nicholas Costa Barroso Prosdocimi, Francisco Parchman, Thomas Lee Schlinger, Barney A. Loiselle, Bette A. Blake, John G. Lim, Haw Chuan Day, Lainy B. Fuxjager, Matthew J. Baldwin, Maude W. Braun, Michael J. Wirthlin, Morgan Dikow, China National GeneBank BGI-Shenzhen Shenzhen China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China BGI-Shenzhen Shenzhen China Villum Centre for Biodiversity Genomics Section for Ecology and Evolution Department of Biology University of Copenhagen Copenhagen Denmark BGI Education Center University of Chinese Academy of Sciences Shenzhen China MOE Laboratory of Biosystems Homeostasis and Protection Life Sciences Institute Zhejiang University Hangzhou China Department of Neuroscience and Developmental Biology University of Vienna Vienna Austria Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China James D. Watson Institute of Genome Sciences Hangzhou China UC Santa Cruz Genomics Institute UC Santa Cruz Santa Cruz CA USA Natural History Museum of Denmark University of Copenhagen Copenhagen Denmark Center for Macroecology Evolution and Climate GLOBE Institute University of Copenhagen Copenhagen Denmark Department of Biological Sciences Louisiana State University Baton Rouge LA USA Museum of Natural Science Louisiana State University Baton Rouge LA USA Centre of Excellence for Omics-Driven Computational Biodiscovery (COMBio) Faculty of Applied Sciences AIMST University Kedah Malaysia Section for Evolutionary Genomics The GLOBE Institute Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Institute of Molecular Biology National Academy of Sciences Yerevan Armenia University Museum Norwegian University of Science and Technology Trondheim Norway Center for Reproductive Medicine The 2nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Novogene Durham NC USA Duke University Medical Center Durham NC USA The Rockefeller University New York NY USA Howard Hughes Medical Institute Chevy Chase MD USA Department of Dermatology Medical University of Vienna Vienna Austria

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Author Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma

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Nature 2024年第8006期628卷 E1页

作者： Guangchun Han Ansam Sinjab Zahraa Rahal Anne M Lynch Warapen Treekitkarnmongkol Yuejiang Liu Alejandra G Serrano Jiping Feng Ke Liang Khaja Khan Wei Lu Sharia D Hernandez Yunhe Liu Xuanye Cao Enyu Dai Guangsheng Pei Jian Hu Camille Abaya Lorena I Gomez-Bolanos Fuduan Peng Minyue Chen Edwin R Parra Tina Cascone Boris Sepesi Seyed Javad Moghaddam Paul Scheet Marcelo V Negrao John V Heymach Mingyao Li Steven M Dubinett Christopher S Stevenson Avrum E Spira Junya Fujimoto Luisa M Solis Ignacio I Wistuba Jichao Chen Linghua Wang Humam Kadara Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Graduate Program in Developmental Biology Baylor College of Medicine Houston TX USA. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. Department of Biostatistics Epidemiology and Informatics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Thoracic Head and Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cardiovascular and Thoracic Surgery The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Medicine The University of California Los Angeles Los Angeles CA USA. Lung Cancer Initiative at Johnson & Johnson Boston MA USA. Section of Computational Biomedicine School of Medicine Boston University Boston MA USA. Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. JChen16@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. JChen16@***. Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. lwang22@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. lwang22@***. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX USA. hkadara@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. hkadara@***.

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The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

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四川生理科学杂志 2022年第7期44卷 1246-1246页

作者： Michael Worobey Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ 85721 USA Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA 92037 USA W. Harry Feinstone Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA Department of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA Department of Human Genetics University of Utah School of Medicine Salt Lake City UT 84112 USA Vaccine and Infectious Disease Organization University of Saskatchewan Saskatoon SK S7N 5E3 Canada Center for Global Health Science and Security Georgetown University Washington DC 20057 USA Department of Zoology University of Oxford Oxford OX1 3SZ UK Wildlife Conservation Research Unit Department of Zoology The Recanati-Kaplan Centre University of Oxford Oxford OX13 5QL UK Pandemic and Disaster Preparedness Centre Erasmus University Medical Center 3015 CE Rotterdam Netherlands Department of Viroscience Erasmus University Medical Center 3015 CE Rotterdam Netherlands Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles CA 90095 USA Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA Department of Medicine University of California San Diego La Jolla CA 92093 USA Department of Microbiology Immunology and Transplantation Rega Institute for Medical Research KU Leuven 3000 Leuven Belgium Global Virus Network (GVN) Baltimore MD 21201 USA MRC-University of Glasgow Center for Virus Research Glasgow G61 1QH UK Tulane University School of Medicine Department of Microbiology and Immu

Understanding how severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in 2019 is critical to preventing zoonotic outbreaks before they become the next *** Huanan Seafood Wholesale Market in Wuhan,China,... 详细信息

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26th Annual computational Neuroscience Meeting (CNS*2017): Part 1

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BMC Neurosci 2017年第SUPPL 1期18卷 58-58页

作者： Sue Denham Panayiota Poirazi Erik De Schutter Karl Friston Ho Ka Chan Thomas Nowotny Dongqi Han Sungho Hong Sophie Rosay Tanja Wernle Alessandro Treves Sarah Goethals Romain Brette Tomas Van Pottelbergh Rodolphe Sepulchre Alex D. Bird Hermann Cuntz Pedro J. Gonçalves Jan-Matthis Lueckmann Giacomo Bassetto Marcel Nonnenmacher Jakob H. Macke Audrey J. Sederberg Jason N. MacLean Stephanie E. Palmer Ulisse Ferrari Christophe Gardella Olivier Marre Thierry Mora Emina Ibrahimovic Martin Müller Jean-Pascal Pfister Tushar Chauhan Timothée Masquelier Alexandre Montlibert Benoit R. Cottereau Moritz Helias Jannis Schuecker David Dahmen Sven Goedeke Alexandre Hyafil Ainhoa Hermoso-Mendizabal Pavel E. Rueda-Orozco Santiago Jaramillo David Robbe Jaime de la Rocha Marie Rooy Fani Koukouli David DiGregorio Uwe Maskos Boris Gutkin Andrey Yu Verisokin Darya V. Verveyko Dmitry E. Postnov Willy Wong Omid Talakoub Robert Chen Milos Popovic Dmitriy Lisitsyn Eric Drebitz Iris Grothe Sunita Mandon Andreas Kreiter Udo Ernst Peter A. Robinson Xuelong Zhao Kevin M. Aquino John D. Griffiths Grishma Mehta-Pandejee Natasha Gabay James MacLaurin Somwrita Sarkar Tim Kunze Jens Haueisen Thomas R. Knösche Subutai Ahmad Yuwei Cui Marcus Lewis Jeff Hawkins Simona Olmi Spase Petkoski Fabrice Bartolomei Maxime Guye Viktor Jirsa Hazem Toutounji Daniel Durstewitz Matteo Cantarelli Adrian Quintana Boris Marin Matt Earnshaw Padraig Gleeson Robert Court Robert McDougal R. Angus Silver Salvador Dura-Bernal Stephen Larson William W. Lytton Giovanni Idili Lorenzo Posani Simona Cocco Karel Ježek Rémi Monasson School of Psychology Faculty of Health & Human Sciences Plymouth University Plymouth Devon PL4 8AA UK Institute of Molecular Biology and Biotechnology (IMBB) Foundation for Research and Technology-Hellas (FORTH) Heraklion Crete Greece Okinawa Institute of Science and Technology Graduate University Okinawa Japan Wellcome Trust Centre for Neuroimaging Institute of Neurology UCL London WC1N 3BG UK School of Engineering and Informatics University of Sussex Brighton BN1 9QJ UK Graduate School Okinawa Institute of Science and Technology Okinawa 904-0495 Japan Computational Neuroscience Unit Okinawa Institute of Science and Technology Okinawa 904-0495 Japan Cognitive Neuroscience Area Scuola Internazionale Superiore di Studi Avanzati Trieste 34136 Italy Kavli Institute for Systems Neuroscience NTNU Trondheim 7030 Norway Institut de la Vision Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Paris 75012 France Department of Engineering University of Cambridge Cambridge Cambridgeshire CB2 1PZ UK Ernst Strüngmann Institute for Neuroscience Max Planck Society Frankfurt Germany Frankfurt Institute for Advanced Studies Frankfurt Germany Neural Systems Analysis Research Center Caesar An Associate of the Max Planck Society Bonn Germany Max Planck Institute for Biological Cybernetics Tübingen Germany Bernstein Center for Computational Neuroscience Tübingen Germany Present Address: Biomedical Engineering Department Georgia Institute of Technology Atlanta GA 30306 USA Department of Neurobiology University of Chicago Chicago IL 60637 USA Department of Organismal Biology and Anatomy University of Chicago Chicago IL 60637 USA Committee on Computational Neuroscience University of Chicago Chicago IL 60637 USA Institut de la Vision Sorbonne Universités INSERM Paris France Laboratoire de Physique Statistique Ecole Normale Supérieure Paris France Institute of Molecular Life Sciences University of Zürich 8057 Zürich Switzerland Institute of Neuroinformatics Univer

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26th Annual computational Neuroscience Meeting (CNS*2017) of the Organization for computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

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The Lancet Respiratory Medicine 2020年第7期8卷 696-708页

作者： Moll, Matthew Sakornsakolpat, Phuwanat Shrine, Nick Hobbs, Brian D DeMeo, Dawn L John, Catherine Guyatt, Anna L McGeachie, Michael J Gharib, Sina A Obeidat, Ma'en Lahousse, Lies Wijnant, Sara R A Brusselle, Guy Meyers, Deborah A Bleecker, Eugene R Li, Xingnan Tal-Singer, Ruth Manichaikul, Ani Rich, Stephen S Won, Sungho Kim, Woo Jin Do, Ah Ra Washko, George R Barr, R Graham Psaty, Bruce M Bartz, Traci M Hansel, Nadia N Barnes, Kathleen Hokanson, John E Crapo, James D Lynch, David Bakke, Per Gulsvik, Amund Hall, Ian P Wain, Louise Soler Artigas, María Jackson, Victoria E Strachan, David P Hui, Jennie James, Alan L Kerr, Shona M Polasek, Ozren Vitart, Veronique Marten, Jonathan Rudan, Igor Kähönen, Mika Surakka, Ida Gieger, Christian Karrasch, Stefan Rawal, Rajesh Schulz, Holger Deary, Ian J Harris, Sarah E Enroth, Stefan Gyllensten, Ulf Imboden, Medea Probst-Hensch, Nicole M Lehtimäki, Terho Raitakari, Olli T Langenberg, Claudia Luan, Jian'an Wareham, Nick Zhao, Jing Hua Hayward, Caroline Murray, Alison Porteous, David J Smith, Blair H Jarvelin, Marjo-Riitta Wielscher, Matthias Joshi, Peter K Kentistou, Katherine A Timmers, Paul RHJ Wilson, James F Cook, James P Lind, Lars Mahajan, Anubha Morris, Andrew P Ewert, Ralf Homuth, Georg Stubbe, Beate Weiss, Stefan Zeggini, Eleftheria Weiss, Scott T Silverman, Edwin K Dudbridge, Frank Tobin, Martin D Cho, Michael H Channing Division of Network Medicine Brigham and Women's Hospital Boston MA United States Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston MA United States Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand Genetic Epidemiology Group Department of Health Sciences University of Leicester Leicester United Kingdom Computational Medicine Core Center for Lung Biology Department of Medicine University of Washington Seattle WA United States Division of Pulmonary Critical Care and Sleep Medicine Department of Medicine University of Washington Seattle WA United States Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle WA United States University of British Columbia Center for Heart Lung Innovation St Paul's Hospital Vancouver BC Canada Department of Epidemiology Erasmus Medical Centre Rotterdam Netherlands Department of Respiratory Medicine Erasmus Medical Centre Rotterdam Netherlands Department of Bioanalysis Faculty of Pharmaceutical Sciences Ghent University Ghent Belgium Department of Respiratory Medicine Ghent University Hospital Ghent Belgium Department of Medicine University of Arizona Tucson AZ United States GlaxoSmithKline Research and Development Collegeville PA United States Center for Public Health Genomics University of Virginia Charlottesville VA United States Department of Public Health Sciences University of Virginia Charlottesville VA United States Department of Public Health Sciences Graduate School of Public Health Seoul National University Seoul South Korea Interdisciplinary Program of Bioinformatics College of National Sciences Seoul National University Seoul South Korea Institute of Health and Environment Seoul National University Seoul South Korea Department of Internal Medicine Kangwon National University Chuncheon South Korea Department of Medicine and Department of Epidemiology Columbia Universit

Background: Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using addi...

Background: Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COPD and associated phenotypes. Methods: We constructed a polygenic risk score using a genome-wide association study of lung function (FEV₁ and FEV₁/forced vital capacity [FVC]) from the UK Biobank and SpiroMeta. We tested this polygenic risk score in nine cohorts of multiple ethnicities for an association with moderate-to-severe COPD (defined as FEV₁/FVC <0·7 and FEV₁ <80% of predicted). Associations were tested using logistic regression models, adjusting for age, sex, height, smoking pack-years, and principal components of genetic ancestry. We assessed predictive performance of models by area under the curve. In a subset of studies, we also studied quantitative and qualitative CT imaging phenotypes that reflect parenchymal and airway pathology, and patterns of reduced lung growth. Findings: The polygenic risk score was associated with COPD in European (odds ratio [OR] per SD 1·81 [95% CI 1·74–1·88] and non-European (1·42 [1·34–1·51]) populations. Compared with the first decile, the tenth decile of the polygenic risk score was associated with COPD, with an OR of 7·99 (6·56–9·72) in European ancestry and 4·83 (3·45–6·77) in non-European ancestry cohorts. The polygenic risk score was superior to previously described genetic risk scores and, when combined with clinical risk factors (ie, age, sex, and smoking pack-years), showed improved prediction for COPD compared with a model comprising clinical risk factors alone (AUC 0·80 [0·79–0·81] vs 0·76 [0·75–0·76]). The polygenic risk score was associated with CT imaging phenotypes, including wall area percent, quantitative and qualitative measures of emphysema, local histogram emphysema patterns, and destructive emphysema subtypes. The po

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