咨询与建议

限定检索结果

文献类型

  • 227 篇 期刊文献
  • 24 篇 会议

馆藏范围

  • 251 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 139 篇 理学
    • 82 篇 生物学
    • 20 篇 化学
    • 12 篇 数学
    • 10 篇 物理学
    • 6 篇 统计学(可授理学、...
    • 3 篇 天文学
  • 104 篇 工学
    • 35 篇 计算机科学与技术...
    • 27 篇 软件工程
    • 26 篇 生物医学工程(可授...
    • 19 篇 生物工程
    • 14 篇 化学工程与技术
    • 7 篇 信息与通信工程
    • 5 篇 仪器科学与技术
    • 5 篇 控制科学与工程
    • 4 篇 材料科学与工程(可...
    • 4 篇 电气工程
    • 4 篇 电子科学与技术(可...
    • 3 篇 光学工程
    • 3 篇 土木工程
  • 71 篇 医学
    • 44 篇 临床医学
    • 32 篇 基础医学(可授医学...
    • 18 篇 公共卫生与预防医...
    • 13 篇 药学(可授医学、理...
  • 35 篇 农学
    • 6 篇 作物学
  • 22 篇 管理学
    • 11 篇 公共管理
    • 6 篇 图书情报与档案管...
    • 5 篇 管理科学与工程(可...
  • 3 篇 教育学
    • 3 篇 教育学
    • 3 篇 心理学(可授教育学...
  • 2 篇 法学
    • 2 篇 社会学
  • 1 篇 经济学

主题

  • 9 篇 proteins
  • 5 篇 genome-wide asso...
  • 5 篇 bioinformatics
  • 4 篇 machine learning
  • 4 篇 gene expression
  • 3 篇 precision medici...
  • 3 篇 molecular dockin...
  • 3 篇 image segmentati...
  • 3 篇 general
  • 3 篇 diseases
  • 3 篇 epidemiology
  • 2 篇 cancer
  • 2 篇 deep learning
  • 2 篇 biomedicine
  • 2 篇 quality of healt...
  • 2 篇 drugs
  • 2 篇 lighting
  • 2 篇 breast cancer
  • 2 篇 educational inst...
  • 2 篇 transcriptomics

机构

  • 10 篇 department of in...
  • 10 篇 health managemen...
  • 9 篇 department of bi...
  • 9 篇 health systems a...
  • 9 篇 department of me...
  • 8 篇 department of tw...
  • 8 篇 center of comple...
  • 7 篇 national institu...
  • 7 篇 department of ph...
  • 7 篇 university of gl...
  • 7 篇 julius centre fo...
  • 7 篇 department of co...
  • 7 篇 department of bi...
  • 6 篇 department of co...
  • 6 篇 university centr...
  • 6 篇 institute for ca...
  • 6 篇 karachi pakistan
  • 6 篇 division of card...
  • 6 篇 international ce...
  • 6 篇 royal stoke univ...

作者

  • 8 篇 caroline hayward
  • 8 篇 wei zheng
  • 7 篇 danish saleheen
  • 7 篇 abu-gharbieh ema...
  • 7 篇 huang hsuan-chen...
  • 6 篇 eleftheria zeggi...
  • 6 篇 veronique vitart
  • 6 篇 mark i mccarthy
  • 6 篇 stella trompet
  • 6 篇 chu dinh-toi
  • 6 篇 juan hsueh-fen
  • 5 篇 hakon hakonarson
  • 5 篇 vilmantas giedra...
  • 5 篇 timothy m frayli...
  • 5 篇 andrew t hatters...
  • 5 篇 bärnighausen til...
  • 5 篇 igor rudan
  • 5 篇 terho lehtimäki
  • 5 篇 maggie c y ng
  • 5 篇 james f wilson

语言

  • 241 篇 英文
  • 9 篇 其他
检索条件"机构=Graduate Program in Computational Biology and Biomedical Informatics"
251 条 记 录,以下是41-50 订阅
排序:
computational prediction and validation of specific EmbR binding site on PknH
收藏 引用
Synthetic and Systems Biotechnology 2021年 第4期6卷 429-436页
作者: Insung Na Huanqin Dai Hantian Li Anvita Gupta David Kreda Powell Zhang Xiangyin Chen Lixin Zhang Gil Alterovitz Computational Health Informatics Program Boston Children’s Hospital/Harvard Medical SchoolBostonMA 02115USA Department of Medicine Brigham and Women’s Hospital/Harvard Medical SchoolBostonMA 02115USA State Key Laboratory of Mycology Institute of MicrobiologyBeijing100101 China Department of Computer Sciences Stanford UniversityStanford CA 94305USA Center for Biomedical Informatics Harvard Medical SchoolBostonMA 02115USA State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghaiChina Department of Biology The Johns Hopkins UniversityBaltimoreMD 21218USA Lexington High School BostonMA 02115USA
Tuberculosis drug resistance continues to threaten global health but the underline molecular mechanisms are not ***(EMB),one of the well-known first-line drugs in tuberculosis treatment is,unfortunately,not free from ... 详细信息
来源: 评论
A geological timescale for bacterial evolution and oxygen adaptation
收藏 引用
Science (New York, N.Y.) 2025年 第6742期388卷 eadp1853页
作者: Davín, Adrián A Woodcroft, Ben J. Soo, Rochelle M. Morel, Benoit Murali, Ranjani Schrempf, Dominik Clark, James W. Álvarez-Carretero, Sandra Boussau, Bastien Moody, Edmund R R Szánthó, Lénárd L Richy, Etienne Pisani, Davide Hemp, James Fischer, Woodward W. Donoghue, Philip C J Spang, Anja Hugenholtz, Philip Williams, Tom A. Szöllősi, Gergely J. University of Queensland School of Chemistry and Molecular Biosciences Australian Centre for Ecogenomics Brisbane QLD Australia Department of Biological Physics Eötvös Loránd University Budapest Hungary Department of Biological Sciences Graduate School of Science University of Tokyo Tokyo Japan Centre for Microbiome Research School of Biomedical Sciences Queensland University of Technology (QUT) Translational Research Institute Woolloongabba Australia Computational Molecular Evolution Group Heidelberg Institute for Theoretical Studies Heidelberg Germany Institute for Theoretical Informatics Karlsruhe Institute of Technology Karlsruhe Germany Division of Geological and Planetary Sciences California Institute of Technology Pasadena CA United States MTA-ELTE "Lendület" Evolutionary Genomics Research Group Budapest Hungary Bristol Palaeobiology Group School of Earth Sciences University of Bristol Bristol United Kingdom Milner Centre for Evolution Department of Life Sciences University of Bath Bath United Kingdom Laboratoire de Biométrie et Biologie Evolutive Univ Lyon CNRS VetAgro Sup Univ Lyon 1 Villeurbanne France School of Biological Sciences University of Bristol Bristol United Kingdom Institute of Evolution Centre for Ecological Research Budapest Hungary Model-Based Evolutionary Genomics Unit Okinawa Institute of Science and Technology Graduate University Okinawa Japan West Valley City UT United States Department of Marine Microbiology and Biogeochemistry NIOZ Royal Netherlands Institute for Sea Research Den Burg Netherlands Department of Evolutionary & Population Biology Institute for Biodiversity and Ecosystem Dynamics (IBED) University of Amsterdam Amsterdam Netherlands
Microbial life has dominated Earth's history but left a sparse fossil record, greatly hindering our understanding of evolution in deep time. However, bacterial metabolism has left signatures in the geochemical rec...
来源: 评论
Decision fusion of circulating markers for breast cancer detection in premenopausal women
Decision fusion of circulating markers for breast cancer det...
收藏 引用
7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
作者: Jesneck, Jonathan L. Mukherjee, Sayan Nolte, Loren W. Lokshin, Anna E. Marks, Jeffrey R. Lo, Joseph Department of Biomedical Engineering Department of Statistical Science Computational Biology and Bioinformatics Program Duke Advanced Imaging Labs. Institute for Genome Sciences and Policy Department of Computer Science Duke University Department of Electrical and Computer Engineering Division of Hematology/Oncology University of Pittsburgh School of Medicine University of Pittsburgh Cancer Institute Pittsburgh PA 15213 United States Department of Experimental Surgery Duke University Medical Center Medical Physics Graduate Program Duke University Durham NC 27708 United States
Current mammographic screeningfor breast cancer is less effective for younger women. To complement mammography for premenopausal women, we investigated the feasibility screening test using 98 blood serum proteins. Bec... 详细信息
来源: 评论
Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and the greater coronavirus family
Research Square
收藏 引用
Research Square 2020年 rs3rs-95030页
作者: Wang, Chen Konecki, Daniel M. Marciano, David C. Govindarajan, Harikumar Williams, Amanda M. Wastuwidyaningtyas, Brigitta Bourquard, Thomas Katsonis, Panagiotis Lichtarge, Olivier Baylor College of Medicine United States Department of Molecular and Human Genetics United States Quantitative and Computational Biosciences Graduate Program United States Cancer and Cell Biology Graduate Program Baylor College of Medicine HoustonTX77030 United States MAbSilico Nouzilly Centre France Computational and Integrative Biomedical Research Center Baylor College of Medicine HoustonTX77030 United States
Since the first recognized case of COVID-19, more than 100 million people have been infected worldwide. Global efforts in drug and vaccine development to fight the disease have yielded vaccines and drug candidates to ... 详细信息
来源: 评论
The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2
收藏 引用
Cell 2025年
作者: Pekar, Jonathan E. Lytras, Spyros Ghafari, Mahan Magee, Andrew F. Parker, Edyth Wang, Yu Ji, Xiang Havens, Jennifer L. Katzourakis, Aris Vasylyeva, Tetyana I. Suchard, Marc A. Hughes, Alice C. Hughes, Joseph Rambaut, Andrew Robertson, David L. Dellicour, Simon Worobey, Michael Wertheim, Joel O. Lemey, Philippe Institute of Ecology and Evolution University of Edinburgh Edinburgh United Kingdom Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla 92093 CA United States Department of Biomedical Informatics University of California San Diego La Jolla 92093 CA United States Department of Medicine University of California San Diego La Jolla 92093 CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Medical Research Council University of Glasgow Centre for Virus Research Glasgow United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States Department of Immunology and Microbiology The Scripps Research Institute La Jolla 92037 CA United States Institute of Genomics and Global Health Redeemer's University Osun State Ede Nigeria Department of Computer Science and Engineering University of California San Diego La Jolla 92093 CA United States Department of Mathematics School of Science and Engineering Tulane University New Orleans LA United States Department of Population Health and Disease Prevention University of California Irvine Irvine 92617 CA United States Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles 90095 CA United States Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States School of Biological Sciences University of Hong Kong Hong Kong Hong Kong China Biodiversity Green Development Foundation Beijing China Spatial Epidemiology Lab (SpELL) Université Libre de Bruxelles CP160/12 50 av. FD Roosevelt Bruxelles 1050 Belgium Department of Microbiology Immunology and Transplantation Rega Institute
The emergence of SARS-CoV in 2002 and SARS-CoV-2 in 2019 led to increased sampling of sarbecoviruses circulating in horseshoe bats. Employing phylogenetic inference while accounting for recombination of bat sarbecovir... 详细信息
来源: 评论
Immersed boundary model of aortic heart valve dynamics with physiological driving and loading conditions
arXiv
收藏 引用
arXiv 2017年
作者: Griffith, Boyce E. Leon H. Charney Division of Cardiology Department of Medicine Program in Computational Biology Sackler Institute of Graduate Biomedical Sciences New York University School of Medicine 550 First Avenue New YorkNY10016 United States
The immersed boundary (IB) method is a mathematical and numerical framework for problems of fluid-structure interaction, treating the particular case in which an elastic structure is immersed in a viscous incompressib... 详细信息
来源: 评论
AAV-mediated silencing of Sox4 leads to long-term amelioration of liver phenotypes in mouse models of Alagille syndrome
收藏 引用
Gastroenterology 2025年
作者: Duncan Fox Jun Xie Jennifer L. Burwinkel Josh M. Adams Kashish Chetal Marzieh Keivandarian Yaniv Faingelernt Sanjay Subramanian Mario F. Lopez Anna L. Peters Nathan Salomonis Neda Zarrin-Khameh Guangping Gao Stacey S. Huppert Hamed Jafar-Nejad Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas Genetics and Genomics Graduate Program Baylor College of Medicine Houston Texas Department of Genetic and Cellular Medicine UMass Chan Medical School Worcester Massachusetts Horae Gene Therapy Center UMass Chan Medical School Worcester Massachusetts Department of Microbiology UMass Chan Medical School Worcester Massachusetts Viral Vector Core UMass Chan Medical School Worcester Massachusetts Division of Gastroenterology Hepatology and Nutrition Cincinnati Children’s Hospital Medical Center Cincinnati Ohio Program in Developmental Biology Baylor College of Medicine Houston Texas Division of Biomedical Informatics Cincinnati Children's Hospital Medical Center Cincinnati Ohio Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio Department of Pathology and Immunology Baylor College of Medicine and Ben Taub Hospital Houston Texas
BACKGROUND & AIMS In patients with Alagille syndrome (ALGS), bile duct paucity often leads to severe cholestatic phenotypes for which liver transplantation remains the only definitive treatment. No FDA-approved me... 详细信息
来源: 评论
Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities
收藏 引用
Biochemistry and Biophysics Reports 2016年 6卷 135-141页
作者: Cherdtrakulkiat, Rungrot Boonpangrak, Somchai Sinthupoom, Nujarin Prachayasittikul, Supaluk Ruchirawat, Somsak Prachayasittikul, Virapong Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Bangkok 10700 Thailand Center for Innovation Development and Technology Transfer Faculty of Medical Technology Mahidol University Bangkok 10700 Thailand Center of Data Mining and Biomedical Informatics Faculty of Medical Technology Mahidol University Bangkok 10700 Thailand Laboratory of Medicinal Chemistry Chulabhorn Research Institute and Program in Chemical Biology Chulabhorn Graduate Institute Bangkok 10210 Thailand Center of Excellence on Environmental Health and Toxicology Commission on Higher Education (CHE) Ministry of Education Thailand
8-Hydroxyquinoline (8HQ) compounds have been reported to possess diverse bioactivities. In recent years, drug repositioning has gained considerable attention in drug discovery and development. Herein, 8HQ (1) and its ... 详细信息
来源: 评论
An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules
收藏 引用
BMC Systems biology 2009年 第1期3卷 1-20页
作者: Qin, Huaxia Chan, Michael W.Y. Liyanarachchi, Sandya Balch, Curtis Potter, Dustin Souriraj, Irene J. Cheng, Alfred S.L. Agosto-Perez, Francisco J. Nikonova, Elena V. Yan, Pearlly S. Lin, Huey-Jen Nephew, Kenneth P. Saltz, Joel H. Showe, Louise C. Huang, Tim H.M. Davuluri, Ramana V. Human Cancer Genetics Program Department of Molecular Virology Immunology and Medical Genetics The Ohio State University Columbus OH 43210 United States Division of Medical Technology School of Allied Medical Professions The Ohio State University Columbus OH 43210 United States Department of Biomedical Informatics The Ohio State University Columbus OH 43210 United States Department of Medical Sciences Indiana University School of Medicine Bloomington IN 47405 United States Department of Life Science Institute of Molecular Biology National Chung Cheng University Min-Hsiung Chia-Yi 621 Taiwan Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong Hong Kong Center for Systems and Computational Biology Molecular and Cellular Oncogenesis Program The Wistar Institute Philadelphia PA United States
Background: The TGF-β/SMAD pathway is part of a broader signaling network in which crosstalk between pathways occurs. While the molecular mechanisms of TGF-β/SMAD signaling pathway have been studied in detail, the g...
来源: 评论
Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer
收藏 引用
BMC Research Notes 2011年 第1期4卷 1-14页
作者: Beyer, Sasha J. Zhang, Xiaoli Jimenez, Rafael E. Lee, Mei-Ling T. Richardson, Andrea L. Huang, Kun Jhiang, Sissy M. Integrated Biomedical Sciences Graduate Program Ohio State University Columbus OH 43210 United States Department of Physiology and Cell Biology Ohio State University Columbus OH 43210 United States Center for Biostatistics Ohio State University Columbus OH 43210 United States Department of Anatomic Pathology Mayo Clinic Rochester MN 55901 United States Department of Epidemiology and Biostatistics University of Maryland College Park MD 20742 United States Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 United States Department of Biomedical Informatics Ohio State University Columbus OH 43210 United States
Background: Na+/I- symporter (NIS)-mediated iodide uptake allows radioiodine therapy for thyroid cancer. NIS is also expressed in breast tumors, raising potential for radionuclide therapy of breast cancer. However, NI... 详细信息
来源: 评论