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arXiv 2022年

作者： Lobentanzer, Sebastian Aloy, Patrick Baumbach, Jan Bohar, Balazs Charoentong, Pornpimol Danhauser, Katharina Doğan, Tunca Dreo, Johann Dunham, Ian Fernandez-Torras, Adrià Gyori, Benjamin M. Hartung, Michael Hoyt, Charles Tapley Klein, Christoph Korcsmaros, Tamas Maier, Andreas Mann, Matthias Ochoa, David Pareja-Lorente, Elena Popp, Ferdinand Preusse, Martin Probul, Niklas Schwikowski, Benno Sen, Bünyamin Strauss, Maximilian T. Turei, Denes Ulusoy, Erva Heidrun Wodke, Judith Andrea Saez-Rodriguez, Julio Heidelberg University Faculty of Medicine Heidelberg University Hospital Institute for Computational Biomedicine Bioquant Heidelberg Germany The Barcelona Institute of Science and Technology Catalonia Barcelona Spain Catalonia Barcelona Spain Institute for Computational Systems Biology University of Hamburg Germany Earlham Institute Norwich United Kingdom Biological Research Centre Szeged Hungary Heidelberg University Im Neuenheimer Feld 267 Heidelberg69120 Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Department of Pediatrics Dr. von Hauner Children’s Hospital University Hospital LMU Munich Germany Biological Data Science Lab Department of Computer Engineering Hacettepe University Ankara Turkey Department of Bioinformatics Graduate School of Health Sciences Hacettepe University Ankara Turkey Computational Systems Biomedicine Lab Department of Computational Biology Institut Pasteur Université Paris Cité Paris France Bioinformatics and Biostatistics Hub Institut Pasteur Université Paris Cité Paris France Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Open Targets Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Laboratory of Systems Pharmacology Harvard Medical School Boston United States Imperial College London London United Kingdom Quadram Institute Bioscience Norwich United Kingdom Proteomics Program Novo Nordisk Foundation Centre for Protein Research University of Copenhagen Copenhagen Denmark Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Neuherberg Germany Medical Informatics Laboratory University Medicine Greifswald Germany

Standardising the representation of biomedical knowledge among all researchers is an insurmountable task, hindering the effectiveness of many computational methods. To facilitate harmonisation and interoperability despite this fundamental challenge, we propose to standardise the framework of knowledge graph creation instead. We implement this standardisation in BioCypher, a FAIR (findable, accessible, interoperable, reusable) framework to transparently build biomedical knowledge graphs while preserving provenances of the source data. Mapping the knowledge onto biomedical ontologies helps to balance the needs for harmonisation, human and machine readability, and ease of use and accessibility to nonspecialist researchers. We demonstrate the usefulness of this framework on a variety of use cases, from maintenance of task-specific knowledge stores, to interoperability between biomedical domains, to on-demand building of task-specific knowledge graphs for federated learning. BioCypher (https://***) frees up valuable developer time;we encourage further development and usage by the community. © 2022, CC BY-NC-ND.

关键词： Ontology

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Chemical complexity of phosphorous bearing species in various regions of the interstellar medium

arXiv

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arXiv 2021年

作者： Sil, Milan Srivastav, Satyam Bhat, Bratati Mondal, Suman Kumar Gorai, Prasanta Ghosh, Rana Shimonishi, Takashi Chakrabarti, Sandip K. Sivaraman, Bhalamurugan Pathak, Amit Nakatani, Naoki Furuya, Kenji Das, Ankan Indian Centre for Space Physics 43 Chalantika Garia Station Road Kolkata700084 India Department of Physics Institute of Science Banaras Hindu University Varanasi221005 India Department of Space Earth & Environment Chalmers University of Technology GothenburgSE-412 96 Sweden Center for Transdisciplinary Research Niigata University Nishi-ku Niigata950-2181 Japan Environmental Science Program Department of Science Faculty of Science Niigata University Nishi-ku Niigata950-2181 Japan Physical Research Laboratory Navrangpura Ahmedabad380009 India Institute for Catalysis Hokkaido University N21W10 Kita-ku Sapporo Hokkaido001-0021 Japan Department of Chemistry Graduate School of Science and Engineering Tokyo Metropolitan University 1-1 Minami-Osawa Hachioji Tokyo192-0397 Japan Center for Computational Sciences University of Tsukuba Tsukuba305-8577 Japan National Astronomical Observatory of Japan Tokyo181-8588 Japan

Phosphorus related species are not known to be as omnipresent in space as hydrogen, carbon, nitrogen, oxygen, and sulfur-bearing species. Astronomers spotted very few P-bearing molecules in the interstellar medium and circumstellar envelopes. Limited discovery of the P-bearing species imposes severe constraints in modeling the P-chemistry. In this paper, we carry out extensive chemical models to follow the fate of P-bearing species in diffuse clouds, photon-dominated or photodissociation regions (PDRs), and hot cores/corinos. We notice a curious correlation between the abundances of PO and PN and atomic nitrogen. Since N atoms are comparatively abundant in diffuse clouds and PDRs than in the hot core/corino region, PO/PN reflects 1 in the late warm-up evolutionary phase of the hot core/corino regions. During the end of the post-warm-up phase, we obtain PO/PN > 1 for hot core and 3along with various impurities. We notice that SO2overlaps with the PH3bending-scissoring modes around ∼ (1000 - 1100) cm-1. We also find that the presence of CO2can strongly influence the intensity of the stretching modes around ∼ 2400 cm-1of PH3 © 2021, CC0.

关键词： Radiative transfer

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An Hydro-Mechanical Model of Edema Formation Applied to Bacterial Myocarditis

An Hydro-Mechanical Model of Edema Formation Applied to Bact...

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2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

作者： Reis, R.F. Rocha, B.M. Santos, R. W. Dos Lobosco, M. Computer Science Department Federal University of Juiz de Fora Juiz de Fora MG36036-900 Brazil Graduate Program in Computational Modelling Federal University of Juiz de Fora Juiz de Fora MG36036-900 Brazil

ISBN: (纸本)9781538654880

In young adults, up to 20% of all cases of sudden death are due to myocarditis, a heart disease caused by inflammation in the myocardium. There are several reasons that lead to myocarditis, including infections caused by a virus, bacteria, protozoa, fungus, and others. Additionally, this inflammatory response is one of the consequences of an infection triggered by an immunological reaction, which causes an edema in the heart. One of the techniques used to visualize myocardial edema is the cardiovascular magnetic resonance of myocardial tissue. Using this imaging exam it is possible to visualize hyperintense signal in the edematous zone. This paper aims to model and simulate the mechanical deformation due to a bacterial infection in a two-dimensional domain that represents a short axis slice of the heart and compares qualitatively the results with data found from literature. This mathematical model consists of partial differential equations (PDEs) that use the Biot theory of poroelasticity applied to living tissue and coupled with an immune system dynamics to model the edema formation. Thus, the mathematical model used in this study is basically divided into two parts: one modelling the immune system response due to a bacterial infection, represented by neutrophils;and another representing the hydro-mechanical problem. The preliminary results show that our model is able to reproduce some key aspects related to an initial myocarditis. © 2018 IEEE.

关键词： Tissue

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A light in the dark: searching for electromagnetic counterparts to black hole-black hole mergers in LIGO/Virgo O3 with the Zwicky Transient Facility

arXiv

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arXiv 2022年

作者： Graham, Matthew J. McKernan, Barry Ford, K.E. Saavik Stern, Daniel Djorgovski, S.G. Coughlin, Michael Burdge, Kevin B. Bellm, Eric C. Helou, George Mahabal, Ashish A. Masci, Frank J. Purdum, Josiah Rosnet, Philippe Rusholme, Ben California Institute of Technology 1200 E. California Blvd PasadenaCA91125 United States Department of Science CUNY Borough of Manhattan Community College 199 Chambers Street New YorkNY10007 United States Department of Astrophysics American Museum of Natural History Central Park West New YorkNY10028 United States Physics Program CUNY Graduate Center 365 5th Avenue New YorkNY10016 United States Center for Computational Astrophysics Flatiron Institute New YorkNY10010 United States Jet Propulsion Laboratory California Institute of Technology 4800 Oak Grove Drive PasadenaCA91109 United States School of Physics and Astronomy University of Minnesota MinneapolisMN55455 United States Department of Physics Massachusetts Institute of Technology CambridgeMA02139 United States Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States DIRAC Institute Department of Astronomy University of Washington 3910 15th Avenue NE SeattleWA98195 United States IPAC California Institute of Technology 1200 E. California Blvd PasadenaCA91125 United States Division of Physics Mathematics and Astronomy California Institute of Technology PasadenaCA91125 United States Center for Data Driven Discovery California Institute of Technology PasadenaCA91125 United States Caltech Optical Observatories California Institute of Technology PasadenaCA91125 United States Université Clermont Auvergne CNRS IN2P3 LPC Clermont-FerrandF-63000 France

The accretion disks of active galactic nuclei (AGN) are promising locations for the merger of compact objects detected by gravitational wave (GW) observatories. Embedded within a baryon-rich, high density environment, mergers within AGN are the only GW channel where an electromagnetic (EM) counterpart must occur (whether detectable or not). Considering AGN with unusual flaring activity observed by the Zwicky Transient Facility (ZTF), we describe a search for candidate EM counterparts to binary black hole (BBH) mergers detected by LIGO/Virgo in O3. After removing probable false positives, we find nine candidate counterparts to BBH mergers during O3 (seven in O3a, two in O3b) with a p-value of 0.0019. Based on ZTF sky coverage, AGN geometry, and merger geometry, we expect ≈ 3(NBBH/83)(fAGN/0.5) potentially detectable EM counterparts from O3, where NBBH is the total number of observed BBH mergers and fAGN is the fraction originating in AGN. Further modeling of breakout and flaring phenomena in AGN disks is required to reduce our false positive rate. Two of the events are also associated with mergers with total masses > 100M☉, which is the expected rate for O3 if hierarchical (large mass) mergers occur in the AGN channel. Candidate EM counterparts in future GW observing runs can be better constrained by coverage of the Southern sky as well as spectral monitoring of unusual AGN flaring events in LIGO/Virgo alert volumes. A future set of reliable AGN EM counterparts to BBH mergers will yield an independent means of measuring cosmic expansion (H0) as a function of redshift. © 2022, CC BY.

关键词： Gravity waves

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Dynamic ¹³C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin (vol 23, 100855, 2020)

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Iscience 2020年第12期23卷 100855页

作者： Quek, Lake-Ee Krycer, James R. Ohno, Satoshi Yugi, Katsuyuki Fazakerley, Daniel J. Scalzo, Richard Elkington, Sarah D. Dai, Ziwei Hirayama, Akiyoshi Ikeda, Satsuki Shoji, Futaba Suzuki, Kumi Locasale, Jason W. Soga, Tomoyoshi James, David E. Kuroda, Shinya Charles Perkins Centre The University of Sydney Sydney NSW 2006 Australia School of Mathematics and Statistics The University of Sydney Sydney NSW 2006 Australia Sydney Medical School The University of Sydney Sydney NSW 2006 Australia Department of Biological Sciences Graduate School of Science University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-0033 Japan School of Life and Environmental Sciences The University of Sydney Sydney NSW 2006 Australia Institute for Advanced Biosciences Keio University Tsuruoka Yamagata 997-0052 Japan YCI Laboratory for Trans-Omics Young Chief Investigator Program RIKEN Center for Integrative Medical Sciences 1-7-22 Suehiro-cho Tsurumi-ku Yokohama Kanagawa 230-0045 Japan Faculty of Engineering and Information Technologies The University of Sydney Sydney NSW 2006 Australia Department of Pharmacology and Cancer Biology Duke University School of Medicine Duke University Durham NC 27710 USA AMED-CREST AMED 1-7-1 Otemachi Chiyoda-Ku Tokyo 100-0004 Japan Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences University of Tokyo 5-1-5 Kashiwanoha Kashiwa Chiba 277-8562 Japan CREST Japan Science and Technology Agency Bunkyo-ku Tokyo 113-0033 Japan

Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient 13 C-tracer dynamic metabolic flux analysis (13C-DMFA) framework for modeling central carbon fluxes that vary over time. We used B-splines to generalize the flux parameterization system and to improve the stability of the optimization algorithm. As proof of concept, we investigated how 3T3-L1 cultured adipocytes acutely metabolize glucose in response to insulin. Insulin rapidly stimulates glucose uptake, but intracellular pathways responded with differing speeds and magnitudes. Fluxes in lower glycolysis increased faster than those in upper glycolysis. Glycolysis fluxes rose disproportionally larger and faster than the tricarboxylic acid cycle, with lactate a primary glucose end product. The uncovered array of flux dynamics suggests that glucose catabolism is additionally regulated beyond uptake to help shunt glucose into appropriate pathways. This work demonstrates the value of using dynamic intracellular fluxes to understand metabolic function and pathway regulation.

关键词： Biological sciences Flux Data Metabolomics Metabolic Flux Analysis

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EMPRESS. X. Spatially resolved mass-metallicity relation in extremely metal-poor galaxies: Evidence of episodic star-formation fueled by a metal-poor gas infall

arXiv

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arXiv 2024年

作者： Nakajima, Kimihiko Ouchi, Masami Isobe, Yuki Xu, Yi Ozaki, Shinobu Nagao, Tohru Inoue, Akio K. Rauch, Michael Kusakabe, Haruka Onodera, Masato Nishigaki, Moka Ono, Yoshiaki Sugahara, Yuma Hattori, Takashi Hirai, Yutaka Hashimoto, Takuya Kim, Ji Hoon Moriya, Takashi J. Yanagisawa, Hiroto Aoyama, Shohei Fujimoto, Seiji Fukushima, Hajime Fukushima, Keita Harikane, Yuichi Hatano, Shun Hayashi, Kohei Ishigaki, Tsuyoshi Kawasaki, Masahiro Kojima, Takashi Komiyama, Yutaka Koyama, Shuhei Koyama, Yusei Lee, Chien-Hsiu Matsumoto, Akinori Mawatari, Ken Motohara, Kentaro Murai, Kai Nagamine, Kentaro Nakane, Minami Saito, Tomoki Sasaki, Rin Shibuya, Takatoshi Suzuki, Akihiro Takeuchi, Tsutomu T. Umeda, Hiroya Umemura, Masayuki Watanabe, Kuria Yabe, Kiyoto Yajima, Hidenobu Zhang, Yechi National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwanoha Chiba Kashiwa277-8582 Japan Osawa 2-21-1 Mitaka Tokyo181-8588 Japan University of Tokyo Chiba Kashiwa277-8583 Japan Kavli Institute for Cosmology University of Cambridge Madingley Road CambridgeCB3 0HA United Kingdom Cavendish Laboratory University of Cambridge 19 JJ Thomson Avenue CambridgeCB3 0HE United Kingdom Waseda Research Institute for Science and Engineering Faculty of Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo169-8555 Japan Department of Physics Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan Department of Astronomy Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan Research Center for Space and Cosmic Evolution Ehime University Bunkyo-cho 2-5 Ehime Matsuyama790-8577 Japan Department of Physics School of Advanced Science and Engineering Faculty of Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo169-8555 Japan Observatories of the Carnegie Institution for Science 813 Santa Barbara St. PasadenaCA91101 United States Observatoire de Genève Université de Genève 51 Chemin de Pégase Versoix1290 Switzerland 650 North Aohoku Place HiloHI96720 United States Department of Physics and Astronomy University of Notre Dame 225 Nieuwland Science Hall Notre DameIN46556 United States Astronomical Institute Tohoku University 6-3 Aoba Aramaki Aoba-ku Miyagi Sendai980-8578 Japan Division of Physics Faculty of Pure and Applied Sciences University of Tsukuba Ibaraki Tsukuba305-8571 Japan Faculty of Pure and Applied Sciences University of Tsukuba Ibaraki Tsukuba305-8571 Japan Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Cent

Using the Subaru/FOCAS IFU capability, we examine the spatially resolved relationships between gas-phase metallicity, stellar mass, and star-formation rate surface densities (Σ★ and ΣSFR, respectively) in extremely metal-poor galaxies (EMPGs) in the local universe. Our analysis includes 24 EMPGs, comprising 9,177 spaxels, which span a unique parameter space of local metallicity (12 + log(O/H) 6.9 to 7.9) and stellar mass surface density (Σ★ ∼ 105 to 107 Mo kpc−2), extending beyond the range of existing large integral-field spectroscopic surveys. Through spatially resolved emission line diagnostics based on the [N ii] BPT-diagram, we verify the absence of evolved active galactic nuclei in these EMPGs. Our findings reveal that, while the resolved mass-metallicity relation exhibits significant scatter in the low-mass regime, this scatter is closely correlated with local star-formation surface density. Specifically, metallicity decreases as ΣSFR increases for a given Σ★. Notably, half of the EMPGs show a distinct metal-poor horizontal branch on the resolved mass-metallicity relation. This feature typically appears at the peak clump with the highest Σ★ and ΣSFR and is surrounded by a relatively metal-enriched ambient region. These findings support a scenario in which metal-poor gas infall fuels episodic star formation in EMPGs, consistent with the kinematic properties observed in these systems. In addition, we identify four EMPGs with exceptionally low central metallicities (12 + log(O/H) 7.2), which display only a metal-poor clump without a surrounding metal-rich region. This suggests that such ultra-low metallicity EMPGs, at less than a few percent of the solar metallicity, may serve as valuable analogs for galaxies in the early stages of galaxy evolution. Copyright © 2024, The Authors. All rights reserved.

关键词： Spectroscopic analysis

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INTRODUCTION

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Bulletin of the American Meteorological Society 2024年第8期105卷 S1-S11页

作者： Boyer, T. Blunden, J. Dunn, R.J.H. NOAA/NESDIS National Centers for Environmental Information Silver Spring Maryland NOAA/NESDIS National Centers for Environmental Information Asheville North Carolina Met Office Hadley Centre Exeter United Kingdom European Centre for Medium-Range Weather Forecasts Reading United Kingdom University of Maryland College Park Maryland Scripps Institution of Oceanography University of California San Diego La Jolla California NOAA/NWS National Centers for Environmental Prediction Climate Prediction Center College Park Maryland Brandenburg University of Technology (BTU) Cottbus-Senftenberg Germany Servicio Meteorológico Nacional Buenos Aires Argentina NOAA/OAR Physical Sciences Laboratory Boulder Colorado European Centre for Medium-Range Weather Forecasts Bonn Germany Center for Geophysical Research and School of Physics University of Costa Rica San José Costa Rica Department of Meteorology and National Centre for Earth Observation University of Reading Reading United Kingdom Centro Nacional de Monitoramento e Alertas de Desastres Naturais CEMADEN São Paulo Brazil Université Grenoble Alpes Institut des Géosciences de l’Environnement IRD CNRS Grenoble INP Grenoble France Hampton University Hampton Virginia Seychelles Meteorological Authority Mahe Seychelles Section for Glaciers Ice and Snow Norwegian Water Resources and Energy Directorate Oslo Norway National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Agriculture Osaka Metropolitan University Sakai Japan Science Faculty Universidad Nacional de Colombia Bogotá Colombia University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder Colorado Servicio Nacional de Meteorología e Hidrología del Perú Lima Perú Centro de Investigaciones sobre Desertificación – Spanish National Research Council (CSIC-UV-GVA) Valencia Spain Hydro-Climate Extremes Lab (H-CEL) Ghent University Ghent Belgium Department o

In 2023, La Niña conditions that generally prevailed in the eastern Pacific Ocean from mid-2020 into early 2023 gave way to a strong El Niño by October. Atmospheric concentrations of Earth’s major greenhouse gases—carbon dioxide, methane, and nitrous oxide—all increased to record-high levels. The annual global average carbon dioxide concentration in the atmosphere rose to 419.3±0.1 ppm, which is 50% greater than the pre-industrial level. The growth from 2022 to 2023 was 2.8 ppm, the fourth highest in the record since the 1960s. The combined short-term effects of El Niño and the long-term effects of increasing levels of heat-trapping gases in the atmosphere contributed to new records for many essential climate variables reported here. The annual global temperature across land and oceans was the highest in records dating as far back as 1850, with the last seven months (June–December) having each been record warm. Over land, the globally averaged temperature was also record high. Dozens of countries reported record or near-record warmth for the year, including China and continental Europe as a whole (warmest on record), India and Russia (second warmest), and Canada (third warmest). Intense and widespread heatwaves were reported around the world. In Vietnam, an all-time national maximum temperature record of 44.2°C was observed at Tuong Duong on 7 May, surpassing the previous record of 43.4°C at Huong Khe on 20 April 2019. In Brazil, the air temperature reached 44.8°C in Araçuaí in Minas Gerais on 20 November, potentially a new national record and 12.8°C above normal. The effect of rising temperatures was apparent in the cryosphere, where snow cover extent by June 2023 was the smallest in the 56-year record for North America and seventh smallest for the Northern Hemisphere overall. Heatwaves contributed to the greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Due to rapid volume loss beginning in 2021, St. A

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Magnetized and quadratic convection based thermal transport in ternary radiative bio-nanofluid via intelligent neural networks: Two hidden layers mechanism

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Results in Physics 2024年 65卷

作者： Ayub, Assad Darvesh, Adil Shah, Syed Zahir Hussain Junjua, Moin-ud-Din Santos, Elizaldo Domingues dos Ahmad, Shabbir Hendy, Ahmed S. Ragab, Adham E. Department of Mathematics & Statistics Hazara University Manshera Pakistan School of Mathematical Sciences Zhejiang Normal University Zhejiang Jinhua 321004 China Programa de Pós-Graduação em Modelagem Computacional/LMCE Escola de Engenharia Universidade Federal do Rio Grande – FURG RS Rio Grande 96203900 Brazil FURG Escola de Engenharia RS Rio Grande Brazil Department of Basic Sciences and Humanities Muhammad Nawaz Sharif University of Engineering and Technology Multan 60000 Pakistan Department of Computational Mathematics and Computer Science Institute of Natural Sciences and Mathematics Ural Federal University 19 Mira St. Yekaterinburg 620002 Russian Federation Department of Industrial Engineering College of Engineering King Saud University P.O. Box 800 Riyadh 11421 Saudi Arabia Department of Mathematics Ghazi University Dera Ghazi Khan 32200 Pakistan Graduate Program of Ocean Engineering School of Engineering Universidade Federal do Rio Grande Italia Avenue km 8 96201-900 Rio Grande Brazil Department of Mechanics and Mathematics Western Caspian University Baku 1001 Azerbaijan

Significance: The thermal analysis of nanofluid in a vertical cylinder (artery) in a magnetized environment holds significant implications in physiological and thermal regulation networks. This research is significant in biomedical engineering with applications like medical diagnostics and treatment strategies. Motive: This study investigates the thermal behavior of a magnetized blood-based ternary Carreau nanofluid flowing through a vertically bounded artery with quadratic convection. Velocity and heat transfer analysis is conducted within the artery, utilizing thermal radiation and quadratic convection in a magnetized setting. The base fluid consists of blood, augmented with three nanoparticles: CuO, Al₂O₃, and TiO₂. The investigation centers on examining the properties of blood nanofluid, arterial geometry, and thermal dynamics. Methodology: The physical model generates a set of partial differential equations (PDEs) and similarities mechanism is utilized to fetch its non dimensional form in terms of ordinary differential equations (ODEs). Furthermore, numerical outcomes are obtained with Matlab function bvp4c and obtained data set is trained through robust scheme Levenberg-Marquardt neural network (LMNN) procedure to predict the solution. Findings: Velocity of blood is reduced with increased values of wiessenberg number, magnetic parameter and mixed convection parameter and velocity increases for Second-order convection parameter. Temperature profile decreases with curvature parameter, mixed convection parameter and permeability parameter. © 2024

关键词： Blood fluid Intelligent neural network Magnetized environment Ternary nanoparticles Thermal scrutiny

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Discovery of a novel class NSD2 inhibitor for multiple myeloma with t(4;14) +

Blood Neoplasia

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Blood Neoplasia 2025年第2期2卷 100091-100091页

作者： Sae Matsuoka Naoki Osada Hirokazu Kubota Ko Kikuzato Hiroo Koyama Takeshi Sonoda Akiko Idei Minoru Yoshida Masaki Kikuchi Takashi Umehara Chiduru Watanabe Teruki Honma Hiroshi Yasui Sho Ikeda Naoto Takahashi Hideki Nakasone Jiro Kikuchi Yusuke Furukawa Division of Emerging Medicine for Integrated Therapeutics Center for Molecular Medicine Jichi Medical University Shimotsuke Japan Drug Discovery Chemistry Platform Unit RIKEN Center for Sustainable Resource Science Wako Japan Drug Discovery Seed Compounds Exploratory Unit RIKEN Center for Sustainable Resource Science Wako Japan Office of University Professors The University of Tokyo Tokyo Japan Laboratory for Epigenetics Drug Discovery RIKEN Center for Biosystems Dynamics Research Yokohama Japan Drug Discovery Computational Chemistry Platform Unit RIKEN Center for Biosystems Dynamics Research Yokohama Japan Institute of Medical Science The University of Tokyo Tokyo Japan Department of Hematology and Oncology St. Marianna University School of Medicine Kawasaki Japan Department of Hematology Nephrology and Rheumatology Akita University Graduate School of Medicine Akita Japan Center for Medical Education Teikyo University of Science Tokyo Japan Drug Discovery Cooperation Division RIKEN Program for Drug Discovery and Medical Technology Platform Yokohama Japan

Abstract The prognosis for multiple myeloma (MM) has continued to improve with the development of a series of novel molecular targeted drugs over time. However, the prognosis remains poor for cases with high-risk chromosomal abnormalities. Of such abnormalities, t(4;14) is the second most common, occurring in 15% of patients with MM. MM cells carrying t(4;14) strongly express histone methyltransferase with a SET domain, called NSD2, making them resistant to drugs against MM. Therefore, NSD2 is a promising therapeutic target for MM carrying t(4;14). Subsequently, we performed high-throughput screening and identified RK-0080552 (RK-552) as a novel class NSD2 inhibitor. RK-552 was significantly cytotoxic against t(4;14) + MM compared with t(4;14) - MM cells in vitro and in vivo via transcriptional suppression of the IRF4 gene, coincided with a decrease in histone H3 lysine 36 dimethylation. Moreover, RK-552 acted additively with pomalidomide in vitro and prolonged the survival of recipient mice without side effects. These results suggest that RK-552 may be a clinically relevant NSD2 inhibitor with specific cytotoxicity to MM cells carrying t(4;14). Our study also provides a molecular basis and rationale for the inclusion in current treatment strategies. Therefore, the clinical use of RK-552 may significantly improve the treatment outcome of MM with t(4;14).

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Publisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

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Nature genetics 2023年第5期55卷 893页

作者： Yuan Yuan Young Seok Ju Youngwook Kim Jun Li Yumeng Wang Christopher J Yoon Yang Yang Inigo Martincorena Chad J Creighton John N Weinstein Yanxun Xu Leng Han Hyung-Lae Kim Hidewaki Nakagawa Keunchil Park Peter J Campbell Han Liang Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK. Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology Daejeon Korea. Department of Health Science and Technology Samsung Advanced Institute for Health Science and Technology Sungkyunkwan University School of Medicine Seoul Korea. Quantitative and Computational Biosciences Graduate Program Baylor College of Medicine Houston TX USA. Division of Biostatistics The University of Texas Health Science Center at Houston School of Public Health Houston TX USA. Department of Medicine and Dan L. Duncan Cancer Center Division of Biostatistics Baylor College of Medicine Houston TX USA. Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Applied Mathematics and Statistics Johns Hopkins University Baltimore MD USA. Department of Biochemistry and Molecular Biology The University of Texas Health Science Center at Houston McGovern Medical School Houston TX USA. Department of Biochemistry Ewha Womans University School of Medicine Seoul Korea. Laboratory for Cancer Genomics RIKEN Center for Integrative Medical Sciences Yokohama Japan. Division of Hematology/Oncology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. kpark@skku.edu. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK. pc8@sanger.ac.uk. Cambridge University Hospitals NHS Foundation Trust Cambridge UK. pc8@sanger.ac.uk. Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA. hliang1@***. Quantitative and Computational Biosciences Graduate Program Baylor College of Medicine Houston TX USA. hliang1@***. Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA. hliang1@mdanderson

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