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Publisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

Nature genetics 2023年第5期55卷 893页

作者： Yuan Yuan Young Seok Ju Youngwook Kim Jun Li Yumeng Wang Christopher J Yoon Yang Yang Inigo Martincorena Chad J Creighton John N Weinstein Yanxun Xu Leng Han Hyung-Lae Kim Hidewaki Nakagawa Keunchil Park Peter J Campbell Han Liang Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK. Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology Daejeon Korea. Department of Health Science and Technology Samsung Advanced Institute for Health Science and Technology Sungkyunkwan University School of Medicine Seoul Korea. Quantitative and Computational Biosciences Graduate Program Baylor College of Medicine Houston TX USA. Division of Biostatistics The University of Texas Health Science Center at Houston School of Public Health Houston TX USA. Department of Medicine and Dan L. Duncan Cancer Center Division of Biostatistics Baylor College of Medicine Houston TX USA. Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Applied Mathematics and Statistics Johns Hopkins University Baltimore MD USA. Department of Biochemistry and Molecular Biology The University of Texas Health Science Center at Houston McGovern Medical School Houston TX USA. Department of Biochemistry Ewha Womans University School of Medicine Seoul Korea. Laboratory for Cancer Genomics RIKEN Center for Integrative Medical Sciences Yokohama Japan. Division of Hematology/Oncology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. kpark@skku.edu. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK. pc8@sanger.ac.uk. Cambridge University Hospitals NHS Foundation Trust Cambridge UK. pc8@sanger.ac.uk. Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA. hliang1@***. Quantitative and Computational Biosciences Graduate Program Baylor College of Medicine Houston TX USA. hliang1@***. Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA. hliang1@mdanderson

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Integrating spatially-resolved transcriptomics data across tissues and individuals: challenges and opportunities

arXiv

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arXiv 2024年

作者： Guo, Boyi Ling, Wodan Kwon, Sang Ho Panwar, Pratibha Ghazanfar, Shila Martinowich, Keri Hicks, Stephanie C. Department of Biostatistics Johns Hopkins Bloomberg School of Public Health BaltimoreMD United States Division of Biostatistics Department of Population Health Sciences Weill Cornell Medicine NY United States Lieber Institute for Brain Development Johns Hopkins Medical Campus BaltimoreMD United States Solomon H. Snyder Department of Neuroscience Johns Hopkins School of Medicine BaltimoreMD United States Biochemistry Cellular and Molecular Biology Graduate Program Johns Hopkins School of Medicine BaltimoreMD United States School of Mathematics and Statistics The University of Sydney NSW2006 Australia Sydney Precision Data Science Centre University of Sydney NSW2006 Australia Charles Perkins Centre The University of Sydney NSW2006 Australia Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine BaltimoreMD United States Johns Hopkins Kavli Neuroscience Discovery Institute BaltimoreMD United States Department of Biomedical Engineering Johns Hopkins University BaltimoreMD United States Center for Computational Biology Johns Hopkins University BaltimoreMD United States Malone Center for Engineering in Healthcare Johns Hopkins University BaltimoreMD United States

Advances in spatially-resolved transcriptomics (SRT) technologies have propelled the development of new computational analysis methods to unlock biological insights. As the cost of generating these data decreases, these technologies provide an exciting opportunity to create large-scale atlases that integrate SRT data across multiple tissues, individuals, species, or phenotypes to perform population-level analyses. Here, we describe unique challenges of varying spatial resolutions in SRT data, as well as highlight the opportunities for standardized preprocessing methods along with computational algorithms amenable to atlas-scale datasets leading to improved sensitivity and reproducibility in the future. © 2024, CC BY-NC-ND.

关键词： Biotic

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Gamma-ray Bursts as Distance Indicators by a Statistical Learning Approach

arXiv

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arXiv 2024年

作者： Dainotti, Maria Giovanna Narendra, Aditya Pollo, Agnieszka Petrosian, Vahé Bogdan, Malgorzata Iwasaki, Kazunari Prochaska, Jason Xavier Rinaldi, Enrico Zhou, David National Astronomical Observatory of Japan Mitaka Tokyo181-8588 Japan The Graduate University for Advanced Studies SOKENDAI Kanagawa240-0193 Japan Space Science Institute BoulderCO80301 United States Doctoral School of Exact and Natural Sciences Jagiellonian University Krakow Poland Astronomical Observatory of Jagiellonian University Krakow Poland Warsaw Poland Department of Physics Stanford University 382 Via Pueblo Mall StanfordCA94305-4060 United States Kavli Institute for Particle Astrophysics and Cosmology Stanford University United States Department of Applied Physics Stanford University United States Department of Mathematics University of Wroclaw 50-384 Poland Department of Statistics Lund University LundSE-221 00 Sweden Center for Computational Astrophysics National Astronomical Observatory of Japan 2 Chome-21-1 Osawa Mitaka Tokyo181-8588 Japan University of California Santa Cruz 1156 High Street Santa CruzCA95064 United States Program RIKEN Saitama Wakoshi 351-0198 Japan Arizona State University 1151 S Forest Ave TempeAZ85281 United States

Gamma-ray bursts (GRBs) can be probes of the early universe, but currently, only 26% of GRBs observed by the Neil Gehrels Swift Observatory GRBs have known redshifts (z) due to observational limitations. To address this, we estimated the GRB redshift (distance) via a supervised statistical learning model that uses optical afterglow observed by Swift and ground-based telescopes. The inferred redshifts are strongly correlated (a Pearson coefficient of 0.93) with the observed redshifts, thus proving the reliability of this method. The inferred and observed redshifts allow us to estimate the number of GRBs occurring at a given redshift (GRB rate) to be 8.47-9yr−1Gpc−1 for 1.9 © 2024, CC BY.

关键词： Stars

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Euclid: Early Release Observations – A preview of the Euclid era through a galaxy cluster magnifying lens

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Astronomy and Astrophysics 2025年 697卷

作者： Atek, H. Gavazzi, R. Weaver, J.R. Diego, J.M. Schrabback, T. Hatch, N.A. Aghanim, N. Dole, H. Hartley, W.G. Taamoli, S. Congedo, G. Jimenez-Teja, Y. Cuillandre, J.-C. Bañados, E. Belladitta, S. Bowler, R.A.A. Franco, M. Jauzac, M. Mahler, G. Richard, J. Rocci, P.-F. Serjeant, S. Toft, S. Abriola, D. Bergamini, P. Biviano, A. Dimauro, P. Ezziati, M. Golden-Marx, J.B. Grillo, C. Hughes, A.C.N. Kang, Y. Kneib, J.-P. Lombardi, M. Mamon, G.A. McPartland, C.J.R. Meneghetti, M. Miyatake, H. Montes, M. Mortlock, D.J. Oesch, P.A. Okabe, N. Rosati, P. Taylor, A.N. Tarsitano, F. Weller, J. Kluge, M. Laureijs, R. Paltani, S. Saifollahi, T. Schirmer, M. Stone, C. Mora, A. Altieri, B. Amara, A. Andreon, S. Auricchio, N. Baldi, M. Balestra, A. Bardelli, S. Basset, A. Bender, R. Bodendorf, C. Bonino, D. Branchini, E. Brescia, M. Brinchmann, J. Camera, S. Candini, G.P. Capobianco, V. Carbone, C. Cardone, V.F. Carretero, J. Casas, S. Castander, F.J. Castellano, M. Cavuoti, S. Cimatti, A. Conselice, C.J. Conversi, L. Copin, Y. Corcione, L. Courbin, F. Courtois, H.M. Da Silva, A. Degaudenzi, H. Di Giorgio, A.M. Dinis, J. Douspis, M. Dubath, F. Dupac, X. Dusini, S. Ealet, A. Farina, M. Farrens, S. Ferriol, S. Fotopoulou, S. Frailis, M. Franceschi, E. Galeotta, S. Gillard, W. Gillis, B. Giocoli, C. Gómez-Alvarez, P. Grazian, A. Grupp, F. Guzzo, L. Hailey, M. Haugan, S.V.H. Hoar, J. Hoekstra, H. Holliman, M.S. Institut d’Astrophysique de Paris UMR 7095 CNRS Sorbonne Université 98 bis boulevard Arago Paris75014 France Aix-Marseille Université CNRS CNES LAM Marseille France Department of Astronomy University of Massachusetts AmherstMA01003 United States Instituto de Física de Cantabria Edificio Juan Jordá Avenida de los Castros Santander39005 Spain Universität Innsbruck Institut für Astro- und Teilchenphysik Technikerstr. 25/8 Innsbruck6020 Austria School of Physics and Astronomy University of Nottingham University Park NottinghamNG7 2RD United Kingdom Université Paris-Saclay CNRS Institut d’astrophysique spatiale Orsay91405 France Department of Astronomy University of Geneva ch. d’Ecogia 16 Versoix1290 Switzerland Physics and Astronomy Department University of California 900 University Ave. RiversideCA92521 United States Institute for Astronomy University of Edinburgh Royal Observatory Blackford Hill EdinburghEH9 3HJ United Kingdom Instituto de Astrofísica de Andalucía CSIC Glorieta de la Astronomía Granada18080 Spain Observatorio Nacional Rua General Jose Cristino 77-Bairro Imperial de Sao Cristovao Rio de Janeiro20921-400 Brazil Université Paris-Saclay Université Paris Cité CEA CNRS AIM Gif-sur-Yvette91191 France Max-Planck-Institut für Astronomie Königstuhl 17 Heidelberg69117 Germany INAF-Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Via Piero Gobetti 93/3 Bologna40129 Italy Jodrell Bank Centre for Astrophysics Department of Physics and Astronomy University of Manchester Oxford Road ManchesterM13 9PL United Kingdom The University of Texas at Austin AustinTX78712 United States Department of Physics Centre for Extragalactic Astronomy Durham University South Road DH1 3LE United Kingdom Department of Physics Institute for Computational Cosmology Durham University South Road DH1 3LE United Kingdom Astrophysics Research Centre University of KwaZulu-Natal Westville Campus Durban4041 South Africa School of

We present the first analysis of the Euclid Early Release Observations (ERO) program that targets fields around two lensing clusters, Abell 2390 and Abell 2764. We use imaging data from the Visible instrument (VIS) and the Near-Infrared Spectrometer and Photometer (NISP) to produce photometric catalogs for a total of ∼500 000 objects. The imaging data reach a typical depth of 5 σ in the range 25.1–25.4 AB in the NISP bands and 27.1–27.3 AB in the VIS band. Using the Lyman-break method in combination with photometric redshifts, we searched for high-redshift galaxies. We identified 30 Lyman-break galaxy (LBG) candidates at z > 6 and 139 extremely red sources (ERSs), most of which likely lie at lower redshift. The VIS imaging is deeper than the NISP imaging, which means that we can routinely identify high-redshift Lyman-break galaxies at about a magnitude of 3, which reduces contamination by brown dwarf stars and low-redshift galaxies. The difficulty of spatially resolving most of these sources in 0′′ . 3 pix−1 imaging means that it is difficult to distinguish between galaxies and quasars. Spectroscopic follow-up campaigns of these bright sources will help us to constrain the bright end of the ultraviolet galaxy luminosity function and the quasar luminosity function at z > 6, and it will constrain the physical nature of these objects. Additionally, we performed a combined strong- and weak-lensing analysis of A2390, and we show that Euclid will contribute to constraining the virial mass of galaxy clusters better. We also identify optical and near-infrared counterparts of known z > 0.6 clusters in these data. These counterparts exhibit strong-lensing features. This establishes that Euclid can characterize high-redshift clusters. Finally, we provide a glimpse of the ability of Euclid to map the intracluster light out to larger radii than current facilities, which enables us to understand the cluster assembly history better and to map the dark matter distribution. This ini

关键词： Moon

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EMPRESS. IX. Extremely Metal-Poor Galaxies are Very Gas-Rich Dispersion-Dominated Systems: Will JWST Witness Gaseous Turbulent High-z Primordial Galaxies?

arXiv

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arXiv 2022年

作者： Isobe, Yuki Ouchi, Masami Nakajima, Kimihiko Ozaki, Shinobu Bouché, Nicolas F. Wise, John H. Xu, Yi Emsellem, Eric Kusakabe, Haruka Hattori, Takashi Nagao, Tohru Chiaki, Gen Fukushima, Hajime Harikane, Yuichi Hayashi, Kohei Hirai, Yutaka Kim, Ji Hoon Maseda, Michael V. Nagamine, Kentaro Shibuya, Takatoshi Sugahara, Yuma Yajima, Hidenobu Aoyama, Shohei Fujimoto, Seiji Fukushima, Keita Hatano, Shun Inoue, Akio K. Ishigaki, Tsuyoshi Kawasaki, Masahiro Kojima, Takashi Komiyama, Yutaka Koyama, Shuhei Koyama, Yusei Lee, Chien-Hsiu Matsumoto, Akinori Mawatari, Ken Moriya, Takashi J. Motohara, Kentaro Murai, Kai Nishigaki, Moka Onodera, Masato Ono, Yoshiaki Rauch, Michael Saito, Tomoki Sasaki, Rin Suzuki, Akihiro Takeuchi, Tsutomu T. Umeda, Hiroya Umemura, Masayuki Watanabe, Kuria Yabe, Kiyoto Zhang, Yechi Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwanoha Chiba Kashiwa277-8582 Japan Department of Physics Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan University of Tokyo Chiba Kashiwa277-8583 Japan Univ Lyon Univ Lyon1 ENS de Lyon CNRS Centre de Recherche Astrophysique de Lyon UMR5574 Saint-Genis-LavalF-69230 France Center for Relativistic Astrophysics School of Physics Georgia Institute of Technology AtlantaGA30332 United States Department of Astronomy Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan European Southern Observatory Karl-Schwarzschild-Straße 2 Garching85748 Germany Observatoire de Genéve Université de Genéve 51 Ch. des Maillettes Versoix1290 Switzerland 650 North A'ohoku Place HiloHI96720 United States Research Center for Space and Cosmic Evolution Ehime University Bunkyo-cho 2-5 Ehime Matsuyama790-8577 Japan Center for Computational Sciences University of Tsukuba Ten-nodai 1-1-1 Tsukuba Ibaraki305-8577 Japan Department of Physics and Astronomy University College London Gower Street LondonWC1E 6BT United Kingdom National Institute of Technology Ichinoseki College Hagisho Ichinoseki021-8511 Japan Astronomical Institute Tohoku University 6-3 Aoba Aramaki Aoba-ku Miyagi Sendai980-8578 Japan Department of Physics and Astronomy University of Notre Dame 225 Nieuwland Science Hall Notre DameIN46556 United States Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Department of Astronomy University of Wisconsin-Madison 475 N. Charter Street MadisonWI53706 United States Theoretical Astrophysics Department of Earth & Space S

We present kinematics of 6 local extremely metal-poor galaxies (EMPGs) with low metallicities (0.016 − 0.098 Z☉) and low stellar masses (104.7 − 107.6M☉). Taking deep medium-high resolution (R ∼ 7500) integral-field spectra with 8.2-m Subaru, we resolve the small inner velocity gradients and dispersions of the EMPGs with Hα emission. Carefully masking out sub-structures originated by inflow and/or outflow, we fit 3-dimensional disk models to the observed Hα flux, velocity, and velocity-dispersion maps. All the EMPGs show rotational velocities (vrot) of 5-23 km s−1 smaller than the velocity dispersions (σ0) of 17-31 km s−1, indicating dispersion-dominated (vrot/σ0 = 0.29−0.80 gas 0.9 − 1.0. Comparing our results with other Hα kinematics studies, we find that vrot/σ0 decreases and fgas increases with decreasing metallicity, decreasing stellar mass, and increasing specific star-formation rate. We also find that simulated high-z (z ∼ 7) forming galaxies have gas fractions and dynamics similar to the observed EMPGs. Our EMPG observations and the simulations suggest that primordial galaxies are gas-rich dispersion-dominated systems, which would be identified by the forthcoming James Webb Space Telescope (JWST) observations at z ∼ 7. Copyright © 2022, The Authors. All rights reserved.

关键词： Galaxies

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EMPRESS. XII. Statistics on the Dynamics and Gas Mass Fraction of Extremely-Metal Poor Galaxies

arXiv

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arXiv 2023年

作者： Xu, Yi Ouchi, Masami Isobe, Yuki Nakajima, Kimihiko Ozaki, Shinobu Bouché, Nicolas F. Wise, John H. Emsellem, Eric Kusakabe, Haruka Hattori, Takashi Nagao, Tohru Chiaki, Gen Fukushima, Hajime Harikane, Yuichi Hayashi, Kohei Hirai, Yutaka Kim, Ji Hoon Maseda, Michael V. Nagamine, Kentaro Shibuya, Takatoshi Sugahara, Yuma Yajima, Hidenobu Aoyama, Shohei Fujimoto, Seiji Fukushima, Keita Hatano, Shun Inoue, Akio K. Ishigaki, Tsuyoshi Kawasaki, Masahiro Kojima, Takashi Komiyama, Yutaka Koyama, Shuhei Koyama, Yusei Lee, Chien-Hsiu Matsumoto, Akinori Mawatari, Ken Moriya, Takashi J. Motohara, Kentaro Murai, Kai Nishigaki, Moka Onodera, Masato Ono, Yoshiaki Rauch, Michael Saito, Tomoki Sasaki, Rin Suzuki, Akihiro Takeuchi, Tsutomu T. Umeda, Hiroya Umemura, Masayuki Watanabe, Kuria Yabe, Kiyoto Zhang, Yechi Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwanoha Chiba Kashiwa277-8582 Japan Department of Astronomy Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan University of Tokyo Chiba Kashiwa277-8583 Japan Department of Physics Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan Univ Lyon Univ Lyon1 ENS de Lyon CNRS Centre de Recherche Astrophysique de Lyon UMR5574 Saint-Genis-LavalF-69230 France Center for Relativistic Astrophysics School of Physics Georgia Institute of Technology AtlantaGA30332 United States European Southern Observatory Karl-Schwarzschild-Straße 2 Garching85748 Germany Observatoire de Genéve Université de Genéve 51 Ch. des Maillettes Versoix1290 Switzerland 650 North A’ohoku Place HiloHI96720 United States Research Center for Space and Cosmic Evolution Ehime University Bunkyo-cho 2-5 Ehime Matsuyama790-8577 Japan Center for Computational Sciences University of Tsukuba Ten-nodai 1-1-1 Tsukuba Ibaraki305-8577 Japan Department of Physics and Astronomy University College London Gower Street LondonWC1E 6BT United Kingdom National Institute of Technology Ichinoseki College Hagisho Ichinoseki021-8511 Japan Astronomical Institute Tohoku University 6-3 Aoba Aramaki Aoba-ku Miyagi Sendai980-8578 Japan Department of Physics and Astronomy University of Notre Dame 225 Nieuwland Science Hall Notre DameIN46556 United States Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Department of Astronomy University of Wisconsin-Madison 475 N. Charter Street MadisonWI53706 United States Theoretical Astrophysics Department of Earth & Space S

We present demography of the dynamics and gas-mass fraction of 33 extremely metal-poor galaxies (EMPGs) with metallicities of 0.015 − 0.195 Zo and low stellar masses of 104 − 108 Mo in the local universe. We conduct deep optical integral-field spectroscopy (IFS) for the low-mass EMPGs with the medium high resolution (R = 7500) grism of the 8m-Subaru FOCAS IFU instrument by the EMPRESS 3D survey, and investigate Hα emission of the EMPGs. Exploiting the resolution high enough for the low-mass galaxies, we derive gas dynamics with the Hα lines by the fitting of 3-dimensional disk models. We obtain an average maximum rotation velocity (vrot) of 15 ± 3 km s−1 and an average intrinsic velocity dispersion (σ0) of 27 ± 10 km s−1 for 15 spatially resolved EMPGs out of the 33 EMPGs, and find that all of the 15 EMPGs have vrot/σ0 rot/σ0 with the decreasing stellar mass and metallicity. We derive the gas mass fraction (fgas) for all of the 33 EMPGs, and find no clear dependence on stellar mass and metallicity. These vrot/σ0 and fgas trends should be compared with young high-z galaxies observed by the forthcoming JWST IFS programs to understand the physical origins of the EMPGs in the local universe. © 2023, CC BY.

关键词： Galaxies

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EMPRESS. X. Spatially resolved mass-metallicity relation in extremely metal-poor galaxies: Evidence of episodic star-formation fueled by a metal-poor gas infall

arXiv

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arXiv 2024年

作者： Nakajima, Kimihiko Ouchi, Masami Isobe, Yuki Xu, Yi Ozaki, Shinobu Nagao, Tohru Inoue, Akio K. Rauch, Michael Kusakabe, Haruka Onodera, Masato Nishigaki, Moka Ono, Yoshiaki Sugahara, Yuma Hattori, Takashi Hirai, Yutaka Hashimoto, Takuya Kim, Ji Hoon Moriya, Takashi J. Yanagisawa, Hiroto Aoyama, Shohei Fujimoto, Seiji Fukushima, Hajime Fukushima, Keita Harikane, Yuichi Hatano, Shun Hayashi, Kohei Ishigaki, Tsuyoshi Kawasaki, Masahiro Kojima, Takashi Komiyama, Yutaka Koyama, Shuhei Koyama, Yusei Lee, Chien-Hsiu Matsumoto, Akinori Mawatari, Ken Motohara, Kentaro Murai, Kai Nagamine, Kentaro Nakane, Minami Saito, Tomoki Sasaki, Rin Shibuya, Takatoshi Suzuki, Akihiro Takeuchi, Tsutomu T. Umeda, Hiroya Umemura, Masayuki Watanabe, Kuria Yabe, Kiyoto Yajima, Hidenobu Zhang, Yechi National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwanoha Chiba Kashiwa277-8582 Japan Osawa 2-21-1 Mitaka Tokyo181-8588 Japan University of Tokyo Chiba Kashiwa277-8583 Japan Kavli Institute for Cosmology University of Cambridge Madingley Road CambridgeCB3 0HA United Kingdom Cavendish Laboratory University of Cambridge 19 JJ Thomson Avenue CambridgeCB3 0HE United Kingdom Waseda Research Institute for Science and Engineering Faculty of Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo169-8555 Japan Department of Physics Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan Department of Astronomy Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan Research Center for Space and Cosmic Evolution Ehime University Bunkyo-cho 2-5 Ehime Matsuyama790-8577 Japan Department of Physics School of Advanced Science and Engineering Faculty of Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo169-8555 Japan Observatories of the Carnegie Institution for Science 813 Santa Barbara St. PasadenaCA91101 United States Observatoire de Genève Université de Genève 51 Chemin de Pégase Versoix1290 Switzerland 650 North Aohoku Place HiloHI96720 United States Department of Physics and Astronomy University of Notre Dame 225 Nieuwland Science Hall Notre DameIN46556 United States Astronomical Institute Tohoku University 6-3 Aoba Aramaki Aoba-ku Miyagi Sendai980-8578 Japan Division of Physics Faculty of Pure and Applied Sciences University of Tsukuba Ibaraki Tsukuba305-8571 Japan Faculty of Pure and Applied Sciences University of Tsukuba Ibaraki Tsukuba305-8571 Japan Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Cent

Using the Subaru/FOCAS IFU capability, we examine the spatially resolved relationships between gas-phase metallicity, stellar mass, and star-formation rate surface densities (Σ★ and ΣSFR, respectively) in extremely metal-poor galaxies (EMPGs) in the local universe. Our analysis includes 24 EMPGs, comprising 9,177 spaxels, which span a unique parameter space of local metallicity (12 + log(O/H) 6.9 to 7.9) and stellar mass surface density (Σ★ ∼ 105 to 107 Mo kpc−2), extending beyond the range of existing large integral-field spectroscopic surveys. Through spatially resolved emission line diagnostics based on the [N ii] BPT-diagram, we verify the absence of evolved active galactic nuclei in these EMPGs. Our findings reveal that, while the resolved mass-metallicity relation exhibits significant scatter in the low-mass regime, this scatter is closely correlated with local star-formation surface density. Specifically, metallicity decreases as ΣSFR increases for a given Σ★. Notably, half of the EMPGs show a distinct metal-poor horizontal branch on the resolved mass-metallicity relation. This feature typically appears at the peak clump with the highest Σ★ and ΣSFR and is surrounded by a relatively metal-enriched ambient region. These findings support a scenario in which metal-poor gas infall fuels episodic star formation in EMPGs, consistent with the kinematic properties observed in these systems. In addition, we identify four EMPGs with exceptionally low central metallicities (12 + log(O/H) 7.2), which display only a metal-poor clump without a surrounding metal-rich region. This suggests that such ultra-low metallicity EMPGs, at less than a few percent of the solar metallicity, may serve as valuable analogs for galaxies in the early stages of galaxy evolution. Copyright © 2024, The Authors. All rights reserved.

关键词： Spectroscopic analysis

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26th Annual computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Research Square

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Research Square 2021年

作者： Zhang, Martin Jinye Hou, Kangcheng Pasaniuc, Bogdan Price, Alkes L. Dey, Kushal K. Jagadeesh, Karthik A. Weinand, Kathryn Sakaue, Saori Taychameekiatchai, Aris Rao, Poorvi Pisco, Angela Oliveira Zou, James Wang, Bruce Gandal, Michael Raychaudhuri, Soumya Harvard University United States Osaka University Japan Department of Epidemiology Harvard T.H. Chan School of Public Health BostonMA United States Program in Medical and Population Genetics Broad Institute of MIT and Harvard CambridgeMA United States Bioinformatics Interdepartmental Program University of California Los Angeles Los AngelesCA United States Department of Pathology and Laboratory Medicine David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Center for Data Sciences Brigham and Women’s Hospital BostonMA United States Division of Genetics Department of Medicine Brigham and Women’s Hospital Harvard Medical School BostonMA United States Division of Rheumatology Inflammation and Immunity Department of Medicine Brigham and Women’s Hospital Harvard Medical School BostonMA United States Department of Biomedical Informatics Harvard Medical School BostonMA United States Department of Medicine and Liver Center University of California San Francisco San FranciscoCA United States Developmental and Stem Cell Biology Graduate Program University of California San Francisco San FranciscoCA United States Chan Zuckerberg Biohub San FranciscoCA United States Department of Electrical Engineering Stanford University Palo AltoCA United States Department of Biomedical Data Science Stanford University Palo AltoCA United States Department of Psychiatry David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Program in Neurobehavioral Genetics Semel Institute David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Versus Arthritis Centre for Genetics and Genomic

Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin of diseases and complex traits. Here, we introduce single-cell Disease Relevance Score (scDRS), an approach that links scRNA-seq with polygenic risk of disease at individual cell resolution;scDRS identifies individual cells that show excess expression levels for genes in a disease-specific gene set constructed from GWAS data. We determined via simulations that scDRS is well-calibrated and powerful in identifying individual cells associated to disease. We applied scDRS to GWAS data from 74 diseases and complex traits (average N =341K) in conjunction with 16 scRNA-seq data sets spanning 1.3 million cells from 31 tissues and organs. At the cell type level, scDRS broadly recapitulated known links between classical cell types and disease, and also produced novel biologically plausible findings. At the individual cell level, scDRS identified subpopulations of disease-associated cells that are not captured by existing cell type labels, including subpopulations of CD4+ T cells associated with inflammatory bowel disease, partially characterized by their effector-like states;subpopulations of hippocampal CA1 pyramidal neurons associated with schizophrenia, partially characterized by their spatial location at the proximal part of the hippocampal CA1 region;and subpopulations of hepatocytes associated with triglyceride levels, partially characterized by their higher ploidy levels. At the gene level, we determined that genes whose expression across individual cells was correlated with the scDRS score (thus reflecting co-expression with GWAS disease genes) were strongly enriched for gold-standard drug target and Mendelian disease genes. © 2021, CC BY.

关键词： RNA

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Predicting the spectrum of UGC 2885, Rubin's Galaxy with machine learning

arXiv

引用

arXiv 2021年

作者： Holwerda, Benne W. Wu, John F. Keel, William C. Young, Jason Mullins, Ren Hinz, Joannah Ford, K.E. Saavik Barmby, Pauline Chandar, Rupali Bailin, Jeremy Peek, Josh Pickering, Tim Böker, Torsten Physics & Astronomy Department University of Louisville LouisvilleKY40292 United States Space Telescope Science Institute 3700 San Martin Drive BaltimoreMD21219 United States Department of Physics and Astronomy University of Alabama Box 870324 TuscaloosaAL35487-0324 United States Mount Holyoke College 50 College Street South HadleyMA01075 United States Steward Observatory University of Arizona 933 North Cherry Avenue TucsonAZ85721- 0065 United States MMT Observatory P.O. Box 210065 TucsonAZ85721-0065 United States Dept. of Science Borough of Manhattan Community College City University of New York New YorkNY10007 United States Dept. of Astrophysics American Museum of Natural History New YorkNY10024 United States Physics Program CUNY Graduate Center City University of New York New YorkNY10016 United States Center for Computational Astrophysics Flatiron Institute New YorkNY10010 United States Department of Physics & Astronomy Institute for Earth & Space Exploration University of Western Ontario 1151 Richmond Street LondonON Canada Department of Physics & Astronomy The University of Toledo ToledoOH43606 United States Department of Physics & Astronomy Johns Hopkins University BaltimoreMD21218 United States European Space Agency c/o STScI 3700 San Martin Drive BaltimoreMD21219 United States

Wu & Peek (2020) predict SDSS-quality spectra based on Pan-STARRS broad-band grizy images using machine learning (ML). In this letter, we test their prediction for a unique object, UGC 2885 ("Rubin's galaxy"), the largest and most massive, isolated disk galaxy in the local Universe (D ∗ = 1011 M☉), which uncharacteristically shows no sign of interaction or mergers, manages to fuel its central AGN remains to be investigated. © 2021, CC BY.

关键词： Galaxies

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