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A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes

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Cell Reports Medicine 2025年第5期6卷 102084-102084页

作者： Han, Xudong Zhang, Yichi Petrosky, Jillian N. Bald, Sarah Sherva, Richard M. Labadorf, Adam Cherry, Jonathan D. Chung, Jaeyoon Farrell, Kurt Abdolmohammadi, Bobak Durape, Shruti Martin, Brett M. Palmisano, Joseph N. Farrell, John J. Alvarez, Victor E. Huber, Bertrand R. Dwyer, Brigid Daneshvar, Daniel H. Jun, Gyungah R. Lunetta, Kathryn L. Goldstein, Lee E. Katz, Douglas I. Cantu, Robert C. Shenton, Martha E. Cummings, Jeffrey L. Reiman, Eric M. Stern, Robert A. Alosco, Michael L. Tripodis, Yorghos Farrer, Lindsay A. Stein, Thor D. Crary, John F. McKee, Ann C. Mez, Jesse Bioinformatics Graduate Program Boston University Boston MA United States Section of Biomedical Genetics Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston MA United States Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston MA United States Boston University Alzheimer's Disease Research Center Boston University Chobanian & Avedisian School of Medicine Boston MA United States Boston VA Healthcare System Boston MA United States Boston University Chronic Traumatic Encephalopathy Center Boston University Boston MA United States Department of Pathology and Laboratory Medicine Boston University Chobanian & Avedisian School of Medicine Boston MA United States Departments of Pathology Neuroscience and Artificial Intelligence & Human Health Neuropathology Brain Bank & Research CoRE Friedman Brain Institute Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York NY United States Biostatistics and Epidemiology Data Analytics Center Boston University School of Public Health Boston MA United States Bedford VA Healthcare System Bedford MA United States Braintree Rehabilitation Hospital Braintree MA United States Department of Physical Medicine and Rehabilitation Harvard Medical School Boston MA United States Department of Rehabilitation and Human Performance Brain Injury Research Center Icahn School of Medicine at Mount Sinai New York NY United States Department of Neurology Icahn School of Medicine at Mount Sinai New York NY United States Department of Biostatistics Boston University School of Public Health Boston MA United States Department of Ophthalmology Boston University Chobanian & Avedisian School of Medicine Boston MA United States Departments of Biomedical Electrical & Computer Engineering Boston University College of Engineering Boston MA United States Departments of Radiology and Psychiatry Boston University Chobanian & Avedisia

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. Genetic variation in the 17q21.31 region, containing microtubule-associated protein tau (MAPT), has been implicated in tauopathies but has not been investigated in CTE. The region includes a megabase-long inversion (H1/H2) and copy-number variations, including α, β, and γ segments, which can be characterized as nine segregating structural haplotypes. We leveraged array SNP data and a reference panel across the 17q21.31 region to impute structural haplotypes and test their association with CTE endophenotypes in 447 European ancestry brain donors with RHI exposure. The H1β1γ1 haplotype was significantly associated with dementia and semi-quantitative tau burden in multiple cortical and medial temporal regions commonly affected in CTE. H1β1γ1 differential expression analyses in dorsolateral frontal cortex implicated cis-acting genes and inflammatory pathways. Taken together, the H1β1γ1 haplotype may help explain CTE heterogeneity among those with similar RHI exposure. © 2025 The Authors

关键词： 17q21.31 chronic traumatic encephalopathy dementia differential gene expression immune system MAPT repetitive head impacts structural haplotypes tauopathy traumatic brain injury

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Inventory control systems with safety stock and reorder point approach 1

Inventory control systems with safety stock and reorder poin...

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1st International Conference on Information and Communications Technology, ICOIACT 2018

作者： Efrilianda, Devi Ajeng Mustafid Isnanto, R. Rizal Master Program of Information Systems School of Post Graduate Studies Diponegoro University Semarang Indonesia Department of Statistics Faculty of Science and Mathematics Diponegoro University Semarang Central Java Indonesia Department of Computer Systems Faculty of Engineering Diponegoro University Semarang Indonesia

ISBN: (纸本)9781538609545

The inventory control systems has an important role to monitor the condition of the goods at the supply chain stage of goods distribution from the central warehouse to retail in accordance with consumer demand. The research aims to develop inventory control systems on the supply chain distribution of goods from suppliers to retail through the central warehouse with minimal supply chain costs. Minimization of supply chain cost using martingale model of forecast evaluation, and the result as the basis for calculation of safety stock and reorder point. The results of research are the system that can be used to control inventory and renewal of goods in the central warehouse by calculating the minimization of supply chain cost based on consumer demand. Case studies were conducted on the supply chain distribution of goods from the central warehouse to the retail in Semarang. The observation data derived from the goods distribution from central warehouse to retail for certain products over 4 time periods. Through such inventory control system, can minimize supply chain cost, and product inventory level can be maintained in time and amount of inventory that must be fulfilled. © 2018 IEEE.

关键词： Supply chains

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Fundamental bounds on the operation of Fano nonlinear isolators

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Physical Review B 2018年第11期97卷 115431-115431页

作者： Dimitrios L. Sounas Andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Photonics Initiative Advanced Science Research Center City University of New York New York 10031 USA Physics Program Graduate Center City University of New York New York 10016 USA Department of Electrical Engineering City College of The City University of New York New York 10031 USA

Nonlinear isolators have attracted significant attention for their ability to break reciprocity and provide isolation without the need of an external bias. A popular approach for the design of such devices is based on Fano resonators, which, due to their sharp frequency response, can lead to very large isolation for moderate input intensities. Here, we show that, independent of their specific implementation, these devices are subject to fundamental bounds on the transmission coefficient in the forward direction versus their quality factor, input power, and nonreciprocal intensity range. Our analysis quantifies a general tradeoff between forward transmission and these metrics, stemming directly from time-reversal symmetry, and that unitary transmission is only possible for vanishing nonreciprocity. Our results also shed light on the operation of resonant nonlinear isolators, reveal their fundamental limitations, and provide indications on how it is possible to design nonlinear isolators with optimal performance.

关键词： Electromagnetism Metamaterials Nonlinear optics

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Expert-based text mining with Delphi method for crude oil price prediction

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International Journal of Industrial and Systems engineering 2017年第4期25卷 545-563页

作者： Chuaykoblap, Somboon Chutima, Parames Chandrachai, Achara Nupairoj, Natawut Technopreneurship and Innovation Management Program Graduate School Chulalongkorn University 1405-1409 14th Fl. Chamchuri Sq. Bldg. Payathai Rd. Patumwan Bangkok10330 Thailand Department of Industrial Engineering Engineering Faculty Chulalongkorn University Bangkok Thailand Commerce and Accountancy Faculty Chulalongkorn University Bangkok Thailand Department of Computer Engineering Engineering Faculty Chulalongkorn University Bangkok Thailand

As crude is one of the most important commodities, the crude price forecasting has continuously been a centre of interest. The traditional techniques are focusing on econometric models which could not cope with the short term abnormality. Text data mining from news articles could be an effective method to predict the crude oil price variation caused by irregularities, but, the main issues in text mining originate from the particularities of natural language. In this research, the expert-based Delphi text mining (EDTM) is proposed to predict the movement of crude prices when the irregularity occurs. We employ the hierarchical clustering algorithm to reveal implicit knowledge hidden in news streams. Next, the Delphi method is introduced to give weighted ratings for different corresponding events extracted from the news. Finally, a comprehensive experiment is illustrated to show the effectiveness. ©2017 Inderscience Enterprises Ltd.

关键词： Crude oil

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Noninvasive Glucose Sensor Based on Parity-Time Symmetry

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Physical Review Applied 2019年第4期11卷 044049-044049页

作者： Yun Jing Zhang Hoyeong Kwon Mohammad-Ali Miri Efthymios Kallos Helena Cano-Garcia Mei Song Tong Andrea Alu Department of Electrical and Computer Engineering The University of Texas at Austin Austin 78712 USA Department of Electronic Science and Technology Tongji University Shanghai 201804 China Department of Physics Queens College of the City University of New York Queens New York 11367 USA Physics Program Graduate Center City University of New York New York 10016 USA Medical Wireless Sensing Ltd London E1 2AX UK King’s College London London WC2R 2LS UK Photonics Initiative Advanced Science Research Center City University of New York New York 10031 USA Department of Electrical Engineering City College of The City University of New York New York 10031 USA

We discuss a noninvasive technique to detect glucose changes with enhanced sensitivity based on parity-time (PT) symmetry. We detect glucose level changes within the skin by measuring the frequency shift in the electromagnetic resonance induced within a PT-symmetric system that sandwiches the tissue sample under analysis. Even though the sample itself is lossy, and therefore, resonances would be damped, the introduction of balanced gain and loss enables an efficient sensing mechanism that bypasses the conventional limitations of passive sensing schemes. Our results indicate that the resonance shift can be made fairly linear with respect to the glucose concentration variations, and the expected accuracy is large. We also investigate a realistic system to implement the noninvasive PT-symmetric glucose sensor using loop antennas and negative impedance converters, exploring its sensitivity with respect to design errors and disorder.

关键词： Medical physics Optical parametric oscillators & amplifiers Optoelectronics Metamaterials Solid-state detectors PT-symmetry Microwave techniques Resonance techniques

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Nonlinear Isolators and Circulators Based on Networks of Coupled Resonators 12

Nonlinear Isolators and Circulators Based on Networks of Cou...

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12th International Congress on Artificial Materials for Novel Wave Phenomena, METAMATERIALS 2018

作者： Sounas, D.L. Soric, J. Draguanno, G. Alu, A. University of Texas at Austin Department of Electrical and Computer Engineering AustinTX78712 United States Raytheon AndoverMA United States Johns Hopkins University Applied Physics Laboratory LaurelMD United States Photonics Initiative Advanced Science Research Center City University of New York New YorkNY10031 United States Physics Program Graduate Center City University of New York New YorkNY10016 United States Department of Electrical Engineering City College of New York New YorkNY10031 United States

ISBN: (纸本)9781538647028

We present our recent results in the area of nonlinear nonreciprocal devices, including isolators and circulators. We show that the nonlinear isolators based on single Fano resonators are subject to a fundamental trade-off between transmission and isolation intensity range or bandwidth, stemming from time reversal symmetry. We also show how we can overcome this limitation by using multiple nonlinear resonators. Finally, we show that networks with many nonlinear resonators can also be used to realize more advanced devices, such as circulators. © 2018 IEEE.

关键词： Resonators

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Web based testing application security system using semantic comparison method 2

Web based testing application security system using semantic...

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2nd Nommensen International Conference on Technology and engineering, NICTE 2018

作者： Iskandar, Akbar Fahlepi Tuasamu, Muhammad Resa Syamsu, Suryadi Mansyur, M. Listyorini, Tri Sallu, Sulfikar Supriyono, S. Saddhono, Kundharu Napitupulu, Darmawan Rahim, Robbi Informatics Engineering STMIK AKBA Makassar Indonesia Graduate Program Universitas Negeri Makassar Makassar Indonesia Informatics Engineering Universitas Maria Kudus Central Java Indonesia Computer Information Systems Universitas Sembilan Belas November Kolaka Indonesia Department of Geography Education Universitas Prof Dr Hazairin SH Bengkulu Indonesia Indonesian Language Education Departement Faculty of Teacher Training and Education Universitas Sebelas Maret Surakarta Indonesia Research Center for Quality System and Testing Technology Indonesian Institute of Sciences Indonesia Sekolah Tinggi Ilmu Manajemen Sukma Medan Indonesia

computer and web security system is an attempt to avoid attacks from crackers because a form and method of crime on internet network can not be predicted. Therefore, we just keep trying to use various methods in securing the system that is running. It is the same in web testing that can be accessed online by people who are not responsible from along distance to change and remove the test results or even damage the web testing system. So, the purpose of this paper is to design and implement web security testing system by using semantic comparison method to avoid structured query language injection (SQLI) attack and to do security on web testing application using Message Digest 5 encryption (MD5). Research data were obtained by using direct observation and documentation and literature review. After the design and application of the system, it can be obtained that by using semantic comparison method in web testing can prevent the occurrence of SQL injection attacks and can secure account from web testing users by using MD5. © Published under licence by IOP Publishing Ltd.

关键词： Semantics

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Blockchain technology for managing an architectural model of decentralized medical record

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Journal of Physics: Conference Series 2019年第7期1402卷

作者： M Harika S Rahmadika D R Ramdania Department of Computer and Informatics Engineering Politeknik Negeri Bandung Indonesia Interdisciplinary Program of Information Security Graduate School PKNU Department of IT Convergence and Application Engineering Pukyong National University Busan South Korea Department of Informatics UIN Sunan Gunung Djati Bandung Indonesia

Medical record (MedRec) of the patient is derived from several healthcare providers i.e. hospital, the national provider, and laboratories which contains personally identifiable information test yet referred to therapeutic procedures and medications of the patient. MedRec has been compiled and maintained by several providers thus resulting in separated and disseminated the data among the parties. Mostly, the MedRecs are stored in provider's database and the patients have no control to manage and access their data. Hence, in this paper, we propose a conceptual model for managing the data of medical record using blockchain technology in the peer-to-peer network with several protocols are embedded in the system. The proposed model aims to facilitate the patients in order to manage their data from various providers into a single view. Blockchain offers the promise of an immutable, single source of truth from multiple sources and facilitates a trust as well as validates an identity without the third-party involvement.

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The Use of Relations and Functions Games Based on Balanced Design in Mathematics Subjects to Improve Student Learning Outcomes

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Journal of Physics: Conference Series 2019年第1期1175卷 012069-012069页

作者： Diena Rauda Ramdania Harika, Maisevli Rahmadika, Sandi Azmiana, Gina Giftia Informatics Engineering UIN Sunan Gunung Djati Bandung Computer Engineering and Informatics Politeknik Negeri Bandung Interdisciplinary Program of Information Security Graduate School PKNU Pukyong National University Busan South Korea Department of Phyloshopy UIN Sunan Gunung Djati Bandung

Game Relations and Functions are digital game-based learning in junior high school mathematics subjects. In this study will discuss how to use the game Relationships and Functions that have been designed using the Balanced Design method. The research method used was a quasi-experiment with the One group Pretest Post-test design. A total of 40 junior high school students were involved in this study to determine differences in student learning outcomes in the cognitive domain before and after using the Relationship and Function games. The instrument used is a type of multiple choice objective test of 20 questions with details of 8 questions related to relations material and 12 questions related to functions material. The results showed that there were differences in the improvement of student learning outcomes before and after using the game Relations and Functions in Mathematics subjects.

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Combination of curcumin or chitosan with photodynamic therapy as an effective alternative therapy for overcoming wound infection associated with multidrug-resistant Acinetobacter baumannii

Microbe (Netherlands)

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Microbe (Netherlands) 2025年 7卷

作者： Yonpiam, Manta Wannigama, Dhammika Leshan Shein, Aye Mya Sithu Liao, Tingting Hurst, Cameron Monk, Peter N. Amarasiri, Mohan Phattharapornjaroen, Phatthranit Ounjai, Puey Saethang, Thammakorn Badavath, Vishnu Nayak Luk-in, Sirirat Nilgate, Sumanee Rirerm, Ubolrat Srisakul, Sukrit Ngamwongsatit, Natharin Leelahavanichkul, Asada Ragupathi, Naveen Kumar Devanga Kanjanabuch, Talerngsak Narkban, Phurin Miyanaga, Kazuhiko Cui, Longzhu Boontaveeyuwat, Einapak Higgins, Paul G. Kicic, Anthony Hamamoto, Hiroshi Abe, Shuichi Hongsing, Parichart Chatsuwan, Tanittha Department of Microbiology Faculty of Medicine Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand Center of Excellence in Antimicrobial Resistance and Stewardship Research Faculty of Medicine Chulalongkorn University Bangkok Thailand Dual degree Medical Science program Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan School of Medicine Faculty of Health and Medical Sciences The University of Western Australia Nedlands WA Australia Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries The University of Sheffield Sheffield United Kingdom Pathogen Hunter's Research Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan Department of Infectious Diseases Faculty of Medicine Yamagata University Yamagata Japan Department of Clinical Epidemiology Faculty of Medicine Thammasat University Rangsit 10120 Thailand Department of Infection Immunity & Cardiovascular Disease University of Sheffield Medical School United Kingdom Department of Civil and Environmental Engineering Graduate School of Engineering Tohoku University Miyagi Japan Faculty of Health Science Technology Chulabhorn Royal Academy Bangkok 10210 Thailand HRH Princess Chulabhorn Disaster and Emergency Medicine Center Chulabhorn Royal Academy Bangkok 10210 Thailand Department of Biology Faculty of Science Mahidol University Bangkok Thailand Department of Computer Science Faculty of Science Kasetsart University Bangkok Thailand School of Pharmacy & Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Hyderabad 509301 India Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Bangkok Thailand Department of Clinical Sciences and Public Health Faculty of Veteri

The increasing prevalence of multidrug-resistant Acinetobacter baumannii as an opportunistic pathogen in wound infections raises significant concerns due to its antibiotic resistance and biofilm-mediated antibiotic tolerance. This underscores the urgent need to explore an alternative approach to effectively managing wound infections caused by MDR A. baumannii. In this study, combining subinhibitory concentrations of curcumin (25 µg/ml) or chitosan (156 µg/ml) with photodynamic therapy-PDT (10 J/cm²) resulted in a significant reduction of planktonic viabilities and biofilm biovolume of MDR A. baumannii clinical isolates in vitro. In murine A. baumannii-associated wound infection, a combination of curcumin (25 µg/ml) or chitosan (156 µg/ml) with PDT (10 J/cm²) resulted in complete bacterial eradication with wound healing at Day 15 of post-treatments with these combination therapies. Our study demonstrated that combining curcumin or chitosan with PDT at their subinhibitory concentrations represents a promising alternative strategy as localized therapy for effectively managing A. baumannii-associated wound infection. © 2025 The Authors

关键词： Acinetobacter baumannii Alternative therapy Biofilm eradication Chitosan Curcumin Multidrug-resistant (MDR) Photodynamic therapy (PDT) Wound infection

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