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Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Scientific data 2017年第1期4卷 170179页

作者： Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmu Department of Molecular Biology Massachusetts General Hospital Boston Massachusetts USA. Program in Medical and Population Genetics Broad Institute Cambridge Massachusetts USA. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor Michigan USA. Wellcome Trust Centre for Human Genetics Nuffield Department of Medicine University of Oxford Oxford UK. Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts USA. Department of Statistics University of Oxford Oxford UK. Genetics of Complex Traits University of Exeter Medical School University of Exeter Exeter UK. MRC Epidemiology Unit Institute of Metabolic Science University of Cambridge Cambridge UK. Department of Twin Research and Genetic Epidemiology King's College London London UK. Oxford Centre for Diabetes Endocrinology and Metabolism Radcliffe Department of Medicine University of Oxford Oxford UK. Department of Human Genetics Wellcome Trust Sanger Institute Hinxton Cambridgeshire UK. School of Computer Science McGill University Montreal Quebec Canada. McGill University and Génome Québec Innovation Centre Montreal Quebec Canada. Human Genetics Center The University of Texas Graduate School of Biomedical Sciences at Houston The University of Texas Health Science Center at Houston Houston Texas USA. Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA. National Heart Lung and Blood Institute's Framingham Heart Study Framingham Massachusetts USA. Medical Genomics and Metabolic Genetics Branch National Human Genome Research Institute National Institutes of Health Bethesda Maryland USA. Department of Biostatistics Harvard School of Public Health Boston Massachusetts USA. Chronic Disease Epidemiology Swiss Tropical and Public Health Institute University of Basel Basel Switzerland. Institute of Genetic Epidemiology Helmholtz Zentrum München German R

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.

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Smart antenna using a combination of D3LS and NCLS algorithms

Smart antenna using a combination of D3LS and NCLS algorithm...

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2012 9th International Conference on Electrical engineering/Electronics, computer, Telecommunications and Information Technology, ECTI-CON 2012

作者： Nilsuwan, Phichet Boonpoonga, Akkarat Tagapanij, Jukkrit Sirisuk, Phaophak Electrical Engineering Graduate Program Faculty of Engineering Mahanakorn University of Technology Bangkok Thailand Department of Electrical and Computer Engineering Faculty of Engineering King Mongkut's University of Technology North Bangkok Bangkok Thailand Department of Telecommunication Engineering Mahanakorn University of Technology Bangkok Thailand International College King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand

ISBN: (纸本)9781467320245

This paper presents a smart antenna system using a combination of nonconventional least square (NCLS) optimization and direct data domain least square (D3LS) for direction-of-arrival (DOA) estimation and beamforming, respectively. In the proposed system, NCLS optimization is utilized to estimate DOA of incoming signal first. The estimated DOA is then assisted for initial processing of D3LS in beamforming. The performance in term of estimated signal amplitude and estimated DOA of the proposed system is evaluated via simulations. © 2012 IEEE.

关键词： Direction of arrival

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Performance evaluation of D3LS and NCLS smart antenna in mobile communications

Performance evaluation of D3LS and NCLS smart antenna in mob...

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2012 17th International Symposium on Antennas and Propagation, ISAP 2012

作者： Boonpoonga, Akkarat Nilsuwan, Phichet Tagapanij, Jukkrit Sirisuk, Phaophak Department of Electrical and Computer Engineering Faculty of Engineering King Mongkut's University of Technology North Bangkok Bangkok Thailand Electrical Engineering Graduate Program Faculty of Engineering Mahanakorn University of Technology Bangkok Thailand Department of Telecommunication Engineering Mahanakorn University of Technology Bangkok Thailand International College King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand

ISBN: (纸本)9784885522703

A smart antenna was proposed to improve wireless communication systems. The smart antenna may comprises direction-of-arrival (DOA) estimation and/or adaptive antenna. The DOA estimation technique is used to estimate direction of transmitted signals. An adaptive antenna has ability of suppressing undesired signals namely interference or jammers in specific directions while receive only the desired one. There are a number of methods proposed to conduct in such way, including multiple signal classification (MUSIC), least mean squares (LMS), sample matrix inversion (SMI), recursive least squares (RLS), and their derivative forms as seen in the literatures in [1]. These methods require a training sequence or known information for adaptation and/or DOA estimation. Although a constant modulus algorithm (CMA) was proposed without the need of training sequence, it has a slow convergence. © 2012 IEICE.

关键词： Multiple signal classification

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A method to validate quantitative high-frequency power Doppler ultrasound with fluorescence in vivo video microscopy

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Proceedings of Meetings on Acoustics 2013年第1期19卷

作者： James Lacefield Stephen Z. Pinter Dae-Ro Kim M. N. Hague Ann F. Chambers Ian C. MacDonald Electrical & Computer Engineering and Medical Biophysics Western University Thompson Engineering Bldg Rm 279 London Ontario N6A 5B9 Canada Biomedical Engineering Graduate Program Western University London Ontario Canada Medical Biophysics Western University London Ontario Canada London Regional Cancer Program London Ontario Canada

Flow quantification with high-frequency power Doppler ultrasound can be performed using the wall-filter selection curve (WFSC) method [M. Elfarnawany et al., Ultrasound Med. Biol. 38, 1429-1439 (2012)]. The WFSC method plots color pixel density (CPD) as a function of wall filter cut-off velocity as a means of objectively selecting an operating point cut-off velocity. In this study, an in vivo video microscopy (IVVM) system was used to measure the size of small (140-400 μm diameter) mouse testicular vessels immediately after the vessels were imaged with 30 MHz power Doppler. The mouse remained on the same platform throughout ultrasound and IVVM imaging. Measurements in four image planes from three mice demonstrated that, similar to previously reported flow-phantom data, in vivo WFSCs exhibit distinct, sloped "characteristic intervals" at cut-off velocities where the CPD approaches the gold-standard IVVM estimate of vascular volume fraction. A wide range of operating point cut-off velocities (4.5 to 12 mm/s) was obtained, which indicates that use of a predetermined cut-off can produce substantial errors in cross-sectional studies that employ power Doppler to quantify vascularity. The WFSC method is a promising strategy for adapting the cut-off velocity to intersubject and longitudinal variations in blood flow during microvascular imaging experiments.

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Absolute Gradient Algorithm for Adaptive IIR Notch Filter

Absolute Gradient Algorithm for Adaptive IIR Notch Filter

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International Conference on Electrical engineering/Electronics, computer, Telecommunications and Information Technology, ECTI-CON

作者： A. Nosan R. Punchalard The Computer Engineering Graduate Program Faculty of Engineering Mahanakorn University of Technology Thailand Department of Telecommunication Engineering Mahanakorn University of Technology Bangkok Thailand

The gradient algorithm used absolute value of error signal as a criterion to adjust the filter coefficient of adaptive IIR notch filter is presented in this paper. The objective is to estimate or track the frequency of a single sinusoidal signal corrupted by additive white Gaussian noise. The proposed algorithm can solve the problem of selecting an initial condition as met in the previous method. Moreover, it also has a high convergence speed.

关键词： IIR filters Adaptive filters Filtering algorithms Frequency estimation Convergence Signal processing algorithms Mathematical model

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Frequency modulation using digital sinusoidal oscillator

Frequency modulation using digital sinusoidal oscillator

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International Conference on Electrical engineering/Electronics, computer, Telecommunications and Information Technology, ECTI-CON

作者： R. Punchalard A. Nosan Department of Telecommunication Engineering Mahanakorn University of Technology Bangkok Thailand The Computer Engineering Graduate Program Faculty of Engineering Mahanakorn University of Technology Thailand

This paper presents an alternative method to generate the digital frequency modulation (FM) signal. By summing an information signal m(k) with the oscillating frequency ω 0 and putting the result into the cosine function of digital oscillator coefficient which is −2 cos (ω 0 +m(k)), the FM signal is obtained. computer simulations are conducted to show the validity of the proposed FM signal generator

关键词： Frequency modulation Oscillators Finite impulse response filter Bandwidth Adaptive filters Amplitude shift keying

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Accelerated DSP functions on the CBE for the X-Midas Toolkit

Accelerated DSP functions on the CBE for the X-Midas Toolkit

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International Waveform Diversity and Design Conference

作者： Joseph A. Jezak Charles Berdanier Steven P. Levitan Donald M. Chiarulli Computer Engineering Graduate Program University of Pittsburgh USAF AFRL/RYMDA Wright Patterson Air Force Base Department of Electrical and Computer Engineering University of Pittsburgh Department of Computer Science University of Pittsburgh

We characterize the impact of the Cell Broadband Engine architecture, on commonly used radar DSP algorithms. We use the capabilities of the CBE to accelerate several key computational kernels including Matrix Multiplication, Matrix Inversion, and the Finite Impulse Response (FIR) filter. These algorithms are implemented and benchmarked as library routines within the X-Midas Toolkit. We observe speedups as large as 1200x for complex matrix multiplication, but speedups of 40x to 60x are more typical. We find that system I/O overhead within the X-Midas toolkit severely limited the performance of the applications.

关键词： Finite impulse response filters Acceleration Benchmark testing computer architecture Pipelines Optimization Digital signal processing

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Effect of sponge and position on the frequency response and total harmonic distortion of earbud-type earphone

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Journal of the Chinese Society of Mechanical Engineers, Transactions of the Chinese Institute of Engineers, Series C/Chung-Kuo Chi Hsueh Kung Ch'eng Hsuebo Pao 2012年第6期33卷 537-544页

作者： Pawar, S.J. Huang, Jin H. Program in Mechanical and Aeronautical Engineering Feng Chia University Taichung 40724 Taiwan Taiwan 211004 India Electroacoustic Graduate Program and Department of Mechanical and Computer-Aided Engineering Feng Chia University Taichung 40724 Taiwan Taiwan

This paper presents the effect of sponge on the earphone and position of earbud-type earphone in concha on sound pressure level (SPL) and total harmonic distortion (THD). Head and torso simulator (HATS) with silicon pinna, which resembles an exact acoustic field around human subject, is employed to replace human head. Based on anatomy of human ear, and earphone usage, three different earphone's positions in the concha are identified. To measure SPL and THD, electroacoustic equipments are employed in an anechoic chamber. The earphone with sponge enhances the SPL and lowers THD. The position of earphone in concha affects SPL and THD more prominently at low frequency below earphone's resonant frequency. For common user, it is recommended to place earphone in concha directly against its surface and supported along circumference by tragus, anti-tragus and cms helias while the tragus slightly covers the earphone. Additionally, its wire should be located along the tragal notch.

关键词： Frequency response

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Accelerating the artificial bee colony algorithm by hardware parallel implementations

Accelerating the artificial bee colony algorithm by hardware...

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2012 IEEE 3rd Latin American Symposium on Circuits and Systems, LASCAS 2012

作者： Muñoz, Daniel M. Llanos, Carlos H. Coelho, Leandro Dos S. Ayala-Rincón, Mauricio Department of Mechanical Engineering Automation and Control Group/GRACO University of Brasilia Brasilia D.F. Brazil Industrial and Systems Engineering Graduate Program LAS/PPGEPS Pontifical Catholic University of Parana Curitiba Parana Brazil Department of Computer Science and Mathematics University of Brasilia Brasilia D.F. Brazil

ISBN: (纸本)9781467312080

Artificial bee colony (ABC) is an optimization algorithm inspired on the intelligent behavior of honey bee swarms. It is suitable to be applied when mathematical techniques are impractical or provide suboptimal solutions. As a population-based algorithm, the ABC suffers on large execution times specifically for embedded optimization problems with computational limitations. For that we propose a hardware parallel architecture of the opposition-based ABC algorithm (HPOABC) that facilitates the implementation in Field programmable Gate Arrays (FPGAs). Numerical simulations using four well-known benchmark problems demonstrate that the opposition-based approach allows the algorithm to improve its functionality, preserving the swarm diversity. Additionally, synthesis results point outs that the HPOABC architecture is effectively mapped in hardware and is suitable for embedded applications. © 2012 IEEE.

关键词： Global optimization

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rTMS as a Treatment of Alzheimer's Disease with and without Comorbidity of Depression: A Review

Neuroscience journal

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Neuroscience journal 2013年第1期2013卷 679389页

作者： Grant Rutherford Rebecca Gole Zahra Moussavi Department of Electrical and Computer Engineering University of Manitoba Winnipeg MB Canada R3T 5V6 Graduate Program in Biomedical Engineering Faculty of Engineering University of Manitoba Winnipeg MB Canada R3T 5V6. Department of Electrical and Computer Engineering University of Manitoba Winnipeg MB Canada R3T 5V6. Graduate Program in Biomedical Engineering Faculty of Engineering University of Manitoba Winnipeg MB Canada R3T 5V6 Riverview Health Center 1 Morley Avenue Winnipeg MB Canada R3L 2P4.

With an ever-increasing population of Alzheimer's disease (AD) patients worldwide, a noninvasive treatment for AD is needed. In this paper, the application of repetitive transcranial magnetic stimulus (rTMS) as a treatment for patients with probable AD is compared to the application of rTMS as a treatment for depression. Comorbidity of depression and dementia is discussed, as well as possible links between the two diseases. The possible confounding antidepressant effects of rTMS on cognitive improvements in AD patients are discussed.

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