Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While tr...
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Wireless sensor networks can be used in habitat monitoring for detecting fire, in disaster for helping rescue teams and in agriculture for sensing humidity. Node localization is essential for some important sensor net...
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Wireless sensor networks can be used in habitat monitoring for detecting fire, in disaster for helping rescue teams and in agriculture for sensing humidity. Node localization is essential for some important sensor network applications. Despite the high relative accuracy of some localization algorithms, node localization is still an opened research area, due to the physical phenomena such as attenuation, reflection, diffraction, scattering and so forth. The current developed algorithms have different accuracy when are tested under dissimilar environments. We propose to use Smart Beacon Nodes (SBNs) to infer the Obstruction Level Indicator over an occupied area, then, use this indicator for estimating the distance among nodes. In our experimental simulation, SBNs decrease the node localization error of Triangular Centroid Localization and Weighted Centroid Localization up to 18%.
This paper describes a design of an educational platform for a mobile learning architecture, which is a state of the an topic in distance education. The product will allow users to interact in an efficient, flexible, ...
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This paper describes a design of an educational platform for a mobile learning architecture, which is a state of the an topic in distance education. The product will allow users to interact in an efficient, flexible, and transparent fashion with a web-based education environment, in this case Module Object-Oriented Dynamic Learning Environment (Moodle), using Android mobile devices. In order to provide a strong and lasting architecture, the Service Oriented Architecture (SOA) methodology is used given that it allows easy software re-utilization as well as integration of heterogeneous services. The architecture is based on web services implemented with Representational State Transfer (REST), as it has been demonstrated to be lighter and less consuming than other protocols, for devices with limited resources such as mobile devices. Web services provide the communication means between the server side and the client side of the architecture, whereas agents are used to deliver the services itself. The authors propose the development of an environment that facilitates the integration of various educational resources to support m-learning. An important aspect of the proposal is the offering of a tool to provide customized alerts for students and teachers, enabling them to remain updated about activities taking place in the courses.
Eosinophilic esophagitis (EoE) is a food allergy-associated disease characterized by esophageal eosinophilia and associated inflammation. EoE has become increasingly common in industrialized countries. However, curren...
Eosinophilic esophagitis (EoE) is a food allergy-associated disease characterized by esophageal eosinophilia and associated inflammation. EoE has become increasingly common in industrialized countries. However, current management strategies, such as treatment with swallowed steroids and dietary restrictions, are nonspecific or negatively impact the quality of life of EoE patients. In addition, use of more specific therapies that target immunoglobulin E (IgE) and interleukin (IL)-5 have been largely unsuccessful in ameliorating EoE. Thus, there is an urgent need to identify novel, specific immunological pathways that underlie the pathogenesis of EoE that could be targeted to treat this disease. Recently, a genome-wide association study identified that EoE is associated with a gain-of-function polymorphism in the gene that encodes thymic stromal lymphopoietin (TSLP). TSLP is an IL-7 family member cytokine that promotes allergic inflammation by eliciting T helper type 2 cytokine responses, IgE production, and the expansion of a distinct population of basophils . However, whether TSLP directly promotes allergic inflammation in the esophagus and the mechanisms by which TSLP might contribute to the pathogenesis of EoE remain unknown. Here, we describe a new murine model of experimental EoE-like disease that was used to investigate the role of TSLP in allergic inflammation of the esophagus. Murine experimental EoE-like disease developed independently of IgE but was dependent on TSLP-elicited basophils. Critically, therapeutic antibody-mediated neutralization of TSLP or depletion of basophil populations ameliorated established EoE-like disease in mice. Finally, elevated TSLP levels and exaggerated basophil responses were observed in esophageal biopsies from EoE patients, and a gain-of-function polymorphism in TSLP correlated with increased basophil responses in patients with EoE. Together, these data indicate that TSLP-elicited basophil responses may play a key role in medi
Enhanced rates of oxide growth have been observed on silicon when exposed to high-energy x-ray irradiation. This observed effect could potentially be utilized for remote total ionizing dose-sensing applications.
Enhanced rates of oxide growth have been observed on silicon when exposed to high-energy x-ray irradiation. This observed effect could potentially be utilized for remote total ionizing dose-sensing applications.
The effect of back biasing on the performance of a planar tunnel field-effect transistor (TFET) implemented on a silicon-on-insulator substrate is investigated. It is found that reverse back biasing reduces the subthr...
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The effect of back biasing on the performance of a planar tunnel field-effect transistor (TFET) implemented on a silicon-on-insulator substrate is investigated. It is found that reverse back biasing reduces the subthreshold swing SS and increases the range of drain current over which SS is less than ( k B T / q ) ln (10); hence, it is effective for improving the TFET on/off current ratio for low operating voltages (≤ 0.5 V).
This paper presents a framework, aiming to develop the mass customization for textile and apparel industries in Thailand. The developed model as presented is the relationship of the connection pertaining to customers...
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This paper presents a framework, aiming to develop the mass customization for textile and apparel industries in Thailand. The developed model as presented is the relationship of the connection pertaining to customers’ needs at industrial levels, most of which are Original Design Manufacturer (OEM), a type of textile and apparel business. The outstanding of OEM is the presentation of newly created designs to customers with a variety of products. Importantly, in order to gain such effective production management, an appropriate administrative system with high flexibility, efficient production (Small Lot Size), and punctual delivery is crucially required. In relation to the framework for mass customization development, it concerns three main related involvements: customers, OEM industries, and suppliers, all of which will be assessed so as to be promptly employed in such firms manufacturing products in accordance with the productive systems of mass customization *** conceptual from mass customization systems will facilitate the management in terms of the production designing in factories, aiming at clustering which is complex to the creation of platform from common parts, leading to the development of a variety of goods by the process of product family.
This paper consists in a novel transport protocol description for Delay-Tolerant Networks and Disruption Tolerant Networks (both DTN). This protocol was designed to offer a better information delivery rate in DTNs sce...
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This paper consists in a novel transport protocol description for Delay-Tolerant Networks and Disruption Tolerant Networks (both DTN). This protocol was designed to offer a better information delivery rate in DTNs scenarios. Fountain codes techniques are used to achieve our needs. The performance results were tested taking into account the hosts buffer size, the TTL (Time To Live) of the messages and the amount of redundant information generated into the network. A better delivery rate and performance were achieved using the proposed protocol.
Because of their luminescent properties, phosphors make excellent candidates for radiation detectors. The materials are inclined to luminesce when exposed to a variety of radiation sources including gammas, protons, a...
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Because of their luminescent properties, phosphors make excellent candidates for radiation detectors. The materials are inclined to luminesce when exposed to a variety of radiation sources including gammas, protons, alphas and so forth. However, the vast majority of research and use of phosphors as radiation sensors are as scintillators-when luminescence spontaneously occurs due to the incident radiation. In this case, incident radiation promotes electrons to excited levels. The excited electrons subsequently decay to produce photons that can be detected. The luminescence is therefore a result of ionizing radiation.
Poly(Ε-caprolactone) (PCL) films have been applied for vascular tissue engineering. However, few studies studied the effects of fabrication process of PCL film on vascular cell proliferation. In this study, we used d...
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ISBN:
(纸本)9781424492763
Poly(Ε-caprolactone) (PCL) films have been applied for vascular tissue engineering. However, few studies studied the effects of fabrication process of PCL film on vascular cell proliferation. In this study, we used different processing methods, incorporating stretching, to fabricate various PCL films. Thickness of films before and after stretch and proliferation ability of human fetal mesenchymal stem cells (hfMSCs) on these films were investigated. Our results showed that stretching significantly reduces the thickness of solvent cast, heat press and cast stretch films (0.22, 0.59, 0.60, p
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