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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： N.D. Nanayakkara B. Chiu A. Samani J.D. Spence J. Samarabandu A. Fenster Imaging Research Laboratories Robarts Research Institute and Graduate Program in Biomedical Engineering University of Western Ontario London ONT Canada Department of Medical Biophysics and Graduate Program in Biomedical Engineering University of Western Ontario London ONT Canada Departments of Neurology and Clinical Pharmacology Robarts Research Institute University of Western Ontario and Stroke Prevention and Atherosclerosis Research Centre London ONT Canada Department of Electrical & Computer Engineering University of Western Ontario London ONT Canada

Atherosclerosis at the carotid bifurcation resulting in cerebral emboli is a major cause of ischemic stroke. Most strokes associated with carotid atherosclerosis can be prevented by lifestyle/dietary changes and pharmacological treatments if identified early by monitoring carotid plaque changes. Sensitive monitoring of plaque changes in volume and morphology requires that 3D ultrasound (US) images of carotid plaque obtained at different time points be registered and evaluated for change. This registration technique should be non-rigid, since different head positions in image acquisitions cause relative bending and torsion in the neck, producing non-linear deformations between the images. We modeled the movement of the neck using a "twisting and bending model" with only six parameters for non-rigid registration. We used a Mutual Information (MI) based image similarity measure with the Powell optimization method as they have been used effectively in US image registration applications. For evaluation of our algorithm, we acquired 3D US carotid images from three subjects at two different head positions to simulate images acquired at different times. Then, we registered each image set using our "twisting bending model" based non-rigid registration algorithm. We calculated the Mean Registration Error (MRE) between the segmented vessel surfaces in the target image and the registered image using a distance-based error metric. We repeated the experiment with only rigid registration to compare the capabilities of the proposed algorithm in improving registration of 3D carotid US images. The average registration error was 1.03plusmn0.23 mm using our non-rigid registration technique, while it was 1.50plusmn0.50 mm when we applied the rigid registration alone

关键词： Image registration Ultrasonic imaging Atherosclerosis Monitoring Head Neck Bifurcation Morphology Mutual information Optimization methods

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A genetic algorithm for the optimization of cable routing

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Systems and computers in Japan 2006年第7期37卷 61-71页

作者： Ma, Xuan Iida, Kazuhiro Xie, Mengchun Nishino, Junji Odaka, Tomohiro Ogura, Hisakazu Graduate School of Engineering University of Fukui Fukui City 910-8507 Japan Wakayama National College of Technology Gobo City 644-0023 Japan Faculty of Automation and Information Engineering Xi an University of Technology B Techno College Department of Electrical and Computer Engineering Wakayama National College of Technology Information Processing Society of Japan China Mechanical Design Society Department of Systems Engineering University of Electro-Communications Japan Society for Fuzzy Theory and Intelligent Informatics Japanese Academy of Facial Studies Japan Society of Kansei Engineering Graduate Program of Nuclear Power and Energy Safety Engineering Graduate School of Engineering Fukui University IEEE CS ACM IPSJ IEICE JSMBET Department of Human and Artificial Intelligent Systems JSAI Japan SOFT IEEE

In this paper the authors propose a structural method for a genetic algorithm (GA) for the optimization problem of cable routing in which cables have to be laid optimally. When there are no limits on the layout routes, the optimal routes for the individual cables can be found using the Dijkstra method in a finite discrete graph. However, when there are limits on the capacity in the layout routes, optimization cannot be performed using the Dijkstra method. The proposed GA is a two-level hierarchical GA that uses chromosome coding involving two levels. The routes for each cable and the combinations of cable routes are defined respectively, and layout route selection is optimized overall through genetic operations involving these levels. Block crossover and block mutation are used as genetic operations in the first level. In addition, a method to take advantage of lethal genes, which do not satisfy the constraints and are generated in the second level is used. computer simulations confirm that the two-level hierarchical GA with these genetic operations functions effectively for the optimization problem of cable routing. © 2006 Wiley Periodicals, Inc.

关键词： Electric cable laying

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Capturing Cellular Communication with Guided Electrode Network on a Silicon Integrated Circuit Chip

Capturing Cellular Communication with Guided Electrode Netwo...

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2006 8th International Conference on Solid-State and Integrated Circuit Technology

作者： Mansun Chan Chi-Kong Yeung Yijin Wang Jin He Sven Ingebrandt Andreas Offenhaeusser Dept.of Electronic and Computer Engineering Hong Kong University of Science & Technology Bioengineering Graduate Program Hong Kong University of Science & Technology Institute of Microelectronic Peking University Juelich Research Center Institute for Thin Films and Interfaces(ISG-2)Leo-Brandt Str.52425 JuelichGermany

ISBN: (纸本)1424401607

This paper describes the development of a Multi-Electrode Array(MEA)with Guided Network for Cell-to-Cell Communication Transduction using a standard integrated circuit(IC) fabrication *** conventional electronic system,bio-system requires a special handling environment that is uncommon in conventional IC *** work presented here demonstrated the interaction between electrically active cells such as neuron and cardiac cells and an IC based *** a carefully designed array,and ionic action of a cell, extracellular signals can be captured and imaged.

关键词： Capturing Cellular Communication with Guided Electrode Network on a Silicon Integrated Circuit Chip

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Real-time organ motion tracking and fast image registration system for MRI-guided surgery

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Systems and computers in Japan 2006年第1期37卷 83-92页

作者： Tokuda, Junichi Hirano, Masaya Tsukamoto, Tetsuji Dohi, Takeyoshi Hata, Nobuhiko Graduate School of Information Science and Technology University of Tokyo Tokyo 113-8656 Japan GE Yokogawa Medical Systems Ltd. Hino 191-8503 Japan International Society for Computer-Aided Surgery Japan Society for Computer-Aided Surgery Japan Society for Magnetic Resonance in Medicine GE Yokogawa Medical Systems Ltd. Imaging Application Tech. Center MR Group R and D Laboratory Technology Center GE Yokogawa Medical Systems Ltd. Society for Magnetic Resonance in Medicine Graduate School of Information Science and Technology Society for Life Support Technology Japan Society for Organ Preservation Biology and Medicine Society for Precision Engineering Society for Medical Image Computing and Computer Assisted Intervention International Union for Physics and Engineering Sciences in Medicine JSMEBE Japan Society for Life Assistance Technology Brigham and Women's Hospital Harvard Medical School MR Therapy Program

The advantage of magnetic resonance imaging (MRI)-guided surgery, in which MR images taken during surgery are used to guide the surgery, has been recognized recently. However, there is a problem, due to long imaging time of MRI, that it is difficult to capture the respiratory organ motion. It is often a constraint that the patient must hold his or her breath, especially in the treatment of the abdominal region. Consequently, this paper proposes a method of eliminating this constraint in MRI-guided surgery by real-time monitoring of the movement of the organ involved in the surgery by means of the signal derived from MRI. Specifically, the navigator echo is extracted in imaging during surgery. The movement of the organ involved in surgery is detected on the basis of the change in the calculated projection profile, and the results are presented to the surgeon. In this study, the procedure is built into a 1.5-T clinical MRI system. The feasibility of the proposed system was examined under clinical conditions by evaluating its accuracy and delay in a phantom experiment, and also in an in vivo experiment on the liver of a volunteer. The results are reported in this paper. © 2005 Wiley Periodicals, Inc.

关键词： Motion estimation

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Transforming K-12 education via the collaborative large-scale engineering analysis network for environmental research (CLEANER) project

Transforming K-12 education via the collaborative large-scal...

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113th Annual ASEE Conference and Exposition, 2006

作者： Eschenbach, Elizabeth Johnson, James H. Brus, Chris Carlson, Patricia Giammar, Dan Grauer, Bette Hotaling, Liesl Oguntimein, Gbekeloluwa Safferman, Steven Wentling, Tim Humboldt State University United States Department of Environmental Resources Engineering Humboldt State University United States Howard University United States Department of Environmental Engineering College of Engineering Architecture and Computer Sciences Howard University United States Board of Scientific Counselors Executive Committee U.S. Environmental Protection Agency Office of Research and Development United States EPA's Science Advisory Board Department of Energy-sponsored HBCU/MI Environmental Technology Consortium Board Environmental Studies and Toxicology and the Engineering Council of the American Society for Engineering Education United States University of Iowa United States Program University of Iowa United States Rose-Hulman Institute of Technology United States Department of Rhetoric Rose-Hulman Institute ot Technology U.S. Air Forcer United States Army's Aberdeen Proving Ground NASA's Classroom of the Future Wheeling WV United States Washington University United States Department of Civil Engineering Washington University St. Louis United States Environmental Engineering Science Program Center for Materials Innovation United States McPherson High School United States McPherson High School McPherson KS United States Stevens Institute of Technology United States Stevens Institute of Technology United States Morgan State University United States Michigan State University United States Biosystems and Agricultural Engineering Department Michigan State University United States University of Dayton United States U.S. EPA Office of Research and Development United States National Center for Supercomputing Applications United States Department of Information Science Graduate School of Library and Information Science National Center for Supercomputing Applications University of Illinois United States

The Collaborative Large-scale engineering Analysis Network for Environmental Research (CLEANER) Project Office has been established with funding from the National Science Foundation (NSF) to the University of Illinois Urbana-Champaign (UIUC) and a coalition of 11 other institutions. The project office is coordinating the creation of a strategic plan consisting of research, cyberinfrastructure, and education plans that set forth a roadmap for the collaborative engineering analysis network for the study of environmental problems. This report will be completed by July 2007 and requires input from K-12 educators, administrators and other stakeholders in K-12 education. This paper describes the CLEANER project, provides an example of the CLEANER Education Committee's vision for the K-12 area and lists contacts for further information. The intention of this paper is to elicit input from the K-12 engineering education community, including K-12 educators, on how the CLEANER Education Plan could better meet the future needs of K-12 students and educators © American Society for engineering Education, 2006.

关键词： engineering education

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Chitosan for Biofunctionalization of Microsystems

Chitosan for Biofunctionalization of Microsystems

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IEEE/NLM Life Science Systems and Applications Workshop

作者： Stephan T. Koev Michael A. Powers Vlad Badilita Hyunmin Yi William E. Bentley Gregory F. Payne Gary W. Rubloff Reza Ghodssi Institute for Systems Research ISR University of Maryland College Park MD USA University System of Maryland Adelphi MD US Department of Materials Science and Engineering University of Maryland College Park MD USA Department of Chemical Engineering University of Maryland College Park MD 20742 University of Maryland Biotechnology Institute (UMBI) University of Maryland College Park MD 20742 Bioengineering Graduate Program University of Maryland College Park MD 20742 University of Maryland College Park MD USA University of Maryland Biotechnology Institute College Park MD USA Institute for Systems Research (ISR) University of Maryland College Park MD 20742 Department of Materials Science and Engineering University of Maryland College Park MD 20742 Department of Electrical and Computer Engineering University of Maryland College Park MD 20742 Institute for Systems Research (ISR) University of Maryland College Park MD 20742

ISBN: (纸本)1424402778

We present the use of the polysaccharide chitosan for immobilizing biomolecules on microfabricated device surfaces. The main advantages of chitosan are its abundance of primary amine groups and its ability to be electrodeposited. Biomolecules are easily attached to chitosan 's amines by standard glutaraldehyde chemistry. The electrodeposition of chitosan allows accurate spatial and temporal control of biomolecule placement. We have demonstrated this biofunctionalization method for two different bioMEMS devices: a biophotonic sensor and a micromechanical biosensor. We have successfully assembled probe DNA on each of them and detected hybridization with target DNA as a demonstration of sensor operation. Here, we briefly present the fabrication procedure and testing results for both of these bioMEMS sensing devices

关键词： DNA Biosensors Molecular biophysics Probes Micromechanical devices Optical sensors Optical surface waves Optical interferometry Assembly Biomedical optical imaging

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Power efficient error control for bluetooth-based sensor networks

Power efficient error control for bluetooth-based sensor net...

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IEEE Conference on Local computer Networks - 30th Anniversary, LCN 2005

作者： Kleinschmidt, João H. Borelli, Walter C. Pellenz, Marcelo E. School of Electrical and Computer Engineering State University of Campinas - UNICAMP Graduate Program in Computer Science Pontifical Catholic University of Paraná - PUCPR

ISBN: (纸本)0769524214

This paper- studies different error control schemes in wireless sensor networks with Bluetooth technology. The tradeoff between reliability and energy consumption of Bluetooth packets are analyzed, using different error control techniques, such as retransmission and channel coding The AUX1 packet is utilized for custom coding and also are proposed adaptive techniques based on the number of hops of the network. The wireless channel is modeled with Rayleigh fading. The results obtained may be used as references to determine the packet type in a sensor application. © 2005 IEEE.

关键词： Wireless telecommunication systems

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A kernel method for MicroRNA target prediction using sensible data and position-based features

A kernel method for MicroRNA target prediction using sensibl...

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2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05

作者： Kim, Sung-Kyu Nam, Jin-Wu Lee, Wha-Jin Zhang, Byoung-Tak Graduate Program in Bioinformatics School of Computer Science and Engineering Seoul National University Seoul 151-744 Korea Republic of

ISBN: (纸本)0780393872

MicroRNAs (miRNAs) are small endogenous RNAs of ∼22nt that act as direct post-transcriptional regulators in animals and plants. MicroRNAs generally perform a function by binding to the complementary site on the 3' untranslated region of Its target gene and especially the Smers on the 5' part of miRNA seems important as a seed. Computational methods for miRNA target prediction have been focusing on this seed region, but recent researches revealed that the specificity of the seed region may be sharply decreased even by a point mutation. In this paper, we present a kernel method for miRNA target prediction in animals, which improves the prediction performance with biologically sensible data and position-based features reflecting the way of miRNA:mRNA pairing mechanism. In building a training dataset, we choose experimentally verified data only to improve the quality of dataset by excluding randomly synthesized one and consequently to make the result of learning valid. We use sensitivity, specificity, and area under ROC curve as performance measures of our algorithm and compare the results of various dataset configurations. The overall results were 92.1% in sensitivity, 83.3% in specificity, and 0.931 in area under ROC curve. With position-based features, an increase of 3.3% in sensitivity and 1.6% in specificity were observed. In the feature selection experiment to investigate the role of individual position-based features, the result suggests that pairing at positions 4, 5, 6 of the seed part is of greater importance than the other positions together with the general stability of the seed part. © 2005 IEEE.

关键词： RNA

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Signals and systems using MATLAB: An integrated suite of applications for exploring and teaching media signal processing

Signals and systems using MATLAB: An integrated suite of app...

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Frontiers in Education - 35th Annual Conference 2005, FIE' 05

作者： Sturm, Bob L. Gibson, Jerry D. Graduate Program 3431 South Hall University of California Santa Barbara Santa Barbara CA 93106 Department of Media Arts and Technology and Electrical and Computer Engineering

ISBN: (纸本)0780390776

Effectively teaching introductory media signal processing (MSP) to students requires a means of communicating complex concepts without advanced mathematics. At the Media Arts and Technology program at UCSB we are teaching graduate media arts students concepts of MSP. These students, while interested in learning how their digital tools work, have an incredibly tough time working through the material the way traditional engineering students do. To address this we have used MATLAB to build a comprehensive suite of exploratory demonstrations and applications tailored to illustrate sophisticated concepts, and to inspire students that may not possess a strong background in mathematics. Our application, "Signals and Systems Using MATLAB" (SSUM), is presented here, and its use in a course designed to teach MSP to media arts students is discussed. Its usefulness extends beyond media arts to engineering and computer science curriculum. SSUM can be obtained for free from http://***/***. © 2005 IEEE.

关键词： Teaching

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AGQ: A model of student question generation supported by one-on-one educational computing

AGQ: A model of student question generation supported by one...

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International Conference on computer Supported Collaborative Learning

作者： Chang, Sung-Bin Tung, Kuan-Jung Huang, Hsien-Ming Chan, Tak-Wai Department of Computer Science and Information Engineering National Central University Taiwan Degree Program of E-Learning National Chiao Tung University Taiwan Graduate Institute of Network Learning Technology National Central University Taiwan

ISBN: (纸本)0805857826

One-on-one educational computing refers to I student I computing device, which means every student in a group uses a digital learning device. In this paper, we present a model of student question generation called AGQ, which stands for "asking a good question," supported by one-on-one educational computing in the classroom settings. AGQ is designed for engaging students in a challenging learning activity that potentially involves higher-level cognitive processing operations. We shall describe the general design of AGQ, called Product Evolution, and that the current version is a variation of it.

关键词： one-on-one educational computing peer question generation question posing

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