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BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2023年第6期20卷 824-835页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species that is representative of the data obtained in many neuroscience laboratories interested in neuron tracing. Here, we report generated gold standard manual annotations for a subset of the available imaging datasets and quantified tracing quality for 35 automatic tracing algorithms. The goal of generating such a hand-curated diverse dataset is to advance the development of tracing algorithms and enable generalizable benchmarking. Together with image quality features, we pooled the data in an interactive web application that enables users and developers to perform principal component analysis, t-distributed stochastic neighbor embedding, correlation and clustering, visualization of imaging and tracing data, and benchmarking of automatic tracing algorithms in user-defined data subsets. The image quality metrics explain most of the variance in the data, followed by neuromorphological features related to neuron size. We observed that diverse algorithms can provide complementary information to obtain accurate results and developed a method to iteratively combine methods and generate consensus reconstructions. The consensus trees obtained provide estimates of the neuron structure ground truth that typically outperform single algorithms in noisy datasets. However, specific algorithms may outperform the consensus tree strategy in specific imaging conditions. Finally, to aid users in predicting the most accurate automatic tracing results without manual annotations for comparison, we used support vector machine regression to predict reconstruction quality given an image volume and a set of automatic tracings.

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Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics

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Nature communications 2025年第1期16卷 4900页

作者： Dhammika Leshan Wannigama Mohan Amarasiri Phatthranit Phattharapornjaroen Cameron Hurst Charin Modchang John Jefferson V Besa Kazuhiko Miyanaga Longzhu Cui Stefan Fernandez Angkana T Huang Puey Ounjai W K C P Werawatte Ali Hosseini Rad S M Porames Vatanaprasan Dylan John Jay Thammakorn Saethang Sirirat Luk-In Phitsanuruk Kanthawee Wanwara Thuptimdang Ratana Tacharoenmuang Bernadina Cynthia S P H Spencer Vitharana Natharin Ngamwongsatit Hitoshi Ishikawa Takashi Furukawa Yangzhong Wang Andrew C Singer Naveen Kumar Devanga Ragupathi Tanittha Chatsuwan Kazunari Sei Asuka Nanbo Asada Leelahavanichkul Talerngsak Kanjanabuch Hiroshi Hamamoto Paul G Higgins Daisuke Sano Anthony Kicic José O Valdebenito Jonas Bonnedahl Sam Trowsdale Parichart Hongsing Aisha Khatib Kenji Shibuya Shuichi Abe Department of Infectious Diseases Faculty of Medicine Yamagata University Yamagata Japan. leshanwannigama@med.id.yamagata-u.ac.jp. Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan. leshanwannigama@med.id.yamagata-u.ac.jp. Pathogen Hunter's Research Collaborative Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan. leshanwannigama@med.id.yamagata-u.ac.jp. Yamagata Prefectural University of Health Sciences Kamiyanagi Yamagata Japan. leshanwannigama@med.id.yamagata-u.ac.jp. The Lygodium Ceylon Health and Environmental Policy Research Center Colombo Sri Lanka. leshanwannigama@med.id.yamagata-u.ac.jp. Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries The University of Sheffield Sheffield UK. leshanwannigama@med.id.yamagata-u.ac.jp. Pathogen Hunter's Research Collaborative Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan. Department of Civil and Environmental Engineering Graduate School of Engineering Tohoku University Sendai Miyagi Japan. Faculty of Health Science Technology Chulabhorn Royal Academy Bangkok Thailand. HRH Princess Chulabhorn Disaster and Emergency Medicine Center Chulabhorn Royal Academy Bangkok Thailand. Department of Clinical Epidemiology Faculty of Medicine Thammasat University Rangsit Thailand. Center of Excellence in Applied Epidemiology Thammasat University Rangsit Thailand. Mater Research Institute University of Queensland Brisbane QLD Australia. Biophysics Group Department of Physics Faculty of Science Mahidol University Bangkok Thailand. Centre of Excellence in Mathematics MHESI Bangkok Thailand. Thailand Center of Excellence in Physics Ministry of Higher Education Science Research and Innovation Bangkok Thailand. Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan. Co

Avian influenza viruses (AIVs) pose a growing global health threat, particularly in low- and middle-income countries (LMICs), where limited surveillance capacity and under-resourced healthcare systems hinder timely detection and response. Migratory birds play a significant role in the transboundary spread of AIVs, yet data from key regions along migratory flyways remain sparse. To address these surveillance gaps, we conducted a study between December 2021 and February 2023 using fresh bird guano collected across 10 countries in the Global South. Here, we show that remote, uninhabited regions in previously unsampled areas harbor a high diversity of AIV strains, with H5N1 emerging as the most prevalent. Some of these H5N1 samples also carry mutations that may make them less responsive to the antiviral drug oseltamivir. Our findings documented the presence of AIVs in several underrepresented regions and highlighted critical transmission hotspots where viral evolution may be accelerating. These results underscore the urgent need for geographically targeted surveillance to detect emerging variants, inform public health interventions, and reduce the risk of zoonotic spillover.

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Abstracts and Workshops 7th National Spinal Cord Injury Conference November 9-11, 2017 Fallsview Casino Resort Niagara Falls, Ontario, Canada Abstracts

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JOURNAL OF SPINAL CORD MEDICINE 2017年第6期40卷 813-869页

作者： [Anonymous] a NET Team Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. fo Neural Engineering and Therapeutic Team Lyndhurst Centre Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. c Rick Hansen Institute Vancouver BC Canada. ev Rick Hansen Institute Vancouver BC Canada. fc Stan Cassidy Hospital University of New Brunswick Fredericton NB Canada. fd Dalhousie University Halifax NS Canada. e University of Saskatchewan Saskatoon SK Canada. aa University of Calgary Calgary AB Canada. y Dalhousie University Halifax NS Canada. fa Health Sciences Centre Winnipeg MB Canada. fb University of Manitoba Winnipeg MB Canada. h University of Alberta Edmonton AB Canada. i Universite Laval Quebe c City QC Canada. bd Rick Hansen Institute Vancouver BC Canada. fz Clinician Investigator Lyndhurst Centre Toronto Rehabilitation Institute University Health Network and Assistant Professor Department of Medicine Division of Physical Medicine and Rehabilitation University of Toronto. v University of Toront o Toronto ON Canada. n Institute of Biomaterials and Biomedical Engineering University of Toronto Toronto ON Canada. o Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. ga Clinical Scientist Lyndhurst Centre Toronto Rehabilitation Institute University Health Network and Assistant Professor Department of Physical Therapy University of Toronto. dx Department of Electrical and Computer Engineering University of Toronto Toronto ON Canada. fm Lawson Health Research Institute London ON Canada. r Parkwood Institute London ON Canada. bi Parkwood Institute London ON Canada. s University of British Columbia Vancouver BC Canada. t Simon Fraser University Burnaby BC Canada. u DeltaQuest Foundation Concord MA USA. z Institut national d'excellence en santé et en services sociaux (INESSS) Quebec City QC Ca

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Publisher Correction: Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport

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Scientific reports 2018年第1期8卷 8019页

作者： Shiori Toba Mingyue Jin Masami Yamada Kanako Kumamoto Sakiko Matsumoto Takuo Yasunaga Yuko Fukunaga Atsuo Miyazawa Sakiko Fujita Kyoko Itoh Shinji Fushiki Hiroaki Kojima Hideki Wanibuchi Yoshiyuki Arai Takeharu Nagai Shinji Hirotsune Department of Genetic Disease Research Osaka City University Graduate School of Medicine Asahi-machi 1-4-3 Abeno Osaka 545-8585 Japan. Department of Bioscience and Bioinformatics Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology Kawazu 680-4 Iizuka Fukuoka 820-850 Japan. JST-SENTAN 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan. JST-CREST 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan. Graduate School of Life Science University of Hyogo 3-2-1 Kouto Kamigori-cho Ako-gun Hyogo 678-1297 Japan. RSC-University of Hyogo Leading Program Center RIKEN SPring-8 Center 1-1-1 Kouto Sayo-cho Sayo-gun Hyogo 679-5148 Japan. Graduate School of Materials Science Nara Institute of Science and Technology 8916-5 Takayama Ikoma Nara 630-0101 Japan. Department of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine Graduate School of Medical Sciences Kajii-cho Kawaramachi-Hirokoji Kamigyo-ku Kyoto 602-8566 Japan. Advanced ICT Research Institute National Institute of Information and Communications Technology 588-2 Iwaoka Nishi-ku Kobe 651-2492 Japan. Department of Pathology Osaka City University Graduate School of Medicine Asahi-machi 1-4-3 Abeno Osaka 545-8586 Japan. Department of Biomolecular Science and Engineering Institute of Scientific and Industrial Research Osaka University Mihoga-oka 8-1 Osaka 567-0047 Japan. Department of Genetic Disease Research Osaka City University Graduate School of Medicine Asahi-machi 1-4-3 Abeno Osaka 545-8585 Japan. shinjih@med.osaka-cu.ac.jp.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

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Correction to: Comparison of 12 surrogates to characterize CT radiation risk across a clinical population

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European radiology 2021年第10期31卷 8068页

作者： Francesco Ria Wanyi Fu Jocelyn Hoye W Paul Segars Anuj J Kapadia Ehsan Samei Carl E. Ravin Advanced Imaging Labs Duke University Health System 2424 Erwin Road Suite 302 Durham NC 27710 USA. francesco.ria@duke.edu. Clinical Imaging Physics Group Duke University Health System 2424 Erwin Road Suite 302 Durham NC 27710 USA. francesco.ria@duke.edu. Carl E. Ravin Advanced Imaging Labs Duke University Health System 2424 Erwin Road Suite 302 Durham NC 27710 USA. Clinical Imaging Physics Group Duke University Health System 2424 Erwin Road Suite 302 Durham NC 27710 USA. Medical Physics Graduate Program Departments of Radiology Physics Biomedical Engineering and Electrical and Computer Engineering Duke University 2424 Erwin Road Suite 302 Durham NC 27710 USA.

A Correction to this paper has been published: https://***/10.1007/s00330-021-07903-z

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Project 1640 observations of brown dwarf GJ 758 B: Near-infrared spectrum and atmospheric modeling

arXiv

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arXiv 2017年

作者： Nilsson, R. Veicht, A. Giorla Godfrey, P.A. Rice, E.L. Aguilar, J. Pueyo, L. Roberts, L.C. Oppenheimer, R. Brenner, D. Luszcz-Cook, S.H. Bacchus, E. Beichman, C. Burruss, R. Cady, E. Dekany, R. Fergus, R. Hillenbrand, L. Hinkley, S. King, D. Lockhart, T. Parry, I.R. Sivaramakrishnan, A. Soummer, R. Vasisht, G. Zhai, C. Zimmerman, N.T. Astrophysics Department American Museum of Natural History Central Park West at 79th Street New YorkNY10024 United States Department of Astronomy Stockholm University AlbaNova University Center Roslagstullsbacken 21 StockholmSE-106 91 Sweden Department of Astronomy California Institute of Technology 1200 E. California Blvd PasadenaCA91125 United States Physics Program Graduate Center City University of New York New YorkNY10016 United States Department of Engineering Science & Physics College of Staten Island 2800 Victory Blvd. Staten IslandNY10314 United States Department of Physics and Astronomy Johns Hopkins University BaltimoreMD21218 United States Space Telescope Science Institute 3700 San Martin Drive BaltimoreMD21218 United States Jet Propulsion Laboratory California Institute of Technology 4800 Oak Grove Dr. PasadenaCA91109 United States Institute of Astronomy Cambridge University Madingley Road CambridgeCB3 0HA United Kingdom NASA Exoplanet Science Institute California Institute of Technology PasadenaCA91125 United States Caltech Optical Observatories California Institute of Technology PasadenaCA91125 United States Department of Computer Science Courant Institute of Mathematical Sciences New York University 715 Broadway New YorkNY10003 United States School of Physics University of Exeter Stocker Road ExeterEX4 4QL United Kingdom

The nearby Sun-like star GJ 758 hosts a cold substellar companion, GJ 758 B, at a projected separation of 30 au, previously detected in high-contrast multi-band photometric observations. In order to better constrain the companion’s physical characteristics, we acquired the first low-resolution (R ∼ 50) near-infrared spectrum of it using the high-contrast hyperspectral imaging instrument Project 1640 on Palomar Observatory’s 5 m Hale telescope. We obtained simultaneous images in 32 wavelength channels covering the Y , J, and H bands (∼952–1770 nm), and used data processing techniques based on principal component analysis to efficiently subtract chromatic background speckle-noise. GJ 758 B was detected in four epochs during 2013 and 2014. Basic astrometric measurements confirm its apparent northwest trajectory relative to the primary star, with no clear signs of orbital curvature. Spectra of SpeX/IRTF observed T dwarfs were compared to the combined spectrum of GJ 758 B, with χ2 minimization suggesting a best fit for spectral type T7.0±1.0, but with a shallow minimum over T5–T8. Fitting of synthetic spectra from the BT-Settl13 model atmospheres gives an effective temperature Teff = 741 ± 25 K and surface gravity log g = 4.3 ± 0.5 dex (cgs). Our derived best-fit spectral type and effective temperature from modeling of the low-resolution spectrum suggest a slightly earlier and hotter companion than previous findings from photometric data, but do not rule out current results, and confirm GJ 758 B as one of the coolest sub-stellar companions to a Sun-like star to date. Copyright © 2017, The Authors. All rights reserved.

关键词： Principal component analysis

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TECHNOLOGICAL ADVANCES IN AIRCRAFT CARRIER DESIGN

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NAVAL ENGINEERS JOURNAL 1980年第5期92卷 71-85页

作者： REIN, RJ RYAN, JC USN (RET.) Cdr. Robert J. Rein USN (Ret.)currently is the Director of Naval Support Systems for the Columbia Research Corporation Washington D. C. At the time this paper was presented he was on active duty in the U.S. Navy serving as the Ship Design Manager for the CVV Naval Sea Systems Command. Prior to that his duty assignments included Deputy Program Manager for the Sea Control Ship Assistant Ship Material Officer. Staff of Commander Naval Air Force U.S. Pacific Fleet and Type Desk Officer for Cruisers/Destroyers and New Construction (CG 30) at the former Hunter's Point Naval Shipyard. He is a graduate of General Motors Institute an accredited private college sponsored by the General Motors Corporation: the U.S. Naval Postgraduate School Monterey. Calif.: and the Defense Systems Management College. Fort Belvoir. Va. Additionally. he has had extensive postgraduate study in Systems Management at The George Washington University. Cdr. Rein is extremely active in his support of professional engineering societies and as a member of ASNE since 1964 has been responsible for the founding of ASNE Local Sections on the west coast and presently is serving as the Society's National Assistant Secretary-Treasurer. In addition he also was the creator and coordinator for the highly successful. Society sponsored Symposium “Aircraft Carriers — Present and Future.”which was held in October 1976 at the U.S. Grant Hotel. San Diego. Calif. and was the first such Symposium jointly sponsored by an Operating Fleet command and a professional society. Mr. J. Christopher Ryanreceived his B.S. degree in Naval Architecture and Marine Engineering from Webb Institute of Naval Architecture in 1967 and his M.S. degree in Naval Architecture from Massachusetts Institute of Technology in 1969. His initial work experience was at Litton Ship Systems where he was associated primarily with the general arrangements development of the DD 963 Class design. Subsequently. he was employed at the former Naval Ship Engineering Center with work as

Since the signing of the Contract Design Plane for the CVN 68 (the U.S. Navy's latest Class of Aircraft Carriers) In 1963, considerable technological advances have been made in Naval Ship Design. This paper provides specific examples of how new technology has affected traditional Carrier design practices and techniques, and also indicates areas where future advanced technology will be needed. It is divided into four sections: 1) computer Design Application; 2) Total Ship Energy Conservation Analysis; 3) Advances in Structural Design; and 4) Impact of V/STOL Aircraft. The increased use of the computer to define ship characteristics in the initial stage of ship design is discussed, followed by a report on efforts to include energy conservation as an integral part of the design process. The energy conservation approach uses traditional analytical techniques to develop innovative design configurations that will achieve energy savings. Of the many advances in Carrier structural design, two specific examples are given: 1) Elimination of the infamous “knee-knockers” (high sills in passageway openings) common to Gallery Deck structure, and 2) Successful attempts at reducing the thickness of aircraft elevator platforms. The paper concludes by pointing out some possible challenges facing the ship designer and some of the technology already created by the expected introduction of advanced design Vertical/Short Takeoff and Landing (V/STOL) aircraft.

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Euclid: Early Release Observations – A preview of the Euclid era through a galaxy cluster magnifying lens

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Astronomy and Astrophysics 2025年 697卷

作者： Atek, H. Gavazzi, R. Weaver, J.R. Diego, J.M. Schrabback, T. Hatch, N.A. Aghanim, N. Dole, H. Hartley, W.G. Taamoli, S. Congedo, G. Jimenez-Teja, Y. Cuillandre, J.-C. Bañados, E. Belladitta, S. Bowler, R.A.A. Franco, M. Jauzac, M. Mahler, G. Richard, J. Rocci, P.-F. Serjeant, S. Toft, S. Abriola, D. Bergamini, P. Biviano, A. Dimauro, P. Ezziati, M. Golden-Marx, J.B. Grillo, C. Hughes, A.C.N. Kang, Y. Kneib, J.-P. Lombardi, M. Mamon, G.A. McPartland, C.J.R. Meneghetti, M. Miyatake, H. Montes, M. Mortlock, D.J. Oesch, P.A. Okabe, N. Rosati, P. Taylor, A.N. Tarsitano, F. Weller, J. Kluge, M. Laureijs, R. Paltani, S. Saifollahi, T. Schirmer, M. Stone, C. Mora, A. Altieri, B. Amara, A. Andreon, S. Auricchio, N. Baldi, M. Balestra, A. Bardelli, S. Basset, A. Bender, R. Bodendorf, C. Bonino, D. Branchini, E. Brescia, M. Brinchmann, J. Camera, S. Candini, G.P. Capobianco, V. Carbone, C. Cardone, V.F. Carretero, J. Casas, S. Castander, F.J. Castellano, M. Cavuoti, S. Cimatti, A. Conselice, C.J. Conversi, L. Copin, Y. Corcione, L. Courbin, F. Courtois, H.M. Da Silva, A. Degaudenzi, H. Di Giorgio, A.M. Dinis, J. Douspis, M. Dubath, F. Dupac, X. Dusini, S. Ealet, A. Farina, M. Farrens, S. Ferriol, S. Fotopoulou, S. Frailis, M. Franceschi, E. Galeotta, S. Gillard, W. Gillis, B. Giocoli, C. Gómez-Alvarez, P. Grazian, A. Grupp, F. Guzzo, L. Hailey, M. Haugan, S.V.H. Hoar, J. Hoekstra, H. Holliman, M.S. Institut d’Astrophysique de Paris UMR 7095 CNRS Sorbonne Université 98 bis boulevard Arago Paris75014 France Aix-Marseille Université CNRS CNES LAM Marseille France Department of Astronomy University of Massachusetts AmherstMA01003 United States Instituto de Física de Cantabria Edificio Juan Jordá Avenida de los Castros Santander39005 Spain Universität Innsbruck Institut für Astro- und Teilchenphysik Technikerstr. 25/8 Innsbruck6020 Austria School of Physics and Astronomy University of Nottingham University Park NottinghamNG7 2RD United Kingdom Université Paris-Saclay CNRS Institut d’astrophysique spatiale Orsay91405 France Department of Astronomy University of Geneva ch. d’Ecogia 16 Versoix1290 Switzerland Physics and Astronomy Department University of California 900 University Ave. RiversideCA92521 United States Institute for Astronomy University of Edinburgh Royal Observatory Blackford Hill EdinburghEH9 3HJ United Kingdom Instituto de Astrofísica de Andalucía CSIC Glorieta de la Astronomía Granada18080 Spain Observatorio Nacional Rua General Jose Cristino 77-Bairro Imperial de Sao Cristovao Rio de Janeiro20921-400 Brazil Université Paris-Saclay Université Paris Cité CEA CNRS AIM Gif-sur-Yvette91191 France Max-Planck-Institut für Astronomie Königstuhl 17 Heidelberg69117 Germany INAF-Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Via Piero Gobetti 93/3 Bologna40129 Italy Jodrell Bank Centre for Astrophysics Department of Physics and Astronomy University of Manchester Oxford Road ManchesterM13 9PL United Kingdom The University of Texas at Austin AustinTX78712 United States Department of Physics Centre for Extragalactic Astronomy Durham University South Road DH1 3LE United Kingdom Department of Physics Institute for Computational Cosmology Durham University South Road DH1 3LE United Kingdom Astrophysics Research Centre University of KwaZulu-Natal Westville Campus Durban4041 South Africa School of

We present the first analysis of the Euclid Early Release Observations (ERO) program that targets fields around two lensing clusters, Abell 2390 and Abell 2764. We use imaging data from the Visible instrument (VIS) and the Near-Infrared Spectrometer and Photometer (NISP) to produce photometric catalogs for a total of ∼500 000 objects. The imaging data reach a typical depth of 5 σ in the range 25.1–25.4 AB in the NISP bands and 27.1–27.3 AB in the VIS band. Using the Lyman-break method in combination with photometric redshifts, we searched for high-redshift galaxies. We identified 30 Lyman-break galaxy (LBG) candidates at z > 6 and 139 extremely red sources (ERSs), most of which likely lie at lower redshift. The VIS imaging is deeper than the NISP imaging, which means that we can routinely identify high-redshift Lyman-break galaxies at about a magnitude of 3, which reduces contamination by brown dwarf stars and low-redshift galaxies. The difficulty of spatially resolving most of these sources in 0′′ . 3 pix−1 imaging means that it is difficult to distinguish between galaxies and quasars. Spectroscopic follow-up campaigns of these bright sources will help us to constrain the bright end of the ultraviolet galaxy luminosity function and the quasar luminosity function at z > 6, and it will constrain the physical nature of these objects. Additionally, we performed a combined strong- and weak-lensing analysis of A2390, and we show that Euclid will contribute to constraining the virial mass of galaxy clusters better. We also identify optical and near-infrared counterparts of known z > 0.6 clusters in these data. These counterparts exhibit strong-lensing features. This establishes that Euclid can characterize high-redshift clusters. Finally, we provide a glimpse of the ability of Euclid to map the intracluster light out to larger radii than current facilities, which enables us to understand the cluster assembly history better and to map the dark matter distribution. This ini

关键词： Moon

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SWATH—THE VSTOL AIRCRAFT CARRIER FOR THE POST‐1990's

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Naval Engineers Journal 1977年第1期89卷 47-54页

作者： CHILDERS, RADM.K.C. GLOECKLER, FREDERICK M. STEVENS, ROBERT M. USN (RET.) RAdm. K.C. Childers USN (Ret.):graduated from the U.S. Naval Academy in 1939. and later completed his graduate studies at California Institute of Technology from which he received his MS and AE degrees. He was a fighter pilot in the aircraft carriers USS Ranger and USS Essex during World War II and an instructor at the Guided Missile School. Ft. Bliss Texas from 1947 until 1949 at which time he came to Washington. D.C. as an Assistant Division Director Ships Installation Division Bureau of Aeronautics. In addition his active duty career included assignments as Naval Air Systems Command Representative Atlantic Assistant Commander for Material Acquisition Naval Air Systems Command and Deputy Project Manager for the FlllB/Phoenix Program. Bureau of Naval Weapons. During the first five years of the Polaris Program he was responsible for all testing at the Atlantic Missile Range. He also served as Commander of the Naval Missile Center where he directed the test and evaluation of Airborne Weapon Systems and had been on an earlier assignment the Missile Test Officer. His military decorations include the Silver Star the Legion of Merit two Air Medals the Navy Commendation Medal and a Presidential Unit Citation. Currently he is employed as the Manager of the Analysis and Evaluation Department at CERBERONICS. Inc. Falls Church. Va. Mr. Frederick M. Gloeckler: currently a Consultant to CERBERONICS Inc. graduated from New York University from which he received his BS degree. He began his career with the Department of the Navy in 1938. and culminated it with his retirement in 1972 at which time he was engaged in VSTOL aircraft analysis and was the Director Advanced Systems Division Naval Air Systems Command (and its predecessor organizations). During this period he made major contributions to the Fleet Ballistic Missile Program the F-14 A-7 and S-3 Aircraft Programs and the Phoenix Condor and Harpoon Missile Programs. In 1951 Mr. Gloeckler organized‘ and directed the Systems Engineering Divis

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Percutaneous Coronary Intervention With a Drug-Eluting Stent Versus Coronary Artery Bypass Grafting in Patients Receiving Dialysis: A National Study From Taiwan

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Kidney medicine 2024年第2期6卷 100768页

作者： Szu-Yu Pan Ju-Yeh Yang Nai-Chi Teng Yun-Yi Chen Shi-Heng Wang Chien-Lin Lee Kang-Lung Chen Yen-Ling Chiu Shih-Ping Hsu Yu-Sen Peng Yung-Ming Chen Shuei-Liong Lin Likwang Chen Department of Integrated Diagnostics and Therapeutics National Taiwan University Hospital Taipei Taiwan. Division of Nephrology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan. Division of Nephrology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan. Institute of Health Policy and Management College of Public Health National Taiwan University Taipei Taiwan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Research Shin-Kong Wu Ho-Su Memorial Hospital Taipei Taiwan. Institute of Hospital and Health Care Administration National Yang Ming Chiao Tung University Taipei Taiwan. National Center for Geriatrics and Welfare Research National Health Research Institutes Yunlin Taiwan. Department of Cardiology Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Cardiovascular Surgery Far Eastern Memorial Hospital New Taipei City Taiwan. Graduate Program in Biomedical Informatics Department of Computer Science and Engineering College of Informatics Yuan Ze University Taoyuan Taiwan. Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan. Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan.

Rationale & Objective:We aimed to study the comparative effectiveness of percutaneous coronary intervention with drug-eluting stent and coronary artery bypass grafting in patients receiving dialysis. Study Design:This was a retrospective observational cohort study. Setting & Participants:This population-based study identified patients receiving dialysis hospitalized for coronary revascularization between January 1, 2009 and December 31, 2015, in the Taiwan National Health Insurance Research Database. Exposures:Patients received percutaneous coronary intervention with drug-eluting stent versus coronary artery bypass grafting. Outcomes:The study outcomes were all-cause mortality, in-hospital mortality, and repeat revascularization. Analytical Approach:Propensity scores were used to match patients. Cox proportional hazards models and logistic regression models were constructed to examine associations between revascularization strategies and mortality. Interval Cox models were fitted to estimate time-varying hazards during different periods. Results:A total of 1,840 propensity score-matched patients receiving dialysis were analyzed. Coronary artery bypass grafting was associated with higher in-hospital mortality (coronary artery bypass grafting vs percutaneous coronary intervention with drug-eluting stent; crude mortality rate 12.5% vs 3.3%; adjusted OR, 5.22; 95% CI, 3.42-7.97; < 0.001) and longer hospitalization duration (median [IQR], 20 [14-30] days vs 3 [2-8] days; < 0.001). After discharge, repeat revascularization, acute coronary syndrome, and repeat hospitalization all occurred more frequently in the percutaneous coronary intervention with drug-eluting stent group. Importantly, with a median follow-up of 2.8 years, coronary artery bypass grafting was significantly associated with a higher risk of all-cause overall mortality (adjusted HR, 1.19; 95% CI, 1.05-1.35; = 0.006) in the multivariable Cox proportional hazard model. Sensitivity and subgroup analyses yie

关键词： Coronary artery bypass grafting coronary revascularization dialysis drug-eluting stent end-stage kidney disease mortality percutaneous coronary intervention survival

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