This works presents an innovative application of Markov Decision Process (MDP) to a medium-term mining logistics planning problem considering the mine-to-client supply chain. We implemented three distinct algorithms b...
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ISBN:
(数字)9783907144022
ISBN:
(纸本)9781728188133
This works presents an innovative application of Markov Decision Process (MDP) to a medium-term mining logistics planning problem considering the mine-to-client supply chain. We implemented three distinct algorithms based on state-of-the-art approaches to solve large-scale problems, and compared their results. Furthermore, we combined all three variants in a single novel algorithm that attained fast convergence and may be an alternative to circumvent the curse of dimensionality underlying large scale problems.
Context: The technical debt (TD) concept inspires the development of useful methods and tools that support TD identification and management. However, there is a lack of evidence on how different TD identification tool...
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There have been many studies conducted related to Smart City, IT Governance and Big Data. In this study aims to find out how the relationship between the three and how to form a framework to explain it. The methodolog...
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Context: Contemporary software development is typically conducted in dynamic, resource-scarce environments that are prone to the accumulation of technical debt. While this general phenomenon is acknowledged, what rema...
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Context: Contemporary software development is typically conducted in dynamic, resource-scarce environments that are prone to the accumulation of technical debt. While this general phenomenon is acknowledged, what remains unknown is how technical debt specifically manifests in and affects software processes, and how the software development techniques employed accommodate or mitigate the presence of this debt. Objectives: We sought to draw on practitioner insights and experiences in order to classify the effects of agile method use on technical debt management, given the popularity and perceived success of agile methods. We explore the breadth of practitioners' knowledge about technical debt;how technical debt is manifested across the software process;and the perceived effects of common agile software development practices and processes on technical debt. In doing so, we address a research gap in technical debt knowledge and provide novel and actionable managerial recommendations. Method: We designed, tested and executed a multi-national survey questionnaire to address our objectives, receiving 184 responses from practitioners in Brazil, Finland, and New Zealand. Results: Our findings indicate that: 1) Practitioners are aware of technical debt, although, there was under utilization of the concept, 2) Technical debt commonly resides in legacy systems, however, concrete instances of technical debt are hard to conceptualize which makes it problematic to manage, 3) Queried agile practices and processes help to reduce technical debt;in particular, techniques that verify and maintain the structure and clarity of implemented artifacts (e.g., Coding standards and Refactoring) positively affect technical debt management. Conclusions: The fact that technical debt instances tend to have characteristics in common means that a systematic approach to its management is feasible. However, notwithstanding the positive effects of some agile practices on technical debt management, comp
The use of therapeutic peptides for the treatment of cancer has received tremendous attention in recent years. Anticancer peptides (ACPs) are considered new anticancer drugs which have several advantages over chemistr...
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Antigen-specific T cells play an essential role in immunoregulation and many diseases such as cancer. Characterizing the T cell receptor (TCR) sequences that encode T cell specificity is critical for elucidating the a...
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Antigen-specific T cells play an essential role in immunoregulation and many diseases such as cancer. Characterizing the T cell receptor (TCR) sequences that encode T cell specificity is critical for elucidating the antigenic determinants of immunological diseases and designing therapeutic remedies. However, methods of obtaining single-cell TCR sequencing data are labor and cost intensive, typically requiring both cell sorting and full length single-cell RNA-sequencing (scRNA-seq). New high-throughput 3' cell-barcoding scRNA-seq methods can simplify and scale this process;however, they do not routinely capture TCR sequences during library preparation and sequencing. While 5' cell-barcoding scRNA-seq methods can be used to examine TCR repertoire at single-cell resolution, doing so requires specialized reagents which cannot be applied to samples previously processed using 3' cell-barcoding methods. Here, we outline a method for sequencing TCRα and TCRβ transcripts from samples already processed using 3' cell-barcoding scRNA-seq platforms, ensuring TCR recovery at a single-cell resolution. In short, a fraction of the 3' barcoded whole transcriptome amplification (WTA) product typically used to generate a massively parallel 3' scRNA-seq library is enriched for TCR transcripts using biotinylated probes, and further amplified using the same universal primer sequence from WTA. Primer extension using TCR V-region primers and targeted PCR amplification using a second universal primer results in a 3' barcoded single-cell CDR3-enriched library that can be sequenced with custom sequencing primers. Coupled with 3' scRNA-seq of the same WTA, this method enables simultaneous analysis of single-cell transcriptomes and TCR sequences which can help interpret inherent heterogeneity among antigen-specific T cells and salient disease biology. The method presented here can also be adapted readily to enrich and sequence other transcripts of interest from both 3' and 5' barcoded scRNA-seq
Traditionally, for the purpose of classifying the integrity of an engineering structure, one may use the information of the natural frequencies or mode shapes or some other measures derived from the two. In this resea...
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Traditionally, for the purpose of classifying the integrity of an engineering structure, one may use the information of the natural frequencies or mode shapes or some other measures derived from the two. In this research, we propose a classification method on the basis of the general vibration model. The general vibration model is essentially a set of differential equations describing the dynamics of the structure under consideration. For the purpose of damage detection, a deviation of the general vibration model from the dynamic equilibrium point marks the occurrence of the damage. To demonstrate the effectiveness of the method, we study two simplest dynamical systems consisting of one- and two-concentrated masses subjected to a prescribed dynamic load. The structural damages are introduced artificially by reducing the stiffness of spring in the structures. We find that the general vibration model is more sensitive to damages than the traditional methods.
Global warming due to excessive emission greenhouse gases is a significant issue faced by humanity, and collectively, cars and trucks contribute about 20% to the entire global-warming gases. For a reason, recently, ma...
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Global warming due to excessive emission greenhouse gases is a significant issue faced by humanity, and collectively, cars and trucks contribute about 20% to the entire global-warming gases. For a reason, recently, many attempts have been endured to reduce the emission and to increase fuel efficiency, including vehicle platooning, better driving strategy, and increasing engine efficiency. This study intends to provide a more detail assessment regarding the effects of the driving strategy to fuel consumption. For the purpose, the vehicle dynamics are quantified by employing the car-following model based on the optimal velocity model. The fuel consumption is estimated from the regression model of Ahn 18 . The result suggests that the braking distance strongly affects fuel consumption.
Over the course of the COVID-19 pandemic, variants of SARS-CoV-2 have emerged that are more contagious and more likely to cause breakthrough infections. Targeted amplicon sequencing approach is a gold standard for ide...
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The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via sel...
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