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2020 First International Conference of Smart Systems and Emerging Technologies (SMARTTECH)

作者： Rafael Kunst Edison Pignaton Ting Zhou Honglin Hu Applied Computing Graduate Program University of Rio dos Sinos Valley (Unisinos) Sao Leopoldo Brazil Informatics Institute Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai China

ISBN: (数字)9781728174075

ISBN: (纸本)9781728174082

SG technology is becoming a reality, with several deployments appearing around the world. Despite bringing improvements, 5G technology may not adequately support many envisaged applications that will demand large amounts of network resources. Thus, studies on the next generation, the 6G, are highly desirable. Observing this landscape, in this paper, we present a seminal study about the potential usage of 6G to support such highly demanding applications. Towards this study, we model a 6G system at the simulation level and conduct a case study exploring an application of high-definition video monitoring, applying the concepts of drone-swarm based surveillance. This scenario demands the transmission of large amounts of video data through the network. The acquired results present evidence that 6G can address these high network traffic demands.

关键词： 6G mobile communication 5G mobile communication Surveillance Telecommunication traffic Next generation networking

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Inter-comparison of multiple Global Climate Model (GCM) data based on spatial pattern of rainfall over Indonesia 5

Inter-comparison of multiple Global Climate Model (GCM) data...

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5th International Symposium on LAPAN-IPB Satellite for Food Security and Environmental Monitoring 2018, LISAT-FSEM 2018

作者： Aflahah, Elania Latifah, Arnida Lailatul Hidayat, Rahmat Hidayati, Rini Ihwan, Andi Applied Climatology Study Program Graduate School Bogor Agricultural University Bogor16680 Indonesia Laboratorium of High-Performance Computing Research Center for Informatics Indonesian Institute of Sciences West Java Bogor16916 Indonesia Department of Geophysics and Meteorology Bogor Agricultural University Bogor16680 Indonesia

The Coupled Model Inter-comparison Project Phase 5 (CMIP5) is the output of many coupled atmosphere-ocean of global climate models (GCMs) and widely used for climate research, especially for driving regional climate model. There are more than 40 CMIP5 GCMs data available, but no single model can be considered as the best for every region. The use of CMIP5 GCMs data for rainfall projection in Indonesia is important to improve the accuracy of the monthly and seasonal rainfall forecast. Then, this study evaluates the capability of the CMIP5 GCMs data for Indonesia region by quantitatively comparing the spatial pattern of the precipitation mean and standard deviation of the CMIP5 data against GPCP, GPCC, and CRU data in the period 1980-2005. Furthermore, the composite analysis is conducted to observe the model performance in reproducing the precipitation characteristic over some areas in Indonesia. In conclusion, the models NorESM1-M, NorESM1-ME, GFDL-ESM2M, CSIRO-MK3-6-0 perform the rainfall mean better than others, while the standard deviation of the rainfall show that the models NorESM1-M, BNU-ESM, CMCC-CMS are superior in which NorESM1-M gives the best performance. The annual precipitation pattern of the model NorESM1-M over various areas in Indonesia is also highly correlated with the observations. Thus, the most suitable model for Indonesia region is NorESM1-M. © Published under licence by IOP Publishing Ltd.

关键词： Climate models

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Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma

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Biomedicine and Pharmacotherapy 2023年第1期166卷 115429-115429页

作者： Hsieh, Chiao-Hui Huang, Chen-Tsung Cheng, Yi-Sheng Hsu, Chun-Hua Hsu, Wen-Ming Chung, Yun-Hsien Liu, Yen-Lin Yang, Tsai-Shan Chien, Chia-Yu Lee, Yu-Hsuan Huang, Hsuan-Cheng Juan, Hsueh-Fen Department of Life Science National Taiwan University Taipei Taiwan Center for Computational and Systems Biology National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Institute of Plant Biology National Taiwan University Taipei Taiwan Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica Taipei Taiwan Department of Agricultural Chemistry National Taiwan University Taipei Taiwan Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine Taipei Taiwan

Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness. Recent investigations have uncovered that phosphoglycerate dehydrogenase (PHGDH), an essential enzyme for de novo serine synthesis, serves as a non-oncogene dependency in high-risk neuroblastoma. In this study, we show that homoharringtonine (HHT) acts as a PHGDH inhibitor, inducing intricate alterations in cellular metabolism, and thus providing an efficient treatment for neuroblastoma. We have experimentally verified the reliance of neuroblastoma on PHGDH and employed molecular docking, thermodynamic evaluations, and X-ray crystallography techniques to determine the bond interactions between HHT and PHGDH. Administering HHT to treat neuroblastoma resulted in effective cell elimination in vitro and tumor reduction in vivo. Metabolite and functional assessments additionally disclosed that HHT treatment suppressed de novo serine synthesis, initiating intricate metabolic reconfiguration and oxidative stress in neuroblastoma. Collectively, these discoveries highlight the potential of targeting PHGDH using HHT as a potent approach for managing high-risk neuroblastoma. © 2023 The Authors

关键词： Computational molecular docking Drug discovery High-risk neuroblastoma Metabolic reprogramming Molecular target therapy Phosphoglycerate dehydrogenase

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FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare

arXiv

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arXiv 2023年

作者： Lekadir, Karim Feragen, Aasa Fofanah, Abdul Joseph Frangi, Alejandro F. Buyx, Alena Emelie, Anais Lara, Andrea Porras, Antonio R. Chan, An-Wen Navarro, Arcadi Glocker, Ben Botwe, Benard O. Khanal, Bishesh Beger, Brigit Wu, Carol C. Cintas, Celia Langlotz, Curtis P. Rueckert, Daniel Mzurikwao, Deogratias Fotiadis, Dimitrios I. Zhussupov, Doszhan Ferrante, Enzo Meijering, Erik Weicken, Eva González, Fabio A. Asselbergs, Folkert W. Prior, Fred Krestin, Gabriel P. Collins, Gary S. Tegenaw, Geletaw S. Kaissis, Georgios Misuraca, Gianluca Tsakou, Gianna Dwivedi, Girish Kondylakis, Haridimos Jayakody, Harsha Woodruf, Henry C. Mayer, Horst Joachim Aerts, Hugo JWL Walsh, Ian Chouvarda, Ioanna Buvat, Irène Tributsch, Isabell Rekik, Islem Duncan, James Kalpathy-Cramer, Jayashree Zahir, Jihad Park, Jinah Mongan, John Gichoya, Judy W. Schnabel, Julia A. Kushibar, Kaisar Riklund, Katrine Mori, Kensaku Marias, Kostas Amugongo, Lameck M. Fromont, Lauren A. Maier-Hein, Lena Alberich, Leonor Cerdá Rittner, Leticia Phiri, Lighton Marrakchi-Kacem, Linda Donoso-Bach, Lluís Martí-Bonmatí, Luis Cardoso, M. Jorge Bobowicz, Maciej Shabani, Mahsa Tsiknakis, Manolis Zuluaga, Maria A. Bielikova, Maria Fritzsche, Marie-Christine Camacho, Marina Linguraru, Marius George Wenzel, Markus De Bruijne, Marleen Tolsgaard, Martin G. Ghassemi, Marzyeh Ashrafuzzaman, Md Goisauf, Melanie Yaqub, Mohammad Abadía, Mónica Cano Mahmoud, Mukhtar M.E. Elattar, Mustafa Rieke, Nicola Papanikolaou, Nikolaos Lazrak, Noussair Díaz, Oliver Salvado, Olivier Pujol, Oriol Sall, Ousmane Guevara, Pamela Gordebeke, Peter Lambin, Philippe Brown, Pieta Abolmaesumi, Purang Dou, Qi Lu, Qinghua Osuala, Richard Nakasi, Rose Zhou, S. Kevin Napel, Sandy Colantonio, Sara Albarqouni, Shadi Joshi, Smriti Carter, Stacy Klein, Stefan Petersen, Steffen E. Aussó, Susanna Awate, Suyash Raviv, Tammy Riklin Cook, Tessa Mutsvangwa, Tinashe E.M. Rogers, Wendy A. Niessen, Wiro J. Puig-Bosch, Xènia Zeng, Yi Mohammed, Yunusa G. Aquino, Yves Saint James Salahuddin, Zohaib Starmans, Martijn P.A. Department de Matemàtiques i Informàtica Universitat de Barcelona Barcelona Spain Barcelona Spain DTU Compute Technical University of Denmark Kgs Lyngby Denmark Department of Mathematics and Computer Science Faculty of Science and Technology Milton Margai Technical University Freetown Sierra Leone Center for Computational Imaging & Simulation Technologies in Biomedicine Schools of Computing and Medicine University of Leeds Leeds United Kingdom Cardiovascular Science and Electronic Engineering Departments KU Leuven Leuven Belgium Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Faculty of Engineering of Systems Informatics and Sciences of Computing Galileo University Guatemala City Guatemala Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Department of Medicine Women’s College Research Institute University of Toronto Toronto Canada Universitat Pompeu Fabra BarcelonaBeta Brain Research Center Barcelona Spain Department of Computing Imperial College London London United Kingdom School of Biomedical & Allied Health Sciences University of Ghana Accra Ghana Department of Midwifery & Radiography School of Health & Psychological Sciences City University of London United Kingdom Kathmandu Nepal European Heart Network Brussels Belgium Department of Thoracic Imaging University of Texas MD Anderson Cancer Center Houston United States IBM Research Africa Nairobi Kenya Departments of Radiology Medicine and Biomedical Data Science Stanford University School of Medicine Stanford United States Institute for AI and Informatics in Medicine Klinikum rechts der Isar Technical University Munich Munich Germany Department of Computing Imperial College London London United Kingdom Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania United Republic of Ioannina Greece Almaty AI Lab Almaty Kazakhstan

Background: Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. In recent years, concerns have been raised about the clinical, technical, ethical and legal risks associated with healthcare AI. To increase adoption in the real world, it is essential that AI technologies are trusted and accepted by patients, clinicians, health organisations and authorities. This paper describes the FUTURE-AI framework as the first international consensus guideline for trustworthy AI in healthcare. Methods: The FUTURE-AI consortium was founded in 2021 and now comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two-year period, the consortium established guiding principles and best practices for trustworthy and deployable AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. Findings: The FUTURE-AI framework was established based on six guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 30 best practices were defined, addressing technical, clinical, socio-ethical and legal dimensions of trustworthy AI. The recommendations cover the entire lifecycle of healthcare AI, from design, development and validation to regulation, deployment, and monitoring. Interpretation: FUTURE-AI is a structured, risk-informed framework which provides guidance for constructing healthcare AI tools that will be trusted, deployed and adopted in real-world clinical practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of healthcare AI. Copyright © 2023, The Authors. All rights

关键词： Clinical research

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Improving Students Skills to Solve Elementary Equations in K-12 programs Using an Intelligent Tutoring System

Improving Students Skills to Solve Elementary Equations in K...

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Frontiers in Education (FIE) Conference

作者： Arcanjo Miguel Mota Lopes José Francisco de Magalhães Netto Ricardo A. L. de Souza Andreza Bastos Mourão Thais Oliveira Almeida Dhanielly P. R. de Lima Post-Graduate Program in Informatics (PPGI) Institute of Computing (IComp) Federal University of Amazonas (UFAM) Manaus AM Brazil Institute of Exact Sciences (ICE) Federal University of Amazonas (UFAM) Manaus AM Brazil University of State of Amazonas (UEA) Post-Graduate Program in Informatics (PPGI) Institute of Computing (IComp) Federal University of Amazonas (UFAM) Manaus AM Brazil Department of Science Computer Federal University of Roraima Boa Vista RR Brazil

ISBN: (数字)9781728117461

ISBN: (纸本)9781728117478

This full paper of research to practice category describes an experiment using an Intelligent Tutoring System to support teaching and learning that evolve solutions of first-degree equations. The difficulties encountered in solving algebra problems can make students consider math and related science a difficult task. We propose a Tutor to promote the learning of this class of problems. In this article, we describe the functioning and architecture of the tutor composed by the Interface, Student Model, Tutorial Strategies and Domain Model. Also, a Virtual Assistant was included to motivate students in the learning process. The tutoring strategies that comprise the tutor are projected from models found in the literature. To approximate the interactions of the tutor with the actions of the teachers, Lev Vygotsky's Concept of Zone Proximal Development was used. The methodology used in this project was the case study applied in a real-life context, obtaining a combination of quantitative and qualitative evidence about technical and pedagogical usability that show the degree of satisfaction of the students regarding the proposed approach.

关键词： Education Mathematical model informatics Abstract algebra Cognition

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Stroke Lesion Detection Using Convolutional Neural Networks

Stroke Lesion Detection Using Convolutional Neural Networks

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2018 International Joint Conference on Neural Networks, IJCNN 2018

作者： Pereira, Danillo Roberto Filho, Pedro P. Rebouças De Rosa, Gustavo Henrique Papa, João Paulo De Albuquerque, Victor Hugo C. Department of Computing São Paulo State University Bauru SP Brazil Federal Institute of Education Science and Technology of Ceará CE Brazil Graduate Program in Applied Informatics University of Fortaleza Fortaleza CE Brazil

ISBN: (纸本)9781509060146

Stroke is an injury that affects the brain tissue, mainly caused by changes in the blood supply to a particular region of the brain. As consequence, some specific functions related to that affected region can be reduced, decreasing the quality of life of the patient. In this work, we deal with the problem of stroke detection in Computed Tomography (CT) images using Convolutional Neural Networks (CNN) optimized by Particle Swarm optimization (PSO). We considered two different kinds of strokes, ischemic and hemorrhagic, as well as making available a public dataset to foster the research related to stroke detection in the human brain. The dataset comprises three different types of images for each case, i.e., the original CT image, one with the segmented cranium and an additional one with the radiological density's map. The results evidenced that CNN's are suitable to deal with stroke detection, obtaining promising results. © 2018 IEEE.

关键词： Convolution

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Valley notch filter in a graphene strain superlattice: a Green’s function and machine learning approach

arXiv

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arXiv 2019年

作者： Torres, V. Silva, P. De, E.A.T. Souza Silva, L.A. Bahamon, D.A. Instituto de Física Universidade Federal Fluminense Niterói Av. Litorânea sn RJ24210-340 Brazil MackGraphe Mackenzie Presbyterian University Rua da Consolação 930 SP01302-907 Brazil School of Computing and Informatics Graduate Program in Electrical Engineering and Computing

The valley transport properties of a superlattice of out-of-plane Gaussians deformations are calculated using a Green’s function and a Machine Learning approach. Our results show that periodicity significantly improves the valley filter capabilities of a single Gaussian deformation, these manifest themselves in the conductance as a sequence by valley filter plateaus. We establish that the physical effect behind the observed valley notch filter is the coupling between counter-propagating transverse modes;the complex relationship between the design parameters of the superlattice and the valley filter effect make difficult to estimate in advance the valley filter potentialities of a given superlattice. With this in mind, we show that a Deep Neural Network can be trained to predict valley transmission with a precision similar to the Green’s function but with much less computational effort. Copyright © 2019, The Authors. All rights reserved.

关键词： Landforms

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Prototype Selection Using Self-Organizing-Maps and Entropy for Overlapped Classes and Imbalanced Data

Prototype Selection Using Self-Organizing-Maps and Entropy f...

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International Joint Conference on Neural Networks

作者： Marcio Rubbo Leandro A. Silva Graduate Program in Electrical Engineering and Computing Mackenzie Presbyterian University Sao Paulo SP Brazil Computing and Informatics Faculty & Graduate Program in Electrical Engineering and Computing Mackenzie Presbyterian University Sao Paulo SP Brazil

The k nearest neighbor (kNN) is a traditional supervised classifier used in data mining tasks. However, when used in real applications, mainly in a dataset with class imbalance or class overlap, kNN suffers with problems in accuracy performance. In this paper, we propose three prototype selection methods using self-organizing maps (SOM) and information entropy to increase the effectiveness of the kNN classifier in datasets with these conditions. The methods, named SOMEntropyKnn, were able to increase the effectiveness of the kNN classifier in all the 14 datasets used in the experiment, increasing the accuracy performance from datasets with imbalance or overlap problems.

关键词： Prototypes Entropy Self-organizing feature maps Neurons Training Information entropy Electrical engineering

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Valley notch filter in a graphene strain superlattice: Green's function and machine learning approach

引用

Physical Review B 2019年第20期100卷 205411-205411页

作者： V. Torres P. Silva E. A. T. de Souza L. A. Silva D. A. Bahamon Instituto de Física Universidade Federal Fluminense Niterói Av. Litorânea sn 24210-340 RJ-Brazil MackGraphe – Graphene and Nano-Materials Research Center Mackenzie Presbyterian University Rua da Consolação 896 01302-907 São Paulo SP Brazil School of Computing and Informatics & Graduate Program in Electrical Engineering and Computing Mackenzie Presbyterian University Rua da Consolação 896 01302-907 São Paulo SP Brazil

The valley transport properties of a superlattice of out-of-plane Gaussian deformations are calculated using a Green's function and a machine learning approach. Our results show that periodicity significantly improves the valley filter capabilities of a single Gaussian deformation; these manifest themselves in the conductance as a sequence by valley filter plateaus. We establish that the physical effect behind the observed valley notch filter is the coupling between counterpropagating transverse modes; the complex relationship between the design parameters of the superlattice and the valley filter effect make it difficult to estimate in advance the valley filter potentialities of a given superlattice. With this in mind, we show that a deep neural network can be trained to predict valley polarization with a precision similar to the Green's function but with much less computational effort.

关键词： Ballistic transport Quantum transport Strain Graphene Landauer formula Machine learning Tight-binding model

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Information hiding based on histogram and pixel pattern

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Journal of Cyber Security and Mobility 2017年第4期6卷 397-425页

作者： Barmawi, Ari Moesriami Pradeka, Deden Informatics Graduate Program School of Computing Telkom University Indonesia

Recently, information exchange using internet is increasing, such that information security is necessary for securing confidential information because it is possible to eavesdrop the information. There are several methods for securing the exchanged information such as was proposed by Rejani et al. Rejani's method can be noiseless in low capacity but noisy in high capacity. In the case of high capacity, it will raise suspicion. This research proposed a method based on histogram and pixel pattern for keeping the stego image noiseless while still keeping the capacity high. Secret information can be embedded into the cover by evaluating the histogram and map the characters used in the secret message to the consecutive intensity in the cover image histogram. The map of the characters is sent to the recipient securely. Using the proposed method there is no pixel value changes during the embedding process. Based on the result of the experiments, it is shown that in noiseless condition, the proposed method has higher embedding capacity than Rejani's especially when using cover image with sizes larger than 128 × 128. Thus, in noiseless condition the embedding capacity using the proposed method is higher than Rejani's method in noiseless condition. © 2018 the Author(s).

关键词： Graphic methods

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