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12th International Symposium on Digital Forensics and Security, ISDFS 2024

作者： Bistene, Jonas Vasconcelos Das Chagas, Clayton Escouper Dos Santos, Anderson Fernandes Pereira De Souza Dias, Gabriela Moutinho Salles, Ronaldo Moreira Defense Engineering Graduate Program Military Institute of Engineering Rio de Janeiro Brazil Military Institute of Engineering Department of Computer Engineering Rio de Janeiro Brazil Ciicesi Estg Polytechnic of Porto Porto Portugal

ISBN: (纸本)9798350330366

The generation and replication of network traffic are essential tasks for testing, analyzing, simulating, and evaluating the behavior and efficiency of systems, protocols, applications, and network services. However, it faces various challenges and limitations when generating or replicating network traffic in a realistic, responsive, and scalable manner, using appropriate models. This work proposes a modeling of a program for generating and replicating network traffic, called Forensic Training Traffic Generator (ForTT-Gen), aims to address the challenge associated with generating and replicating network traffic generated by malware by creating files that can be used in the analysis of network packets inherent to forensic analysts' training. ForTT-Gen is a tool that can generate and replicate network traffic using a hybrid model that combines the replication of real data and the generation of synthetic data through statistical techniques. Experimental results demonstrate the model's ability to reliably. Accurately reproducing the statistical patterns of the original traffic, is evidenced by a determination coefficient of 1 and a Pearson coefficient of 0.9, all within a 0,58 confidence interval with 95% certainty. © 2024 IEEE.

关键词： Malware

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Exploring 3D Reconstruction with Drone Images: Advances and Challenges in Urban Environments 50

Exploring 3D Reconstruction with Drone Images: Advances and ...

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50th Annual Conference of the IEEE Industrial Electronics Society, IECON 2024

作者： Miranda Baldivieso, Thiago João da Silva Batista, Taise Grazielle Chagas, Fabio Suim Rodrigues Velho, Luiz Carlos Pacheco Ferreira Rosa, Paulo Fernando Defense Engineering Graduate Program Military Institute of Engineering Rio de Janeiro Brazil State Institute of the Environment Inea RJ Rio de Janeiro Brazil Department of Science and Industry systems University of South-Eastern Norway Kongsberg Norway Department of Computer Graphics Institute for Pure and Applied Mathematics Rio de Janeiro Brazil Electrical Engineering Graduate Program Military Institute of Engineering Rio de Janeiro Brazil

ISBN: (纸本)9781665464543

This working-in-progress paper aims to present a three-dimensional reconstruction using aerial images in different environments. The experiments were conducted with aircraft in both external and internal settings, starting with image acquisition, followed by the application of specific photogrammetry software-both commercial and open-source-and concluding with a qualitative evaluation of the results. © 2024 IEEE.

关键词： Aerial photography

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Orphan nuclear receptors-induced ALT-associated PML bodies are targets for ALT inhibition

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Nucleic Acids Research 2024年第11期52卷 6472-6489页

作者： Marie Gaela, Venus Hsia, Hsuan-Yu Joseph, Nithila A. Tzeng, Wan-Yi Ting, Pin-Chao Shen, Yi-Ling Tsai, Chia-Tsen Boudier, Thomas Chen, Liuh-Yow Molecular and Cell Biology Taiwan International Graduate Program Academia Sinica Graduate Institute of Life Sciences National Defense Medical Center Taipei 11529 Taiwan Institute of Molecular Biology Academia Sinica Taipei 11529 Taiwan Insitute of Molecular and Cellular Biology National Taiwan University Taipei 106319 Taiwan Department and Graduate Institute of Microbiology and Immunology National Defense Medical Center Taipei 11490 Taiwan CENTURI multi-engineering platform Aix-Marseille Université Marseille 13288 France

Orphan nuclear receptors (NRs), such as COUP-TF1, COUP-TF2, EAR2, TR2 and TR4, are implicated in telomerase-negative cancers that maintain their telomeres through the alternative lengthening of telomeres (ALT) mechanism. However, how telomere association of orphan NRs is involved in ALT activation remains unclear. Here, we demonstrate that telomeric tethering of orphan NRs in human fibroblasts initiates formation of ALT-associated PML bodies (APBs) and features of ALT activity, including ALT telomere DNA synthesis, telomere sister chromatid exchange, and telomeric C-circle generation, suggesting de novo ALT induction. Overexpression of orphan NRs exacerbates ALT phenotypes in ALT cells, while their depletion limits ALT. Orphan NRs initiate ALT via the zinc finger protein 827, suggesting the involvement of chromatin structure alterations for ALT activation. Furthermore, we found that orphan NRs and deficiency of the ALT suppressor ATRX-DAXX complex operate in concert to promote ALT activation. Moreover, PML depletion by gene knockout or arsenic trioxide treatment inhibited ALT induction in fibroblasts and ALT cancer cells, suggesting that APB formation underlies the orphan NR-induced ALT activation. Importantly, arsenic trioxide administration abolished APB formation and features of ALT activity in ALT cancer cell line-derived mouse xenografts, suggesting its potential for further therapeutic development to treat ALT cancers. © The Author(s) 2024.

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Pathogen inhibition and indication by gelatin nonwoven mats with incorporation of polyphenol derivatives

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RSC Advances 2023年第45期13卷 31602-31615页

作者： Bai, By Meng-Yi Wang, Ting-Teng Chen, Xin-An Wu, Chia-Chun Graduate Institute of Biomedical Engineering and Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology TR-917 AAEON Building No. 43 Keelung Rd. Sec. 4 Da'an Dist. Taiwan Taipei City10607 Taiwan Adjunct Appointment to the National Defense Medical Center Taiwan Taipei11490 Taiwan Institute of Prevention Medicine National Defense Medical Center Taiwan Taipei11490 Taiwan

There is a need for non-pharmaceutical intervention methods that can prevent and indicate the risk of airborne disease spread. In this study, we developed a nonwoven mat based on the polyphenol gallic acid, which can inhibit pathogens growth and also indicate pathogen levels in the surrounding environment. Using nuclear magnetic resonance, Fourier-transform infrared spectroscopy, and high-performance liquid chromatography, we characterized this novel gelatin-based nonwoven mat and investigated the mechanism governing its ability to indicate pathogen levels. We demonstrated that the incorporation of gallic acid serves a vital role in indicating the presence of bacteria, causing the nonwoven mat to change in color from white to brown. We have proposed a plausible mechanism for this color change behavior based on a reaction of gallic acid with components excreted by bacteria, including glutamate, valine, and leucine. The concentrations of these components reflect the bacterial counts, enabling a real-time indication of pathogen levels in the surrounding air. In summary, the nonwoven mat presented herein can serve as an excellent antibacterial agent and as an indicator of nearby bacteria for fabricating personal protection equipment like filtration mask. © 2023 The Royal Society of Chemistry.

关键词： Bacteria

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Fabrication of versatile poly(xylitol sebacate)-co-poly(ethylene glycol) hydrogels through multifunctional crosslinkers and dynamic bonds for wound healing

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Acta Biomaterialia 2023年 170卷 344-359页

作者： Yeh, Ying-Yu Lin, Yi-Yun Wang, Ting-Teng Yeh, Yu-Jia Chiu, Ting-Hsiang Wang, Reuben Bai, Meng-Yi Yeh, Yi-Cheun Institute of Polymer Science and Engineering National Taiwan University Taipei Taiwan Institute of Biomedical Engineering National Taiwan University Taipei Taiwan Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei Taiwan Institute of Food Safety and Health National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan Adjunct Appointment to the Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Program National Taiwan University Taipei Taiwan GIP-TRIAD Master's Degree in Agro-Biomedical Science National Taiwan University Taipei Taiwan

Poly(polyol sebacate) (PPS) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-PEG) has been developed to fabricate PPS-based hydrogels;however, current PXS-co-PEG hydrogels presented limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. Here, we fabricate a new type of PXS-co-PEG hydrogels through the use of multifunctional crosslinkers as well as dynamic bonds. In our design, polyethyleneimine-polydopamine (PEI-PDA) macromers are utilized to crosslink aldehyde-functionalized PXS-co-PEG (APP) through imine bonds and hydrogen bonds. PEI-PDA/APP hydrogels present multiple functional properties (e.g., fluorescent, elastomeric, biodegradable, self-healing, bioadhesive, antioxidant, and antibacterial behaviors). These properties of PEI-PDA/APP hydrogels can be fine-tuned by changing the PDA grafting degrees in the PEI-PDA crosslinkers. Most importantly, PEI-PDA/APP hydrogels are considered promising wound dressings to promote tissue remodeling and prevent bacterial infection in vivo. Taken together, PEI-PDA/APP hydrogels have been demonstrated as versatile biomaterials to provide multiple tailorable properties and desirable functions to expand the utility of PPS-based hydrogels for advanced biomedical applications. Statement of significance: Various strategies have been developed to fabricate poly(polyol sebacate) (PPS)-based hydrogels. However, current PPS-based hydrogels present limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. This work describes that co-engineering crosslinkers and interfacial crosslinking is a promising approach to synthesizing a new type of poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-

关键词： Polyols

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ForTT-Gen: Network Traffic Generator for Malware Forensics Analysis Training

ForTT-Gen: Network Traffic Generator for Malware Forensics A...

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International Symposium on Digital Forensic and Security (ISDFS)

作者： Jonas Vasconcelos Bistene Clayton Escouper das Chagas Anderson Fernandes Pereira dos Santos Gabriela Moutinho de Souza Dias Ronaldo Moreira Salles Defense Engineering Graduate Program Military Institute of Engineering Rio de Janeiro Brazil Department of Computer Engineering Military Institute of Engineering Rio de Janeiro Brazil CIICESI ESTG Polytechnic of Porto Porto Portugal

ISBN: (数字)9798350330366

ISBN: (纸本)9798350330373

关键词： Training Analytical models Systematics Telecommunication traffic Malware Hybrid power systems Generators

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Exploring 3D Reconstruction with Drone Images: Advances and Challenges in Urban Environments

Exploring 3D Reconstruction with Drone Images: Advances and ...

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Annual Conference of Industrial Electronics Society

作者： Thiago João Miranda Baldivieso Taise Grazielle Da Silva Batista Fabio Suim Chagas Luiz Carlos Pacheco Rodrigues Velho Paulo Fernando Ferreira Rosa Defense Engineering Graduate Program Military Institute of Engineering Rio de Janeiro Brazil State Institute of the Environment Inea/RJ Rio de Janeiro Brazil Department of Science and Industry Systems University of South-Eastern Norway Kongsberg Norway Department of Computer Graphics Institute for Pure and Applied Mathematics Rio de Janeiro Brazil Electrical Engineering Graduate Program Military Institute of Engineering Rio de Janeiro Brazil

ISBN: (数字)9781665464543

ISBN: (纸本)9781665464550

This working-in-progress paper aims to present a three-dimensional reconstruction using aerial images in different environments. The experiments were conducted with aircraft in both external and internal settings, starting with image acquisition, followed by the application of specific photogrammetry software—both commercial and open-source—and concluding with a qualitative evaluation of the results.

关键词： Industrial electronics Three-dimensional displays Urban areas Aircraft Image reconstruction Photogrammetry Drones

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Polyelectrolyte-coated liposomes microfluidically assembled in one-step for enhancing cell endocytosis and in-vivo immune responses

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Colloids and Surfaces B: Biointerfaces 2024年 241卷 114030页

作者： Chen, Xin-an Chuang, Chuan-chang Chen, Cheng-cheung Lee, Chia-ying Chin, Chia-ying Young, Jenn-jong Bai, Meng-yi Chuang, Chuan-chung Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei City10607 Taiwan Institute of Preventive Medicine National Defense Medical Center New Taipei City23742 Taiwan Department and Graduate Institute of Microbiology and Immunology National Defense Medical Center Taipei City11490 Taiwan Graduate Institute of Medical Sciences National Defense Medical Center Taipei City11490 Taiwan Adjunct Appointment to the Department of Biomedical Engineering National Defense Medical Center Taipei City11490 Taiwan School of Dentistry and Graduate Institute of Dental Science National Defense Medical Center Taipei City11490 Taiwan Department of dentistry Tri-Service General Hospital Taipei City11490 Taiwan

To enhance the cellular uptake of liposomes, we prepared conventional liposomes with targeting molecules and surface-charged liposomes and evaluated their potential as nano-carriers and vaccine adjuvants by comparing their endocytosis efficiencies using immune cells. Surface-charged liposomes were synthesized via a one-step microfluidic method, which provided a novel, simple, fast, and highly reproducible method for preparing liposomes. Flow cytometry revealed that cationic polyelectrolyte-coated liposomes exhibited higher endocytosis efficiencies (of up to a factor of 100) in A774A.1 cells and JAWs II cells compared with uncoated liposomes or those coated with anionic polyelectrolytes. Positively charged liposomes exhibited some cytotoxicity at quaternary-chitosan coating concentrations higher than 6 mg/mL;however, significantly lower cytotoxicities (by a factor of almost ten) were obtained by protein mixing. Furthermore, BALB/c mice vaccinated with a mixture of Anthrax vaccine adsorbed (AVA) and quaternary chitosan-coated liposomes showed faster and stronger anti-PA IgG inductions compared to those vaccinated with AVA alone, with titers positively correlating with the amount of cationic liposome used. This finding clearly reveals that quaternary chitosan-coated liposomes act as both nano-carriers and vaccine adjuvants that significantly enhance in-vivo immune responses to vaccines with low immunogenicities. © 2024 Elsevier B.V.

关键词： Polyelectrolytes

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Walking Optimization Algorithm for Humanoid Robots Using Genetic Algorithm

Walking Optimization Algorithm for Humanoid Robots Using Gen...

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International Conference on Control, Decision and Information Technologies (CoDIT)

作者： F. S. Chagas L. D. P. de Farias A. A. A. Bechina A. L. L. Ramos P. F. F. Rosa Department of Science and Industry Systems Faculty of Technology Natural Sciences and Maritime Sciences University of South-Eastern Norway Kongsberg Norway Department of Mechanical Engineering Military Institute of Engineering (IME) Rio de Janeiro Brazil Graduate Program in Defense Engineering Military Institute of Engineering (IME) Rio de Janeiro Brazil

ISBN: (数字)9798350373974

ISBN: (纸本)9798350373981

This paper proposes an algorithm to optimize the walking of humanoid robots based on the inverse kinematic model combined with a Genetic Algorithm. The objectives are to improve the sagittal displacement of the robot and reduce possible lateral deviations during a predetermined path. The foot of the humanoid performs a tapered motion, an approximate ellipse. Horizontal and vertical speeds and the angulation of the humanoid trunk are the input parameters of the algorithm. The algorithm utilizes the input information to calculate the inverse kinematics, and then it submits the obtained result to an evaluation function. We develop a virtual simulator and a robotic platform with 14 degrees of freedom to validate the proposed algorithm. We then test a prototype using the best result obtained in the simulations.

关键词： Legged locomotion Humanoid robots Prototypes Kinematics Approximation algorithms Genetics Information technology Biological cells Optimization Genetic algorithms

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A Novel Method for the Fabrication of Antibacterial Stainless Steel with Uniform Silver Dispersions by Silver Nanoparticle/Polyethyleneimine Composites

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Materials 2023年第10期16卷 3719-3719页

作者： Chih, Yu-Kun You, Jhu-Lin Lin, Wei-Hsuan Chang, Yen-Hao Tseng, Chun-Chieh Ger, Ming-Der Graduate School of Defense Science Chung Cheng Institute of Technology National Defense University Taoyuan335 Taiwan Department of Chemical and Materials Engineering Chung Cheng Institute of Technology National Defense University Taoyuan335 Taiwan System Engineering and Technology Program National Chiao Tung University Hsinchu300 Taiwan Combination Medical Device Technology Division Medical Devices and Opto-Electronics Equipment Department Metal Industries Research & Development Centre Kaohsiung821 Taiwan

Only a few studies have so far focused on the addition of silver to SS316L alloys by conventional sintering methods. Unfortunately, the metallurgical process of silver-containing antimicrobial SS is greatly limited due to the extremely low solubility of silver in iron and its tendency to precipitate at the grain boundaries, resulting in an inhomogeneous distribution of the antimicrobial phase and loss of antimicrobial properties. In this work, we present a novel approach to fabricate antibacterial stainless steel 316L by functional polyethyleneimine-glutaraldehyde copolymer (PEI-co-GA/Ag catalyst) composites. PEI is a highly branched cationic polymer, which makes it exhibit very good adhesion on the surface of the substrate. Unlike the effect of the conventional silver mirror reaction, the introduction of functional polymers can effectively improve the adhesion and distribution of Ag particles on the surface of 316LSS. It can be seen from the SEM images that a large number of silver particles are retained and well dispersed in 316LSS after sintering. PEI-co-GA/Ag 316LSS exhibits excellent antimicrobial properties and does not release free silver ions to affect the surrounding environment. Furthermore, the probable mechanism for the influence of the functional composites on the enhancement of adhesion is also proposed. The formation of a large number of hydrogen bonds and van der Waals forces, as well as the negative zeta potential of the 316LSS surface, can effectively enable the formation of a tight attraction between the Cu layer and the surface of 316LSS. These results meet our expectations of designing passive antimicrobial properties on the contact surface of medical devices. © 2023 by the authors.

关键词： Silver nanoparticles

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