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A predictive analytics approach for rational design of nanomedicines with programmable drug release 42

A predictive analytics approach for rational design of nanom...

42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

作者： Mullis, Adam S. Broderick, Scott R. Binnebose, Andrea M. Peroutka-Bigus, Nathan Bellaire, Bryan H. Rajan, Krishna Narasimhan, Balaji Department of Chemical and Biological Engineering Iowa State University United States Department of Materials Design and Innovation University at Buffalo United States Department of Veterinary Microbiology and Preventive Medicine Iowa State University United States Interdepartmental Microbiology Graduate Program Iowa State University United States Nanovaccine Institute Iowa State University United States

ISBN: (纸本)9781510883901

A critical property of antimicrobial-delivering nanoparticles is their ability to control the release kinetics of their payloads. The release kinetics from these nanomedicine formulations is challenging to model from first principles due to interactions between polymer, drug, and nanoparticle properties and a correspondingly large parameter space of properties.1 Common data mining approaches either insufficiently capture nonlinear behavior or obscure interpretation of the structure of the model and dataspace. A multilinear modeling approach is applied to nanoparticle release data to capture nonlinear behavior and reveal design relationships between formulations. Methods: Release kinetics were obtained from polyanhydride nanoparticles encapsulating four antibiotic payloads to build a dataset of 71 formulations with varying copolymer chemistry, encapsulated drug type, and drug loading. Principal component analysis (PCA) and variable importance projection (VIP) were used to identify key polymer, drug, and nanoparticle descriptors that correlated with release kinetics and encapsulation efficiency. A graph theory analysis2 was used to visualize nanoformulation performance in multilinear space and allowed modeling of release behavior. © 2019 Omnipress - All rights reserved.

关键词： Nanoparticles

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Feasibility study of selecting soft components of body armor 8th

Feasibility study of selecting soft components of body armor

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8th International Conference on Key Engineering Materials, ICKEM 2018

作者： Yaiphuak, Thawatchai Wanchat, Sujin Chantarapanich, Nattapon Mechanical and Design Engineering Graduate Program Faculty of Engineering at Sriracha Kasetsart University Thailand Digital Industrial Design and Manufacturing Research Group Department of Mechanical Engineering Faculty of Engineering at Sriracha Kasetsart University Thailand

ISBN: (纸本)9783035713046

A body armor is vital for users in combat filed. Normally, the body armor have two components: soft and hard ones. This paper proposes feasibility assessment technique to evaluate contemporary materials: Kevlar, natural spider silk, and human hair, for making soft component of the body armor. There are four criteria: technical, economic, legal, and operational feasibilities to generate the feasibility assessment matrix. The optimal material in question is human hair which has highest rank at 82%. © 2018 Trans Tech Publications, Switzerland.

关键词： Silk

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Biomechanical Study of Different Femoral Fixation Devices in the Reconstruction of the Medial Patellofemoral Ligament in Porcine Knees

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Revista Brasileira de Ortopedia 2020年第6期55卷 771-777页

作者： Dobke, Lothar Schmechel Bonadiman, João Artur Lopes, Osmar Valadão Saggin, Paulo Renato Israel, Charles Leonardo Spinelli, Leandro De Freitas Knee Surgery Service Instituto de Ortopedia e Traumatologia (IOT) Hospital São Vicente de Paulo (HSVP) Universidade Federal da Fronteira sul (UFFS) Passo Fundo RS Brazil Orthopedics and Traumatology Service Santa Casa de Misericórdia de Porto Alegre Rs Universidade de Passo Fundo RS Brazil Department of Mechanical Engineering Universidade de Passo Fundo Passo Fundo RS Brazil Graduate Program in Design and Manufacturing Processes Universidade de Passo Fundo Passo Fundo RS Brazil Department of Surgical Clinic Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre RS Brazil

Objective: To evaluate different femoral fixation devices for medial patellofemoral ligament reconstruction and compare their effectiveness regarding fixation strength up to failure in porcine knees. Methods: Thirty porcine knees were used, divided into three groups of 10 knees. The removed grafts were dissected from the extensor tendons of porcine feet. In each group, the graft was fixed to the femur with an interference screw, an anchor, or adductor tenodesis. The three methods were subjected to biomechanical tests using a universal Tensile testing machine at a speed of 20 mm/minute. Results: The highest average linear resistance under lateral traction occurred in group 1, screw fixation (185.45 ± 41.22 N), followed by group 2, anchor fixation (152.97 ± 49, 43 N);the lower average was observed in group 3, tenodesis fixation (76.69 ± 18.90 N). According to the fixed error margin (5%), there was a significant difference between groups (p < 0.001);in addition, multiple comparison tests (between group pairs) also showed significant differences. Variability was small, since the variance coefficient was lower than 33.3%. Conclusion: Interference screws in bone tunnels and mountable anchors fixation with high resistance wire are strong enough for femoral fixation in porcine medial patellofemoral ligament reconstruction. Adductor tenodesis, however, was deemed fragile for such purpose. © 2020 Georg Thieme Verlag. All rights reserved.

关键词： animal models biomechanical phenomena joint ligaments orthopedic fixation devices patellofemoral joint suture technique

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Quantum Contextuality Requires Counterfactual Gain

arXiv

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arXiv 2025年

作者： Sagawa, Yuki Hance, Jonte R. Hofmann, Holger F. Ono, Takafumi Program in Advanced Materials Science Faculty of Engineering and Design Kagawa University 2217-20 Hayashi-cho Kagawa Takamatsu761-0396 Japan School of Computing Newcastle University 1 Science Square Newcastle upon TyneNE4 5TG United Kingdom Quantum Engineering Technology Laboratories Department of Electrical and Electronic Engineering University of Bristol Woodland Road BristolBS8 1US United Kingdom Department of Quantum Matter Graduate School of Advanced Science and Engineering Hiroshima University Kagamiyama 1-3-1 Higashi Hiroshima739-8530 Japan

Quantum contextuality, where measurement outcomes depend on the measurement context, implies a failure of classical realism in quantum systems. As recently shown, the transition between measurement contexts can be mapped onto the path that a quantum particle takes through an interferometer. Here, we investigate the relation between contextuality and the counterfactual gain observed in the output ports of such an interferometer when one of the paths is blocked. It is shown that experimental evidence of contextuality can only be obtained when counterfactual gain is observed for a specific combination of blocked path and output port. Using a silicon photonic integrated circuit, we experimentally observe the counterfactual gain for a selection of input states and evaluate the associated evidence for contextuality. The results confirm that contextuality can only be observed in the presence of counterfactual gain. Copyright © 2025, The Authors. All rights reserved.

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Two-dimensional pentagonal material Penta-PdPSe: A first-principle study

arXiv

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arXiv 2021年

作者： Bafekry, Asadolah Fadlallah, M.M. Faraji, M. Shafique, A. Jappor, H.R. Abdolhoseini Sarsari, I. Ang, Yee Sin Ghergherehchi, M. Department of Radiation Application Shahid Beheshti University Tehran*** Iran Department of Physics Faculty of Science Benha University Benha13518 Egypt Micro and Nanotechnology Graduate Program TOBB University of Economics and Technology Sogutozu Caddesi No 43 Sogutozu Ankara06560 Turkey Department of Physics Lahore University of Management Sciences Lahore Pakistan Department of Physics College of Education for Pure Sciences University of Babylon Hilla Iraq Department of Physics Isfahan University of Technology Isfahan84156-83111 Iran Cluster Singapore University of Technology and Design Singapore487372 Singapore Department of Electrical and Computer Engineering Sungkyunkwan University Suwon16419 Korea Republic of

Low-symmetry Penta-PdPSe with intrinsic in-plane anisotropy synthesized successfully [P. Li et al., Adv. Mater., 2102541 (2021)]. Motivated by this experimental discovery, we investigate the structural, mechanical, electronic, optical and thermoelectric properties of PdPSe monolayer via density functional theory calculations. The phonon dispersion, molecular dynamics simulation, the cohesive energy mechanical properties of the penta-PdPSe monolayer is verified to confirm its stability. The phonon spectrum represents a striking gap between the high-frequency and the low-frequency optical branches and an out-of-plane flexure mode with a quadratic dispersion in the long-wavelength limit. The Poisson’s ratio indicates that penta-PdPSe is a brittle monolayer. The pendaPdPSe monolayer is an indirect semiconductor with bandgap of 1.40 (2.07) eV using PBE (HSE06) functional. Optical properties simulation suggests that PdPSe is capable of absorbing a substantial range of visible to ultraviolet light. Band alignment analysis also reveals the compatibility of PdPSe for water splitting photocatalysis application. By combining the electrical and thermal transport properties of PdPSe, we show that a high PF is achievable at room temperature, thus making PdPSe a candidate material for thermoelectric application. Our findings reveal the strong potential of penta-PdPSe monolayer for a wide array of applications, including optoelectronic, water splitting and thermoelectric device applications. © 2021, CC BY.

关键词： Monolayers

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Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education

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iScience 2025年第6期28卷

作者： Ilinca I. Ciubotariu Tamaki Kobayashi Crystal J. Neely Daniel Fiifi Tawia Hagan David Ewusi-Mensah David Van Vactor Elizabeth C. Whipple Emma Camacho Gautam Ghosh Heather M. Lamb Isaac Owusu-Frimpong James Alltop Julia D. Romano Kristen Kelly Lindsay Smith Rogers Lymari Morales Matthew Seibel Roshni Rao Soumia Bekka William T. Mills Gundula Bosch Doctoral and Postdoctoral Life Design Johns Hopkins University Baltimore MD USA Department of Environment Ghent University Ghent Belgium Eco Amet Solutions Limited Accra Ghana Green Living Chats Podcast Accra Ghana Blavatnik Institute of Cell Biology Harvard Medical School Boston MA USA Biological and Biomedical Sciences Graduate Program Harvard Medical School Boston MA USA Informationist Services Welch Medical Library Johns Hopkins University Baltimore MD USA Ohio State Biochemistry Program The Ohio State University Columbus OH USA Department of Molecular Microbiology and Immunology Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA Communications and Marketing Office of External Affairs Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA Department of Science Mount St. Mary’s University Emmitsburg MD USA

The R 3 Center for Innovation in Science Education (R 3 ISE), established at Johns Hopkins Bloomberg School of Public Health, addresses critical gaps in scientific education by instilling the core values of rigorous research, reproducible methods, and scientific responsibility in our students. Through graduate- and professional-level courses, certificate programs, workshops, and open-access resources, R 3 ISE fosters critical thinking, communication, leadership, and other skills essential for scientists. In this Backstory piece, faculty, students, alumni, and network partners reflect on their experiences with R 3 ISE, which were highlighted in the past year’s annual symposium. In this symposium, themes such as ethical leadership, translating classroom theory into practice, and strategies to combat misinformation highlighted R 3 ISE sustained efforts and proposed further directions. These reflections exemplify how the R 3 ISE community continues to grow—fostering scientific integrity, resilience, and empathy within a global network committed to excellence and responsibility in the biomedical sciences.

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Forecasting Lumpy Demand for Planning Inventory: The Case of Community Hospitals in Thailand

Forecasting Lumpy Demand for Planning Inventory: The Case of...

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IEEE International Conference on Industrial Engineering and Engineering Management

作者： P. Kalaya P. Termsuksawad T. Wasusri Integrated Product Design and Manufacturing Program School of Energy Environment and Materials King Mongkut's University of Technology Thonburi Thailand Graduate School of Management and Innovation King Mongkut's University of Technology Thonburi Bangkok Thailand

The pattern of lumpy demand affects the healthcare industry such as small community hospitals which encounter sporadic demands of slow-moving medicines. The objective of this work aimed to study performance of forecasting methods for inventory planning. This work compared two forecasting methods: Croston(CR) and the Teunter, Syntetos, and Babai's (TSB) methods. Furthermore, this work proposed a combination of Exponential and Poisson distribution and the use of average inter-demand interval combining with average demand to forecast lumpy demand. It assumed that amount of on-hand inventory would be equal to forecasting values. Mean square error (MSE) and number of shortage period were used as performance indicators of these methods. The simulation used 2 types of vital medicines, obtained from the community hospital in Mae Hong Son province from January 2015 to December 2017. The results from CR and TSB methods provided lower MSEs when the smoothing constants were unchanged until 12 weeks. Meanwhile, adjusting the smoothing constants every 4 weeks provided lower shortages. Meanwhile, the other two proposed methods led to lower shortages comparing with those of CR and TSB methods.

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Modeling crystallographic anisotropy in interfacial sliding phenomenon in nanoindentation of nanoscale Cu/Nb accumulated rolling bonding (ARB) multilayered materials

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AIP Conference Proceedings 2023年第1期2594卷

作者： A. S. Budiman R. Sahay F. E. Gunawan C. Harito H. Gunawan I. Radchenko E. Navarro S. Escoubas T. Cornelius O. Thomas N. Raghavan Industrial Engineering Department BINUS Graduate Program – Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia Xtreme Materials Lab Engineering Product Development Singapore University of Technology and Design (SUTD) Singapore Industrial Engineering Department Faculty of Engineering Bina Nusantara University Jakarta Indonesia 11480 Center for Advancing Materials Performance from the Nanoscale (CAMP-nano) State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University (XJTU) Xi'an China Aix-Marseille Université CNRS IM2NP UMR 7334 Marseille France

Nanoindentation is widely used to investigate mechanical properties of materials at small scales. In this work, owing to the presence of contrasting interfaces along rolling (RD) and transverse direction (TD), a 16 nm accumulative roll bonding (ARB) Cu/Nb nanolaminate as a test material due to its crystallographic anisotropy was used. Nanoindentation was performed and then Scanning Probe Microscopy (SPM) data was conducted to measure the pile-up height along RD and TD in the nanoscale Cu/Nb multilayered materials. It was found that the 16 nm Cu/Nb ARB nanolayered material along RD showed higher surface pile-up than TD attributed the observation to the variation in the Cu/Nb interface plasticity along RD and TD. Further, a comparation and validation of experimental indentation data by performing 2D axisymmetric Finite Element Analysis (FEA) indicated that the simulation compares well with the experimentally generated load-displacement curves, while qualitative agreement was obtained with the pileup data. It is believed that the characterization of surface pile-up is very important for enabling the nanoscale Cu/Nb ARB nanolaminates as the novel stretchable/flexible metallic conductor materials (with emerging applications such as e-skins, human-computer interaction, and soft robotics) that may prove crucial for the global green and sustainability efforts (soft robots for collecting plastic trashes in ocean).

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Recruitment and retention strategies for community-based longitudinal studies in diverse urban neighborhoods

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JMIR Formative Research 2021年第3期5卷 e18591页

作者： Ferris, Emily B. Wyka, Katarzyna Evenson, Kelly R. Dorn, Joan M. Thorpe, Lorna Catellier, Diane Huang, Terry T.-K. Center for Systems and Community Design Graduate School of Public Health and Health Policy City University of New York New York NY United States Department of Epidemiology Gillings School of Global Public Health University of North Carolina Chapel Hill NC United States Sophie Davis Biomedical Education Program City University of New York School of Medicine New York NY United States Department of Population Health School of Medicine New York University New York NY United States Research Triangle Institute Research Triangle Park Durham NC United States

Longitudinal, natural experiments provide an ideal evaluation approach to better understand the impact of built environment interventions on community health outcomes, particularly health disparities. As there are many participant engagement challenges inherent in the design of large-scale community-based studies, adaptive and iterative participant engagement strategies are critical. This paper shares practical lessons learned from the Physical Activity and Redesigned Community Spaces (PARCS) study, which is an evaluation of the impact of a citywide park renovation initiative on physical activity, psychosocial health, and community well-being. The PARCS study, although ongoing, has developed several approaches to improve participant engagement: building trust with communities, adapting the study protocol to meet participants’ needs and to reflect their capacity for participation, operational flexibility, and developing tracking systems. These strategies may help researchers anticipate and respond to participant engagement challenges in community-based studies, particularly in low-income communities of color. © Emily B Ferris, Katarzyna Wyka, Kelly R Evenson, Joan M Dorn, Lorna Thorpe, Diane Catellier, Terry T-K Huang.

关键词： Built environment intervention Community-based Health disparities Natural experiment Participant engagement Study adaptations

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Dynamic analysis and multi-objective optimization of an integrated solar energy system for Zero-Energy residential complexes

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Energy Conversion and Management 2025年 341卷

作者： Saleh Mobayen Ehsanolah Assareh Ali Dezhdar Siamak Hoseinzadeh Davide Astiaso Garcia Graduate School of Intelligent Data Science National Yunlin University of Science and Technology Douliu Yunlin 640301 Taiwan Built Environment and Engineering Program College of Sport Health and Engineering (CoSHE) Victoria University Melbourne Australia Strategic Research Institute (SRI) Asia Pacific University of Technology and Innovation (APU) Technology Park Malaysia Kuala Lumpur Malaysia Department of Renewable Energy Technology Materials and Energy Research Center Dezful Branch Islamic Azad University Dezful Iran Department of Planning Design Technology of Architecture Sapienza University of Rome Via Flaminia 72 00196 Rome Italy Department of Astronautical Electrical and Energy Engineering Sapienza University of Rome Via Eudossiana 18 Rome Italy

This study introduces and evaluates a novel, integrated solar energy system for achieving sustainable and zero-energy residential buildings. The proposed system integrates photovoltaic-thermal (PVT) solar panels, heat pumps, electrolyzers, fuel cells, reverse osmosis desalination units, and thermal storage tanks to simultaneously supply electricity, heating, cooling, and potable water. A primary challenge in solar energy systems—the intermittency of energy production—is addressed using energy storage solutions, including hydrogen-based electrolysis and fuel cell systems, which stabilize the supply across day-night cycles. The energy system is designed to meet the energy demands of a 160-unit residential complex in San Diego, each unit covering 110 m 2 . A dynamic simulation over an entire year is performed using TRNSYS software. System optimization is conducted via Response Surface Methodology (RSM), targeting three objective functions: total power capacity, life cycle cost (LCC), and thermal comfort represented by the predicted percentage dissatisfied (PPD) index. Optimization system is based on five key decision variables: solar PVT area, fuel cell capacity, electrolyzer capacity, heat pump capacity, and hydrogen tank size. Results demonstrate that, under optimized configurations, the system achieves an annual electricity output of 29,145.8 kWh/year, an LCC of $894,228, and a PPD index of 6.8 %, fully meeting the residential complex’s electricity demand of 200 MWh/year. The results validate the effectiveness of the hybrid system in enhancing efficiency, ensuring system reliability, and mitigating environmental impacts, thus offering a scalable solution for zero-energy building applications.

关键词： Building Energy Solar PVT Panels Fuel Cell Heat Pump Multi-Objective Optimization

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