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The role of input imaging combination and ADC threshold on segmentation of acute ischemic stroke lesion using U-Net

European Radiology 2023年第9期33卷 6157-6167页

作者： Li, Ya-Hui Lin, Shao-Chieh Chung, Hsiao-Wen Chang, Chia-Ching Peng, Hsu-Hsia Huang, Teng-Yi Shen, Wu-Chung Tsai, Chon-Haw Lo, Yu-Chien Lee, Tung-Yang Juan, Cheng-Hsuan Juan, Cheng-En Chang, Hing-Chiu Liu, Yi-Jui Juan, Chun-Jung Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital No. 199 Sec. 1 Xinglong Rd. Zhubei City Hsinchu County 302 Hsinchu Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Department of Management Science National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Radiology School of Medicine College of Medicine China Medical University Taichung Taiwan Department of Medical Imaging Medical University Hospital Taichung Taiwan Department of Neurology China Medical University Hospital Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Department of Automatic Control Engineering Feng Chia University No. 100 Wenhwa Rd. Seatwen Taichung 40724 Taiwan Department of Biomedical Engineering The Chinese University of Hong Kong ERB1112 11/F William M.W. Mong Engineering Building N.T Shatin Hong Kong Multi-Scale Medical Robotics Center The Chinese University of Hong Kong N.T Shatin Hong Kong Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan

Background: To evaluate the effect of the weighting of input imaging combo and ADC threshold on the performance of the U-Net and to find an optimized input imaging combo and ADC threshold in segmenting acute ischemic stroke (AIS) lesion. Methods: This study retrospectively enrolled a total of 212 patients having AIS. Four combos, including ADC-ADC-ADC (AAA), DWI-ADC-ADC (DAA), DWI-DWI-ADC (DDA), and DWI-DWI-DWI (DDD), were used as input images, respectively. Three ADC thresholds including 0.6, 0.8 and 1.8 × 10^–3 mm²/s were applied. Dice similarity coefficient (DSC) was used to evaluate the segmentation performance of U-Nets. Nonparametric Kruskal–Wallis test with Tukey–Kramer post-hoc tests were used for comparison. A p <.05 was considered statistically significant. Results: The DSC significantly varied among different combos of images and different ADC thresholds. Hybrid U-Nets outperformed uniform U-Nets at ADC thresholds of 0.6 × 10^–3 mm²/s and 0.8 × 10^–3 mm²/s (p <.001). The U-Net with imaging combo of DDD had segmentation performance similar to hybrid U-Nets at an ADC threshold of 1.8 × 10^–3 mm²/s (p =.062 to 1). The U-Net using the imaging combo of DAA at the ADC threshold of 0.6 × 10^–3 mm²/s achieved the highest DSC in the segmentation of AIS lesion. Conclusions: The segmentation performance of U-Net for AIS varies among the input imaging combos and ADC thresholds. The U-Net is optimized by choosing the imaging combo of DAA at an ADC threshold of 0.6 × 10^–3 mm²/s in segmentating AIS lesion with highest DSC. Key Points: • Segmentation performance of U-Net for AIS differs among input imaging combos. • Segmentation performance of U-Net for AIS differs among ADC thresholds. • U-Net is optimized using DAA with ADC = 0.6 × 10^–3mm²/s. © 2023, The Author(s), under exclusive licence to European Society of Radiology.

关键词： Deep Learning Diffusion Magnetic Resonance Imaging Ischemic Stroke Neural Networks, Computer Retrospective Study

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Robot Hand Interaction Using Plastic Deformation Control with Inner Position Loop

Robot Hand Interaction Using Plastic Deformation Control wit...

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IEEE/ASME (AIM) International Conference on Advanced Intelligent Mechatronics

作者： Kenichi Murakami Koki Ishimoto Taku Senoo Masatoshi Ishikawa Data Science Research Division Information Technology Center The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo Japan Department of Information Physics and Computing The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo Japan Electrical Systems and Control Engineering Program Graduate School of Advanced Science and Engineering Hiroshima University 1-4-1 Kagamiyama Higashi-Hiroshima City Hiroshima Japan

ISBN: (数字)9781728167947

ISBN: (纸本)9781728167954

In this study, the inner position loop addition for plastic deformation control of the error robustness of the model and actual parameters is proposed. The inner position loop is a type of position feedback control based on the estimation of model parameters and dynamics of robots. This position control system with proportional and derivative gains modifies the trajectory of the end effector close to the desired trajectory. The robustness of the proposed control scheme is evaluated by comparing it with plastic deformation control without an inner position loop in both simulation and actual environments. Finally, the stable reaction with the proposed control is demonstrated for the case where a human pushes the robot finger.

关键词： Strain Plastics Force Deformable models Robots Friction Trajectory

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Determination of NLO Properties from Molecule to Polymer:the Prospective Role of the Elongation Method with Parallelization Technique

Determination of NLO Properties from Molecule to Polymer:the...

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中国化学会第二十五届学术年会

作者： Takeshi Nanri Kazuaki Murakami Petascale System Interconnect （PSI） Project Laboratory Kyushu Univeristy-Computing ＆ Communication Center 3-8-33-710 Momochihama Sawara-ku Fukuoka 814-0001 Japan Petascale System Interconnect （PSI） Project Laboratory Kyushu Univeristy -Computing ＆ Communication Center 3-8-33-710 Momochihama Sawara-ku Fukuoka 814-0001 Japan Department of Informatics Graduate School of Information Science and Electrical Engineering Kyushu University 6-1 Kasuga-koen KasugaFukuoka 816-8580 Japan

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Preliminary Design for Reference tracking feedback for Medical Cyber-Physical Pharmacokinetic Systems

Preliminary Design for Reference tracking feedback for Medic...

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IEEE International Conference on Automatica (ICA-ACCA)

作者： Pedro M. Oliveira Daniel Bustos Rodolfo Lobo Márcio J. Lacerda Jonathan M. Palma Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil Dept. of Translational Medicine Universidad Católica del Maule Talca Chile Ingenieria en Telecomunicaciones e Informática Universidad Diego Portales Santiago Chile Centre for Communications Technology School of Computing and Digital Media London Metropolitan University London UK Faculty of Engineering Universidad de Talca Curicó Chile

ISBN: (数字)9798350378115

ISBN: (纸本)9798350378122

This paper addresses the reference tracking control problem for Medical Cyber-Physical Systems (MCPS). The control theory is employed to guarantee the suitable concentration of drugs in the body of patients to guarantee a safe treatment. The MCPS is modeled as a switched system, and the modes consider the different scenarios for the problem. A discrete-time model is utilized for the pharmacokinetic process, and the zero input control strategy is employed to design state-feedback controllers with a guaranteed exponential convergence rate. A numerical experiment is presented to illustrate the validity and effectiveness of our method.

关键词： Drugs Switched systems Design methodology Process control Medical services Cyber-physical systems Numerical models Control theory Pharmacokinetics Convergence

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Augmented Reality Based Brain Tumor 3D Visualization

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Procedia Computer Science 2017年 113卷 400-407页

作者： Qian Shan Thomas E. Doyle Reza Samavi Mona Al-Rei Department of Computing and Software McMaster University 1280 Main St. W Hamilton ON L8S 4L8 Canada Department of Electrical and Computer Engineering School of Biomedical Engineering McMaster University 1280 Main St. W Hamilton ON L8S 4L8 Canada eHealth Graduate Program McMaster University 1280 Main St. W Hamilton ON L8S 4L8 Canada

In this paper we present an augmented reality system for mobile devices that facilitates 3D brain tumor visualization in real time. The system uses facial features to track the subject in the scene. The system performs camera calibration based on the face size of the subject, instead of the common approach of using a number of chessboard images to calibrate the camera every time the application is installed on a new device. Camera 3D pose estimation is performed by finding its position and orientation based on a set of 3D points and their corresponding 2D projections. According to the estimated camera pose, a reconstructed brain tumor model is displayed at the same location as the subject’s real anatomy. The results of our experiment show the system was successful in performing the brain tumor augmentation in real time with a reprojection accuracy of 97%.

关键词： Augmented reality 3D visualization Tumor visualization Markerless tracking Mobile device

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Fair Patient Model: Mitigating Bias in the Patient Representation Learned from the Electronic Health Records

arXiv

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arXiv 2023年

作者： Sivarajkumar, Sonish Huang, Yufei Wang, Yanshan Intelligent Systems Program School of Computing and Information University of Pittsburgh PittsburghPA United States Department of Electrical and Computer Engineering University of Pittsburgh PittsburghPA United States Department of Health Information Management University of Pittsburgh PittsburghPA United States Department of Biomedical Informatics University of Pittsburgh PittsburghPA United States Clinical and Translational Science Institute University of Pittsburgh PittsburghPA United States

Objective: To pre-train fair and unbiased patient representations from Electronic Health Records (EHRs) using a novel weighted loss function that reduces bias and improves fairness in deep representation learning models. Methods: We defined a new loss function, called weighted loss function, in the deep representation learning model to balance the importance of different groups of patients and features. We applied the proposed model, called Fair Patient Model (FPM), to a sample of 34,739 patients from the MIMIC-III dataset and learned patient representations for four clinical outcome prediction tasks. Results: FPM outperformed the baseline models in terms of three fairness metrics: demographic parity, equality of opportunity difference, and equalized odds ratio. FPM also achieved comparable predictive performance with the baselines, with an average accuracy of 0.7912. Feature analysis revealed that FPM captured more information from clinical features than the baselines. Conclusion: FPM is a novel method to pre-train fair and unbiased patient representations from EHR data using a weighted loss function. The learned representations can be used for various downstream tasks in healthcare and can be extended to other domains where bias and fairness are important. Copyright © 2023, The Authors. All rights reserved.

关键词： Deep learning

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Is Attention All You Need for EEG to Predict Neurological Outcomes in Cardiac Arrest?

Is Attention All You Need for EEG to Predict Neurological Ou...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Jefferson Dionisio Muhammad Rizwan Hidetaka Suzuki Kazi Mahmudul Hassan Ingon Chanpornpakdi Lian-Yu Lin Toshihisa Tanaka Che Lin Department of Smart Medicine and Health Informatics National Taiwan University Taipei Taiwan Artificial Intelligence of Things Taiwan International Graduate Program Academia Sinica Taipei Taiwan Tokyo University of Agriculture and Technology Tokyo Japan Department of Emergency and Critical Care Japanese Red Cross Musashino Hospital Tokyo Japan Department of Internal Medicine Division of Cardiology National Taiwan University College of Medicine and Hospital Taipei Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Graduate Institute of Communication Engineering National Taiwan University Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine National Taiwan University Taipei Taiwan

ISBN: (数字)9798350351552

ISBN: (纸本)9798350351569

Sudden cardiac arrest (SCA) poses a significant health challenge, necessitating accurate predictions of neurological outcomes in comatose patients, where good outcomes are defined as the recovery of most cognitive functions. Electroencephalogram (EEG) serves as a valuable biomarker for monitoring neurological states due to its rich, time-dependent information. This study aims to predict neurological outcomes using early EEG data by employing the Transformer model, which leverages multi-headed attention to identify patterns in lengthy sequences such as hour-long EEG recordings. Unlike traditional methods that use subsampled EEG epochs, we utilize the entire EEG sequences, subdivided into time steps, allowing our model to capture detailed temporal patterns via the attention mechanism. Moreover, we trained our proposed model using each EEG recording as an individual data sample but evaluated our model through aggregated patient-wise predictions. This approach allows us to boost the data sample size. Our results demonstrate promising predictive performance, achieving an AUROC of 0.82 and AUPRC of 0.90 on the holdout test set and an AUROC of 0.73 and AUPRC of 0.93 on an external test set with patient-wise predictions. This study highlights the potential of utilizing attention mechanisms to capture important time series progressions across EEG sequences for improving SCA prognosis.

关键词： Attention mechanisms Biological system modeling Time series analysis Cardiac arrest Predictive models Brain modeling Transformers Electroencephalography Data models Recording

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5th International Conference on Variable Neighborhood Search (ICVNS'17)

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Electronic Notes in Discrete Mathematics 2018年 66卷 1-5页

作者： Vitor Nazário Coelho Haroldo Gambini Santos Igor Machado Coelho Puca Huachi Vaz Penna Thays A. Oliveira Marcone Jamilson Freitas Souza Angelo Sifaleras Institute of Computer Science Universidade Federal Fluminense Niterói Brazil Grupo da Causa Humana Ouro Preto Brazil Department of Computing Universidade Federal de Ouro Preto Ouro Preto Brazil Institute of Mathematics Statitics Universidade Estadual do Rio de Janeiro Rio de Janeiro Brazil Graduate Program of the Department of Engineering and Information and Communication Technologies Universitat Pompeu Fabra Barcelona Spain Department of Applied Informatics School of Information Sciences University of Macedonia 156 Egnatia Str. Thessaloniki 54636 Greece

This volume presents selected, peer-reviewed, short papers that were accepted for presentation in the 5th International Conference on Variable Neighborhood Search (ICVNS'17) which was held in Ouro Preto, Brazil, d... 详细信息

关键词： Metaheuristics Variable Neighborhood Search Discrete Optimization Nonlinear optimization

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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Telemedicine with digital video transport system in Asia-Pacific area

Telemedicine with digital video transport system in Asia-Pac...

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International Conference on Advanced Information Networking and Applications (AINA)

作者： N. Nakashima K. Okamura Joon-Soo Hahm Young-Woo Kim H. Mizushima H. Tatsumi Byung-In Moon Ho-Seong Han Yong-Jin Park Jae-Hwa Lee Sung-Kwan Youm Chul-Hee Kang S. Shimizu Department of Medical Informatics Fukuoka Japan Computing and Communications Center Kyushu University Fukuoka Japan Department of Medicine Hanyang University Medical College Seoul South Korea National Cancer Center Research Institute and Hospital Goyang Gyeonggi South Korea National Cancer Center Research Institute Tokyo Japan Signal Transduction & Medicine Graduate School of Medicine Sapporo Medical University Sapporo Japan Department of Surgery and Breast Center Ewha Womans Mokdong Hospital Seoul South Korea Department of Surgery Bundang Hospital Seoul National University Seoul South Korea Division of Electrical and Computer Engineering Hanyang University Seoul South Korea Korea Advanced Research Network Seoul South Korea School of Electrical Engineering Korea University Seoul South Korea Department of Endoscopic Diagnostics and Therapeutics Kyushu University Fukuoka Japan

We have established a medical network in Asia-Pacific area with high-quality moving image on a super broad-banded Internet line since February 2003. Broadcasting real-time surgery and teleconference with medical-quality videos with digital video transport system (DVTS) were so useful to learn surgical techniques and other medical procedures beyond borders. We have conducted 20 events in categories of teleconference (8 times), live transmission of medical procedure (6 times), and remote attendance to scientific medical meetings (6 times) until September 2004. We had teleconferences among 3 countries in APAN-Hawaii in January 2004 (Japan, Korea and USA), and in APAN-Cairns in July 2004 (Japan, Korea and Australia). There have been no serious transmission/ethical problems so far. With these experiences and current achievements, we hope to extend this advanced network system to whole Asia-Pacific countries to share medical skills and knowledge.

关键词： Telemedicine Biomedical imaging Medical diagnostic imaging Teleconferencing Hospitals Network-on-a-chip Biomedical informatics Computer networks Cancer Oncological surgery

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