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Author Correction: The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci

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Nature computational science 2023年第7期3卷 658页

作者： Gengjie Jia Yu Li Xue Zhong Kanix Wang Milton Pividori Rabab Alomairy Aniello Esposito Hatem Ltaief Chikashi Terao Masato Akiyama Koichi Matsuda David E Keyes Hae Kyung Im Takashi Gojobori Yoichiro Kamatani Michiaki Kubo Nancy J Cox James Evans Xin Gao Andrey Rzhetsky Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China. jiagengjie@***. Computational Bioscience Research Center King Abdullah University of Science and Technology Thuwal Saudi Arabia. Computer Science Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia. Department of Computer Science and Engineering The Chinese University of Hong Kong Hong Kong People's Republic of China. Department of Medicine and Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville TN US. Department of Medicine Institute of Genomics and Systems Biology Committee on Genomics Genetics and Systems Biology University of Chicago Chicago IL US. Department of Operations Business Analytics and Information Systems University of Cincinnati Cincinnati OH US. Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA US. Extreme Computing Research Center Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia. College of Computer Science and Engineering University of Jeddah Jeddah Saudi Arabia. HPE HPC/AI EMEA Research Laboratory Bristol UK. RIKEN Center for Integrative Medical Sciences Yokohama Japan. Clinical Research Center Shizuoka General Hospital Shizuoka Japan. Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Ophthalmology Graduate School of Medical Sciences Kyushu University Fukuoka Japan. Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan. Biological and Environmenta

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Search for Gamma-Ray Spectral Lines from Dark Matter Annihilation up to 100 TeV toward the Galactic Center with MAGIC

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Physical Review Letters 2023年第6期130卷 061002-061002页

作者： H. Abe S. Abe V. A. Acciari T. Aniello S. Ansoldi L. A. Antonelli A. Arbet Engels C. Arcaro M. Artero K. Asano D. Baack A. Babić A. Baquero U. Barres de Almeida J. A. Barrio I. Batković J. Baxter J. Becerra González W. Bednarek E. Bernardini M. Bernardos A. Berti J. Besenrieder W. Bhattacharyya C. Bigongiari A. Biland O. Blanch G. Bonnoli Ž. Bošnjak I. Burelli G. Busetto R. Carosi M. Carretero-Castrillo G. Ceribella Y. Chai A. Chilingarian S. Cikota E. Colombo J. L. Contreras J. Cortina S. Covino G. D’Amico V. D’Elia P. Da Vela F. Dazzi A. De Angelis B. De Lotto A. Del Popolo M. Delfino J. Delgado C. Delgado Mendez D. Depaoli F. Di Pierro L. Di Venere E. Do Souto Espiñeira D. Dominis Prester A. Donini D. Dorner M. Doro D. Elsaesser G. Emery V. Fallah Ramazani L. Fariña A. Fattorini L. Font C. Fruck S. Fukami Y. Fukazawa R. J. García López M. Garczarczyk S. Gasparyan M. Gaug J. G. Giesbrecht Paiva N. Giglietto F. Giordano P. Gliwny N. Godinović J. G. Green D. Green D. Hadasch A. Hahn T. Hassan L. Heckmann J. Herrera D. Hrupec M. Hütten R. Imazawa T. Inada R. Iotov K. Ishio I. Jiménez Martínez J. Jormanainen D. Kerszberg Y. Kobayashi H. Kubo J. Kushida A. Lamastra D. Lelas F. Leone E. Lindfors L. Linhoff S. Lombardi F. Longo R. López-Coto M. López-Moya A. López-Oramas S. Loporchio A. Lorini E. Lyard B. Machado de Oliveira Fraga P. Majumdar M. Makariev G. Maneva N. Mang M. Manganaro S. Mangano K. Mannheim M. Mariotti M. Martínez A. Mas Aguilar D. Mazin S. Menchiari S. Mender S. Mićanović D. Miceli T. Miener J. M. Miranda R. Mirzoyan E. Molina H. A. Mondal A. Moralejo D. Morcuende V. Moreno T. Nakamori C. Nanci L. Nava V. Neustroev M. Nievas Rosillo C. Nigro K. Nilsson K. Nishijima T. Njoh Ekoume K. Noda S. Nozaki Y. Ohtani T. Oka J. Otero-Santos S. Paiano M. Palatiello D. Paneque R. Paoletti J. M. Paredes L. Pavletić M. Persic M. Pihet F. Podobnik P. G. Prada Moroni E. Prandini G. Principe C. Priyadarshi I. Puljak W. Rhode M. Ribó J. Rico C. Righi A. Rugliancich N. Sahakyan T. Saito S. Sakurai K. Satalecka F. G. Sat Japanese MAGIC Group: Institute for Cosmic Ray Research (ICRR) The University of Tokyo Kashiwa 277-8582 Chiba Japan Instituto de Astrofísica de Canarias and Departamento de Astrofísica Universidad de La Laguna E-38200 La Laguna Tenerife Spain National Institute for Astrophysics (INAF) I-00136 Rome Italy Università di Udine and INFN Trieste I-33100 Udine Italy Max-Planck-Institut für Physik D-80805 München Germany Università di Padova and INFN I-35131 Padova Italy Institut de Física d’Altes Energies (IFAE) The Barcelona Institute of Science and Technology (BIST) E-08193 Bellaterra (Barcelona) Spain Technische Universität Dortmund D-44221 Dortmund Germany Croatian MAGIC Group: University of Zagreb Faculty of Electrical Engineering and Computing (FER) 10000 Zagreb Croatia IPARCOS Institute and EMFTEL Department Universidad Complutense de Madrid E-28040 Madrid Spain Centro Brasileiro de Pesquisas Físicas (CBPF) 22290-180 URCA Rio de Janeiro (RJ) Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics 90-236 Lodz Poland Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n 18008 Granada Spain Deutsches Elektronen-Synchrotron (DESY) D-15738 Zeuthen Germany ETH Zürich CH-8093 Zürich Switzerland Università di Pisa and INFN Pisa I-56126 Pisa Italy Universitat de Barcelona ICCUB IEEC-UB E-08028 Barcelona Spain Armenian MAGIC Group: A. Alikhanyan National Science Laboratory 0036 Yerevan Armenia Centro de Investigaciones Energéticas Medioambientales y Tecnológicas E-28040 Madrid Spain Department for Physics and Technology University of Bergen Norway INFN MAGIC Group: INFN Sezione di Catania and Dipartimento di Fisica e Astronomia University of Catania I-95123 Catania Italy INFN MAGIC Group: INFN Sezione di Torino and Università degli Studi di Torino I-10125 Torino Italy INFN MAGIC Group: INFN Sezione di Bari and Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari I-70125 Bari Italy

Linelike features in TeV γ rays constitute a “smoking gun” for TeV-scale particle dark matter and new physics. Probing the Galactic Center region with ground-based Cherenkov telescopes enables the search for TeV spectral features in immediate association with a dense dark matter reservoir at a sensitivity out of reach for satellite γ-ray detectors, and direct detection and collider experiments. We report on 223 hours of observations of the Galactic Center region with the MAGIC stereoscopic telescope system reaching γ-ray energies up to 100 TeV. We improved the sensitivity to spectral lines at high energies using large-zenith-angle observations and a novel background modeling method within a maximum-likelihood analysis in the energy domain. No linelike spectral feature is found in our analysis. Therefore, we constrain the cross section for dark matter annihilation into two photons to ⟨σv⟩≲5×10−28 cm3 s−1 at 1 TeV and ⟨σv⟩≲1×10−25 cm3 s−1 at 100 TeV, achieving the best limits to date for a dark matter mass above 20 TeV and a cuspy dark matter profile at the Galactic Center. Finally, we use the derived limits for both cuspy and cored dark matter profiles to constrain supersymmetric wino models.

关键词： Dark matter Gamma ray astronomy Particle dark matter Milky Way Cosmic ray & astroparticle detectors Cosmic rays & astroparticles Electromagnetic radiation astronomy Telescopes

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Multiwavelength study of GRB 201216C using the sub-TeV emission detected by MAGIC 38

Multiwavelength study of GRB 201216C using the sub-TeV emiss...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Fukami, Satoshi Berti, Alessio Loporchio, Serena Nava, Lara Suda, Yusuke Noda, Koji Asano, Katsuaki Bošnjak, Željka Longo, Francesco Jordana-Mitjans, Nuria Melandri, Andrea Mundell, Carole Shrestha, Manisha Steele, Iain Abe, H. Abe, S. Abhir, J. Acciari, V.A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Arbet Engels, A. Arcaro, C. Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. Barres de Almeida, U. Barrio, J.A. Batković, I. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Burelli, I. Busetto, G. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Ceribella, G. Chai, Y. Chilingarian, A. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Del Popolo, A. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Pierro, F. Di Venere, L. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Emery, G. Escudero, J. Fariña, L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukami, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giesbrecht Paiva, J.G. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Grau, R. Green, D. Green, J.G. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hrupec, D. Hütten, M. Imazawa, R. Inada, T. Iotov, R. Ishio, K. Jiménez Martínez, I. Jormanainen, J. Kerszberg, D. Kluge, G.W. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Láinez Lezáun, M. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. Machado de Oliveira Fraga, B. Majumdar, P. Makariev, M. Maneva, G. Mang, N. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Martínez-Chicharro, M. Mas-Aguilar, A. Mazin, D. Menchiari, S. Mender, S. Institute for Particle Physics and Astrophysics ETH Zürich Otto-Stern-Weg 5 Zürich8093 Switzerland Institute for Cosmic Ray Research The University of Tokyo Kashiwanoha 5-1-5 Kashiwa Japan Max Planck Institut for Physics Föhringer Ring 6 Munich Germany INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica Università e del Politecnico di Bari BariI-70125 Italy RomeI-00136 Italy Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan Faculty of Electrical Engineering and Computing University of Zagreb Zagreb Croatia INFN Sezione di Trieste via Valerio 2 Trieste Italy Department of Physics University of Bath Claverton Down BathBA2 7AY United Kingdom INAF-Osservatorio Astronomico di Brera Via E. Bianchi 46 LC MerateI-23807 Italy European Space Agency European Space Astronomy Centre Villanueva de la Canñada Madrid28692 Spain Astrophysics Research Institute Liverpool John Moores University Liverpool Science Park IC2 146 Brownlow HillL3 5RF United Kingdom Steward Observatory University of Arizona 933 North Cherry Avenue TucsonAZ85721-0065 United States The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Università di Udine INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik MünchenD-80805 Germany Università di Padova INFN PadovaI-35131 Italy Bellaterra BarcelonaE-08193 Spain Technische Universität Dortmund DortmundD-44221 Germany Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Pola

Recently, several gamma-ray bursts (GRBs) have been detected in the very-high-energy (VHE) gamma-ray energy range by ground-based gamma-ray experiments such as MAGIC, H.E.S.S., and LHASSO. For some GRBs, the VHE emission is consistent with synchrotron self-Compton (SSC) emission from high-energy electrons accelerated in the forward shock of the relativistic jet. However, more statistics are needed to further constrain the emission models. GRB 201216C is a long bright GRB detected in a broad energy range from radio to VHE. The redshift is estimated to be 1.1, making the GRB the most distant source detected in the VHE energy range. MAGIC started the observation 56 seconds after the GRB was triggered by the Swift-BAT telescope. We performed a detailed analysis and detected the signal with about 6 sigma in the first 20 minutes. MAGIC continued the observation for 2.2 hours on the same night and 4 hours on the next night. No signal was detected later than 40 minutes after the GRB trigger. We have performed modelling of the multi-wavelength emission using the MAGIC data. We analysed simultaneous optical data from Liverpool Telescope with MAGIC and included the results in the modelling. The sub-TeV emission is consistent with the single-zone SSC model in the forward shock. In this presentation, we show the final results of the MAGIC data analysis of GRB 201216C and discuss the emission mechanism of the multi-wavelength data. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Gamma rays

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Abstracts

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JOURNAL OF SPINAL CORD MEDICINE 2021年第SUPPL 1期44卷 S278-S324页

作者： [Anonymous] Department of Medicine Division of Physical Medicine and Rehabilitation University of Toronto Toronto ON CA KITE - Toronto Rehabilitation Institute University Health Network Toronto ON CA Institute for Health Policy Management and Evaluation University of Toronto Toronto ON CA Rehabilitation Sciences Institute University of Toronto Toronto ON CA Institute of Medical Sciences University of Toronto Toronto ON CA. Rehabilitation Sciences Institute University of Toronto ON CA KITE Research Institute-Toronto Rehab-University Health Network Toronto ON CA Physical Therapy Department University of Toronto ON CA Praxis Spinal Cord Institute Vancouver BC Université de Montréal (École de réadaptation) Montreal QC CA Institut de réadaptation Gingras-Linsay-de-Montréal Montreal QC CA Division of Physical Medicine & Rehabilitation Department of Medicine Faculty of Medicine & Dentistry University of Alberta Edmonton AB CA University of Calgary Calgary AB CA Alberta Health Services Centre for Family Medicine Kitchener ON CA McMaster University Department of Family Medicine Hamilton ON CA Dept. of Physical Therapy University of Toronto Toronto ON CA KITE-University Health Network Toronto ON CA Praxis Spinal Cord Institute Vancouver BC CA Center for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS) Quebec City QC CA Dept. of Rehabilitation Laval University Quebec City QC CA Institute of Health Policy Management and Evaluation University of Toronto Toronto ON CA School of Rehabilitation Science University of Saskatchewan Saskatoon SK CA Ontario Neurotrauma Foundation Toronto ON CA Canadian Spinal Research Organization Toronto ON CA CIUSSS du Centre-Sud-de-l ‘Île-de-Montréal (Installation Gingras-Lindsay) Montréal QC CA École de réadaptation Université de Montréal Montréal QC CA First Steps Wellness Centre Regina SK CA Stan Cassidy Centre for Rehabilitation Horizon Health Network Fredericton NB CA Departmen

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26th Annual Computational Neuroscience Meeting (CNS*2017) of the Organization for Computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Galactic transient sources with the Cherenkov Telescope Array Observatory

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Monthly Notices of the Royal Astronomical Society 2025年第1期540卷 205–238页

作者： Abe, K Abe, S Abhir, J Abhishek, A Acero, F Acharyya, A Adam, R Aguasca-Cabot, A Agudo, I Aguirre-Santaella, A Alfaro, J Alfaro, R Alvarez-Crespo, N Alves Batista, R Amans, J-P Amato, E Ambrosi, G Ambrosino, F Angüner, E O Antonelli, L A Aramo, C Arcaro, C Arnesen, T T H Asano, K Ascasibar, Y Aschersleben, J Ashkar, H Augusto Stuani, L Baack, D Backes, M Balazs, C Balbo, M Baquero Larriva, A Barbosa Martins, V Barres de Almeida, U Barrio, J A Barrios-Jiménez, L Batković, I Batzofin, R Baxter, J Becerra González, J Becker Tjus, J Belmont, R Benbow, W Bernete, J Bernlöhr, K Berti, A Bertucci, B Beshley, V Bhattacharjee, P Bhattacharyya, S Bigongiari, C Bissaldi, E Blanch, O Blazek, J Bocchino, F Boisson, C Bolmont, J Bonnoli, G Bonollo, A Bordas, P Bosnjak, Z Bottacini, E Böttcher, M Bradascio, F Bronzini, E Brown, A M Brunelli, G Bulgarelli, A Burelli, I Burger-Scheidlin, C Burmistrov, L Burton, M Buscemi, M Cailleux, J Campoy-Ordaz, A Cantlay, B K Capasso, G Caproni, A Capuzzo-Dolcetta, R Caraveo, P Caroff, S Carosi, A Carosi, R Carquin, E Carrasco, M-S Cascone, E Cassol, F Castaldini, L Castrejon, N Castro-Tirado, A J Cerasole, D Ceribella, G Cerruti, M Chadwick, P M Chaty, S Chen, A W Chernyakova, M Chiavassa, A Chudoba, J Chytka, L Cicciari, G M Cifuentes, A Coimbra Araujo, C H Colapietro, M Conforti, V Contreras, J L Cortina, J Costa, A Costantini, H Cotter, G Cristofari, P Cuevas, O Curtis-Ginsberg, Z D’Aì, A D’Amico, G D’Ammando, F Dai, S Dazzi, F de Bony de Lavergne, M De Caprio, V De Cesare, G De Frondat Laadim, F de Gouveia Dal Pino, E M De Lotto, B De Lucia, M de Martino, D de Menezes, R de Naurois, M de Ona Wilhelmi, E de Souza, V del Peral, L del Valle, M V Delgado, C Dell’aiera, M Della Valle, M della Volpe, D Depaoli, D Devin, J Di Girolamo, T Di Piano, A Di Pierro, F Di Tria, R Di Venere, L Diebold, S Dignam, C Dima, R Dinesh, A Djuvsland, J Dominik, R M Dominis Prester, D Donini, A Dorner, D Dörner, J Doro, M Dubos, C Ducci, L Dwarkadas, V V Ebr, J Eckner, C Egberts, K Einecke, S Elsässer, D Emery Department of Physics Tokai University 4-1-1 Kita-Kaname Hiratsuka Kanagawa 259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Kashiwa Chiba 277-8582 Japan ETH Zürich Institute for Particle Physics and Astrophysics Otto-Stern-Weg 5 CH-8093 Zürich Switzerland INFN and Università degli Studi di Siena Dipartimento di Scienze Fisiche della Terra e dell’Ambiente (DSFTA) Sezione di Fisica Via Roma 56 I-53100 Siena Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM F-91191 Gif-sur-Yvette Cedex France FSLAC IRL 2009 CNRS/IAC E-38205 La Laguna Tenerife Spain University of Alabama Tuscaloosa Department of Physics and Astronomy Gallalee Hall Box 870324 Tuscaloosa AL 35487-0324 USA Université Côte d’Azur Observatoire de la Côte d’Azur CNRS Laboratoire Lagrange UF 06304 Nice France Laboratoire Leprince-Ringuet CNRS/IN2P3 École Polytechnique Institut Polytechnique de Paris F-91120 Palaiseau France Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 E-08028 Barcelona Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n E-18008 Granada Spain Institute for Computational Cosmology and Department of Physics Durham University South Road Durham DH1 3LE UK Pontificia Universidad Católica de Chile Av. Libertador Bernardo O’Higgins 340 8331150 Santiago Chile Universidad Nacional Autónoma de México Delegación Coyoacán 04510 Ciudad de México Mexico IPARCOS-UCM Instituto de Física de Partículas y del Cosmos and EMFTEL Department Universidad Complutense de Madrid E-28040 Madrid Spain Instituto de Física Teórica UAM/CSIC and Departamento de Física Teórica Universidad Autónoma de Madrid c/ Nicolás Cabrera 13-15 Campus de Cantoblanco UAM E-28049 Madrid Spain LUTH GEPI and LERMA Observatoire de Paris Université PSL Université Paris Cité CNRS 5 place Jules Janssen F-92190 Meudon France INAF – Osservatorio

A wide variety of Galactic sources show transient emission at soft and hard X-ray energies: low- and high-mass X-ray binaries containing compact objects, isolated neutron stars exhibiting extreme variability as magnetars as well as pulsar-wind nebulae. Although most of them can show emission up to MeV and/or GeV energies, many have not yet been detected in the TeV domain by Imaging Atmospheric Cherenkov Telescopes. In this paper, we explore the feasibility of detecting new Galactic transients with the Cherenkov Telescope Array Observatory (CTAO) and the prospects for studying them with Target of Opportunity observations. We show that CTAO will likely detect new sources in the TeV regime, such as the massive microquasars in the Cygnus region, low-mass X-ray binaries with low-viewing angle, flaring emission from the Crab pulsar-wind nebula or other novae explosions, among others. Since some of these sources could also exhibit emission at larger time-scales, we additionally test their detectability at longer exposures. We finally discuss the multiwavelength synergies with other instruments and large astronomical facilities.

关键词： binaries: general stars: magnetars novae cataclysmic variables pulsars: general gamma-rays: general

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BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2023年第6期20卷 824-835页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species that is representative of the data obtained in many neuroscience laboratories interested in neuron tracing. Here, we report generated gold standard manual annotations for a subset of the available imaging datasets and quantified tracing quality for 35 automatic tracing algorithms. The goal of generating such a hand-curated diverse dataset is to advance the development of tracing algorithms and enable generalizable benchmarking. Together with image quality features, we pooled the data in an interactive web application that enables users and developers to perform principal component analysis, t-distributed stochastic neighbor embedding, correlation and clustering, visualization of imaging and tracing data, and benchmarking of automatic tracing algorithms in user-defined data subsets. The image quality metrics explain most of the variance in the data, followed by neuromorphological features related to neuron size. We observed that diverse algorithms can provide complementary information to obtain accurate results and developed a method to iteratively combine methods and generate consensus reconstructions. The consensus trees obtained provide estimates of the neuron structure ground truth that typically outperform single algorithms in noisy datasets. However, specific algorithms may outperform the consensus tree strategy in specific imaging conditions. Finally, to aid users in predicting the most accurate automatic tracing results without manual annotations for comparison, we used support vector machine regression to predict reconstruction quality given an image volume and a set of automatic tracings.

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Author Correction: Proton acceleration in thermonuclear nova explosions revealed by gamma rays

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Nature Astronomy 2022年 760页

作者： V. A. Acciari J. Becerra González E. Colombo R. J. García López J. Herrera A. López-Oramas C. Maggio V. Moreno M. Nievas Rosillo J. Otero-Santos G. Vanzo M. Vazquez Acosta S. Ansoldi B. De Lotto A. Donini F. Longo D. Miceli M. Palatiello M. Persic L. A. Antonelli C. Bigongiari S. Covino V. D’Elia F. Dazzi A. Lamastra F. Leone S. Lombardi L. Maraschi L. Nava S. Paiano C. Righi F. G. Saturni A. Stamerra F. Tavecchio A. Tutone A. Biland S. Fukami M. Artero O. Blanch S. M. Colak M. Delfino J. Delgado E. Do Souto Espiñeira L. Fariña Alonso L. Jouvin D. Kerszberg M. Martínez A. Moralejo E. Moretti C. Nigro C. Priyadarshi J. Rico K. Asano D. Hadasch M. Hütten T. Inada Y. Iwamura Y. Kobayashi D. Mazin K. Noda Y. Ohtani T. Saito S. Sakurai J. Sitarek M. Strzys M. Takahashi R. Takeishi M. Teshima I. Vovk D. Baack H. Bökenkamp D. Elsaesser A. Fattorini L. Linhoff S. Mender W. Rhode K. Schmidt A. Babić Ž. Bošnjak S. Cikota A. Baquero J. A. Barrio J. L. Contreras M. V. Fonseca J. Hoang M. López-Moya A. Mas Aguilar T. Miener D. Morcuende P. Peñil U. Barres de Almeida B. Machado de Oliveira Fraga I. Batković M. Bernardos G. Busetto A. De Angelis M. Doro R. López-Coto M. Mallamaci M. Mariotti E. Prandini A. Spolon W. Bednarek P. Gliwny K. Ishio D. Sobczynska L. Bellizzi S. Menchiari J. M. Miranda R. Paoletti S. Truzzi S. Ventura C. Wunderlich E. Bernardini W. Bhattacharyya M. Garczarczyk K. Satalecka A. Arbet Engels A. Berti J. Besenrieder G. Ceribella Y. Chai G. D’Amico C. Fruck J. G. Green D. Green A. Hahn L. Heckmann R. Mirzoyan D. Paneque M. Pihet T. Schweizer D. Strom J. van Scherpenberg M. Will G. Bonnoli R. Carosi P. Da Vela P. G. Prada Moroni A. Rugliancich M. Cerruti E. Molina J. M. Paredes M. Ribó A. Chilingarian J. Cortina C. Delgado Mendez T. Hassan I. Jiménez Martínez A. Del Popolo D. Depaoli F. Di Pierro C. F. Vigorito L. Di Venere N. Giglietto F. Giordano S. Loporchio D. Dominis Prester M. Manganaro S. Mićanović L. Pavletić T. Terzić D. Dorner K. Mannheim B. Schleicher V. Fallah Ramazani J. Jormanainen E. Lindfors Instituto de Astrofísica de Canarias and Dpto. de Astrofísica Universidad de La Laguna La Laguna Tenerife Spain Departament de Física and CERES-IEEC Universitat Autònoma de Barcelona Bellaterra Spain Università di Udine and INFN Trieste Udine Italy International Center for Relativistic Astrophysics (ICRA) Rome Italy Dipartimento di Fisica Università di Trieste Trieste Italy Laboratoire d’Annecy de Physique des Particules (LAPP) CNRS-IN2P3 Annecy Cedex France INAF Trieste and Dept. of Physics and Astronomy University of Bologna Bologna Italy National Institute for Astrophysics (INAF) Rome Italy ETH Zürich Zürich Switzerland Institut de Física d’Altes Energies (IFAE) The Barcelona Institute of Science and Technology (BIST) Bellaterra Barcelona Spain Port d’Informació Científica (PIC) Bellaterra Barcelona Spain Japanese MAGIC Group: Institute for Cosmic Ray Research (ICRR) The University of Tokyo Kashiwa Chiba Japan Max-Planck-Institut für Physik München Germany Technische Universität Dortmund Dortmund Germany Croatian MAGIC Group: University of Zagreb Faculty of Electrical Engineering and Computing (FER) Zagreb Croatia IPARCOS Institute and EMFTEL Department Universidad Complutense de Madrid Madrid Spain Department of Astronomy University of California Berkeley Berkeley CA USA Centro Brasileiro de Pesquisas Físicas (CBPF) Rio de Janeiro RJ Brazil Università di Padova and INFN Padova Italy University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz Poland Università di Siena and INFN Pisa Siena Italy Deutsches Elektronen-Synchrotron (DESY) Zeuthen Germany Department for Physics and Technology University of Bergen Bergen Norway Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada Spain Università di Pisa and INFN Pisa Pisa Italy University of Innsbruck Innsbruck Austria Universitat de Barcelona ICCUB IEEC-UB Barcelona Spain Armenian MAGIC Group: A. Alikhanyan National Science Labo

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Proton acceleration in thermonuclear nova explosions revealed by gamma rays (Apr, 10.1038/s41550-022-01640-z, 2022)

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NATURE ASTRONOMY 2022年第6期6卷 760-760页

作者： Acciari, V. A. Ansoldi, S. Antonelli, L. A. Engels, A. Arbet Artero, M. Asano, K. Baack, D. Babic, A. Baquero, A. de Almeida, U. Barres Barrio, J. A. Batkovic, I. Gonzalez, J. Becerra Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bokenkamp, H. Bonnoli, G. Bosnjak, Z. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colak, S. M. Colombo, E. Contreras, J. L. Cortina, J. Covino, S. D'Amico, G. D'Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Del Popolo, A. Delfino, M. Delgado, J. Mendez, C. Delgado Depaoli, D. Di Pierro, F. Di Venere, L. Espineira, E. Do Souto Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Elsaesser, D. Ramazani, V. Fallah Alonso, L. Farina Fattorini, A. Fonseca, M. V. Font, L. Fruck, C. Fukami, S. Fukazawa, Y. Lopez, R. J. Garcia Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Green, J. G. Green, D. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hutten, M. Inada, T. Ishio, K. Iwamura, Y. Martinez, I. Jimenez Jormanainen, J. Jouvin, L. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. Lopez-Coto, R. Lopez-Moya, M. Lopez-Oramas, A. Loporchio, S. de Oliveira Fraga, B. Machado Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Maraschi, L. Mariotti, M. Martinez, M. Aguilar, A. Mas Mazin, D. Menchiari, S. Mender, S. Micanovic, S. Miceli, D. Miener, T. Miranda, J. M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Nakamori, T. Nava, L. Neustroev, V. Rosillo, M. Nievas Nigro, C. Nilsson, K. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J. M. Pavletic, L. Penil, P. Persic, M. Pihet, M. Moroni, P. G. Prada Prandini, E. Priyadarshi, C. Puljak, I. Rhode, W. Ribo, M. Rico, Universidad de La Laguna Instituto de Astrofísica de Canarias and Departamento de Astrofísica La Laguna Spain (GRID:grid.10041.34) (ISNI:***) Università di Udine and INFN Trieste Udine Italy (GRID:grid.5390.f) (ISNI:0000 0001 2113 062X) International Center for Relativistic Astrophysics (ICRA) Rome Italy (GRID:grid.5390.f) National Institute for Astrophysics (INAF) Rome Italy (GRID:grid.4293.c) (ISNI:0000 0004 1792 8585) Max-Planck-Institut für Physik Munich Germany (GRID:grid.435824.c) (ISNI:0000 0001 2375 0603) The Barcelona Institute of Science and Technology (BIST) Institut de Física d’Altes Energies (IFAE) Barcelona Spain (GRID:grid.473715.3) (ISNI:0000 0004 6475 7299) Japanese MAGIC Group: Institute for Cosmic Ray Research (ICRR) The University of Tokyo Kashiwa Japan (GRID:grid.26999.3d) (ISNI:0000 0001 2151 536X) Technische Universität Dortmund Dortmund Germany (GRID:grid.5675.1) (ISNI:0000 0001 0416 9637) Croatian MAGIC Group: University of Zagreb Faculty of Electrical Engineering and Computing (FER) Zagreb Croatia (GRID:grid.4808.4) (ISNI:0000 0001 0657 4636) Universidad Complutense de Madrid IPARCOS Institute and EMFTEL Department Madrid Spain (GRID:grid.4795.f) (ISNI:0000 0001 2157 7667) Centro Brasileiro de Pesquisas Físicas (CBPF) Rio de Janeiro Brazil (GRID:grid.418228.5) (ISNI:0000 0004 0643 8134) Università di Padova and INFN Padua Italy (GRID:grid.5608.b) (ISNI:0000 0004 1757 3470) University of Lodz Department of Astrophysics Faculty of Physics and Applied Informatics Lodz Poland (GRID:grid.10789.37) (ISNI:0000 0000 9730 2769) Università di Siena and INFN Pisa Siena Italy (GRID:grid.9024.f) (ISNI:0000 0004 1757 4641) Deutsches Elektronen-Synchrotron (DESY) Zeuthen Germany (GRID:grid.7683.a) (ISNI:0000 0004 0492 0453) ETH Zürich Zurich Switzerland (GRID:grid.5801.c) (ISNI:0000 0001 2156 2780) Instituto de Astrofísica de Andalucía-CSIC Granada Spain (GRID:grid.450285.e) (ISNI:0000 0004 1793 7043) Università di Pisa and INFN Pisa Pisa Italy (GRID:grid.5395.

Classical novae are cataclysmic binary star systems in which the matter of a companion star is accreted on a white dwarf1,2. Accumulation of hydrogen in a layer eventually causes a thermonuclear explosion on the surface of the white dwarf3, brightening the white dwarf to ~105 solar luminosities and triggering ejection of the accumulated matter. Novae provide the extreme conditions required to accelerate particles, electrons or protons, to high energies. Here we present the detection of gamma rays by the MAGIC telescopes from the 2021 outburst of RS Ophiuchi, a recurrent nova with a red giant companion, which allowed us to accurately characterize the emission from a nova in the 60 GeV to 250 GeV energy range. The theoretical interpretation of the combined Fermi LAT and MAGIC data suggests that protons are accelerated to hundreds of gigaelectronvolts in the nova shock. Such protons should create bubbles of enhanced cosmic ray density, of the order of 10 pc, from the recurrent *** of the 2021 outburst of the nova RS Oph in very-high-energy gamma rays by the MAGIC telescopes is reported. Investigation of the gamma-ray emission provides evidence for acceleration of protons within the nova shock, which then propagate outwards to create bubbles of enhanced cosmic ray density.

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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