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Contributors to the Lab on a Chip cell and tissue engineering in microsystems special issue

Lab on a Chip 2007年第6期7卷 667-671页

作者： Bhatia, Sangeeta N. Chen, Christoper Bashir, Rashid Beebe, David J. Desai, Tejal Gottwald, Eric Khademhosseini, Ali Langer, Robert S. Piel, Matthieu Takayama, Shuichi Thorsen, Todd Tien, Joe Voldman, Joel Vunjak-Novakovic, Gordana Wu, Mingming Yu, Hanry Massachusetts Institute of Technology Harvard-MIT Division of Health Sciences and Technology Department of Electrical Engineering and Computer Science United States Laboratory for Multiscale Regenerative Technologies United States Department of Innovation University of Pennsylvania Department of Bioengineering United States Cell Biology and Physiology Program Cell Growth and Cancer Program Tissue Microfabrication Laboratory Department of Electrical and Computer Engineering and Biomedical Engineering Purdue University United States Department of Electronics University of Glasgow United Kingdom Department of Physiology and Bioengineering University of California San Francisco CA United States California Institute for Quantitative Biomedical Research UCSF/UC Berkeley Graduate Group in Bioengineering United States Laboratory of Therapeutic Micro and Nanotechnology Institute for Biological Interfaces Germany 3D-Cell Culture Techniques Group Institute for Biological Interfaces Germany Department of Medicine and Health Sciences and Technology Massachusetts Institute of Technology (MIT) United States Institut Curie UMR 144 IC/CNRS France Biomedical Engineering Department University of Michigan United States Department of Biomedical Engineering Macromolecular Science and Engineering Program United States Sibley School of Mechanical and Aerospace Engineering School of Chemical and Molecular Engineering Cornell University United States National University of Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR Singapore

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Guaranteed methods based on constrained zonotopes for set-valued state estimation of nonlinear discrete-time systems

arXiv

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arXiv 2019年

作者： Rego, Brenner S. Raffo, Guilherme V. Scott, Joseph K. Raimondo, Davide M. Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte MG 31270-901 Brazil Department of Electronics Engineering Federal University of Minas Gerais Belo Horizonte MG 31270-901 Brazil Department of Chemical and Biomolecular Engineering Clemson University ClemsonSC United States Department of Electrical Computer and Biomedical Engineering University of Pavia Italy

This paper presents new methods for set-valued state estimation of nonlinear discrete-time systems with unknown-but-bounded uncertainties. A single time step involves propagating an enclosure of the system states through the nonlinear dynamics (prediction), and then enclosing the intersection of this set with a bounded-error measurement (update). When these enclosures are represented by simple sets such as intervals, ellipsoids, parallelotopes, and zonotopes, certain set operations can be very conservative. Yet, using general convex polytopes is much more computationally demanding. To address this, this paper presents two new methods, a mean value extension and a first-order Taylor extension, for efficiently propagating constrained zonotopes through nonlinear mappings. These extend existing methods for zonotopes in a consistent way. Examples show that these extensions yield tighter prediction enclosures than zonotopic estimation methods, while largely retaining the computational benefits of zonotopes. Moreover, they enable tighter update enclosures because constrained zonotopes can represent intersections much more accurately than zonotopes. Copyright © 2019, The Authors. All rights reserved.

关键词： Enclosures

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Characteristics Fluctuation of Sub-3-nm Bulk FinFET Devices Induced by Random Interface Traps

Characteristics Fluctuation of Sub-3-nm Bulk FinFET Devices ...

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IEEE Conference on Nanotechnology

作者： Sekhar Reddy Kola Min-Hui Chuang Yiming Li Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Electronics and Electrical Engineering Institute of Communications Engineering Institute of Biomedical Engineering Institute of Pioneer Semiconductor Innovation Institute of Artificial Intelligence Innovation National Yang Ming Chiao Tung University Hsinchu Taiwan

Three-dimensional (3D) bulk fin-typed field effect transistors (FinFETs) have emerged as key devices that can scale down the technology node beyond 22-nm. However, the scaled devices have created new sources of fluctuation inherent in 3D geometry. The interface trap is one such fluctuation that is caused by the trapping and de-trapping of charge carriers and has an adverse effect on device characteristics and variability. In this work, we study impacts of random interface traps (RITs) on electrical characteristic of bulk FinFETs by using a 3D quantum-mechanically corrected device simulation. RIT position effects on short channel effects (SCEs) are examined with physical governed influence to show the major fluctuations. More than 50% reductions of the RITs-induced characteristic fluctuation of the germanium (Ge) devices are observed, compared with Si devices. The Ge ones can reduce SCE variations and exhibit high immunity to RITs.

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Predicting Microsatellite Instability from Histology Images with Dilated Neighborhood Attention Transformer in Colorectal Cancer

Predicting Microsatellite Instability from Histology Images ...

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IEEE Symposium on Bioinformatics and Bioengineering (BIBE)

作者： Yun-Chi Chen Tung Chao Wimaya Nitya Phandita Tzu-Yu Sun Huai-Zhi Wang Yi-Hsien Hsieh Le-Yin Hsu Che Lin Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University (NTU) Taipei Taiwan College of Bioresources and Agriculture NTU Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University of Science and Technology Taipei Taiwan Graduate Institute of Communication Engineering NTU Taipei Taiwan Data Science Degree Program NTU Taipei Taiwan Department of Electrical Engineering NTU Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine NTU Taipei Taiwan Smart Medicine and Health Informatics Program NTU Taipei Taiwan

ISBN: (数字)9798331518622

ISBN: (纸本)9798331518639

Microsatellite instability (MSI) is a pivotal genetic marker influencing the efficacy of immunotherapy in colorectal cancer. Traditional MSI examination often requires additional genetic or immunohistochemical tests, whereas histology images, widely available in colorectal cancer diagnosis, offer a valuable alternative for MSI prediction. Although Transformer-based models have demonstrated promising outcomes in predicting MSI from histology images, they are hampered by traditional local attention mechanisms that struggle to capture long-range interdependencies and establish a comprehensive global receptive field. In this study, we introduce DiNAT-MSI, a novel framework for histology-based MSI prediction that incorporates the Dilated Neighborhood Attention Transformer (DiNAT). This model enhances global context recognition and substantially expands receptive fields, all without additional computational burden. Our results demonstrate that DiNAT-MSI achieves a superior patientwise AUROC compared to ResNet18 and Swin Transformer, along with commendable explainability. Our work not only illustrates a more accessible diagnostic tool for leveraging histological data but also underscores the potential of Transformerbased models with sophisticated attention designs in advancing precision medicine for colorectal cancer patients.

关键词： Attention mechanisms Histopathology Computational modeling Precision medicine Small satellites Immunotherapy Colorectal cancer Predictive models Transformers Genetics

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A Comparative Study of DeepLabCut and Other Open-Source Pupillometry Data Analysis Algorithms – Which to Choose?

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Machine Graphics and Vision 2024年第2期33卷 77-90页

作者： Badkul, Amitesh Mishra, Sonakshi Kommajosyula, Srinivasa P. Department of Electrical & Electronics Engineering Birla Institute of Technology and Science Hyderabad Campus Jawahar Nagar Hyderabad India Department of Pharmacy Birla Institute of Technology and Science Hyderabad Campus Jawahar Nagar Hyderabad India Ph.D. Program in Computer Science The Graduate Center The City University of New York New YorkNY United States

Pupillometry measures pupil size, and several open-source algorithms are available to analyse pupillometry data. However, only a few studies compared these algorithms’ accuracy and computational resources. This study aims to compare the accuracy of computer vision-based algorithms (Swirski, Starburst, PuRe, ElSe, ExCuSe algorithms) and the machine learning algorithm, DeepLabCut, to the double-blinded human examiners (gold-standard). Training of DeepLabCut with different architectures and a variable number of markers (2-9 markers) was done on an open-source dataset. The duration of training was statistically longer for the ResNet152 model compared to the MobileNet model. The pupil diameters in computer vision-based software such as PuRe, Starburst, and Swirski were statistically different from human measurements. MobileNet 2 and 3 marker models were the closest to the human measurements. In conclusion, this work highlights the efficiency of lower marker models based on MobileNet architecture in DeepLabCut, which consumes fewer computational resources and is more accurate. © 2024 Institute of Information Technology, Warsaw University of Life Sciences - SGGW. All rights reserved.

关键词： Adversarial machine learning

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Identification of D- and L-Phenylalanine Enantiomeric Mixtures by Employing Deep Neural Network Models

SSRN

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SSRN 2023年

作者： Nigdelioglu, Ebru Toprak, Elif Guney Akkurt, Melike Erol Barkana, Duygun Kazanci, Murat Uyaver, Sahin Calik, Nurullah Istanbul Medeniyet University Nanoscience and Nanoengineering Program Graduate School Istanbul Medeniyet University Istanbul34700 Turkey Istanbul Medeniyet University School of Engineering and Natural Sciences Department of Biomedical Engineering Istanbul Turkey Istanbul34700 Turkey Yeditepe University Faculty of Engineering Department of Electrical and Electronics Engineering Kayışdagı Istanbul34755 Turkey Marmara University Faculty of Technology Department of Computer Engineering Maltepe Istanbul34854 Turkey

Phenylalanine is an aromatic essential amino acid that exhibits the tendency to self-aggregate into fibrillar structures in its enantiomerically pure form. This observation was indicated as the underlying mechanism of phenylketonuria, which is a genetic condition associated with various neurological, physical, and developmental issues, characterized with phenylalanine buildup in the brain. The presence of D-phenylalanine was demonstrated previously to inhibit the formation of fibrils by L-phenlyalanine, indicating its potential use in phenylketonuria treatment. In this study, several combinations of D and L-phenylalanine were examined with the help of state-of-the-art deep learning methods for their fibril forming capacity, demonstrating the usefulness and accuracy of deep learning methods in distinguishing between different self-assembled structures. © 2023, The Authors. All rights reserved.

关键词： Self assembly

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Asynchronous Multi-Task Learning Based on One Stage YOLOR Algorithm

Asynchronous Multi-Task Learning Based on One Stage YOLOR Al...

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IEEE International Symposium on Industrial electronics (ISIE)

作者： Cheng-Fu Liou Tsung-Han Lee Jiun-In Guo Graduate Degree Program of College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan Pervasive Artificial Intelligence Research Labs (PAIR Labs) Wistron-NCTU Embedded Artificial Intelligence Research Center Institute of Electronics National Yang Ming Chiao Tung University Hsinchu Taiwan

The You Only Learn One Representation (YOLOR) approach is an object detector that can encode implicit knowledge and explicit knowledge of multiple tasks simultaneously. However, the requirement of jointly feeding data is not a friendly setting for an edge device due to the high computational cost. A better strategy is to learn the concept of the new task on the device individually, one by one, without access to the old data. In other words, the model has to deal with multiple tasks asynchronously. In this work, we extend the multi-purpose network YOLOR to asynchronous multi-task learning to learn domain invariant features, which focus on capturing the relatedness between the weight of the previous task and data of the subsequent task. Further, as the number of tasks gradually increases, we accumulate significant weights by introducing task-specific masks and expert modules; the former can automatically identify important filters to prevent modification caused by new tasks, and the latter address the kernel space misalignment problem to perform multi-task feature selection. We experimentally demonstrate that the proposed training strategy significantly outperforms the traditional solution in learning multiple tasks at different times on a public dataset, which supports that the proposed approach is more competitive for resource-limited edge devices.

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A Security Testbed for Networked DES Control Systems

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IFAC-PapersOnLine 2022年第28期55卷 128-134页

作者： Michel R.C. Alves Karen Rudie Patrícia N. Pena Graduate Program in Electrical Engineering - Universidade Federal de Minas Gerais - Av. Antônio Carlos 6627 31270-901 Belo Horizonte MG Brazil Department of Electrical and Computer Engineering and Ingenuity Labs Research Institute Queen's university Kingston Ontario K7L 3N6 Canada Department of Electronics Engineering - Universidade Federal de Minas Gerais - Av. Antônio Carlos 6627 31270-901 Belo Horizonte MG Brazil

In this paper we present an implementation scheme for a networked control system where the coordination between devices is done by supervisory control theory. The system is intended to be used as a testbed for DES security-related techniques. We provide some examples of attacks whose effect can be evaluated using the proposed setup. The hardware and software are based on low-cost devices and can be modified to suit different control systems. The details of the implementation are available on a free online repository.

关键词： Discrete-Event Systems Supervisory control Deception attacks Networked Control

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Temperature Dependent Anomalous Threshold Voltage Modulation of a-IGZO TFT by Incorporating Variant Gate Stresses

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ECS Journal of Solid State Science and Technology 2024年第6期13卷 065008-065008页

作者： Aslam, Muhammad Chang, Shu-Wei Chen, Yi-Ho Lee, Yao-Jen Li, Yiming Lee, Wen-Hsi Electrical Engineering and Computer Science International Graduate Program National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Department of Electrical Engineering National Cheng Kung University Tainan 701401 Taiwan Graduate Degree Program of College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Institute of Pioneer Semiconductor Innovation Industry Academic Innovation School National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan

Amorphous indium gallium zinc oxide (a-IGZO) has recently made significant advancement as a key material for electronic component design owing to its compatibility with complementary metal oxide semiconductor technologies. A comprehensive analysis of reliability-related issues is required to determine the true potential of a-IGZO-based devices for next-generation electronics applications. To address this objective, we electrically characterize scaled-channel a-IGZO thin film transistors (TFTs) under positive bias (temperature) stress (PB(T)S). Both PBS and PBTS are characterized by positive and negative V_th shift, respectively, during the various gate stresses. In particular, the negative V_th shift is explained by the generation of donor-like traps stimulated by ionization of oxygen vacancy/hydrogen at elevated temperature. The TFTs exhibit relatively decent stability during the PBS operation. The analysis of devices with variant channel dimensions implies that long-channel devices exhibit relatively higher stability and performance compared to the short-channel ones. We also observe that the V_th can be controllably adjusted by employing the top gate (TG) with bottom gate sweep. Moreover, the stress-induced partial recovery mechanism is experimentally observed owing to detrapping of charges. Generally, the reported results infer a perceptive understanding of scaled-channel a-IGZO-TFTs which helps with shaping performance-enhancement strategies. © 2024 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited

关键词： amorphous IGZO-TFT electrical instabilities hydrogen-impact scaling impact on reliability

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Improving project design through process awareness agents

Improving project design through process awareness agents

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International Conference on computer Supported Cooperative Work in Design

作者： A. Vivacqua D. Pinho J. de Souza S. Medeiros Computer Science Program Graduate School of Engineering COPPE DCC/IM-Institute of Mathematics Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil DEL/POLI-Department of Electronics and Computing Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil

We start from a case study of an architecture company and move on to a framework of agents to identify and inform conceptual design. The processes and problems exhibited by the company involved are quite common and can be found in other similar companies. Our intent is to instrument the current process using agent technology, in an effort to improve global awareness during the conceptual design phase, allowing the designers to design so as to facilitate later steps and optimize the process as a whole.

关键词： Process design Companies Design engineering computer science Mathematics computer architecture Instruments Design optimization Feedback Delay

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