检索结果-内蒙古大学图书馆

Picrasidine I Regulates Apoptosis in Melanoma Cell Lines by Activating ERK and JNK Pathways and Suppressing AKT Signaling

引用

Environmental Toxicology 2024年第12期39卷 5309-5320页

作者： Shieu, Mu-Kuei Lin, Chia-Chieh Ho, Hsin-Yu Lo, Yu-Sheng Chuang, Yi-Ching Hsieh, Ming-Ju Department of Dermatology Changhua Christian Hospital Changhua Taiwan Oral Cancer Research Center Changhua Christian Hospital Changhua Taiwan Graduate Institute of Clinical Medicine College of Medicine National Chung Hsing University Taichung Taiwan Doctoral Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan

World Health Organization data indicate a continuous increase in melanoma incidence, with metastatic melanoma characterized by poor prognosis and drug resistance. The exploration of therapeutics derived from natural products remains an active area of in vitro research. The aim of this study was to determine the antitumor effects of picrasidine I, a natural compound extracted from Picrasma quassioides, against two melanoma cell lines. We selected two metastatic melanoma cell lines, HMY-1 and A2058, for molecular studies, including Western blotting, 4′,6-diamidino-2-phenylindole staining, and flow cytometry. Picrasidine I demonstrated cytotoxic effects against the HMY-1 and A2058 melanoma cell lines. It induced cell cycle arrest in the sub-G1 phase and downregulated cell cycle–related proteins (e.g., cyclin A2, D1, cyclin-dependent kinases 4, and 6). In the intrinsic apoptosis pathway, picrasidine I activated proapoptotic proteins (e.g., Bax, Bak, t-Bid, BimL/S) and suppressed the expression of antiapoptotic proteins (e.g., Bcl-2, Bcl-xL), with an observed increase in the quantity of depolarized cells. In addition, the apoptotic effects of picrasidine I were linked to the activation of the c-Jun N-terminal kinase and extracellular signal-regulated kinase pathways and the inhibition of the protein kinase B signaling pathway. A human apoptosis array indicated claspin inhibition upon picrasidine I treatment, suggesting the potential involvement of picrasidine I in apoptosis and cell cycle regulation. Our findings suggest that picrasidine I has potential as a candidate for treating advanced melanoma, and thus these findings warrant further investigation. The modulation of claspin expression by picrasidine I could be investigated further as a potential biomarker to predict its efficacy in related to advanced stages of melanoma. © 2024 The Author(s). Environmental Toxicology published by Wiley Periodicals LLC.

关键词： Dermatology

来源：评论

学校读者我要写书评

暂无评论

Assessing Distributed Energy Resource Hosting Capacity Under Different Grid-Tie Inverter Control Strategies 8

Assessing Distributed Energy Resource Hosting Capacity Under...

引用

8th Workshop on Communication Networks and Power Systems, WCNPS 2023

作者： Santos, Brenda L. M. Barros, Luciano S. Barbosa, Daniel Moreira, Fernando A. Federal University of Bahia Graduate Program in Electrical Engineering Salvador Brazil Federal University of Paraíba Computer Systems Department João Pessoa Brazil Federal University of Bahia Department of Electrical and Computer Engineering Salvador Brazil

ISBN: (纸本)9798350343571

Despite the potential benefits that the integration of distributed energy resources (DERs) can bring to the system, it may cause problems related to power quality constraints, such $as$ reverse power flow in substation and overvoltages. An effective approach to address these problems involves the adoption of reactive and active power control in grid-tie inverters associated with DER. Therefore, this paper assesses the impacts of grid-tie inverter control modes, including both Volt-Var and Volt-Watt strategies, on the DER hosting capacity. In order to improve the overall system operation, modifications in the Volt-Var and Volt-Watt curves were proposed. It is noteworthy that these control strategies can have adverse effects on certain distribution system performance indicators, such $as$ voltage deviation and power losses;for this reason, these indicators are also evaluated in this study. A stochastic approach was adopted to deal with the uncertainties associated with DERs and loads. Finally, from tests conducted in the IEEE 33-bus test system, it was concluded that the proper adjustment of the Volt-Var and Volt-Watt control curves significantly influences DER hosting capacity, $as$ well $as$ voltage deviation and power losses. © 2023 IEEE.

关键词： Reactive power

来源：评论

学校读者我要写书评

暂无评论

The Impact of Total Quality Management and Perceived Service Quality on Patient Satisfaction in Healthcare: A Systematic Review

The Impact of Total Quality Management and Perceived Service...

引用

2022 Advances in Science and engineering Technology International Conferences, ASET 2022

作者： Alshrbaji, Mohammad Mohammed, Maryam Shamayleh, Abdulrahim American University of Sharjah Biomedical Engineering Graduate program College of Engineering Sharjah United Arab Emirates University of Sharjah College of Engineering American Industrial Engineering Department Sharjah United Arab Emirates

ISBN: (纸本)9781665418010

The main goal of Total Quality Management (TQM) and Perceived Service Quality (PSQ) in the healthcare sector is to provide high-quality care to patients to meet their needs and expectation. Even in very unique circumstances like the COVID-19 outbreak, there is a need to evaluate how much the prementioned approaches affect patient satisfaction. However, patient satisfaction requires a proper synchronization between what the patient value and what the management perceives. In addition, there should be a focus on what impact the dimensions of TQM and PCQ have on patient satisfaction. As a result, studies have been conducted to identify what the patients value the most related to PSQ and TQM by designing and distributing questionnaires to a sample of patients and analyzing their responses. In this study, a review is conducted of empirical studies from various databases covering the period between 2008 and 2021. The objective is to analyze the influence of TQM and PSQ dimensions on patient satisfaction in healthcare organizations. © 2022 IEEE.

关键词： Health care

来源：评论

学校读者我要写书评

暂无评论

Impact of Morphological and Structural Properties of Submicron Core-Shell Fe-Silica Particles on High-Current Power Converter Performance in Electronics

引用

ACS Omega 2025年第22期10卷 23387-23396页

作者： Ratnasari, Delyana Septiani, Eka Lutfi Nandiyanto, Asep Bayu Dani Cao, Kiet Le Anh Hirano, Tomoyuki Okuda, Nobuhiro Matsumoto, Hiroyuki Ogi, Takashi Chemical Engineering Program Department of Advanced Science and Engineering Graduate School of Advanced Science and Engineering Hiroshima University 1-4-1 Kagamiyama Hiroshima Higashi-Hiroshima 739-8527 Japan Program Studi Teknik Kimia Fakultas Pendidikan Matematika dan Ilmu Pengetahuan Alam Universitas Pendidikan Indonesia Jl. Setiabudhi No. 229 West Java Bandung 40154 Indonesia Materials Research Center Technology & Intellectual Property HQ TDK Corporation 570-2 Matsugashita Minami-Hadori Chiba Narita 286-8588 Japan

As the demand for energy-efficient solutions grows in industries such as electric vehicles and renewable energy systems, the need for high-current power converters, powder core inductors, has become increasingly critical. These converters are essential for managing the flow of energy while maintaining efficiency under demanding conditions. However, achieving the necessary performance, particularly in terms of energy storage and minimizing energy losses, requires advanced materials with tailored magnetic properties. This study addresses these needs by introducing a novel class of magnetic materials, i.e., submicrometer-sized silica-coated iron (Fe@SiO₂) particles. These particles are produced through a one-step aerosol process, enabling precise control over particle morphology, size, and structural characteristics. The tuned Fe@SiO₂ particles demonstrated improved packing density and saturation current as well as reduced eddy current losses, significantly boosting the stability and efficiency of power converters to meet the demands of modern high-current electronic systems. This research highlights the importance of advanced magnetic materials in the ongoing evolution of power electronics, offering new possibilities for more efficient and reliable power conversion systems in a range of applied electronic technologies. © 2025 The Authors. Published by American Chemical Society.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Resume Recommendation using RNN Classification and Cosine Similarity 7th

Resume Recommendation using RNN Classification and Cosine Si...

引用

7th International Scientific Conference on Intelligent Information Technologies for Industry, IITI 2023

作者： Huseyinov, Ilham Diallo, Issa Raed, Mhd Wasim Software Engineering Department Istanbul Aydin University Istanbul Turkey Graduate Institute of Science Artificial Intelligence and Data Science Program Istanbul Aydin University Istanbul Turkey Computer Engineering Department Istanbul Aydin University Istanbul Turkey

ISBN: (纸本)9783031437885

One way to save time and resources in the human recruitment and hiring process is to post open job positions on the Internet, but the overload of applications creates challenges for hiring managers and companies to select an adequate candidate. One of the solutions is to apply intelligent tools such as Deep Learning and recommender system algorithms to speed up the hiring process and identify the right candidates. In this paper, we propose a two-fold algorithmic approach to 1) building an RNN classifier for resume classification;2) using cosine similarity for resume recommendation to find a candidate that fits job requirements best after selecting all the resumes that belong to the right category. The performance of the proposed RNN classifier is evaluated in terms of accuracy, precision, recall, F1-score, and confusion matrix criteria. The experiment results have shown that the RNN classifier performs better than the other classifiers such as GNB, Linear SVM, RF, and BERT on the same dataset. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

关键词： Recommender systems

来源：评论

学校读者我要写书评

暂无评论

Joint Design of Spirograph Method and Reconfigurable Intelligent Surface for Future Communication Systems

Joint Design of Spirograph Method and Reconfigurable Intelli...

引用

2024 IEEE Global Communications Conference, GLOBECOM 2024

作者： Yafis, Balqis Huang, Jane-Hwa Yu, Chih-Min Wang, Li-Chun National Yang Ming Chiao Tung University Eecs Int'l Graduate Program Hsinchu Taiwan National Chi Nan University Dept. of Electrical Engineering Nantou County Taiwan Chung Yuan Christian University Department of Information and Computer Engineering Taoyuan City Taiwan

ISBN: (纸本)9798350351255

Reconfigurable Intelligent Surface (RIS) is a transformative technology using the passive beamforming capabilities to create the programmable wireless environments. However, the control overhead is a challenging issue. The system needs to deliver the high-precision reflection coefficients to the RIS controller, for adjusting the phase shifts of the numerous RIS elements. Therefore, we propose a Spirograph-based discrete beamdirection strategy, which selects a set of non-uniformly distributed beam directions based on the generic patterns generated by the Spirograph (SG). We evaluate the achievable data rate and the number of controlling bits of SG-based method. We compare the SG-based method, the ideal continuous phase-shift method, and the SISO method. Simulation results show that with the properly-selected discrete beam directions, the SG-based method can achieve a comparable data rate as the ideal method, while having a lower control overhead. © 2024 IEEE.

关键词： Beamforming

来源：评论

学校读者我要写书评

暂无评论

Antibiotic resistant bacteria and genes (ARB and ARG) in water and sewage treatment units: A review

引用

Environmental Nanotechnology, Monitoring and Management 2024年 21卷

作者： Flach, Kauane Andressa Bones, Ubiratan Alegransi Wolff, Delmira Beatriz de Oliveira Silveira, Andressa da Rosa, Genesio Mario Carissimi, Elvis Silvestri, Siara Graduate Program in Environmental Engineering Federal University of Santa Maria Brazil Graduate Program in Environmental Science and Technology Federal University of Santa Maria Brazil

Microorganisms have historically coexisted with humans, animals, and the environment in a natural way. Like any other living being, microorganisms are subjected to environmental pressures that can eventually extinguish or strengthen their existence. In recent years, the emergence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) has raised an alert about their influence on human and animal health. In addition to ARBs found in nosocomial environments, recent studies point to the environment as an auxiliary hotspot for the spread of antimicrobial resistance. In this sense, this review covers research that investigated ARB and ARG in E. coli and Salmonella, occurrence and potential environmental reservoirs for the spread of antimicrobial resistance, as well as a discussion on how bacterial resistance affects public health, the detection and treatment methods currently employed to reduce or remove this pollutant from water treatment plants (WTP) and sewage treatment plants (WWTP). The results indicated that the great increase in bacterial resistance may be linked, among other reasons, to repetitive contact with residual concentrations of antibiotics present in the environment, causing the bacteria to suffer from selective pressure and if resistant to one or more antibiotics. Thus, public health is compromised, since commonly used antibiotics are often ineffective in treating disease-resistant pathogenic bacteria. From this perspective, studies have shown the importance of consistent detection methods, which allow the tracking and analysis of sources of antimicrobial resistance on a global scale, in addition to the need to improve advanced treatment to reduce the ARG and ARB of WTPs and WWTPs. The first two sections of this review article present an overview of the problems related to the occurrence and dissemination of antimicrobial resistance (AMR) in bacteria, with a focus on E. coli and Salmonella, identified by the WHO as bacteria of globa

关键词： Advanced treatments Analytical determination Antimicrobial resistance Environmental compartments Public health

来源：评论

学校读者我要写书评

暂无评论

Performance Evaluation of "XRPIX" Event-Driven SOI Pixel Detector for Cosmic MeV Gamma-ray Observation 38

Performance Evaluation of "XRPIX" Event-Driven SOI Pixel Det...

引用

38th International Cosmic Ray Conference, ICRC 2023

作者： Hashizume, Masaki Suda, Yusuke Fukazawa, Yasushi Tsuru, Takeshi Go Takeda, Ayaki Physics Program Graduate School of Advanced Science and Engineering Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima Hiroshima Japan Kyoto University Graduate School of Science Yoshida-Honmachi Sakyo-ku Kyoto Japan University of Miyazaki Department of Technology 1-1 Gakuen Kibanadai-nishi Miyazaki Japan

Cosmic MeV gamma-ray observations are important for elucidating physics in high-energy objects such as gamma-ray bursts and active galactic nuclear jet blazars, for detecting nuclear gamma-rays in supernova explosions, and for advancing multi-messenger astronomy. However, there has been no progress since the COMPTEL detector on board the CGRO satellites in the 1990s, and a satellite for MeV gamma-ray observations is essential. Compton scattering is the dominant interaction between MeV gamma-rays and matter. The minimal way to reconstruct the arrival direction of an incident gamma-ray is to utilize both the deposit energy and hit position measured in both the scatterer and absorber, giving an event circle. The circle can be reduced to an arc if the initial direction of the Compton scattered electron is measured. Thus such an electron-tracking Compton camera is expected to improve the source sensitivity by reducing background events. Therefore, our goal is to enable more accurate Compton imaging by using an event-driven SOI pixel detector "XRPIX" as a scatterer in an electron-track Compton camera. The pixel size of XRPIX is as small as 36 um square, so it is expected to capture electron trajectories for scattering of gamma-rays of several hundred keV. In this contribution, we report on the evaluation of the depletion layer thickness of XRPIX8.5, which can be fully depleted at room temperature, the sensor response when irradiated with gamma-rays such as 662 keV of Cs-137 and 511 keV of Na-22, and a method for estimating the direction of scattered electrons. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Cosmology

来源：评论

学校读者我要写书评

暂无评论

Neuromodulation of the peripheral nervous system:Bioelectronic technology and prospective developments

引用

BMEMat(BioMedical engineering Materials) 2024年第1期2卷 88-114页

作者： Hayoung Song Moohyun Kim Enji Kim Jakyoung Lee Inhea Jeong Kyeonghee Lim Seoung Young Ryu Myoungjae Oh Younhee Kim Jang-Ung Park Department of Materials Science and Engineering Yonsei UniversitySeoulSouth Korea Center for Nanomedicine Institute for Basic Science(IBS)SeoulSouth Korea Department of Neurosurgery Yonsei University College of MedicineSeoulSouth Korea Graduate Program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoulSouth Korea

The peripheral nervous system(PNS)is a fascinatingly complex and crucial component of the human body,responsible for transmitting vital signals throughout the body's intricate network of *** efficient functioning is paramount to our health,with any dysfunction often resulting in serious medical conditions,including motor disorders,neurological diseases,and psychiatric *** strides in science and technology have made neuromodulation of the PNS a promising avenue for addressing these health *** involves modifying nerve activity using a range of techniques,such as electrical,chemical,optical,and mechanical *** plays a critical role in this effort,allowing for precise,controlled,and sustained stimulation of the *** paper provides an overview of the PNS,discusses the current state of neuromodulation devices,and presents emerging trends in the field,including advances in wireless power transfer and materials,that are shaping the future of neuromodulation.

关键词： bioelectronics neuromodulation peripheral nervous system

来源：评论

学校读者我要写书评

暂无评论

DAMAGE TOLERANCE OF DOUBLE-DOUBLE LAMINATES 23

DAMAGE TOLERANCE OF DOUBLE-DOUBLE LAMINATES

引用

23rd International Conference on Composite Materials, ICCM 2023

作者： Melo, Jose Daniel D. Cunha, Rayane D. Targino, Talita G. Freire Junior, Raimundo C.S. Ferreira, Evans P.C. Medeiros, Antonio M. Department of Materials Engineering Federal University of Rio Grande do Norte Natal Brazil Graduate Program in Materials Science and Engineering Federal University of Rio Grande do Norte Natal Brazil SENAI Innovation Institute Natal Brazil

Double-double (DD) lay-up is a new configuration strategy for the design of composite laminates, which allows the use of simplified stacking sequences that leads to potential advantages, such as improved manufacturability and design optimization, as compared to traditional quadriaxial laminates (Quad), which are limited to ply angles of 0°, ±45° and 90°. With the double-double concept, through-the-thickness homogenization is facilitated using thinner sub-laminates and, consequently, profile optimization through thickness tapering becomes possible. In this work, damages after impact and after CAI tests of a double-double laminate (+50/0/-50/0)10 and a hard conventional laminate of equivalent in-plane stiffness (03/90/±45/02/±45)2S are compared. According to the data presented, maximum delaminated areas were of the same order of magnitude for the quad and for the DD laminates, under both conditions: after impact and after CAI tests. The results contribute to the understanding of potential benefits of the double-double concept to damage resistance and damage tolerance of composite laminates. © 2023 International Committee on Composite Materials. All rights reserved.

关键词： Damage tolerance

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：