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Effect of double coating on microencapsulation of levofloxacin using the particles from gas-saturated solutions process as a controlled-release system

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Discover Chemistry 2025年第1期2卷 1-13页

作者： Sharmin, Tanjina Takeshita, Toshihiro Ouchi, Mikio Yoshida, Koji Znad, Hussein Saptoro, Agus Sarker, Zaidul Islam Irie, Keiichi Satho, Tomomitsu Nioh, Atsushi Masuda, Takaaki Muneyoshi, Yuuki Terayama, Suzuko Mishima, Kenji Department of Chemical Engineering Faculty of Engineering Fukuoka University Fukuoka Japan Research Institute of Composite Materials Fukuoka University Fukuoka Japan Resource Circulation Faculty of Environmental Engineering Fukuoka University Fukuoka Japan Faculty of Sciences Fukuoka University Fukuoka Japan Western Australian School of Mines: Minerals Energy and Chemical Engineering Faculty of Science and Engineering Curtin University Perth Australia Department of Chemical Engineering Faculty of Engineering Curtin Malaysia Graduate School Miri Sarawak Malaysia Department of State Program and Food Science Northern Marianas College Saipan USA Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan Yokohama Research Center Pola Chemical Industries Yokohama Japan

A novel double-coating technique was employed to encapsulate levofloxacin (LVF), a potent antibacterial drug, using the particles from gas-saturated solutions (PGSS) process to achieve extended release. The primary coating utilized glyceryl tristearate (GT), a lipid with a high melting point (72 °C), followed by a secondary coating with trimyristin (TM), a lipid with a lower melting point (52 °C). For comparison, a single-coating approach was also explored, using the biocompatible polymer poly-(ε-caprolactone) (PCL). The resulting particles were characterized for their shape, size, and LVF encapsulation efficiency, with confirmation of LVF entrapment provided by Fourier transform infrared (FTIR) spectroscopy, and X‐ray powder diffraction (XRD) analysis. The particles, with an average diameter of 95.3 ± 16.5 μm, exhibited an encapsulation efficiency of up to 92.1 ± 2.5%. Furthermore, in vitro release studies revealed that the double-coated microcapsules effectively suppressed the initial burst release and provided controlled, extended release of LVF (t30D = 36.3%), demonstrating the efficiency of this encapsulation method for prolonged drug delivery.

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How different spatial resolutions of digital models affects the geospatial distribution evaluation of the Index of Connectivity

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Journal of South American Earth Sciences 2025年 163卷

作者： Eberval Marchioro Geraldo André Rosseto Barreto Ialy Gomes Ferreira Adelsom Soares Filho Diogo Costa Buarque Department of Geography (DGEO) Graduate Program in Geography (PPGG) Federal University of Espírito Santo/Brazil (UFES) Coordinator of the Laboratory for Monitoring and Modeling Environmental Systems (Lamosa) Brazil Graduate Program in Management and Regulation of Water Resources (ProfÁgua/UFES) Brazil Graduate Program in Geography at UFES Brazil Graduate Program in Civil Engineering at UFV Brazil Department of Geography Graduate Program in Geography Federal University of Grande Dourados (UFGD) Brazil Department of Environmental Engineering Graduate Program in Environmental Engineering (PPGEA) Professional Master's in Water Resources Management and Regulation (ProfÁgua/UFES) Federal University of Espírito Santo/Brazil (UFES) Brazil

Digital Terrain Models (DTM) and Digital Elevation Models (DEM) are important for obtaining the Index of Connectivity, as they provide valuable information to assess the possibility of sediments reaching the riverbed in watershed basins. This is crucial for proactive management, as it allows the adoption of preventive and mitigating measures. Therefore, this study aims to analyze the effect of the spatial resolution of DEMs with resolutions of 5 m and 2 m, and between the DTM and DEM at 2 m, in determining the Index of Connectivity (IC). Additionally, it was investigated whether it is possible to use only one spatial resolution of digital models to assess the geospatial distribution of IC for all hydrogeomorphological landscapes of the Duas Bocas River watershed, located in the Metropolitan Region of Greater Vitória, in the state of Espírito Santo, Southeast Brazil. For this study, the Borselli Index of Connectivity model (et al., 2008) was used, originally developed for rural areas of Italy and widely applied in different regions worldwide. The data used, including Digital Elevation and Terrain Models and land use and cover information, were obtained from the Integrated Geospatial Base System of the State of Espírito Santo (Brazil), which is publicly *** results indicate that a better geospatial representation of IC occurs when changing the spatial resolution of DEMs from a 5 m pixel to a 2 m pixel and when using the 2 m DTM instead of the 2 m DEM. When analyzing the relationship between IC and the hydrogeomorphological landscapes in the basin, it was observed that, in the absence of models with an even finer pixel resolution, the 2 m DTM is the most suitable option, as it presented IC values consistent within and between landscapes in the Escalated Terraces of Southern Espírito Santo, Coastal Hills and Massifs, and Coastal Plateaus sectors. The exception was the fluvio-lagoon plain, which requires an even finer pixel resolution, necessitating further st

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Dynamically changing extracellular matrix stiffness drives Schwann cell phenotype

Matrix Biology Plus

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Matrix Biology Plus 2025年 25卷 100167页

作者： Montgomery, Alyssa Westphal, Jennifer Bryan, Andrew E. Harris, Greg M. Department of Biomedical Engineering University of Cincinnati Cincinnati 45221 OH United States Department of Chemical and Environmental Engineering University of Cincinnati Cincinnati 45221 OH United States Neuroscience Graduate Program University of Cincinnati College of Medicine Cincinnati 45267 OH United States Cincinnati VA Medical Center Cincinnati 45220 OH United States

Schwann cells (SCs) hold key roles in axonal function and maintenance in the peripheral nervous system (PNS) and are a critical component to the regeneration process following trauma. Following PNS trauma, SCs respond to both physical and chemical signals to modify phenotype and assist in the regeneration of damaged axons and extracellular matrix (ECM). There is currently a lack of knowledge regarding the SC response to dynamic, temporal changes in the ECM brought on by swelling and the development of scar tissue as part of the body's wound-healing process. Thus, this work seeks to utilize a biocompatible, mechanically tunable biomaterial to mimic changes in the microenvironment following injury and over time. Previously, we have reported that ECM cues such as ligand type and substrate stiffness impact SC phenotype and plasticity, which was demonstrated by SCs on mechanically stable biomaterials. However, to better realize SC potential for plasticity following traumatic injury, a UV-tunable polydimethylsiloxane (PDMS) substrate with dynamically changing stiffness was utilized to mimic changes over time in the microenvironment. The dynamic biomaterial showed an increase in stress fibers, greater YAP expression, and fluctuations in c-Jun production in SCs in comparison to stiff and soft static controls. Utilizing biomaterials to better understand the role between temporal mechanical dynamics and SC phenotype holds a very high potential for developing future PNS therapies. © 2024

关键词： Biomaterials Extracellular matrix Fibrosis Mechanotransduction PNS injury Schwann cell

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Statistical trend characteristics of rainfall over Kerala, India evaluated through analysing modern era retrospective analysis for research and applications (MERRA-2) reanalysis data

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Bulletin of Atmospheric Science and Technology 2025年第1期6卷 1-38页

作者： Modon Valappil, Ninu Krishnan de Oliveira Júnior, José Francisco Mendes, David Jamjareegulgarn, Punyawi Hamza, Vijith Environmental Technology Division School of Industrial Technology Universiti Sains Malaysia Pulau Pinang 11800 Malaysia Laboratory of Applied Meteorology and Environment (LAMMA) Institute of Atmospheric Sciences (ICAT) Federal University of Alagoas (UFAL) LourivalMeloMota avenue S/N Alagoas Tabuleiro dos Martins Maceió CEP: 57072-970 Brazil Post-Graduate Program in Aerospace Engineering – PPGEA Federal University of Rio Grande do Norte – UFRN Campus Universitário Lagoa Nova RN Natal Brazil Prince of Chumphon Campus King Mongkut’s Institute of Technology Ladkrabang Chumphon 86160 Thailand Kerala State Disaster Management Authority Kerala Thiruvananthapuram 695033 India

Statistical trends of rainfall (annual and seasonal rainfalls) in Kerala, India were characterised using the 44-years (1980–2023) data of Modern-Era Retrospective Analysis for Research and Applications (MERRA) version 2. Monthly rainfall data were collected from the selected fifty locations which represent the state as a whole, and the collected data were then categorised into annual as well as seasonal (winter, summer, monsoon and post-monsoon) datasets based on the classification proposed by Indian Meteorological Organisation (IMD). Lag-1 autocorrelation, modified Mann Kendall (mMK), Pettitt test and Theil-Sen’s slope methods were used to determine the statistical characteristics of rainfalls in Kerala. Mean rainfalls were 3124 mm, 66 mm, 527 mm, 1667 mm and 862 mm, respectively, for annual, winter, summer, monsoon and post-monsoon periods. mMK based statistical trend analysis revealed an overall decreasing trend characteristics in annual (-0.54 mm.y⁻¹), monsoon (-1.20 mm.y⁻¹), and post-monsoon (-0.93 mm.y⁻¹) seasons whereas winter and summer rainfalls showed an increasing trend (0.67 mm.y⁻¹ and 3.40 mm.y⁻¹, respectively) for the state as a single unit. Pettitt test indicated four dominant periods of change in rainfall characteristics in the study area that spanned over the decades of 1980, 1990, 2000 and 2010, in which major changes in annual and seasonal rainfalls were occurred during 1990’s, 2000’s and 2010’s. Theil-Sen’s slope-based estimation of rate of change in rainfall showed an average variation of -4.33 mm.y⁻¹, 0.17 mm.y⁻¹, 6.27 mm.y⁻¹, -6.54 mm.y⁻¹ and − 3.28 mm.y⁻¹ for annual, winter, summer, monsoon and post-monsoon seasons, respectively. Though the winter and summer rainfalls showed an increase in its rate during the period of analysis, annual rainfall showed an overall reduction in the amount of rainfall received in the state. The study ulti

关键词： MERRA-2 Modified Mann Kendall Period of change Rainfall variation Spatial statistics

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Development of ceramic membranes from sugarcane bagasse ash for microfiltration of biodiesel production effluents

Open Ceramics

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Open Ceramics 2025年 22卷

作者： Pin, Clarissa Ferreira Brandler, Danieli Flores, Gabriela Cristina Perusin Kubiaki Levandoski, William Mateus Bruschi, Giovani Jordi Pelissaro, Deise Trevizan Dervanoski, Adriana Korf, Eduardo Pavan Pasquali, Gean Delise Leal Graduate Program in Enviromental Science and Technology Federal University of Fronteira Sul Erechim/RS 99700-970 Brazil Departament of Civil Engineering Integrated Regional University of Alto Uruguai and Missões – Erechim/RS 99709-910 Brazil Departament of Environmental and Sanitary Engineering Federal University of Fronteira Sul Erechim/RS 99700-970 Brazil

Ceramic membranes have emerged as a promising solution for microfiltration processes, offering advantages such as cost-effectiveness, environmental benefits, and the utilization of abundant raw materials derived from agro-industrial solid waste. This study investigates the fabrication and performance of ceramic membranes composed of kaolin the varying proportions of sugarcane bagasse ash (SCBA - 40 wt % and 60 wt %), with focus on efficiency in treating biodiesel wastewater. The membranes were characterized (porosity, average pore diameter, and mechanical strength). The membrane containing 40 wt % SCBA - employed without any pre-treatment- exhibited the best overall performance, achieving porosity of 38.5 %, an pore diameter of 0.9 µm, and mechanical strength of 27 MPa, indicating a favorable balance between permeability and structural integrity. The best-performing membrane achieved removal efficiencies of color 83 % and turbidity 67 %. Microstructural analysis revealed a network of interconnected mesopores, which are particularly effective for the retention of colloidal and suspended contaminants. © 2025 The Authors

关键词： Agro-industrial solid waste Industrial effluent Membrane filtration

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Intensifying intermittent aeration for optimizing nutrient and hormone removal in vertical-flow constructed wetlands filled with aerated concrete

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Chemosphere 2025年 370卷 143941页

作者： Donato, Mayra Alves de Oliveira Souza, Adelania Pacheco, Amanda de Carvalho Silva, Lucas Svenar, Silvana Nagalli, André Passig, Fernando Hermes Brasil Bernardelli, Jossy Karla Querne de Carvalho, Karina - Civil Engineering Graduate Program. Deputado Heitor de Alencar Furtado St. 5000 Ecoville Paraná Curitiba81280-340 Brazil – Environmental Sciences and Technology Graduate Program. Deputado Heitor de Alencar Furtado St. 5000 Ecoville Paraná Curitiba81280-340 Brazil - Civil Construction Academic Department Deputado Heitor de Alencar Furtado St. 5000 Ecoville Paraná Curitiba81280-340 Brazil - Biology and Chemistry Academic Department. Deputado Heitor de Alencar Furtado St. 5000 Ecoville Paraná Curitiba81280-340 Brazil

Operational strategies have been applied in constructed wetlands to optimize the removal of nutrients and hormones that are still a concern in wastewater treatment. The strategy of intensifying intermittent aeration was investigated in two microcosm-scale vertical-flow constructed wetlands (VFCWs) planted with Eichhornia crassipes onto autoclaved aerated concrete (AC) in the removal of nutrients, estrone (E1), 17β-estradiol (E2) and 17α-ethinylestradiol (EE2). CW-1 (2.4 LO2 min−1) and CW-2 (1.4 LO2 min−1) were fed with synthetic wastewater in sequencing-batch mode (cycles 48-48-72 h) and intermittently aerated for 1 h, followed by 7 h without aeration for 377 days. Combined with the intensification strategy, the use of planted free-floating macrophytes and concrete-based material (emergent) as filtering media stand out as the innovation and originality aspects of this study. Despite the hormone addition, intensifying aeration enhanced the efficiencies since CW-1 achieved the highest removals with 91% COD, 77% TN, 74% TAN, 60% nitrate, and 97% TP in Stage I (no hormone addition) and 90% COD, 80% TN, 93% TAN, 63% nitrate, and 82% TP in Stage II (with hormone addition). CW-1 achieved the highest removal efficiencies of E1 (84%), E2 (95%), and EE2 (73%). Conversely, the efficiencies decreased under the lower aeration rate (in CW-2) for all parameters. Macrophyte uptake and adsorption stood out for TN (>60.25%) and TP (>27.6%) removal as the main mechanisms in the VFCWs. The characteristics of AC favored ion exchange and precipitation, reinforcing the potential of this material as filtering media in VFCWs. Intensification of intermittent aeration combined with hormone addition diverse and riched the microbial community with the presence of Thauera, Lentimicrobium (denitrification), Candidatus Accumulibacter (phosphorus removal), Pseudomonas, Fusibacter, and Azoarcus (EE2 degradation). Intensifying intermittent aeration was an important strategy to enhance the simultaneou

关键词： Wastewater treatment

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Nitrite impairs bioreactor performance due to decreased replication of Candidatus Brocadia sapporoensis by unbalanced energy allocation

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Water Research 2025年 283卷 123806页

作者： Qiao, Xuejiao Zhang, Liyu Qiu, Zhiguang Wu, Yang Deng, Chunfang Geng, Yanni Zhang, Yichi Yan, Yan Li, Bing Zhang, Lijuan Zhuang, Wei-Qin Yu, Ke Eco-environment and Resource Efficiency Research Laboratory School of Environment and Energy Peking University Shenzhen Graduate School Guangdong Shenzhen518055 China -Preferred Program Peking University Shenzhen518055 China State Key Laboratory of Isotope Geochemistry CAS Center for Excellence in Deep Earth Science Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangdong Guangzhou510000 China Shenzhen Engineering Research Laboratory for Sludge and Food Waste Treatment and Resource Recovery Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Department of Civil and Environmental Engineering The University of Auckland Auckland New Zealand

The effects of nitrite on anammox activities have been extensively studied. However, the molecular mechanisms of specific microorganisms responding to nitrite in anammox systems remain unexplored. This study investigates how excessive nitrite affects the core metabolisms of AnAOB and symbiotic bacteria, further elucidating the mechanisms by which it regulates microbial growth and nitrogen removal performance. Specifically, the nitrogen removal process in a continuous-flow anammox membrane bioreactor collapsed when the nitrite concentration reached 243 mg N/L. Integrated meta-omics analyses demonstrated that excessive nitrite disrupted the energy metabolism of Ca. Brocadia sapporoensis (AMXB1), reducing the energy available for developing tolerance. Subsequently, it disrupted cell replication by impairing the biosynthesis process of AMXB1, particularly DNA replication and the formation of vital cell structures such as the cell membrane and cell wall, as well as the cellular protection system, leading to the collapse of the anammox system. Additionally, the cross-feeding of amino acids and cofactors between AMXB1 and symbiotic bacteria plays an important role in the recovery of nitrogen removal performance of anammox consortia after nitrite inhibition. The findings provide a novel strategy and direction for improving the tolerance and resilience of anammox consortia in engineered ecosystems. © 2025

关键词： Listeria

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Improving the Performance of Asphalt Mixtures with Highly Acidic Aggregates in Central Vietnam Using Modifier Based on Styrene-Butadiene-Styrene and Rosin Resin

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Journal of Materials in Civil engineering 2025年第7期37卷

作者： Nguyen, Lan Ngoc Lee, Hosin David Bui, Lam Tung Kim, Young-Ik Truong, Van Quyet Nguyen, May Huu Nguyen, Du Van Dept. of Construction Materials Faculty of Construction Engineering Univ. of Transport and Communications No. 03 Cau Giay Hanoi100000 Viet Nam Dept. of Civil and Environmental Engineering Iowa Technology Institute The Univ. of Iowa Iowa CityIA52242 United States Research Dept. Hansoo Natech Co. Ltd. 6-20 Yuseong-daero 1205beon-gil Yuseong-gu Daejeon34104 Korea Republic of Civil and Environmental Engineering Program Graduate School of Advanced Science and Engineering Hiroshima Univ. 1-4-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8527 Japan Faculty of Civil Engineering Univ. of Transport and Communications Campus in Ho Chi Minh City Ho Chi Minh City700000 Viet Nam

In Central Vietnam, the aggregate typically originates from highly acidic rocks containing a significant amount of silicon dioxide (SiO2), leading to poor adhesion quality with virgin asphalt binder. Hence, the asphalt mixture production usually needs to utilize adhesion promoters. Based on the chemical compositions of the sample aggregate (up to 72.3% SiO2), research has been conducted to introduce an adhesive agent called rubber modified compound (RMC-160), which is composed of styrene-butadiene-styrene (SBS) with petroleum hydrocarbon resin, treated clay and mineral oil. This article presents the research findings regarding the adhesion effectiveness of RMC-160-modified asphalt binder to high acid-based aggregate through laboratory and field tests, along with the mixture performance under both short-term oven aging (STOA) and long-term oven aging (LTOA). The test results exhibited remarkable effects, whereby the asphalt binder modified with RMC-160 additive significantly increased the adhesion level from Grade 2 to Grade 4, and the asphalt mixtures containing RMC-160 had lower rutting and higher cracking tolerance (CTIndex) under both the STOA and LTOA conditions. © 2025 American Society of Civil Engineers.

关键词： Silicon oxides

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Microalgae biotechnology applied to wastewater treatment and biopolymer production: A sustainable alternative for resource recovery

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Journal of Water Process engineering 2025年 75卷

作者： Assemany, Paula de Souza, Isabelly L. Muchico, Joaquina da Márcia J. Scalco, Kaique M.F.C. Balbino, Marcos Vinícius M. Santurbano, Victor Nascimento, Lívia C. da Paz de Oliveira, Otávio N. Siniscalchi, Luciene A.B. Post-Graduate Program in Environmental Engineering Federal University of Lavras (Universidade Federal de Lavras) MG Brazil Department of Environmental Engineering Federal University of Lavras (Universidade Federal de Lavras) MG Brazil

Cultivating microalgae in wastewater offers the dual benefit of efficiently removing pollutants while generating biomass suitable for high-value bioplastics, thus supporting the principles of a circular bioeconomy. Despite this potential, integrating microalgae cultivation for biopolymer obtention into wastewater treatment remains unresolved. Unlike existing reviews, this manuscript primarily aims to explore effective large-scale strategies for accumulating valuable compounds such as polysaccharides, proteins, and polyhydroxyalkanoates from biomass within a wastewater treatment plant context. It addresses the main routes for obtaining biopolymers through the valorization of microalgae biomass, emphasizing a comprehensive approach that blends biomass with other plastic sources, employs two-stage anaerobic digestion, and recovers organic acids for polyhydroxyalkanoate production alongside operational strategies to enhance biomass quality. High-rate algal ponds arranged in series and a two-stage cultivation process are proposed as promising operational strategies to increase the value of biomass for biopolymer production. Key challenges include scalable production processes and improved economic viability to encourage wider industry adoption. The manuscript also offers insights for enhancing the sustainability performance of bioplastics, emphasizing the need to tackle the social and environmental impacts, the last derived from low biodegradability and toxicity due to additives and solvents. Regulatory and public policies, along with transforming wastewater treatment plants into wastewater biorefineries, are also crucial factors in making the technology more commercially feasible. By consolidating current research, this review aims to promote sustainable strategies through microalgal applications that optimize environmental and economic outcomes. © 2025 Elsevier Ltd

关键词： Algal biomass valorization Biopolymer Green plastics Wastewater treatment

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Removal of sodium diclofenac from aqueous solutions by rice hull biochar

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Biochar 2021年第2期3卷 189-200页

作者： Judilyn QFilipinas Kim Katrina PRivera Dennis C.Ong Sheila Mae BPingul‑Ong Ralf Ruffel MAbarca Mark Daniel G.de Luna Environmental Engineering Program National Graduate School of EngineeringUniversity of the Philippines Diliman1101 Quezon CityPhilippines

Diclofenac is an ecotoxic pharmaceutical compound affecting both aquatic and terrestrial ecosystems even at low *** this study,batch adsorption experiments were conducted to remove sodium diclofenac(SD)from aqueous solutions using rice hull biochar(RHB)*** SD removals were obtained with increasing initial SD concentration,RHB dosage,contact time,and decreasing initial *** studies revealed that Langmuir isotherm best fitted the experimental data with the highest coefficient of determination for both pH 2(R2=0.9827)and pH 7(R2=0.9460).For kinetic studies,the pseudo second-order model gave R2=0.9999 for both pH 2 and pH *** removals reached up to 97%at pH 2 and up to 80%at pH *** SD removals were achieved at solution pH lower than the adsorbent pHpzc since electrostatic repulsion was ***-transform infrared analysis showed the major involvement of C=O in the adsorption *** study demonstrated the potential of using agricultural residues such as rice hulls for the treatment of wastewater contaminated with pharmaceutical compounds.

关键词： Adsorption Biochar Isotherm Kinetics Rice hull Sodium diclofenac

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