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Bulletin of the American Meteorological Society 2024年第8期105卷 S1-S11页

作者： Boyer, T. Blunden, J. Dunn, R.J.H. NOAA/NESDIS National Centers for Environmental Information Silver Spring Maryland NOAA/NESDIS National Centers for Environmental Information Asheville North Carolina Met Office Hadley Centre Exeter United Kingdom European Centre for Medium-Range Weather Forecasts Reading United Kingdom University of Maryland College Park Maryland Scripps Institution of Oceanography University of California San Diego La Jolla California NOAA/NWS National Centers for Environmental Prediction Climate Prediction Center College Park Maryland Brandenburg University of Technology (BTU) Cottbus-Senftenberg Germany Servicio Meteorológico Nacional Buenos Aires Argentina NOAA/OAR Physical Sciences Laboratory Boulder Colorado European Centre for Medium-Range Weather Forecasts Bonn Germany Center for Geophysical Research and School of Physics University of Costa Rica San José Costa Rica Department of Meteorology and National Centre for Earth Observation University of Reading Reading United Kingdom Centro Nacional de Monitoramento e Alertas de Desastres Naturais CEMADEN São Paulo Brazil Université Grenoble Alpes Institut des Géosciences de l’Environnement IRD CNRS Grenoble INP Grenoble France Hampton University Hampton Virginia Seychelles Meteorological Authority Mahe Seychelles Section for Glaciers Ice and Snow Norwegian Water Resources and Energy Directorate Oslo Norway National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Agriculture Osaka Metropolitan University Sakai Japan Science Faculty Universidad Nacional de Colombia Bogotá Colombia University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder Colorado Servicio Nacional de Meteorología e Hidrología del Perú Lima Perú Centro de Investigaciones sobre Desertificación – Spanish National Research Council (CSIC-UV-GVA) Valencia Spain Hydro-Climate Extremes Lab (H-CEL) Ghent University Ghent Belgium Department o

In 2023, La Niña conditions that generally prevailed in the eastern Pacific Ocean from mid-2020 into early 2023 gave way to a strong El Niño by October. Atmospheric concentrations of Earth’s major greenhouse gases—carbon dioxide, methane, and nitrous oxide—all increased to record-high levels. The annual global average carbon dioxide concentration in the atmosphere rose to 419.3±0.1 ppm, which is 50% greater than the pre-industrial level. The growth from 2022 to 2023 was 2.8 ppm, the fourth highest in the record since the 1960s. The combined short-term effects of El Niño and the long-term effects of increasing levels of heat-trapping gases in the atmosphere contributed to new records for many essential climate variables reported here. The annual global temperature across land and oceans was the highest in records dating as far back as 1850, with the last seven months (June–December) having each been record warm. Over land, the globally averaged temperature was also record high. Dozens of countries reported record or near-record warmth for the year, including China and continental Europe as a whole (warmest on record), India and Russia (second warmest), and Canada (third warmest). Intense and widespread heatwaves were reported around the world. In Vietnam, an all-time national maximum temperature record of 44.2°C was observed at Tuong Duong on 7 May, surpassing the previous record of 43.4°C at Huong Khe on 20 April 2019. In Brazil, the air temperature reached 44.8°C in Araçuaí in Minas Gerais on 20 November, potentially a new national record and 12.8°C above normal. The effect of rising temperatures was apparent in the cryosphere, where snow cover extent by June 2023 was the smallest in the 56-year record for North America and seventh smallest for the Northern Hemisphere overall. Heatwaves contributed to the greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Due to rapid volume loss beginning in 2021, St. A

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New potent epitopes from Leptospira borgpetersenii for the stimulation of humoral and cell-mediated immune responses: Experimental and theoretical studies

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Informatics in Medicine Unlocked 2021年 25卷

作者： Tansiri, Yada Sritrakul, Tepyuda Saparpakorn, Patchreenart Boondamnern, Timporn Chimprasit, Aunlika Sripattanakul, Sineenat Hannongbua, Supa Prapong, Siriwan Center for Advanced Studies for Agriculture and Food (CASAF) Kasetsart University Bangkok 10900 Thailand Faculty of Medicine King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand Faculty of Veterinary Medicine Kasetsart University Kamphaeng Sean Campus Nakhon Pathom 73140 Thailand Department of Chemistry Faculty of Science Kasetsart University Bangkok 10900 Thailand Department of Physiology Faculty of Veterinary Medicine Kasetsart University Bangkok 10900 Thailand The Interdisciplinary Graduate Program in Genetic Engineering The Graduate School Kasetsart University Bangkok 10900 Thailand Akkhraratchakumari Veterinary College Walailak University. 222 Thaiburi Thasala District Nakhon Si Thammarat 80160 Thailand

The rhKU_Sej_LRR_2271 protein is introduced as one of the leptospiral vaccine candidates since it contains the predicted immunogenic epitopes. The in-silico sequence and structural based analysis have been used in this study to analyze MHC class I and class II-restricted epitopes of the protein. Six epitope prediction programs were employed, which the epitopes with high prediction scores from each program were aligned. The 21 of potentially unrestrained epitopes with prediction scores above the cut-off value from at least two prediction programs were selected. The 3D-molecular modeling, docking, and molecular dynamic simulation were performed to evaluate the affinity binding between peptide-MHC complex and T-cell receptor. One promising epitope, which is 171-LLFLPLIKI, showed the potency in binding to both MHC class I and II alleles. Two newly designed peptides containing epitopes which can bind to over 3 of MHC alleles, LL17:171-LLFLPLIKILYVDRNKL-187 and SL19:209-SLNSGIKALPFNYEKLVNL-227, significantly increased interferon-gamma (IFNg)-producing specific T-cell responses in the rhKU_Sej_LRR_2271 immunized rabbits compared to nonimmunized rabbits. The LL17 peptide can also induce interferon-gamma-producing specific CD4⁺ T-cell responses in the immunized rabbits. For the evaluation of humoral immune responses, the immunized rabbits have a significantly greater amount of specific IgG in plasma than the nonimmunized rabbits. Ex-vivo study of T-cell responses in animal model using flow cytometry confirmed an accomplishment of the theoretically in-silico analysis for discovering potential T-cell epitopes of the protein. The results show that the rhKU_Sej_LRR_2271 protein containing promiscuous T-cell epitopes, which can induce both humoral and cell-mediated immune responses, is a prospective protein candidate for leptospiral vaccine development. © 2021 The Authors

关键词： Epitopes Leptospiral vaccine MHC Molecular docking Molecular dynamic simulation T-cell receptor (TCR)

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Evaluating the antiviral efficacy and specificity of chlorogenic acid and related herbal extracts against SARS-CoV-2 variants via spike protein binding intervention

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Journal of Traditional and Complementary Medicine 2024年

作者： Hsieh, Wen-Yu Yu, Chu-Nien Chen, Chang-Chang Chiou, Chun-Tang Green, Brian D. Lee, Oscar K. Wu, Chia-Chune Doan, Ly Hien Huang, Chi-Ying F. Huang, Cheng Liu, Chien-Ju Chen, Yu-Hsin Cheng, Jing-Jy Pan, Heng-Chih Liu, Hui-Kang Biomedical Industry Ph.D. Program National Yang Ming Chiao Tung University Taipei 11221 Taiwan Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei 11221 Taiwan Division of Chinese Materia Medica Development National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 11221 Taiwan Institute for Global Food Security School of Biological Sciences Queen's University Belfast Belfast BT7 1NN United Kingdom Department of Orthopedics China Medical University Hospital Taichung Taiwan Institute of Biopharmaceutical Sciences College of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei 11221 Taiwan Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Viet Nam Program in Molecular Medicine College of Life Sciences National Yang Ming Chiao Tung University Taipei 11221 Taiwan Taiwan National Graduate Program in Molecular Medicine Academia Sinica National Yang Ming Chiao Tung University Taipei 11221 Taiwan Institute of Clinical Medicine College of Medicine National Yang Ming Chiao Tung Taipei 11221 Taiwan Department of Biotechnology and Laboratory Science in Medicine School of Biomedical Science and Engineering National Yang Ming Chiao Tung Taipei 11221 Taiwan Department of Biochemistry School of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Earth and Life Sciences University of Taipei Taipei 11036 Taiwan Tea and Beverage Research Station Ministry of Agriculture Yangmei Township Taoyuan County 326011 Taiwan Taichung District Agricultural Research and Extension Station Ministry of Agriculture Chang-Hwa County 515008 Taiwan Division of Basic Chinese Medicine National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 11221 Taiwan Department of Nephrology Chang Gung Memorial Hospital Keelung City 204201 Taiwan Ph.D. Program in the Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus infect the respiratory tract through surface proteins, causing similar symptoms. Since the onset of the COVID-19 pandemic, both viruses have posed significant ongoing global health threats. Like the influenza virus, SARS-CoV-2 evolves into variants that can reduce vaccine efficacy. Thus, herbal medicines are being explored as supplementary options to enhance protection against these infections. This study aimed to investigate the therapeutic potential of chlorogenic acid (3-CQA) and related extracts from green coffee beans and Echinacea purpurea against SARS-CoV-2 variants and H1N1 infection. The methods employed included an ELISA-based trimeric spike protein binding assay, viral infection assays, plaque assays, and molecular docking studies. Results showed that 3-CQA blocked spike protein/angiotensin converting enzyme 2 (ACE2) binding for most SARS-CoV-2 variants of concern, except the Delta variant. Extracts from Green coffee bean and E. purpurea effectively blocked all variants tested. Additionally, antibodies blocked spike protein binding up to Omicron BA.2. Molecular docking suggested that 3-CQA binding to Omicron BA.1, BA.2, and BA.4, though not to the Delta spike protein, may lead to steric hindrance, preventing receptor-binding domain interactions with ACE2. Finally, both 3-CQA and E. purpurea extract showed preventive effects against H1N1 viral infection, though with lower potency compared to SARS-CoV-2. In conclusion, 3-CQA has potential as a phytoconstituent marker for herbs with bioactive properties against SARS-CoV-2 and H1N1 viral infections. © 2024 Center for food and Biomolecules, National Taiwan University

关键词： Chlorogenic acid COVID-19 Echinacea purpurea Green coffee bean H1N1 influenza virus SARS-CoV-2 variants Spike protein

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Extracts from Paeonia lactiflora Pallas, Rehmannia Glutinosa var. Purpurea Makino, Perilla Frutescens var. Acuta Kudo may increase the endometrial receptivity through expression of leukemia inhibitory factor and adhesion molecules

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Journal of Traditional Chinese Medicine 2019年第1期39卷 15-25页

作者： Eun-Yeong Kim Tae-Wook Chung Hee-Jung Choi Yeon-Seop Jung Syng-Ook Lee Jun-Yong Choi Hyung Sik Kim Sooseong You Myeong Soo Lee Ki-Tae Ha School of Korean Medicine and Korean Medical Research Center for Healthy Aging Pusan National UniversityYangsan 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-aging Pusan National UniversityYangsan 50612Republic of Korea Department of Food Science and Technology Keimyung UniversityDaegu 42601Republic of Korea National Clinical Research Center for Korean Medicine Korean Medicine Hospital of Pusan National UniversityYangsan 50612Republic of Korea Laboratory of Molecular Toxicology School of PharmacySungKyunKwan UniversitySuwon 16419Republic of Korea Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea

OBJECTIVE: To find out the combination of the extracts from Paeonia lactiflora Pallas(PL), Rehmannia Glutinosa var. Purpurea Makino(RG), Perilla Frutescens var. Acuta Kudo(PF) to increase endometrial ***: Herbal medicines were extracted with boiling water and polysaccharides were *** examined the effect of PL, RG, and PF(PRP), a most effective herbal formula deduced from constitutive ingredient herbs of Antai Yin which is composed of PRP, on the leukemia inhibitory factor(LIF) expression and endometrial ***: The combination of the extracts from PRP induced the LIF expression in Ishikawa cells and increased the adhesion between Ishikawa and JAr cells. In addition, PRP-induced attachment of JAr cells onto Ishikawa cells and expression of adhesion molecules, ITGAV, ITGB5, CD44 s, and Lselectin, are significantly reduced by knock-down of LIF ***: Induced by the combination of the PRP extracts, the adhesion between trophoblast and endometrial cells are mediated by expression of LIF and adhesion molecules. Thus, we suggest the combination of the PRP extracts may be a novel therapy for enhancing embryo implantation rate.

关键词： Paeonia Rehmannia Perilla Embryo implantation Endometrium Leukemia inhibitory factor Cell adhesion molecules

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Valorization of cassava residues for biogas production in Brazil based on the circular economy: An updated and comprehensive review

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Cleaner Engineering and technology 2021年 4卷

作者： Cruz, Ianny Andrade Santos Andrade, Larissa Renata Bharagava, Ram Naresh Nadda, Ashok Kumar Bilal, Muhammad Figueiredo, Renan Tavares Romanholo Ferreira, Luiz Fernando Graduate Program in Process Engineering Tiradentes University Av. Murilo Dantas 300 Farolândia Aracaju 49032-490 SE Brazil Laboratory for Bioremediation and Metagenomics Research (LBMR) Department of Environmental Microbiology (DEM) Babasaheb Bhimrao Ambedkar University (A Central University) Vidya Vihar Raebareli Road Lucknow 226 025 Uttar Pradesh India Department of Biotechnology and Bioinformatics Jaypee University of Information Technology Waknaghat Solan 173 234 Himachal Pradesh India School of Life Science and Food Engineering Huaiyin Institute of Technology Huaian 223003 China Institute of Technology and Research. Av. Murilo Dantas 300 Farolândia Aracaju 49032-490 SE Brazil

Biorefining is an essential component for achieving a sustainable economy. This approach makes use of zero-waste technologies and generates renewable energy. Besides converting organic waste into profit, the technology also avoids competition with biomass and different food-based feedstocks, water use, and impacts on biodiversity, making it a viable alternative to energy crops. In this context, anaerobic digestion (AD) allows proper waste management through controlling pollution/waste accumulation and converting organic matter into higher-value products: biogas and biofertilizer. Considering these points, Brazil has substantial agricultural productivity and generates a significant amount of waste residues that has enormous potential for biogas and bioenergy production. Cassava is an important staple crop for the country, particularly in northern and northeastern regions, where it is produced and processed mainly by families on a small-scale. It produces solid residues (peels, stems, and leaves) and wastewater, known as cassava wastewater, which is characterized by a high chemical oxygen demand, many mineral nutrients and cyanide. Nonetheless, all of these residues are usually disposed of in the vicinity without any treatment, rather than being used to produce higher value-added products. Hence, this review explored the potential role of anaerobic digestion for cassava residues management in association with the bio-based circular economy. Overall, the current manuscript emphasized cassava waste residue's potential for biogas generation, process intensification, scale scale-up strategies, and challenges. © 2021 The Authors

关键词： Anaerobic digestion Bioenergy production Biofuels Biorefinery Cassava residues Waste valorization

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Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants

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Antiviral research 2024年 227卷 105920页

作者： Uyen Nguyen Phuong Le Yu-Jen Chang Chih-Hao Lu Yeh Chen Wen-Chi Su Shao-Ting Chao Lia A Baltina Svetlana F Petrova Sin-Rong Li Mien-Chie Hung Michael M C Lai Lidia A Baltina Cheng-Wen Lin Graduate Institute of Biological Science and Technology China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan. Department of Food Science and Biotechnology National Chung Hsing University Taichung 402 Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan. Ufa Institute of Chemistry Ufa Federal Research Center of the Russian Academy of Sciences Russia. Department of Laboratory Medicine China Medical University Hospital Taichung 404327 Taiwan. Research Center for Cancer Biology China Medical University Taichung 404327 Taiwan Center for Molecular Medicine China Medical University Hospital Taichung 404327 Taiwan. Institute of Molecular Biology Academia Sinica Taipei 115201 Taiwan. Ufa Institute of Chemistry Ufa Federal Research Center of the Russian Academy of Sciences Russia. Electronic address: baltina@anrb.ru. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan. Electronic address: cwlin@mail.cmu.edu.tw.

COVID-19 pandemic is predominantly caused by SARS-CoV-2, with its main protease, Mpro, playing a pivotal role in viral replication and serving as a potential target for inhibiting different variants. In this study, potent Mpro inhibitors were identified from glycyrrhizic acid (GL) derivatives with amino acid methyl/ethyl esters. Out of the 17 derivatives semisynthesized, Compounds 2, 6, 9, and 15, with methionine methyl esters, D-tyrosine methyl esters, glutamic acid methyl esters, and methionines in the carbohydrate moiety, respectively, significantly inhibited wild-type SARS-CoV-2 Mpro-mediated proteolysis, with IC50 values ranging from 0.06 μM to 0.84 μM. They also demonstrated efficacy in inhibiting trans-cleavage by mutant Mpro variants (Mpro_P132H, Mpro_E166V, Mpro_P168A, Mpro_Q189I), with IC50 values ranging from 0.05 to 0.92 μM, surpassing nirmatrelvir (IC50: 1.17-152.9 μM). Molecular modeling revealed stronger interactions with Valine166 in the structural complex of Mpro_E166V with the compounds compared to nirmatrelvir. Moreover, these compounds efficiently inhibited the post-entry viral processes of wild-type SARS-CoV-2 single-round infectious particles (SRIPs), mitigating viral cytopathic effects and reducing replicon-driven GFP reporter signals, as well as in vitro infectivity of wild-type, Mpro_E166V, and Mpro_Q189I SRIPs, with EC50 values ranging from 0.02 to 0.53 μM. However, nirmatrelvir showed a significant decrease in inhibiting the replication of mutant SARS-CoV-2 SRIPs carrying Mpro_E166V (EC50: >20 μM) and Mpro_Q189I (EC50: 13.2 μM) compared to wild-type SRIPs (EC50: 0.06 μM). Overall, this study identifies four GL derivatives as promising lead compounds for developing treatments against various SARS-CoV-2 strains, including Omicron, and nirmatrelvir-resistant variants.

关键词： Glycyrrhizic acid derivative Inhibitor Mpro Nirmatrelvir-resistant variant Omicron SARS-CoV-2

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Neutrophils Recruited by NKX2-1 Suppression via Activation of CXCLs/CXCR2 Axis Promote Lung Adenocarcinoma Progression

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Advanced science 2024年第38期11卷 e2400370页

作者： La'ah, Anita S Tsai, Ping-Hsing Yarmishyn, Aliaksandr A. Ching, Lo-Jei Chen, Chih-Ying Chien, Yueh Chen, Jerry Chieh-Yu Tsai, Ming-Long Chen, Yi-Chen Ma, Chun Hsu, Po-Kuei Luo, Yung-Hung Chen, Yuh-Min Chiou, Guang-Yuh Lu, Kai-Hsi Lin, Wen-Chang Chou, Yu-Ting Wang, Mong-Lien Chiou, Shih-Hwa Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei115 Taiwan Department of Medical Research Taipei Veterans General Hospital Taipei112 Taiwan Institute of Pharmacology School of Medicine National Yang Ming Chiao Tung University Taipei112 Taiwan Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei112 Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei112 Taiwan Department of Surgery Taipei Veterans General Hospital Taipei112 Taiwan Department of Chest Medicine Taipei Veterans General Hospital Taipei112 Taiwan Taipei Cancer Center Taipei Medical University Taipei110 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University HsinChu300093 Taiwan Department of Medical Research and Education Cheng-Hsin General Hospital Taipei112 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei115 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu300044 Taiwan Institute of Food Safety and Health Risk Assessment School of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei112 Taiwan Genomic Research Center Academia Sinica Taipei115 Taiwan

NK2 Homeobox 1 (NKX2-1) is a well-characterized pathological marker that delineates lung adenocarcinoma (LUAD) progression. The advancement of LUAD is influenced by the immune tumor microenvironment through paracrine signaling. However, the involvement of NKX2-1 in modeling the tumor immune microenvironment is still unclear. Here, the downregulation of NKX2-1 is observed in high-grade LUAD. Meanwhile, single-cell RNA sequencing and Visium in situ capturing profiling revealed the recruitment and infiltration of neutrophils in orthotopic syngeneic tumors exhibiting strong cell-cell communication through the activation of CXCLs/CXCR2 signaling. The depletion of NKX2-1 triggered the expression and secretion of CXCL1, CXCL2, CXCL3, and CXCL5 in LUAD cells. Chemokine secretion is analyzed by chemokine array and validated by qRT-PCR. ATAC-seq revealed the restrictive regulation of NKX2-1 on the promoters of CXCL1, CXCL2, and CXCL5 genes. This phenomenon led to increased tumor growth, and conversely, tumor growth decreased when inhibited by the CXCR2 antagonist SB225002. This study unveils how NKX2-1 modulates the infiltration of tumor-promoting neutrophils by inhibiting CXCLs/CXCR2-dependent mechanisms. Hence, targeting CXCR2 in NKX2-1-low tumors is a potential antitumor therapy that may improve LUAD patient outcomes. © 2024 The Author(s). Advanced science published by Wiley-VCH GmbH.

关键词： Tumors

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Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition

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Clinical Nutrition 2025年 49卷 202-208页

作者： Fukushima, R. Compher, C.W. Correia, M.I.T.D. Gonzalez, M.C. McKeever, L. Nakamura, K. Lee, Z.Y. Patel, J.J. Singer, P. Stoppe, C. Ayala, J.C. Barazzoni, R. Berger, M.M. Cederholm, T. Chittawatanarat, K. Cotoia, A. Lopez-Delgado, J.C. Earthman, C.P. Elke, G. Hartl, W. Hasan, M.S. Higashibeppu, N. Jensen, G.L. Lambell, K.J. Lew, C.C.H. Mechanick, J.I. Mourtzakis, M. Nogales, G.C.C. Oshima, T. Peterson, S.J. Rice, T.W. Rosenfeld, R. Sheean, P. Silva, F.M. Tah, P.C. Uyar, M. Department of Surgery Teikyo University School of Medicine Department of Health and Dietetics Faculty of Health and Medical Science Teikyo Heisei University Tokyo Japan Biobehavioral Health Sciences Department and Nutrition Programs University of Pennsylvania School of Nursing Philadelphia PA United States Department of Surgery Universidade Federal de Minas Gerais Belo Horizonte Brazil Postgraduate Program in Nutrition and Food Federal University of Pelotas RS Brazil Department of Clinical Nutrition Rush University Medical Center Chicago IL United States Department of Critical Care Medicine Yokohama City University Hospital Kanagawa Japan Department of Anaesthesiology Faculty of Medicine University of Malaya Kuala Lumpur 50603 Malaysia Department of Cardiac Anesthesiology and Intensive Care Medicine Charité Berlin Berlin Germany Division of Pulmonary and Critical Care Medicine Medical College of Wisconsin 9200 West Wisconsin Avenue HUB 8th floor Milwaukee 53225 WI United States Intensive Care Unit Herzlia Medical Center Reichman University Herzlia and Institute for Nutrition Research Intensive Care Department Beilinson Hospital Rabin Medical Center Petah Tikva Israel Department of Anaesthesiology Intensive Care Emergency and Pain Medicine University Hospital Würzburg Würzburg Germany Department of Surgery Clinica del Country of Medicine FUCS Bogotá Colombia Department of Medical Technological and Translational Sciences University of Trieste Ospedale di Cattinara Trieste Italy Faculty of Biology and Medicine Lausanne University Lausanne Switzerland Department of Public Health and Caring Sciences Clinical Nutrition and Metabolism Uppsala University Uppsala and Theme Inflammation & Aging Karolinska University Hospital Stockholm Sweden Division of Trauma and Surgical Critical Care Clinical Surgical Research Center Department of Surgery Faculty of Medicine Chiang Mai University Chiang Mai 50200 Thailand Department of Medical and Surgical Sc

Background: Patients with critical illness may present with disease-related malnutrition upon intensive care unit (ICU) admission. They are at risk of development and progression of malnutrition over the disease trajectory because of inflammation, dysregulated metabolism, and challenges with feeding. Methods: The Global Leadership Initiative on Malnutrition (GLIM) convened a panel of 36 clinical nutrition experts to develop consensus-based guidance statements addressing the diagnosis of malnutrition during critical illness, using a modified Delphi approach with a requirement of ≥75% agreement. Results: 1. To identify pre-existing malnutrition, we suggest evaluation within 48 hours of ICU admission when feasible (100% agreement) or within 4 days (94% agreement). 2. To identify the development and progression of malnutrition, we suggest reevaluation of all patients every 7-10 days (97% agreement). 3. To identify progressive loss of muscle mass, we suggest evaluation of muscle mass as soon as feasible (92% agreement), and again after 7-10 days (89% agreement). 4. To identify the development and progression of malnutrition prior to and after ICU discharge, we suggest reevaluating nutritional status prior to ICU discharge and during clinical visits that follow (100% agreement). Conclusion: Research using consistent etiologic and phenotypic variables offers great potential to assess the efficacy of nutrition interventions for critically ill patients with malnutrition. Assessment of these variables at during and beyond the ICU stay will clarify the trajectory of malnutrition and enable exploration of impactful treatment modalities at each juncture. GLIM offers a diagnostic approach that can be used to identify malnutrition in critically ill patients. © 2025 The Authors

关键词： Global Leadership Initiative on Malnutrition ICU Malnutrition Muscle mass

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Ion-exchanged zeolite as a hybrid system: Fluoxetine removal and antibacterial activity

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Microporous and Mesoporous Materials 2025年

作者： Gabriela Maria Matos Demiti Natália Cândido Homem Helena Prado Felgueiras Anna Carla Ribeiro Benício Alves de Abreu Filho Mara Heloisa Neves Olsen Scaliante Miguel Torres Rodríguez Rosângela Bergamasco State University of Maringá Department of Chemical Engineering Av. Colombo 5790 Maringá 87020-900 Paraná Brazil Centre for Textile Science and Technology (2C2T) University of Minho (UMinho) Azurém Campus University Street 4800-058 Guimarães Portugal Simoldes Plastics Research and Innovation Department Comendador António da Silva Rodrigues Street 100 3720-502 Oliveira de Azeméis Portugal State University of Maringá Department of Biotechnology Genetics and Cell Biology Av. Colombo 5790 Maringá 87020-900 Paraná Brazil State University of Maringá Post-Graduate Program in Food Science Av. Colombo 5790 Maringá 87020-900 Paraná Brazil Metropolitan Autonomous University Division of Basic Science and Engineering Av. San Pablo Xalpa 180 San Martin Xochinahuac Azcapotzalco Ciudad de México 02128 Mexico

The increasing consumption of antidepressants, aggravated by the coronavirus disease 2019 (COVID-19) pandemic, has resulted in the detection of compounds such as fluoxetine in drinking water. This substance is highly toxic to aquatic organisms and has the potential for bioaccumulation in aquatic environments. This study evaluated the effects of modifying natural zeolites through ion exchange to enhance their adsorption capacity and assess their multifunctional potential. Natural zeolites were modified by immersion in 0.1 mol L −1 solutions of AgNO 3 , MgCl 2 , FeSO 4 , and FeCl 3 , and their performance in fluoxetine removal was systematically compared. The samples were characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, X-ray fluorescence spectroscopy, thermogravimetric analysis, point of zero charge, scanning electron microscopy, and transmission electron microscopy. Adsorption experiments were conducted with an adsorbent concentration of 1 g L −1 and an initial fluoxetine concentration of 20 mg L −1 . The silver-modified zeolite (ZN-AgNO 3 ), which achieved the best performance among the tested materials, was selected for further testing. The pseudo-second-order and Langmuir models provided the best kinetic and isotherm fits, respectively, with a maximum adsorption capacity of 36.36 mg g −1 , achieved at 308 K and an equilibrium time of 21 h. Desorption experiments showed that the adsorbent maintained recovery rates above 50% over four cycles of reuse. The main adsorption mechanisms involved ion exchange, electrostatic interactions, and hydrogen bonding, in addition to the affinity of silver with the functional groups of fluoxetine. The adsorbent also inhibited the growth of Escherichia coli . Overall, ZN-AgNO 3 demonstrated potential for fluoxetine removal and antibacterial activity.

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Corrigendum to "miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression" [Biochem. Pharmacol. 188 (2021) 114539]

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Biochemical pharmacology 2023年 208卷 115389页

作者： Sichong Han Zhe Wang Jining Liu Hui-Min David Wang Qipeng Yuan State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 PR China. Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung City 402 Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung City 404 Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung City 807 Taiwan College of Food and Biological Engineering Jimei University Xiamen City 361021 Fujia Province PR China Undergraduate Program Study of Biomedical Engineering Physics Department Airlangga University Surabaya City 60115 Indonesia. Electronic address: davidw@dragon.nchu.edu.tw. State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 PR China. Electronic address: yuanqp@***.

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