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Neutrophils Recruited by NKX2-1 Suppression via Activation of CXCLs/CXCR2 Axis Promote Lung Adenocarcinoma Progression

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Advanced science 2024年第38期11卷 e2400370页

作者： La'ah, Anita S Tsai, Ping-Hsing Yarmishyn, Aliaksandr A. Ching, Lo-Jei Chen, Chih-Ying Chien, Yueh Chen, Jerry Chieh-Yu Tsai, Ming-Long Chen, Yi-Chen Ma, Chun Hsu, Po-Kuei Luo, Yung-Hung Chen, Yuh-Min Chiou, Guang-Yuh Lu, Kai-Hsi Lin, Wen-Chang Chou, Yu-Ting Wang, Mong-Lien Chiou, Shih-Hwa Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei115 Taiwan Department of Medical Research Taipei Veterans General Hospital Taipei112 Taiwan Institute of Pharmacology School of Medicine National Yang Ming Chiao Tung University Taipei112 Taiwan Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei112 Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei112 Taiwan Department of Surgery Taipei Veterans General Hospital Taipei112 Taiwan Department of Chest Medicine Taipei Veterans General Hospital Taipei112 Taiwan Taipei Cancer Center Taipei Medical University Taipei110 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University HsinChu300093 Taiwan Department of Medical Research and Education Cheng-Hsin General Hospital Taipei112 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei115 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu300044 Taiwan Institute of Food Safety and Health Risk Assessment School of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei112 Taiwan Genomic Research Center Academia Sinica Taipei115 Taiwan

NK2 Homeobox 1 (NKX2-1) is a well-characterized pathological marker that delineates lung adenocarcinoma (LUAD) progression. The advancement of LUAD is influenced by the immune tumor microenvironment through paracrine signaling. However, the involvement of NKX2-1 in modeling the tumor immune microenvironment is still unclear. Here, the downregulation of NKX2-1 is observed in high-grade LUAD. Meanwhile, single-cell RNA sequencing and Visium in situ capturing profiling revealed the recruitment and infiltration of neutrophils in orthotopic syngeneic tumors exhibiting strong cell-cell communication through the activation of CXCLs/CXCR2 signaling. The depletion of NKX2-1 triggered the expression and secretion of CXCL1, CXCL2, CXCL3, and CXCL5 in LUAD cells. Chemokine secretion is analyzed by chemokine array and validated by qRT-PCR. ATAC-seq revealed the restrictive regulation of NKX2-1 on the promoters of CXCL1, CXCL2, and CXCL5 genes. This phenomenon led to increased tumor growth, and conversely, tumor growth decreased when inhibited by the CXCR2 antagonist SB225002. This study unveils how NKX2-1 modulates the infiltration of tumor-promoting neutrophils by inhibiting CXCLs/CXCR2-dependent mechanisms. Hence, targeting CXCR2 in NKX2-1-low tumors is a potential antitumor therapy that may improve LUAD patient outcomes. © 2024 The Author(s). Advanced science published by Wiley-VCH GmbH.

关键词： Tumors

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Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition

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Clinical Nutrition 2025年 49卷 202-208页

作者： Fukushima, R. Compher, C.W. Correia, M.I.T.D. Gonzalez, M.C. McKeever, L. Nakamura, K. Lee, Z.Y. Patel, J.J. Singer, P. Stoppe, C. Ayala, J.C. Barazzoni, R. Berger, M.M. Cederholm, T. Chittawatanarat, K. Cotoia, A. Lopez-Delgado, J.C. Earthman, C.P. Elke, G. Hartl, W. Hasan, M.S. Higashibeppu, N. Jensen, G.L. Lambell, K.J. Lew, C.C.H. Mechanick, J.I. Mourtzakis, M. Nogales, G.C.C. Oshima, T. Peterson, S.J. Rice, T.W. Rosenfeld, R. Sheean, P. Silva, F.M. Tah, P.C. Uyar, M. Department of Surgery Teikyo University School of Medicine Department of Health and Dietetics Faculty of Health and Medical Science Teikyo Heisei University Tokyo Japan Biobehavioral Health Sciences Department and Nutrition Programs University of Pennsylvania School of Nursing Philadelphia PA United States Department of Surgery Universidade Federal de Minas Gerais Belo Horizonte Brazil Postgraduate Program in Nutrition and Food Federal University of Pelotas RS Brazil Department of Clinical Nutrition Rush University Medical Center Chicago IL United States Department of Critical Care Medicine Yokohama City University Hospital Kanagawa Japan Department of Anaesthesiology Faculty of Medicine University of Malaya Kuala Lumpur 50603 Malaysia Department of Cardiac Anesthesiology and Intensive Care Medicine Charité Berlin Berlin Germany Division of Pulmonary and Critical Care Medicine Medical College of Wisconsin 9200 West Wisconsin Avenue HUB 8th floor Milwaukee 53225 WI United States Intensive Care Unit Herzlia Medical Center Reichman University Herzlia and Institute for Nutrition Research Intensive Care Department Beilinson Hospital Rabin Medical Center Petah Tikva Israel Department of Anaesthesiology Intensive Care Emergency and Pain Medicine University Hospital Würzburg Würzburg Germany Department of Surgery Clinica del Country of Medicine FUCS Bogotá Colombia Department of Medical Technological and Translational Sciences University of Trieste Ospedale di Cattinara Trieste Italy Faculty of Biology and Medicine Lausanne University Lausanne Switzerland Department of Public Health and Caring Sciences Clinical Nutrition and Metabolism Uppsala University Uppsala and Theme Inflammation & Aging Karolinska University Hospital Stockholm Sweden Division of Trauma and Surgical Critical Care Clinical Surgical Research Center Department of Surgery Faculty of Medicine Chiang Mai University Chiang Mai 50200 Thailand Department of Medical and Surgical Sc

Background: Patients with critical illness may present with disease-related malnutrition upon intensive care unit (ICU) admission. They are at risk of development and progression of malnutrition over the disease trajectory because of inflammation, dysregulated metabolism, and challenges with feeding. Methods: The Global Leadership Initiative on Malnutrition (GLIM) convened a panel of 36 clinical nutrition experts to develop consensus-based guidance statements addressing the diagnosis of malnutrition during critical illness, using a modified Delphi approach with a requirement of ≥75% agreement. Results: 1. To identify pre-existing malnutrition, we suggest evaluation within 48 hours of ICU admission when feasible (100% agreement) or within 4 days (94% agreement). 2. To identify the development and progression of malnutrition, we suggest reevaluation of all patients every 7-10 days (97% agreement). 3. To identify progressive loss of muscle mass, we suggest evaluation of muscle mass as soon as feasible (92% agreement), and again after 7-10 days (89% agreement). 4. To identify the development and progression of malnutrition prior to and after ICU discharge, we suggest reevaluating nutritional status prior to ICU discharge and during clinical visits that follow (100% agreement). Conclusion: Research using consistent etiologic and phenotypic variables offers great potential to assess the efficacy of nutrition interventions for critically ill patients with malnutrition. Assessment of these variables at during and beyond the ICU stay will clarify the trajectory of malnutrition and enable exploration of impactful treatment modalities at each juncture. GLIM offers a diagnostic approach that can be used to identify malnutrition in critically ill patients. © 2025 The Authors

关键词： Global Leadership Initiative on Malnutrition ICU Malnutrition Muscle mass

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Ion-exchanged zeolite as a hybrid system: Fluoxetine removal and antibacterial activity

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Microporous and Mesoporous Materials 2025年 396卷

作者： Gabriela Maria Matos Demiti Natália Cândido Homem Helena Prado Felgueiras Anna Carla Ribeiro Benício Alves de Abreu Filho Mara Heloisa Neves Olsen Scaliante Miguel Torres Rodríguez Rosângela Bergamasco State University of Maringá Department of Chemical Engineering Av. Colombo 5790 Maringá 87020-900 Paraná Brazil Centre for Textile Science and Technology (2C2T) University of Minho (UMinho) Azurém Campus University Street 4800-058 Guimarães Portuguese Republic Simoldes Plastics Research and Innovation Department Comendador António da Silva Rodrigues Street 100 3720-502 Oliveira de Azeméis Portuguese Republic State University of Maringá Department of Biotechnology Genetics and Cell Biology Av. Colombo 5790 Maringá 87020-900 Paraná Brazil State University of Maringá Post-Graduate Program in Food Science Av. Colombo 5790 Maringá 87020-900 Paraná Brazil Metropolitan Autonomous University Division of Basic Science and Engineering Av. San Pablo Xalpa 180 San Martin Xochinahuac Azcapotzalco Ciudad de México 02128 United Mexican States

The increasing consumption of antidepressants, aggravated by the coronavirus disease 2019 (COVID-19) pandemic, has resulted in the detection of compounds such as fluoxetine in drinking water. This substance is highly toxic to aquatic organisms and has the potential for bioaccumulation in aquatic environments. This study evaluated the effects of modifying natural zeolites through ion exchange to enhance their adsorption capacity and assess their multifunctional potential. Natural zeolites were modified by immersion in 0.1 mol L −1 solutions of AgNO 3 , MgCl 2 , FeSO 4 , and FeCl 3 , and their performance in fluoxetine removal was systematically compared. The samples were characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, X-ray fluorescence spectroscopy, thermogravimetric analysis, point of zero charge, scanning electron microscopy, and transmission electron microscopy. Adsorption experiments were conducted with an adsorbent concentration of 1 g L −1 and an initial fluoxetine concentration of 20 mg L −1 . The silver-modified zeolite (ZN-AgNO 3 ), which achieved the best performance among the tested materials, was selected for further testing. The pseudo-second-order and Langmuir models provided the best kinetic and isotherm fits, respectively, with a maximum adsorption capacity of 36.36 mg g −1 , achieved at 308 K and an equilibrium time of 21 h. Desorption experiments showed that the adsorbent maintained recovery rates above 50 % over four cycles of reuse. The main adsorption mechanisms involved ion exchange, electrostatic interactions, and hydrogen bonding, in addition to the affinity of silver with the functional groups of fluoxetine. The adsorbent also inhibited the growth of Escherichia coli . Overall, ZN-AgNO 3 demonstrated potential for fluoxetine removal and antibacterial activity.

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Corrigendum to "miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression" [Biochem. Pharmacol. 188 (2021) 114539]

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Biochemical pharmacology 2023年 208卷 115389页

作者： Sichong Han Zhe Wang Jining Liu Hui-Min David Wang Qipeng Yuan State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 PR China. Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung City 402 Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung City 404 Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung City 807 Taiwan College of Food and Biological Engineering Jimei University Xiamen City 361021 Fujia Province PR China Undergraduate Program Study of Biomedical Engineering Physics Department Airlangga University Surabaya City 60115 Indonesia. Electronic address: davidw@dragon.nchu.edu.tw. State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 PR China. Electronic address: yuanqp@***.

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Genomic Surveillance of SARS-CoV-2 in Taiwan: A Perspective on Evolutionary Data Interpretation and Sequencing Issues

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Biomedical journal 2024年 100820页

作者： Yu-Nong Gong Nai-Yu Kuo Ting-Syuan Yeh Shin-Ru Shih Guang-Wu Chen Research Center for Emerging Viral Infections College of Medicine Chang Gung University Taoyuan Taiwan International Master Degree Program for Molecular Medicine in Emerging Viral Infections College of Medicine Chang Gung University Taoyuan Taiwan Department of Laboratory Medicine Linkou Chang Gung Memorial Hospital Taoyuan Taiwan. Medical Education Department Linkou Chang Gung Memorial Hospital Taoyuan Taiwan. National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Taiwan. Department of Laboratory Medicine Linkou Chang Gung Memorial Hospital Taoyuan Taiwan Department of Medical Biotechnology and Laboratory Science College of Medicine Chang Gung University Taoyuan Taiwan Research Center for Chinese Herbal Medicine Research Center for Food and Cosmetic Safety and Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan Taiwan. Department of Computer Science and Information Engineering College of Engineering Chang Gung University Taoyuan Taiwan. Electronic address: gwchen@mail.cgu.edu.tw.

This review presents a comprehensive perspective on the genomic surveillance of SARS-CoV-2 in Taiwan, with a focus on next-generation sequencing and phylogenetic interpretation. This article aimed to explore how Taiwan has utilized genomic sequencing technologies and surveillance to monitor and mitigate the spread of COVID-19. We examined databases and sources of genomic sequences and highlighted the role of data science methodologies in the explanation and analyses of evolutionary data. This review addressed the challenges and limitations inherent in genomic surveillance, such as concerns regarding data quality and the necessity for interdisciplinary expertise for accurate data interpretation. Special attention was given to the unique challenges faced by Taiwan, including its high population density and major transit destination for international travelers. We underscored the far-reaching implications of genomic surveillance data for public health policy, particularly in influencing decisions regarding travel restrictions, vaccine administration, and public health decision-making. Studies were examined to demonstrate the effectiveness of using genomic data to implement public health measures. Future research should prioritize the integration of methodologies and technologies in evolutionary data science, particularly focusing on phylodynamic analytics. This integration is crucial to enhance the precision and applicability of genomic data. Overall, we have provided an overview of the significance of genomic surveillance in tracking SARS-CoV-2 variants globally and the pivotal role of data science methodologies in interpreting these data for effective public health interventions.

关键词： SARS-CoV-2 data science genomic surveillance next-generation sequencing phylodynamics

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Corrigendum to "Dual regulatory effects of neferine on amyloid-β and tau aggregation studied by in silico, in vitro, and lab-on-a-chip technology" [Biomed. Pharmacother. 172 (2024) 1-14/116226]

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024年 181卷 117686页

作者： Yunkwon Nam Ritu Prajapati Sujin Kim Soo Jung Shin Da Yeon Cheong Yong Ho Park Hyun Ha Park Danyou Lim Yoojeong Yoon Gyudo Lee Hyun Ah Jung Insu Park Dong-Hyun Kim Jae Sue Choi Minho Moon Department of Biochemistry College of Medicine Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Department of Food and Life Science Pukyong National University Busan 48513 Republic of Korea. Department of Biochemistry College of Medicine Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea Research Institute for Dementia Science Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Department of Biotechnology and Bioinformatics Korea University Sejong 30019 Republic of Korea Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong 30019 Republic of Korea. Department of Biomedical Engineering Konyang University Daejeon 35365 Republic of Korea. Department of Food Science and Human Nutrition Chonbuk National University Jeonju 54896 Republic of Korea. Department of Biomedical Engineering Konyang University Daejeon 35365 Republic of Korea. Electronic address: insupark@konyang.ac.kr. Departments of Pharmacology and Advanced Translational Medicine School of Medicine Konkuk University Seoul 05029 Republic of Korea. Electronic address: mose79@kku.ac.kr. Department of Food and Life Science Pukyong National University Busan 48513 Republic of Korea. Electronic address: choijs@pknu.ac.kr. Research Institute for Dementia Science Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Electronic address: hominmoon@konyang.ac.kr.

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Molecular screening of bovine β-casein (CSN2) A2 variant in Indonesian Holstein dairy cattle as attempt to produce digestive friendly milk

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IOP Conference Series: Earth and Environmental science 2021年第1期902卷

作者： A M P Nuhriawangsa T Mulyani G Pambuko R Vanessa Purwadi N Widyas S Prastowo Department of Animal Science Faculty of Agriculture Universitas Sebelas Maret Surakarta Indonesia Animal Food Science and Technology Research Group Faculty of Agriculture Universitas Sebelas Maret Surakarta Indonesia Master Program of Animal Science Faculty of Agriculture Universitas Sebelas Maret Surakarta Indonesia Graduate School of Bioscience Faculty of Mathematic and Natural Science Universitas Sebelas Maret Surakarta Indonesia Faculty of Animal Husbandry Universitas Boyolali Boyolali Indonesia Animal Breeding Reproduction and Biostatistics Research Group Faculty of Agriculture Universitas Sebelas Maret Surakarta Indonesia

Cow's milk-intolerance is a digestive problem on people who not able to digest milk. This problem may relate to the variant of (3-casein (CSN2), especially A1, suggested due to (3-casomorphins (BCM-7) formation during enzymatic digestion, for that selecting cattle free BCM-7 become a concern to produce digestive friendly milk. This study aimed to differentiate A1 and A2 allele variant of CSN2 gene in selected population of Indonesian Holstein cattle. In total 70 cows DNA were collected, and fragment of CSN2 exon 7 which contain Single Nucleotide Polymorphism (SNP) rs43703011 and rs43703013 were amplified. Variant analysis was done by mutation site analysis using PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) with Mspl restriction enzyme and DNA sequence for confirmation. Result shows 2 allele variants of (3-casein that are B type, representing A1 family variant, and A2 in mutation site rs43703013C>G. We found A2 allele in the studied population is superior in frequency than A1 (0.916 vs. 0.084). Of that, 8.6% cattle were heterozygotes that is BA2 and 91.4% were homozygotes A2A2. Cattle which carry A1 allele variant should be excluded from dairy cattle breeding program for further milk production free of BCM-7.

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Genetic variation of somaclonal mutants from the 8th generation of Pekalongan accession rodent tuber (typhonium flagelliforme lodd.) based on RAPD-PCR analysis 2

Genetic variation of somaclonal mutants from the 8th generat...

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2nd International Conference on Eco Engineering Development 2018, ICEED 2018

作者： Purnamaningsih, Ragapadmi Sianipar, Nesti Fronika Assidqi, Khoirunnisa Spits Warnars, Harco Leslie Hendric Indonesia Center for Agricultural Biotechnology and Genetic Resources Research and Development Bogor16111 Indonesia Food Technology Department Faculty of Engineering Bina Nusantara University Jakarta11480 Indonesia Research Interest Group Food Biotechnology Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program - Doctor of Computer Science Bina Nusantara University Jakarta11480 Indonesia

Rodent tuber is a potential plant which can be developed as an anticancer drug. The rodent tuber plant has a low anticancer compound which does not have an economic value to be utilized on an industrial scale, particularly to explore as an anticancer drug. The material plant was used 30 clones of Rodent Tuber Pekalongan to increase its bioactive compounds using a combination of in vitro culture with gamma-ray irradiation. The selection process has been done until the 8th generation and obtained 14 somaclonal mutants that have higher bioactive compounds than control plant (non-mutant). This study aimed to analyze the genetic variation of 14 somaclonal mutants of rodent tuber using RAPD with 14 primers. The results were produced 513 total bands with the size of 200-5000 bp and 380 polymorphic bands between somaclonal mutants. OPB-18 primer produced the most polymorphic bands and five specific polymorphic bands of 1336 bp, 1070 bp, 901 bp, 861 bp and 728 bp in the somaclonal mutant M23 (20-4-2-1-1-1). OPD-20 primer produced seven specific polymorphic bands of 1574 bp, 1557 bp, 1501 bp, 1496 bp, 1234 bp, 1229 bp and 1086 bp in the M23 somaclonal mutant. The phylogenetic analysis showed that there were two main groups with the coefficient similarity between 0.77 and 0.83. The highest genetic variation obtained was found in the M23 somaclonal mutant with a genetic difference of 23% compared with control. There are five somaclonal mutants (M24, M22, M21, M16, M14) that have a genetic variation of up to 22% over the control. This study shows that OPB-18 and OPD-20 primers were efficient in detecting somaclonal mutant variants. © 2018 Institute of Physics Publishing. All rights reserved.

关键词： Gamma rays

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Halstead Metric for Quality Measurement of Various Version of Statcato 5

Halstead Metric for Quality Measurement of Various Version o...

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5th International Conference on Information technology, Computer and Electrical Engineering, ICITACEE 2018

作者： Binanto, Iwan Warnars, Harco Leslie Hendric Spits Abbas, Bahtiar Saleh Sianipar, Nesti Fronika Informatics Department Sanata Dharma University Yogyakarta55002 Indonesia Computer Science Department BINUS Graduate Program Doctor of Computer Science Bina Nusantara University Jakarta11480 Indonesia Food Technology Department Bina Nusantara University Jakarta11480 Indonesia Research Interest Group Biotechnology Bina Nusantara University Jakarta11480 Indonesia

ISBN: (纸本)9781538655276

Halstead metric is one of software quality measurement technique. Some studies call it as Primitive and/or Classic Software Metric, although some researchers find vagueness of it. This paper utilizing Halstead metric to measuring the quality of various versions of Statcato software. Measurements are performed in each class of each version of Statcato software. Python programming used to facilitate this. This paper find that in terms of Halstead metric, this software seems stable during its lifecycle. So, the quality of the newer versions of Statcato are better in terms of stability of Halstead metrics than the earlier version, although its feature is increasing. © 2018 IEEE.

关键词： High level languages

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A first-principles study on the quantum tunneling of methylhydroxycarbene isomerization in various solvents

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Journal of Physics: Conference Series 2020年第1期1568卷 012003-012003页

作者： E D Susanti F Rusydi I Puspitasari R N Fadilla N D Aisyah A Ahmad Research Center for Quantum Engineering Design Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya 60115 Indonesia Department of Physics Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya 60115 Indonesia Visiting Researcher at Precision Sciences & Technology and Applied Physics Graduate School of Engineering Osaka University Suita 565-0871 Japan Information System Study Program Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya 60115 Indonesia School of Chemical Science and Food Technology Faculty of Science and Technology Universiti Kebangsaan Malaysia Bangi Selangor 43600 Malaysia

Quantum tunneling phenomenon allows a high-barrier reaction to occur even though thermal energy is not sufficient to surmount the barrier. The phenomenon has been suggested to exist in the isomerization of methylhydroxycarbene which occured at 11 K. Here we study the quantum tunneling that occured in the isomerization of methylhydroxycarbene to acetaldehyde and to vinyl alcohol based on density functional calculations. The isomerization pathways are determined under the effect of various solvents which are modeled by polarizable continuum model (PCM). We use Wentzel-Kramers-Brillouin (WKB) approximation to calculate the tunneling probability (T) and extend the usefulness of T into isomerization rate. The results show that the solvents give a significant effect on the isomerization rate of methylhydroxycarbene to acetaldehyde but an insignificant one on the isomerization rate to vinyl alcohol.

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