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Anti-inflammatory and antinociceptive effects of Aloysia gratissima leaves essential oil: An in vivo study

Journal of Traditional and Complementary Medicine 2024年

作者： Souza, Maryelen A. Kunh, Ketelin Sanaiotto, Otávio Provinelli, Ana C. Barufke, Mayara Schindler, Monica S.Z. Mazon, Samara Cristina Oliveira, J. Vladimir Brusco, Indiara Scapinello, Jaqueline Magro, Jacir Dal Müller, Liz G. Graduate Program in Environmental Sciences Community University of Chapecó Region (Unochapecó) Chapecó Brazil School of Health Sciences Community University of Chapecó Region (Unochapeco) Chapecó Brazil Department of Chemical and Food Engineering Federal University of Santa Catarina (UFSC) SC Florianópolis Brazil Graduate Program in Food Science and Technology - State University of Santa Catarina - UDESC Pinhalzinho Brazil

Background and aim: Aloysia gratissima is used in popular medicine as an analgesic and sedative. However, studies on its biological activities are still scarce. Therefore, this work aimed to evaluate the antinociceptive and anti-inflammatory effect of A. gratissima leaves essential oil (OAG) in mice. Experimental procedure: The OAG was obtained by hydrodistillation and its composition was determined by gas chromatography-mass spectrometry. The sesquiterpenes pinocamphone, β-pinene, and guaiol were the major constituents of OAG. The effect of OAG (1, 10, and 30 mg/kg, p.o.) was assessed by pre-treating male mice 1h before the formalin assay, carrageenan-induced peritonitis test, or the paw edema induced by arachidonic acid (AA). The acute toxicity of OAG (2000 mg/kg, p.o.) was also investigated. Results and conclusion: The minimum effective dose of OAG in the formalin test was 1 mg/kg. This dose did not affect the locomotor activity of mice. The OAG decreased the number of leukocytes/mm³ in the peritoneal exudate of mice and reduced paw edema 45 min after the arachidonic acid injection. OAG treatment elicited a reduction in NPSH levels in the paw tissue and increased NPSH levels in mice blood plasma and did not cause mice mortality. The OAG is devoid of acute toxicity and shows anti-inflammatory activity, which can be related to the presence of pinocamphone, guaiol, and β-pinene and is mediated, at least in part, by mechanisms that involve the participation of NPSH. © 2024 Center for food and Biomolecules, National Taiwan University

关键词： Acute toxicity test Anti-inflammatory agents Antinociceptive agents Natural products Verbenaceae

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Enhanced extraction of Pleurotus ostreatus polysaccharides via plasma-ultrasound synergy: Kinetics modeling and functional characterization

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Innovative food science and Emerging Technologies 2025年 103卷

作者： Punthi, Fuangfah Mulyani, Rizka Chang, Chao-Kai Adi, Prakoso Gavahian, Mohsen Yudhistira, Bara Listyaningrum, Ratna Sari Cheng, Kuan-Chen Hou, Chih-Yao Hsieh, Chang-Wei Department of Food Science and Biotechnology National Chung Hsing University Taichung City402202 Taiwan International Doctoral Program in Agriculture National Chung Hsing University Taichung City402202 Taiwan Department of Agricultural Product Technology Sebelas Maret University Surakarta City57126 Indonesia Department of Food Science National Pingtung University of Science and Technology Pingtung City912301 Taiwan Department of Food Science and Technology Sebelas Maret University Surakarta City57126 Indonesia Department of Food Technology Muhammadiyah University of Bandung Bandung City40614 Indonesia Graduate Institute of Food Science and Technology National Taiwan University Taipei City10617 Taiwan Institute of Biotechnology National Taiwan University Taipei City10617 Taiwan Department of Medical Research China Medical University Hospital Taichung City404327 Taiwan Department of Food Science Fu Jen Catholic University New Taipei City242062 Taiwan Department of Optometry Asia University Taichung City413305 Taiwan Department of Seafood Science National Kaohsiung University of Science and Technology Kaohsiung City81157 Taiwan Department of Food Science National Ilan University Yilan City260007 Taiwan

The limitations of traditional extraction methods in terms of efficiency and environmental sustainability have highlighted the urgent need for advancements in extraction technology. Pleurotus ostreatus (oyster mushroom), a functional mushroom known for its antioxidant properties, was investigated for its potential in nutraceutical and food applications. This study evaluates the extraction efficiency, structural integrity, bioactivity, and energy efficiency of Pleurotus ostreatus polysaccharides obtained through eco-friendly, non-thermal techniques known to enhance mass transfer and disrupt cell wall structures. These include ultrasound-assisted extraction (UAE), plasma-assisted extraction (PAE), and plasma pretreatment-ultrasound extraction (PPUE), in comparison to conventional hot water extraction (HWE). PPUE, under optimal conditions (1 min plasma pretreatment and 30 min ultrasound), achieved the highest crude polysaccharide yield (12.0 %), surpassing PAE, UAE, and HWE by 23.7 %, 57.5 %, and 72.4 %, respectively. PPUE also exhibited superior energy efficiency (975.6 kJ/g), indicating lower energy consumption per unit of extracted polysaccharide. Additionally, it showed enhanced water solubility index (65.7 %) and water holding capacity (4.66 g/g), alongside the highest total phenolic content (67.07 μg GAE/g) and antioxidant activity (ABTS, 81.5 %), reflecting its ability to preserve functional compounds effectively. Structural analyses revealed that PPUE synergistically combines oxidative cleavage by plasma-generated reactive oxygen and nitrogen species with ultrasound cavitation, thereby enhancing cell wall disruption, permeability, mass transfer, and polysaccharide release. Kinetic modeling confirmed that PPUE follows a two-site extraction mechanism, effectively balancing rapid desorption and controlled diffusion. While this study demonstrates PPUE as a promising and energy-efficient extraction method, further investigation is recommended to validate its applica

关键词： Osmosis

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Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

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Phytochemistry Letters 2024年 61卷 115-119页

作者： Cheng, Ting-Yu Yang, Chia-Jung Chen, Po-Jen Chen, Yu-Li Peng, Bo-Rong Kung, Te-An Wen, Zhi-Hong Lai, Kuei-Hung Chung, Hsu-Ming Department of Applied Chemistry National Pingtung University Pingtung 900393 Taiwan Clinical Immunology Laboratory Department of Medical Research E-Da Hospital I-Shou University Kaohsiung 824005 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 33305 Taiwan Graduate Institute of Biomedical Sciences Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 33305 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Institute of Food Safety Management National Pingtung University of Science and Technology Pingtung 91201 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan Institute of BioPharmaceutical Sciences National Sun Yat-sen University Kaohsiung 804201 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei 11031 Taiwan

Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, ¹H NMR, and ¹³C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions. © 2024 Phytochemical Society of Europe

关键词： Capnella imbricata COX-2 INOS Steroid

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Vegan salad dressing based on cashew nuts with or without Spirulina platensis : Physicochemical, rheological, and sensory characterization and in vitro digestion of phenolic compounds

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International Journal of Gastronomy and food science 2025年 41卷

作者： Edilene Ferreira da Silva Bruna Rafaela da Silva Monteiro Wanderley Natália Duarte de Lima Carlen Bettim Bianchini Carlise Beddin Fritzen-Freire Renata Dias de Mello Castanho Amboni Silvani Verruck Itaciara Larroza Nunes Graduate Program in Food Science Department of Food Science and Technology Federal University of Santa Catarina (UFSC) Florianopolis 88034-001 Brazil

The growing demand for plant-based foods has driven the development of innovative vegan products. In this context, cashew nuts represent an excellent plant-based matrix for sauces, while Spirulina platensis emerges as a promising ingredient due to its phenolic compounds. This study aimed to develop innovative vegan salad dressings based on cashew nuts, incorporating Spirulina platensis as a functional ingredient. By combining these components, the formulation offers a novel plant-based alternative that aligns with the growing demand for nutritious, clean-label products free from animal-derived ingredients. Three formulations were developed: F1 without S. platensis (control), and F2 and F3 with 1 % and 2 % S. platensis biomass, respectively. The formulations were subjected to proximate composition, microbiological, and sensory analyses. During refrigerated storage, the formulations were evaluated for physicochemical characteristics, color, rheological properties and texture, in vitro digestion, antioxidant activity, and the bioaccessibility of phenolic compounds. The salad dressing formulations presented a similar average lipid (8.84 %) and protein (4.86 %) contents, and can be considered to have a reduced lipid content. F1 had the highest carbohydrate content (13.07 %), and F3 had the highest ash content (2.29 %). When adding S. platensis biomass, the brightness decreased and there was a tendency to develop a green color during storage, while the rheological behavior and textural profile remained the same. Based on in vitro digestion, F3 stood out as a source of phenolic compounds, presenting a higher concentration in the intestinal phase (0.85 g gallic acid equivalents g −1 ). The bioaccessibility of phenolic compounds increased as the S. platensis biomass increased. For the sensory evaluation, most of the panelists expressed interest in consuming foods containing microalgae. S. platensis had no significant influence on the overall acceptance, color, and aroma, and

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Impact of absence of lactose on the dynamic sensory profile of yogurt: A multiple-intake TDS approach

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LWT 2022年 162卷

作者： Souza Olegario, Lary González-Mohino, Alberto Estévez, Mario Madruga, Marta Suely Ventanas, Sonia Post-Graduate Program in Food Science and Technology Department of Food Engineering Technology Centre Federal University of Paraiba Paraíba João Pessoa58051-900 Brazil IPROCAR Research Institute TECAL Research Group Universidad de Extremadura Cáceres10003 Spain

This paper aims to evaluate the impact of lactose free yogurt version on dynamic sensory perception and consumer acceptability. A total of 46 participants evaluated classical (SNY) and lactose-free (SLF-Y) commercial version of yogurts using the multiple-intake TDS technique, providing information about the dominant sequence of six flavor and texture sensory attributes. Moreover, information regarding the overall liking of the evaluated products was obtained. During the first intake, in SLF-Y samples, sourness presented a higher dominance rate compared to SNY. A similar dominance profile was obtained during the second intake between the two yogurts. During the third intake, SNY consumption was dominated by dairy attribute whereas during SLF-Y intake, fermented and creaminess were the dominance attributes. Yogurt version and the numbers of intakes presented a significant impact on temporal perception. Moreover, similar liking scores were reported for both evaluated yogurts. The present study revealed that absence of lactose showed an impact of temporal sensory perception of yogurt and the potential modifications on sensory perception can be revealed by applying the multiple intake TDS approach. © 2022 The Authors

关键词： Sensory perception

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Development of biodegradable food packaging in the context of COVID-19: sustainability more urgent than ever

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Sustainability Nexus Forum 2023年第1期30卷 1-11页

作者： Pinheiro de Souza, Thaiza Serrano Rabelo Vaz Matheus, Julia Salles Barone, Andreza Mota Ferreira, Danielle Cristine Pelissari, Franciele Maria Fai, Ana Elizabeth Cavalcante Food and Nutrition Graduate Program Federal University of the State of Rio de Janeiro (UNIRIO) Rio de Janeiro Brazil School of Agriculture Food and Ecosystem Sciences Faculty of Science The University of Melbourne Melbourne Australia Laboratory of Green Materials Institute of Science and Technology Federal University of Jequitinhonha and Mucuri Valleys (UFVJM) Diamantina Brazil Laboratory of Food Materials Studies Department of Food Technology University of Viçosa (UFV) Viçosa Brazil Laboratory of Multidisciplinary Practices for Sustainability (LAMPS) Department of Basic and Experimental Nutrition Institute of Nutrition State University of Rio de Janeiro (UERJ) Rio de Janeiro Brazil

The indiscriminate overconsumption of non-biodegradable packaging, particularly single-use food packaging, resulting from COVID-19 is exacerbating an age-old environmental problem. This is due to changes in consumer behavior that is concerned with safety issues when buying food, which has led to a preference for purchase in delivery and take-out. In addition, health department agencies indicate the use of disposable products to prevent contamination (e.g., disposable foods; and pre-packaged foods). To date, there is no evidence of SARS-CoV‑2 contamination through food ingestion, however, COVID-19 has raised awareness about packaging for hygienic-sanitary protection of food. This thesis paper discusses arguments from the literature regarding the current development of biodegradable food packaging in the context of COVID-19. It takes an international perspective concerning the impact of the pandemic and correlates it with the changes in current and post-pandemic perspectives. To minimize the impacts related to the increase in the consumption of plastics, there must be a greater investment in research for the development of biodegradable packaging focusing on recyclability. Besides that, there is a necessity to change the type of economy adopted nowadays—that is, the linear economy, to the circular economy.

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Waterborne atenolol disrupts neurobehavioral and neurochemical responses in adult zebrafish

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Environmental science and Pollution Research 2024年第36期31卷 49200-49213页

作者： Adedara, Isaac A. Gonçalves, Falco L. Mohammed, Khadija A. Borba, João V. Canzian, Julia Resmim, Cássio M. Claro, Mariana T. Macedo, Gabriel T. Mostardeiro, Vitor B. Assmann, Charles E. Monteiro, Camila S. Emanuelli, Tatiana Schetinger, Maria R. C. Barbosa, Nilda V. Rosemberg, Denis B. Department of Food Technology and Science Center of Rural Sciences Federal University of Santa Maria Camobi RS Santa Maria97105-900 Brazil Drug Metabolism and Toxicology Research Laboratories Department of Biochemistry College of Medicine University of Ibadan Ibadan Nigeria Laboratory of Experimental Neuropsychobiology Department of Biochemistry and Molecular Biology Natural and Exact Sciences Center Federal University of Santa Maria Camobi 1000 Roraima Avenue RS Santa Maria97105-900 Brazil Graduate Program in Biological Sciences: Toxicological Biochemistry Federal University of Santa Maria Camobi 1000 Roraima Avenue RS Santa Maria97105-900 Brazil 309 Palmer Court SlidellLA70458 United States

Environmental contamination by pharmaceuticals from industrial waste and anthropogenic activities poses adverse health effects on non-target organisms. We evaluated the neurobehavioral and biochemical responses accompanying exposure to ecological relevant concentrations of atenolol (0, 0.1, 1.0, and 10 µg/L) for seven uninterrupted days in adult zebrafish (Danio rerio). Atenolol-exposed fish exhibited anxiety-like behavior, characterized by significant bottom-dwelling with marked reduction in vertical exploration. Atenolol-exposed fish exhibited marked increase in the duration and frequency of aggressive events without altering their preference for conspecifics. Biochemical data using brain samples indicated that atenolol disrupted antioxidant enzyme activities and induced oxidative stress. Exposure to atenolol markedly decreased ATP and AMP hydrolysis without affecting ADP hydrolysis and acetylcholinesterase (AChE) activity. Atenolol significantly upregulated tryptophan hydroxylase 1 (tph1) mRNA expression but downregulated brain-derived neurotrophic factor (bdnf) mRNA. Collectively, waterborne atenolol elicits aggressive and anxiety-like responses in adult zebrafish, accompanied by oxidative stress, reduced nucleotide hydrolysis, altered tph1 and bdnf mRNA expression, which may impact the survival and health of fish in aquatic environment. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Fish

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Evaluation of Oxalic Acid Extraction and Quantification Methods in the Different Purslane (Portulaca Oleracea L.) Matrices and Spinach (Spinacea Oleracea)

SSRN

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SSRN 2024年

作者： de Souza, Pâmela Gomes Pallone, Juliana Azevedo Lima Orlando, Eduardo Adilson Costa-Santos, Augusto César Ayres, Ellen Mayra Menezes Rosenthal, Amauri Teodoro, Anderson Junger Laboratory of Food Analysis Graduate Program in Food Nutrition Fluminense Federal University Rua Mário Santana Braga 30 RJ Niteroi Brazil Laboratory of Food Analysis by Spectroscopy Faculty of Food Engineering State University of Campinas Rua Monteiro Lobato 80 Barão Geraldo SP Campinas Brazil Sensory and Consumer Science Laboratory Postgraduate Program in Food and Nutrition Federal University of the State of Rio de Janeiro Laboratorio Av. Pasteur -Urca 29 Rio de Janeiro Brazil Embrapa Food Technology Av. das América Guaratiba RJ Rio de Janeiro29501 Brazil

Purslane (Portulaca oleracea L.) is considered a Non-Conventional food Plant (NCFP), as it is a vegetable that is underutilized by the population. This specie, like spinach (Spinacea oleracea), has high levels of oxalic acid, an antinutrient that interferes with the bioaccessibility of minerals such as calcium and iron. The valuation of NCFP through scientific research has gained strength over the last few years and the oxalic acid content in vegetables and juices containing conventional or non-conventional vegetables, which have considerable levels of antinutrients, needs to be investigated. Therefore, evaluating and developing new alternative methods that determine the oxalic acid content with less matrix interference, such as the use of Flame Atomic Absorption Spectrometry (FAAS), can contribute to science and consumers. © 2024, The Authors. All rights reserved.

关键词： Sustainable chemistry

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Enhanced bioavailability and improved antimicrobial, antibiofilm, and antivirulence activities of fish gelatin-based nanoformulations prepared by coating of maltol-gold nanoparticles

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Chemosphere 2025年 379卷

作者： Tabassum, Nazia Khan, Fazlurrahman Jeong, Geum-Jae Oh, Do Kyung Kim, Young-Mog Marine Integrated Biomedical Technology Center The National Key Research Institutes in Universities Pukyong National University Busan48513 Korea Republic of Research Center for Marine Integrated Bionics Technology Pukyong National University Busan48513 Korea Republic of Ocean and Fisheries Development International Cooperation Institute Pukyong National University Busan48513 Korea Republic of International Graduate Program of Fisheries Science Pukyong National University Busan48513 Korea Republic of Interdisciplinary Program of Marine and Fisheries Sciences and Convergent Technology Pukyong National University Busan48513 Korea Republic of Department of Food Science and Technology Pukyong National University Busan48513 Korea Republic of

Biofilm formation by a single and multiple microbial species poses a significant challenge to healthcare due to biofilm-related antibiotic resistance. This study aimed to develop a nanoformulation (Mal-AuNP-Gel) by synthesizing gold nanoparticles (AuNPs) with maltol (Mal), and coating them with fish gelatin (Gel) to reduce biofilm formation and virulence characteristics of microbial pathogens. Mal-AuNP-Gel showed increased antibacterial activity against all pathogens studied, including bacterial (Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Listeria monocytogenes, Escherichia coli, and methicillin-resistant S. aureus) and fungal pathogens (e.g., Candida albicans), with MICs up to 2-fold lower than those of Mal-AuNPs. At the sub-MIC level, Mal-AuNPs-Gel, compared to Mal-AuNPs, improved the inhibition of initial-stage biofilm development by a single species of P. aeruginosa, S. aureus, and C. albicans as well as the mixed-species biofilm of S. aureus and C. albicans. Additionally, these nanoparticles significantly inhibited several virulence characteristics such as hemolysis, pyoverdine and pyocyanin production, protease activity, and motility of P. aeruginosa. Furthermore, the expression of genes associated with biofilm formation, quorum sensing, motility, and virulence factors in P. aeruginosa was found to be suppressed by Mal-AuNPs-Gel at a higher level than that of Mal-AuNPs, corroborating the phenotypic effects. The non-cytotoxic effects of Mal-AuNPs and Mal-AuNPs-Gel at sub-MIC levels, as evidenced by results of in vitro cell cytotoxicity and in vivo phytotoxicity tests, further indicated biocompatibility of the synthesized nanoparticles. © 2025 Elsevier Ltd

关键词： Gold coatings

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Digitizing Farmers' Land Data Collection Systems in Indonesia with the Use of Tani Millenial Apps 4

Digitizing Farmers' Land Data Collection Systems in Indonesi...

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4th International Conference on Cybernetics and Intelligent System, ICORIS 2022

作者： Bimantio, Mohammad Prasanto Putra, Dian Pratama Suparyanto, Teddy Ferhat, Amallia Nugraha, Nanda Satya Hidayat, Alam Ahmad Pardamean, Bens Institute of Agriculture STIPER Department of Food and Agricultural Technology Yogyakarta Indonesia Institute of Agriculture STIPER Department of Agrotechnology Yogyakarta Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Institute of Agriculture STIPER Department of Agricultural Socio-Economics Yogyakarta Indonesia Institute of Agriculture STIPER Department of Forestry Yogyakarta Indonesia Bina Nusantara University BINUS Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9781665453950

In this era of digital world information, farmers face challenges about information management of huge data and the complexity of processes in precision farming. The data collection carried out so far can cause several difficulties, especially if the data is needed by the government or academics to support decision-making. Agricultural data collection applications only cover 12% of the market share of Android-based agriculture-based applications. In this study, Tani Milenial application is present as an alternative to support agricultural data collection activities in Indonesia. This application encourages farmers to be active and contribute independently to their role as subjects of agricultural development and is accustomed to digitally recording their agricultural activities. In this developed application system, the community, especially farmers and farmer groups, will find it easier to get information about agricultural potential data around where they carry out agricultural activities and can access this information online. Tani Milenial works as a guide to help farmers and transform agriculture but still have some gaps which should be checked and removed. The data collected can be used by various parties for research and decision-making. The app can be further improved to develop new features related to education, market information, and goods. © 2022 IEEE.

关键词： Decision making

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