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Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers Abstracts

FLUIDS AND BARRIERS OF THE CNS 2017年第SUPPL 2期14卷 27-27页

作者： [Anonymous] The Jerzy Kukuczka Academy of Physical Education Katowice Poland The Institute of Animal Physiology and Food Research Polish Academy of Sciences Olsztyn Poland University of Miami Miami FL USA Institute of Pharmaceutical Science King’s College London London United Kingdom Department of Ophthalmology and Molecular and Integrative Physiology The University of Michigan Ann Arbor MI USA Department of Internal Medicine and Cardiology The University of Michigan Ann Arbor MI USA School of Medicine Department of Cellular and Molecular Medicine Koc University Istanbul Turkey Department of Cellular and Molecular Medicine Medical Faculty Koc University Istanbul Turkey Department of Neuroscience School of Medicine Koc University Istanbul Turkey Department of Neuroscience Medical Faculty Koc University Istanbul Turkey Department of Laboratory Animals Science Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey Department of Neuroscience Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey School of Medicine Koc University Istanbul Turkey Department of Forensic Science Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Histology and Embryology School of Medicine Koc University Istanbul Turkey Department of Histology and Embryology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Physiology School of Medicine Koc University Istanbul Turkey Theodor Kocher Institute University of Bern Bern Switzerland Institute of Veterinary Physiology Vetsuisse Faculty University of Zurich Zurich Switzerland Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Zurich Center of Integrative Human Physiology University of Zurich Zurich Switzerland Institute for Veterinary Physiology and Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Institute of Veterinary Physiology Univer

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Different responses of the skin temperature to physical exercise: Systematic review

Different responses of the skin temperature to physical exer...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Eduardo B. Neves José Vilaça-Alves Natacha Antunes Ivo M.V. Felisberto Claudio Rosa Victor M. Reis Brazilian Army and Graduate Program in Biomedical Engineering Federal Technological University of Paraná Brazil Research Center for Sports Health Sciences and Human Development CIDESD University Trás-os-Montes Montes & Alto Douro Vila Real Portugal

Studies suggest that skin temperature behavior varies according to the type of exercise, intensity, duration, muscle mass and subcutaneous fat layer. In this sense, the aim of this study was to investigate the skin temperature behavior in the active muscles and other body segments, during and after exercise, according to the type and intensity of the exercise. A systematic literature review was conducted between November 2014 and March 2015 in the Web of Science database, using the terms “thermography” and “exercise” and “muscle” to achieve the objective of this study. During the research were found 55 scientific articles which were subjected to a selection process. Inclusion criteria were: Studies in human beings and original research. The exclusion criterion was the presence of subjects with some kind of disease. The seven papers that make up the present review are dated between 2008 and 2015. From all analyzed studies, it was possible to understand the general behavior of the active muscle skin temperature during the exercise, immediately after and in the 48h after exercise, according to the type and intensity of the exercise performed, which are illustrated in two figures. It can be concluded that the skin temperature over active muscles increases during high intensity anaerobic exercise, decreases slowly after exercise and increases again in the days after the exercise. On the other hand, during low intensity aerobic exercise, skin temperature over active muscles decreases, returning to normal values a few minutes after it and present a small rise in the following days. With regard to the skin temperature over non-active muscles, it can be seen that it decreases during exercise, returning to normal values a few minutes after it and rise similarly to the skin temperature over active muscles in the following days, in all types of exercises studied.

关键词： Skin Muscles Temperature sensors Temperature Heating Protocols Training

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PS141. Depressive Symptoms, as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

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International Journal of Neuropsychopharmacology 2016年第SUPPL_1期19卷 48-48页

作者： Murakami, Yuki Tomita, Eiichi Nishikawa, Makiya Mouri, Akihiro Kubo, Hisako Yamamoto, Yasuko Kim, Hyoung-Chun Nabeshima, Toshitaka Saito, Kuniaki Human Health Sciences Graduate School of Medicine and Faculty of Medicine Kyoto University Kyoto 606–8507 Japan Organization for Research Initiatives and Development Doshisha University Kyoto 610-0394 Japan Department of Gastroenterology Gifu Municipal Hospital Gifu 500–8513 Japan Department of Biopharmaceutics and Drug Metabolism Graduate School of Pharmaceutical Sciences Kyoto University Kyoto 606–8501 Japan Advanced Diagnostic System Research Laboratory Fujita Health University Graduate School of Health Sciences Toyoake Aichi 470–1192 Japan Department of Disease Control and Prevention Fujita Health University Graduate School of Health Sciences Toyoake Aichi 470–1192 Japan Neuropsychopharmacology & Toxicology Program College of Pharmacy Kangwon National University Gangwon 200–701 Republic of Korea

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24: Maternal immunoglobulin D induced by antepartum vaccination undergoes placental transfer to the fetus

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American Journal of Obstetrics and Gynecology 2016年第6期215卷 S825-S825页

作者： Guterman, J. Pawlitz, M.D. Pei, B. Goyert, J. Puder, K.S. Gonik, B. Chen, K. Department of Obstetrics and Gynecology Wayne State University Detroit Michigan 48201 USA Perinatology Research Branch Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Detroit Michigan 48201 USA Graduate Program in Immunology and Microbiology Department of Immunology and Microbiology Wayne State University Detroit Michigan 48201 USA Department of Oncology Wayne State University Detroit Michigan 48201 USA Tumor Biology and Microenvironment Program Barbara Ann Karmanos Cancer Center Detroit Michigan 48201 USA Mucosal Immunology Studies Team National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland 20892 USA

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World Congress Integrative Medicine & health 2017: Part one: Berlin, Germany. 3-5 May 2017

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BMC Complement Altern Med 2017年第SUPPL 1期17卷 322-322页

作者： Benno Brinkhaus Torkel Falkenberg Aviad Haramati Stefan N. Willich Josephine P. Briggs Merlin Willcox Klaus Linde Töres Theorell Lisa M. Wong Jeffrey Dusek Darong Wu David Eisenberg Bettina Berger Kathi Kemper Beate Stock-Schröer Hedda Sützl-Klein Rosaria Ferreri Gary Kaplan Harald Matthes Gabriele Rotter Elad Schiff Zahi Arnon Eckhard Hahn Christina M. Luberto David Martin Silke Schwarz Diethard Tauschel Andrew Flower Harsha Gramminger Hedwig H. Gupta S. N. Gupta Annette Kerckhoff Christian S. Kessler Andreas Michalsen Eun S. Kim Eun H. Jang Rana Kim Sae B. Jan Martin Mittwede Wiebke Mohme Eran Ben-Arye Massimo Bonucci Bashar Saad Thomas Breitkreuz Elio Rossi Rejin Kebudi Michel Daher Samaher Razaq Nahla Gafer Omar Nimri Mohamed Hablas Gunver Sophia Kienle Noah Samuels Michael Silbermann Lena Bandelin Anna-Lena Lang Eva Wartner Christoph Holtermann Maxwell Binstock Robert Riebau Edin Mujkanovic Holger Cramer Romy Lauche Andres Michalsen Lesley Ward Dominik Irnich Wolfram Stör Geoffrey Burnstock Hans-Georg Schaible Thomas Ots Jost Langhorst Tobias Sundberg Catherina Amarell Melanie Anheyer Marion Eckert Mercedes Ogal Annette Schönauer Birgit Reisenberger Bernhard Brand Dennis Anheyer Gustav Dobos Matthias Kroez Aldo Ammendola Jun J. Mao Claudia Witt Yufei Yang Miriam Oritz Markus Horneber Petra Voiß Alexandra von Rosenstiel Catharina Amarell Friedemann Schad Marc Schläppi Matthias Kröz Arndt Büssing Gil Bar-Sela David Avshalomov Samuel Attias Sian Cotton Miek Jong Mats Jong Christian Scheffer Friedrich Edelhäuser Abdullah AlBedah Myeong Soo Lee Mohamed Khalil Keiko Ogawa Yoshiharu Motoo Junsuke Arimitsu Masao Ogawa Genki Shimizu Rainer Stange Karin Kraft Kenny Kuchta Kenji Watanabe D Bonin Harald Gruber Sabine Koch Urs Pohlmann Christine Caldwell Barbara Krantz Ria Kortum Lily Martin Lisa S. Wieland Ben Kligler Susan Gould-Fogerite Yuqing Zhang John J. Riva Michael Lumpkin Emily Ratner Liu Ping Pei Jian Gesa-Meyer Hamme Xiaosong Mao Han Chouping Sven Schröder Josef Hummelsberger Michael Wullinger Marc Brodzky Chr Institute for Social Medicine Epidemiology and Health Economics Charité – Universitätsmedizin Berlin Berlin Germany Department of Neurobiology Care Sciences and Society Division of Nursing Research Group Integrative Care Karolinska Institutet Stockholm Sweden I C – The Integrative Care Science Center Järna Sweden Department of Biochemistry Molecular and Cellular Biology Georgetown University Medical Center Washington DC USA Department of Medicine Georgetown University Medical Center Washington DC USA NCCIH NIH Bethesda MD USA Department of Primary Care and Population Sciences University of Southampton Aldermoor Health Centre Coxford Rd Southampton 2016 5ST UK Institute of General Practice Technical University Munich Munich Germany Department of Neuroscience Karolinska Institute Stockholm Sweden Stress Research Institute Stockholm University Stockholm Sweden Arts and Humanities Initiative Harvard Medical School Boston MA 02115 USA Psychosomatic medicine Neuropsychology Allina Health Minneapolis MN USA nd Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China Department of Nutrition Harvard University T H Chan School of Public Health Boston MA 02115 USA Department of Health University of Witten/Herdecke Witten/Herdecke Germany OSU Blacklick OH USA Carstens-Foundation and FORUM D-45276 Essen Germany ESIHR (European Society for Integrative Health Care) A-1070 Vienna Austria Hospital Centre of Integrated Medicine Hospital of Pitiglian o ASL SudEst Toscana Grosseto Italy The Kaplan Center for Integrative Medicine Georgetown University McLean VA USA Hospital Havelhöhe Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité University Hospital Berlin Germany Internal medicine and Complementary medicine service Bnai Zion Medical Center Haifa Israel Complementary-Integrative Surgery Service Bnai Zion Medical Center Haifa Israel The Emek Yezreel Academic College Yezreel Valley Israel Medicine

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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H Dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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Abstracts from the Food Allergy and Anaphylaxis Meeting 2016 Abstracts

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CLINICAL AND TRANSLATIONAL ALLERGY 2017年第SUPPL 1期7卷 10-10页

作者： [Anonymous] Department of Pediatrics Children’s Hospital Roubaix France Division of Pulmonology and Allergology Department of Pediatrics Faculty of Medicine and Children’s Hospital Lille France Allergy Vigilance Network Vandoeuvre les Nancy France Université Lille 2 CHU Lille EA 2694 - Santé Publique: épidémiologie et qualité des soins Lille France Biostatistics Unit Maison Régionale de la Recherche Clinique CHRU Lille Lille France Department of Allergology Emile Durkheim Hospital Epinal France Centre d’Epidémiologie sur les Causes Médicales de Décès INSERM CHU de Bicêtre Le Kremlin-Bicêtre France The Allergy Vigilance Network University Hospital Nancy Nancy France Pediatric Pulmonology and Allergy Department Hôpital Jeanne de Flandre CHU Lille Lille France Charité - Universitätsmedizin Berlin Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité - Universitätsmedizin Berlin Berlin Germany Institute of Social Medicine Epidemiology and Health Economics Charité Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité – Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergy Allergie-Centrum-Charité Charité-Universiätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité Universitätsmedizin Berlin Berlin Germany University Hospital Basel Basel Switzerland Allergy Unit Department of Dermatology University Hospital Basel Switzerland Universitätsklinikum Salzburg Salzburg Austria Department of Dermatology and Allergy Centre Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark Odense University Hospital Odense Denmark Serviço de ImunoalergologiaCentro Hospitalar de São João E.P.E. Porto Portugal GRIAC Research Institute University of Groningen University Medical Center Groningen Groningen The Netherlands Serviço de Imunoalergologia Centr

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WAO International Scientific Conference (WISC 2016) Abstracts

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WORLD ALLERGY ORGANIZATION JOURNAL 2017年第SUPPL 1期10卷 25-25页

作者： [Anonymous] Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Pediatric Respirology Shanghai China Cincinnati Childrens Hospital Medical Center Division of Allergy and Immunology Cincinnati OH USA Cincinnati Childrens Hospital Medical Center Division of Asthma Research Cincinnati OH USA Cincinnati Childrens Hospital Medical Center Division of Human Genetics Cincinnati OH USA Universidad La Salle Facultad Mexicana de Medicina Mexico City Mexico Hospital Infantil de Mexico Federico Gomez Pediatric Allergy & Clinical Immunology Mexico City Mexico Beijing TongRen Hospital Department of Otolaryngology Head and Neck Surgery Beijing China Beijing Institute of Otolaryngology Beijing Key Laboratory of Nasal Diseases Beijing China Beijing TongRen Hospital Department of Allergy Beijing China Ghent University Hospital Upper Airways Research Laboratory Ghent Belgium University of Manitoba Section of Allergy and Immunology Department of Paediatrics and Child Health Winnipeg Canada India Department of Pharmacology Pune Poona College of Pharmacy Bharati Vidyapeeth Deemed University Department of Pharmacology Erandwane Paud Road Pune 411038 Maharashtra India Brigham and Women Pulmonary Critical Care Boston MA USA Harvard University Harvard Clinical Research Institute Boston MA USA Harvard TH Chan School of Public Health Environmental Health Boston MA USA Brigham and Women’s Hospital Pulmonary Critical Care Boston MA USA National Jewish Health Pulmonary Critical Care Denver CO USA American Academy of Family Physicians Family Medicine Denver CO USA University of Minnesota Family and Community Health Minneapolis Minnesota MN USA Soonchynhyang University Respiratory-Allergy Bucheon South Korea Utah University Biology Salt Lake City UT USA Sydney University Mathematics Sydney Australia Kaohsiung Veterans General Hospital Pediatrics Kaohsiung Taiwan Kaohsiung Veterans General Hospital Cardiac Surgery Kaohsiung Taiwan Kaohsiung Veterans General Hospital Patho

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Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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Nature communications 2017年第1期8卷 1414页

作者： M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Department of Internal Medicine Erasmus MC Rotterdam 3000 The Netherlands. Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) Leiden 2593 The Netherlands. Department of Biostatistics Boston University School of Public Health Boston MA 02118 USA. Hebrew SeniorLife Institute for Aging Research Roslindale MA 02131 USA. Harvard Medical School Boston MA 02115 USA. Molecular and Integrative Physiological Sciences Program Harvard School of Public Health Boston MA 02115 USA. Program in Personalized and Genomic Medicine and Department of Medicine Division of Endocrinology Diabetes and Nutrition University of Maryland School of Medicine Baltimore MD 21201 USA. Broad Institute Cambridge MA 02142 USA. Sackler Faculty of Medicine Department of Anatomy and Anthropology Tel Aviv University Tel Aviv 6997801 Israel. Department of Twin Research and Genetic Epidemiology King's College London St Thomas' Campus London WC2R 2LS UK. Department of Epidemiology Erasmus MC Rotterdam 3000 The Netherlands. Department of Medical Genetics University of Lausanne Lausanne 1011 Switzerland. Swiss Institute of Bioinformatics Lausanne 1015 Switzerland. Centre Hospitalier Universitaire (CHUV) University Institute for Social and Preventive Medicine Lausanne 1010 Switzerland. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN 46202 USA. MRC Epidemiology Unit University of Cambridge School of Clinical Medicine Cambridge Biomedical Campus Cambridge CB2 OQQ UK. Institute of Epidemiology II Helmholtz Zentrum München - German Research Center for Environmental Health Neuherberg 85764 Germany. Icelandic Heart Association Kopavogur 201 Iceland. Faculty of Medicine University of Iceland Reykjavik 101 Iceland. deCODE Genetics Reykjavik 101 Iceland. Department of Internal Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg SE-405 30 Sweden. Dep

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IRF8 Restrains Monocyte-Dendritic Cell Progenitors fro Differentiating into Neutrophils by Inhibiting C/EBPα Activity

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BLOOD 2013年第21期122卷 2438-2438页

作者： Kurotaki, Daisuke Yamamoto, Michio Nishiyama, Akira Uno, Kazuhiro Sasaki, Haruka Ozato, Keiko Tamura, Tomohiko Department of Immunology Yokohama City University Graduate School of Medicine Yokohama Japan Program in Genomics of Differentiation National Institute of Child Health and Human Development NIH Bethesda MD USA

Introduction During hematopoiesis, myeloid progenitors lose their potential to generate neutrophils when they progress towards monocyte-dendritic cell progenitors (MDPs). However, the mechanism of how this lineage restriction occurs remains poorly *** Regulatory Factor-8 (IRF8) is a transcription factor essential for the development of dendritic cells (DCs) and monocytes, while it inhibits neutrophil differentiation. Irf8–/–mice develop immunodeficiency and a chronic myeloid leukemia-like disease. IRF8 is expressed in monocytes/DCs but not in neutrophils. In contrast to well-studied IRF8 action in stimulating differentiation, how IRF8 inhibits neutrophil differentiation remains unknown. Results Immunostaining followed by flow cytometry demonstrated that IRF8 protein expression was barely detected in hematopoietic stem cells but sharply increased at the stage of MDPs during myeloid differentiation. Detailed flow cytometric analysis showed that Irf8–/– myeloid progenitors accumulated at the stage of CD117+ MDPs. When transplanted into irradiated mice, Irf8–/– MDPs failed to efficiently generate DCs and monocytes in vivo. We found that these Irf8–/– CD117+ MDPs instead gave rise to a large number of neutrophils both in vivo and in *** investigate the mechanism by which IRF8 inhibits neutrophil differentiation in MDPs, we performed transcriptome analysis by microarray in WT and Irf8–/– MDPs. Computational pathway analysis predicted that C/EBP transcription factor(s) is aberrantly activated in Irf8–/– MDPs. Among C/EBPs, C/EBPα and C/EBPε are known to potently drive myeloid progenitor cells to differentiate into neutrophils. In Irf8–/–MDPs, however, mRNA and protein expression of these C/EBPs were not upregulated, and only C/EBPα protein was readily detectable. Therefore we speculated that IRF8 might regulate the activity, rather than the expression, of C/EBPα.Reporter assay using HEK293T cells demonstrated that IRF8 inhibited transcription acti

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