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arXiv 2025年

作者： Martín-Luna, Pablo Bonatto, Alexandre Bontoiu, Cristian Lei, Bifeng Xia, Guoxing Resta-López, Javier Universitat de València - Consejo Superior de Investigaciones Científicas Paterna46980 Spain Graduate Program in Information Technology and Healthcare Management The Beam Physics Group Federal University of Health Sciences of Porto Alegre RS Porto Alegre90050-170 Brazil Department of Physics The University of Liverpool LiverpoolL69 3BX United Kingdom The Cockcroft Institute Sci-Tech Daresbury WarringtonWA4 4AD United Kingdom Department of Physics and Astronomy The University of Manchester ManchesterM13 9PL United Kingdom Universidad de Valencia Valencia46071 Spain

The interaction of fast charged particles with graphene layers can generate electromagnetic modes. This wake effect has been recently proposed for short-wavelength, high-gradient particle acceleration and for obtaining brilliant radiation sources. In this study, the excitation of wakefields produced by a point-like charged particle moving parallel to a multilayer graphene array (which may be supported by an insulated substrate) is studied using the linearized hydrodynamic theory. General expressions for the excited longitudinal and transverse wakefields have been derived. The dependencies of the wakefields on the positions of the layers and the substrate, the velocity and the surface density have been extensively analyzed. This study provides a deeper understanding of the physical phenomena underlying plasmonic excitations in graphene layers, paving the way for potential applications of these structures in particle acceleration, nanotechnology and materials science. © 2025, CC BY-NC-ND.

关键词： Plasmons

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WCN24-2346 NUTRITIONAL PARAMETERS OF PATIENTS AFTER PLANNED AND UNPLANNED START OF PERITONEAL DIALYSIS: A PROSPECTIVE STUDY

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Kidney International Reports 2024年第4期9卷 S606-S607页

作者： Maryanne Silva Barbara Vogt Fabiana Costa Daniela Ponce Bengt Lindholm Carla Avesani Jacqueline Caramori Botucatu Internal Medicine Brazil Graduate Program in Health Sciences Federal University of Uberlândia Uberlândia Internal Medicine São Paulo State University Botucatu Division of Renal Medicine and Baxter Novum Department of Clinical Science Technology and Intervention Karolinska Institutet Stockholm

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In vitro biocompatibility of polycaprolactone/hydroxyapatite nanocomposite membranes modified by oleic acid for bone regeneration

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Colloids and Surfaces A: Physicochemical and Engineering Aspects 2024年 688卷

作者： Lin, Ruei-Hong Hung, Huey-Shan Tang, Cheng-Ming Tsou, Hsi-Kai Chen, Po-Hsiang Yueh, Chun-Yu Wang, Hui-Min David Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung40293 Taiwan Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung40227 Taiwan Translational Medicine Research China Medical University Hospital Taichung404327 Taiwan Graduate Institute of Biomedical Science China Medical University Taichung404333 Taiwan Institute of Oral Sciences Chung Shan Medical University Taichung40201 Taiwan Department of Dentistry Chung Shan Medical University Hospital Taichung40201 Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung40293 Taiwan Department of Rehabilitation Jen-Teh Junior College of Medicine Nursing and Management Miaoli County35664 Taiwan College of Health National Taichung University of Science and Technology Taichung403027 Taiwan School of Medicine China Medical University Taichung404333 Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung80708 Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung40227 Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung40402 Taiwan

The bone defect is common in the orthopedic clinic, possibly due to trauma, tumor, or congenital diseases. Also, some patients with alveolar bone defects in the dental clinic result from the different proliferation speeds between soft and hard tissue. Biomaterials made of polymers and bioceramics have been developed to deal with these problems but mixing them directly can result in a low-mechanical strength complex. To solve this, we used oleic acid (C18) as a surfactant to improve the dispersity of hydroxyapatite (HA) in the polycaprolactone (PCL) matrix, and then immerse the material in a simulated biomineralization process. The results showed that the low crystallinity PCL formed an evenly distributed mineralized layer that had phosphate ions signal and a hydroxyapatite peak. The biocompatibility of the material was assessed using MC3T3 cells, and found that the PCL-HA membrane and PCL-C18-HA membranes had significant cell filopodia and lamellipodia. Additionally, the polycaprolactone/oleic acid/hydroxyapatite (PCL-C18-HA) membrane had the highest cell viability among all groups. The addition of C18 also decreased the platelets activation degree but had a significant difference in the reactive oxygen species (ROS) amount compared to the control, which requires further investigation. Overall, this study successfully fabricated a safe and promising polycaprolactone/hydroxyapatite/oleic acid nanocomposite membrane as a potential solution for bone biomaterials. © 2024 Elsevier B.V.

关键词： Hydroxyapatite

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Plasmonic excitations in double-walled carbon nanotubes

arXiv

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arXiv 2024年

作者： Martín-Luna, Pablo Bonatto, Alexandre Bontoiu, Cristian Xia, Guoxing Resta-López, Javier Universitat de València Consejo Superior de Investigaciones Científicas Paterna46980 Spain Graduate Program in Information Technology and Healthcare Management Beam Physics Group Federal University of Health Sciences of Porto Alegre RS Porto Alegre90050-170 Brazil Department of Physics The University of Liverpool LiverpoolL69 3BX United Kingdom Department of Physics and Astronomy The University of Manchester ManchesterM13 9PL United Kingdom Universidad de Valencia Valencia46071 Spain The Cockcroft Institute Sci-Tech Daresbury WarringtonWA4 4AD United Kingdom

The interactions of charged particles moving paraxially in multi-walled carbon nanotubes (MWCNTs) may excite electromagnetic modes. This wake effect has recently been proposed as a potential novel method of short-wavelength high-gradient particle acceleration. In this work, the excitation of wakefields in double-walled carbon nanotubes (DWCNTs) is studied by means of the linearized hydrodynamic theory. General expressions have been derived for the excited longitudinal and transverse wakefields and related to the resonant wavenumbers which can be obtained from the dispersion relation. In the absence of friction, the stopping power of the wakefield driver, modelled here as a charged macroparticle, can be written solely as a function of these resonant wavenumbers. The dependencies of the wakefields on the radii of the DWCNT and the driving velocity have been studied. DWCNTs with inter-wall distances much smaller than the internal radius may be a potential option to obtain higher wakefields for particle acceleration compared to single-walled carbon nanotubes (SWCNTs). © 2024, CC BY-NC-SA.

关键词： Charged particles

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Low-concentration imiquimod treatment promotes enhanced skin barrier functions through epidermal melanization reaction regulation

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Environmental Toxicology 2024年第9期39卷 4360-4371页

作者： Lin, Tzu-Kai Tsai, Chia-Lun Tsai, Bruce Chi-Kang Kuo, Chia-Hua Ho, Tsung-Jung Hsieh, Dennis Jine-Yuan Kuo, Wei-Wen Huang, Chih-Yang Department of Dermatology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan School of Medicine Tzu Chi University Hualien Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Sports Sciences University of Taipei Taipei Taiwan Laboratory of Exercise Biochemistry Institute of Sports Sciences University of Taipei Tianmu Campus Taipei Taiwan Department of Kinesiology and Health Science College of William and Mary WilliamsburgVA United States Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Integration Center of Traditional Chinese and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan School of Post-Baccalaureate Chinese Medicine College of Medicine Tzu Chi University Hualien Taiwan School of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan

The primary function of the skin is to form a mechanical, permeability, antimicrobial, and ultraviolet radiation barrier, which is essential for maintaining physiological homeostasis. Our previous studies demonstrated that cutaneous pigmentation could promote skin barrier function in addition to providing anti-ultraviolet irradiation defense. The present study aimed to develop a new regimen that enhances skin barrier function by regulating skin pigmentation using low-concentration imiquimod. Results showed that topical application of low-concentration imiquimod effectively induced skin hyperpigmentation in the dorsal skin and external ear of mice without inducing inflammatory cell infiltration. An in vitro study also revealed that low-concentration imiquimod did not induce any cytotoxic effects on melanoma cells but triggered excessive melanin synthesis. In coculture systems, low-concentration imiquimod was noted to increase tyrosinase activity in a broader cellular context, revealing the potential role of neighboring cells in melanin production. The next-generation sequencing result indicated that PKCη and Dnm3 might regulate melanin synthesis and release during imiquimod treatment. Overall, our study presents new insights into the regulation of melanin production by low-concentration imiquimod, both in a mice model and cultured cells. Furthermore, our study highlights the potential benefits of imiquimod in promoting melanin synthesis without causing skin disruptions or inducing inflammation, validating its potential to serve as a method for enhancing skin barrier functions by regulating the epidermal melanization reaction. © 2024 Wiley Periodicals LLC.

关键词： Irradiation

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Plasmonic Excitations in Double-Walled Carbon Nanotubes

SSRN

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SSRN 2024年

作者： Martín-Luna, Pablo Bonatto, Alexandre Bontoiu, Cristian Xia, Guoxing Resta-López, Javier Universitat de València - Consejo Superior de Investigaciones Científicas Paterna46980 Spain Graduate Program in Information Technology and Healthcare Management The Beam Physics Group Federal University of Health Sciences of Porto Alegre RS Porto Alegre90050-170 Brazil Department of Physics The University of Liverpool LiverpoolL69 3BX United Kingdom The Cockcroft Institute Sci-Tech Daresbury WarringtonWA4 4AD United Kingdom Department of Physics and Astronomy The University of Manchester ManchesterM13 9PL United Kingdom Universidad de Valencia Valencia46071 Spain

关键词： Charged particles

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One pot synthesis of UiO-66-NH2 containing curcumin and cytotoxic evaluation toward liver cancer cells

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Materials Letters 2024年 365卷

作者： Susilowati, Oni Wahyu Lestari, Witri Handayani, Murni Sukowati, Caecilia Tiribelli, Claudio Crocè, Lory Saveria Masykur, Abu Rakhman Wibowo, Fajar Dwi Ardyanto, Tonang Adi Saputra, Ozi Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Sebelas Maret Central Java Surakarta57126 Indonesia Tangerang Selatan15314 Indonesia Jakarta Pusat10340 Indonesia Liver Cancer Unit Fondazione Italiana Fegato ONLUS AREA Science Park Basovizza34049 Italy Department of Medicine Surgery and Health Sciences University of Trieste Italy Clinical Pathology Department Faculty of Medicine Universitas Sebelas Maret Surakarta57126 Indonesia Department of Chemical Engineering College of Engineering National Taiwan University Taipei10617 Taiwan Institute of Chemistry and Taiwan International Graduate Program Sustainable Chemical Science and Technology Academia Sinica Taipei115 Taiwan

Curcumin, a potent natural compound known for its health benefits, encounters challenges such as low bioavailability and poor solubility. To overcome these obstacles, incorporating curcumin into metal–organic frameworks (MOFs) has emerged as a promising approach. This study explores the in-situ modification of UiO-66-NH2 (UiO stands for Universitetet i Oslo) with curcumin, aiming to assess its release and delivery potential. Chemical, structural, morphological, and textural analyses confirmed the successful synthesis of the materials. Nitrogen sorption isotherm, field-emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) revealed that curcumin addition led to decrease in surface area (from 829.6 m2/g to 679.92 m2/g) and porosity, as well as alterations in particle size (from 0.162 to 0.068 μm) and shape from octahedral to spherical. The release behavior of curcumin exhibited pH-dependent profiles, with cumulative releases (∼20 % at pH 4.8, and 30.56 % at pH 7.4) fitting Kosmeyer-Peppas model. Biological activity assays indicated non-toxicity, suggesting potential for curcumin delivery. © 2024

关键词： Bioactivity

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BPS2025 - Metabolic generation and regulation of mitochondrial outer membrane potential by VDAC

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Biophysical Journal 2025年第3期124卷 449a-449a页

作者： Megha Rajendran Kaitlin Abrantes Bethel G. Beyene William M. Rosencrans Wendy Fitzgerald Sergey M. Bezrukov Tatiana K. Rostovtseva Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA Physiology Biophysics and Systems Biology Graduate Program Weill Cornell Medicine New York NY USA Department of Chemistry and Biochemistry University of Maryland Baltimore County Baltimore MD USA Division of Biology and Biological Engineering California Institute of Technology Pasadena CA USA

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Bioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Scientific World Journal

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Scientific World Journal 2025年第1期2025卷 9466270页

作者： Floriano, Juliana Ferreira Rodrigues, Daniel Ohara, Rie Almeida, Nara Lígia Martins Lara, Vanessa Soares Sartorelli, Patricia Graeff, Carlos Frederico de Oliveira Grecco, Simone dos Santos González, Alejandra Hortencia Miranda D’Alpino, Paulo Henrique Perlatti Imperial College London National Heart and Lung Institute imperial.ac.uk GBR London United Kingdom Botucatu Medical School São Paulo State University (UNESP) São Paulo unesp.br BRA Botucatu Brazil Bioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP) unesp.br BRA Araraquara São Paulo Brazil Biotechnology and Innovation in Health Program Universidade Anhanguera de São Paulo (UNIAN) São Paulo BRA Brazil Brazil Department of Health Management Fundação Nacional de Gestão de Saúde São Paulo Brazil Undergraduate Program Medical School Universidade Nove de Julho Bauru São Paulo Brazil Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP) São Paulo usp.br BRA Bauru Brazil Department of Chemistry Institute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo São Paulo unifesp.br BRA Diadema Brazil Department of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP) São Paulo Bauru Brazil Department of Research and Development (RD) and Innovation Center Triplet Biotechnology Solutions Inc Bauru São Paulo Brazil Post-Graduate Program in Dentistry Uniderp Anhanguera University Mato Grosso do Sul Campo Grande Brazil Post-Graduate Program in Integrated Dental Sciences University of Cuiabá (UNIC) Mato Grosso do Sul Cuiabá Brazil Department of Physics School of Sciences São Paulo State University (UNESP) São Paulo unesp.br BRA Bauru Brazil

Chronic wounds have a significant impact on patients’ quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product’s spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (p < 0.05). No lethal dose was observed, indicating the safety of the ointment at all concentrations. The ointment also stimulated a notably more organized, significantly higher collagen production compared to control groups (p < 0.05). In vivo preclinical analyses also demonstrated no adverse responses being effective in the healing process compared to the control group (silver sulfadiazine) in terms of wound contraction and ulcer re-epithelization (p < 0.05). Significantly higher means of wound contraction were observed in the groups treated with the bioactive-containing ointment when compared to both the positive control group (sulfadiazine) and the control untreated groups (p < 0.05). The regenerative ointment exhibited excellent biocompatibility and bi

关键词： biocompatibility chronic wounds natural compounds preclinical tests wound care

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Reshaped Weyl fermionic dispersions driven by Coulomb interactions in MoTe2

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Physical Review B 2022年第4期105卷 045143-045143页

作者： Seoung-Hun Kang Sangjun Jeon Hyun-Jung Kim Wonhee Ko Suyeon Cho Se Hwang Kang Sung Wng Kim Heejun Yang Hyo Won Kim Young-Woo Son Korea Institute for Advanced Study Seoul 02455 Korea Department of Physics Chung-Ang University Seoul 06974 Korea Peter Grünberg Institut and Institute for Advanced Simulation Forschungszentrum Jülich and JARA D-52425 Jülich Germany Samsung Advanced Institute of Technology Suwon 16678 Korea Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA Department of Chemical Engineering and Materials Science Graduate Program in System Health Science and Engineering Ewha Womans University Seoul 03760 Korea Department of Energy Science Sungkyunkwan University Suwon 16419 Korea Department of Physics Korea Advanced Institute of Science and Technology Daejeon 34141 Korea

We report the direct evidence of impacts of the Coulomb interaction in a prototypical Weyl semimetal, MoTe2, that alter its bare bands in a wide range of energy and momentum. Our quasiparticle interference patterns measured using scanning tunneling microscopy are shown to match the joint density of states of quasiparticle energy bands including momentum-dependent self-energy corrections, while electronic energy bands based on the other simpler local approximations of the Coulomb interaction fail to explain neither the correct number of quasiparticle pockets nor the shape of their dispersions observed in our spectrum. With this, we predict a transition between type-I and type-II Weyl fermions with doping and resolve its disparate quantum oscillation experiments, thus highlighting the critical roles of Coulomb interactions in layered Weyl semimetals.

关键词： Electronic structure First-principles calculations Quasiparticles & collective excitations Topological materials Weyl fermions Scanning electron microscopy Scanning tunneling spectroscopy

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