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Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks

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eBioMedicine 2023年 94卷 104723-104723页

作者： Li, Hsing-Han Su, Matthew P. Wu, Shih-Cheng Tsou, Hsiao-Hui Chang, Meng-Chun Cheng, Yu-Chieh Tsai, Kuen-Nan Wang, Hsin-Wei Chen, Guan-Hua Tang, Cheng-Kang Chung, Pei-Jung Tsai, Wan-Ting Huang, Li-Rung Yueh, Yueh Andrew Chen, Hsin-Wei Pan, Chao-Ying Akbari, Omar S. Chang, Hsiao-Han Yu, Guann-Yi Marshall, John M. Chen, Chun-Hong National Mosquito-Borne Disease Control Research Center NHRI Miaoli 350401 Taiwan National Institute of Infectious Diseases and Vaccinology NHRI Miaoli 350401 Taiwan Division of Biological Sciences Section of Cell and Developmental Biology University of California San Diego La Jolla 92093 CA United States Graduate School of Science Nagoya University Nagoya 464-8602 Japan Institute for Advanced Research Nagoya University Nagoya 464-8601 Japan Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Taipei 10048 Taiwan Department of Laboratory Medicine National Taiwan University Hospital College of Medicine National Taiwan University Taipei 10021 Taiwan Institute of Population Health Sciences National Health Research Institutes Zhunan Miaoli 350401 Taiwan Graduate Institute of Biostatistics College of Public Health China Medical University Taichung 40402 Taiwan Department of Life Science & Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Program of Plant Protection and Health Academy of Circular Economy National Chung Hsing University Taichung 402202 Taiwan Institute of Molecular and Genomic Medicine NHRI Miaoli 350401 Taiwan Institute of Biotechnology and Pharmaceutical Research NHRI Miaoli 350401 Taiwan Department of Health Kaohsiung City Government Kaohsiung 800852 Taiwan Divisions of Biostatistics and Epidemiology School of Public Health University of California Berkeley 94720 CA United States

Background: Dengue virus outbreaks are increasing in number and severity worldwide. Viral transmission is assumed to require a minimum time period of viral replication within the mosquito midgut. It is unknown if alternative transmission periods not requiring replication are possible. Methods: We used a mouse model of dengue virus transmission to investigate the potential of mechanical transmission of dengue virus. We investigated minimal viral titres necessary for development of symptoms in bitten mice and used resulting parameters to inform a new model of dengue virus transmission within a susceptible population. Findings: Naïve mice bitten by mosquitoes immediately after they took partial blood meals from dengue infected mice showed symptoms of dengue virus, followed by mortality. Incorporation of mechanical transmission into mathematical models of dengue virus transmission suggest that this supplemental transmission route could result in larger outbreaks which peak sooner. Interpretation: The potential of dengue transmission routes independent of midgut viral replication has implications for vector control strategies that target mosquito lifespan and suggest the possibility of similar mechanical transmission routes in other disease-carrying mosquitoes. Funding: This study was funded by grants from the National health Research Institutes, Taiwan (04D2-MMMOST02), the Human Frontier Science program (RGP0033/2021), the National Institutes of health (1R01AI143698-01A1, R01AI151004 and DP2AI152071) and the Ministry of Science and technology, Taiwan (MOST104-2321-B-400-016). © 2023 The Authors

关键词： Aedes aegypti mosquito Animal models of dengue virus Dengue transmission Mathematical modelling of disease outbreak

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Global cross-cultural validation of a brief measure for identifying potential suicide risk in 42 countries

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Public health 2024年 229卷 13-23页

作者： Gewirtz-Meydan, A. Koós, M. Nagy, L. Kraus, S.W. Demetrovics, Z. Potenza, M.N. Ballester-Arnal, R. Batthyány, D. Bergeron, S. Billieux, J. Burkauskas, J. Cárdenas-López, G. Carvalho, J. Castro-Calvo, J. Chen, L. Ciocca, G. Corazza, O. Csako, R. Fernandez, D.P. Fujiwara, H. Fernandez, E.F. Fuss, J. Gabrhelík, R. Gjoneska, B. Gola, M. Grubbs, J.B. Hashim, H.T. Islam, M.S. Ismail, M. Jiménez-Martínez, M.C. Jurin, T. Kalina, O. Klein, V. Költő, A. Lee, S.-K. Lewczuk, K. Lin, C.-Y. Lochner, C. López-Alvarado, S. Lukavská, K. Mayta-Tristán, P. Miller, D.J. Orosová, O. Orosz, G. Ponce, F.P. Quintana, G.R. Quintero Garzola, G.C. Ramos-Diaz, J. Rigaud, K. Rousseau, A. De Tubino Scanavino, M. Schulmeyer, M.K. Sharan, P. Shibata, M. Shoib, S. Sigre-Leirós, V. Sniewski, L. Spasovski, O. Steibliene, V. Stein, D.J. Strong, C. Ünsal, B.C. Vaillancourt-Morel, M.-P. Van Hout, M.C. Bőthe, B. School of Social Work Faculty of Social Welfare and Health Sciences University of Haifa Israel Institute of Psychology ELTE Eötvös Loránd University Budapest Hungary Institute of Forensic Psychiatry and Sex Research University of Duisburg-Essen Essen Germany Doctoral School of Psychology ELTE Eötvös Loránd University Budapest Hungary Department of Psychology University of Nevada Las Vegas Las Vegas NV United States Centre of Excellence in Responsible Gaming University of Gibraltar Gibraltar Gibraltar Yale University School of Medicine New Haven CT United States Connecticut Council on Problem Gambling Wethersfield CT United States Departmento de Psicología Básica Clínica y Psicobiología University Jaume I of Castellón Spain Institute for Behavioural Addictions Sigmund Freud University Vienna Austria Département de Psychologie Université de Montréal Montréal Canada Institute of Psychology University of Lausanne Lausanne Switzerland Center for Excessive Gambling Addiction Medicine Lausanne University Hospitals (CHUV) Lausanne Switzerland Laboratory of Behavioral Medicine Neuroscience Institute Lithuanian University of Health Sciences Lithuania Virtual Teaching and Cyberpsychology Laboratory School of Psychology National Autonomous University of Mexico Mexico William James Center for Research Departamento de Educação e Psicologia Universidade de Aveiro Aveiro Portugal Department of Personality Assessment and Psychological Treatments University of Valencia Spain Department of Psychology College of Humanity and Social Science Fuzhou University China Section of Sexual Psychopathology Department of Dynamic and Clinical Psychology and Health Studies Sapienza University of Rome Rome Italy Department of Clinical Pharmaceutical and Biological Sciences University of Hertfordshire United Kingdom Department of Psychology and Cognitive Science University of Trento Italy Department of Psychology and Neuroscience Auckland University of Technology Auckland New Z

Objectives: This study aimed to examine the psychometric properties of the P4 suicide screener in a multinational sample. The primary goal was to evaluate the reliability and validity of the scale and investigate its convergent validity by analyzing its correlation with depression, anxiety, and substance use. Study design: The study design is a cross-sectional self-report study conducted across 42 countries. Methods: A cross-sectional, self-report study was conducted in 42 countries, with a total of 82,243 participants included in the final data set. Results: The study provides an overview of suicide ideation rates across 42 countries and confirms the structural validity of the P4 screener. The findings indicated that sexual and gender minority individuals exhibited higher rates of suicidal ideation. The P4 screener showed adequate reliability, convergence, and discriminant validity, and a cutoff score of 1 is recommended to identify individuals at risk of suicidal behavior. Conclusions: The study supports the reliability and validity of the P4 suicide screener across 42 diverse countries, highlighting the importance of using a cross-cultural suicide risk assessment to standardize the identification of high-risk individuals and tailoring culturally sensitive suicide prevention strategies. © 2024 The Royal Society for Public health

关键词： Assessment Cross-cultural Suicide Validation

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Reducing EHR navigation time with an advanced hyperlipidemia management Tool: An evaluation of efficiency

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International Journal of Medical Informatics 2025年

作者： Chin-Chen Chen Yu-Chen Liu Guan-Ling Lin Annisa Ristya Rahmant Der-Ming Liou Hsuan-Chia Yang Information Technology Department Cardinal Tien Hospital New Taipei City Taiwan Information Technology Department Yonghe Cardinal Tien Hospital New Taipei City Taiwan Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan School of Nursing College of Medicine National Taiwan University Taipei Taiwan Department Health Policy and Management Faculty of Medicine Public Health and Nursing Universitas Gadjah Mada Yogyakarta Indonesia Department of Computer Science Faculty of Science and Technology Middlesex University London UK Master Program in Medical Informatics National Tsing Hua University Hsinchu City Taiwan International Center for Health Information Technology (ICHIT) Taipei Medical University Taipei Taiwan Clinical Big Data Research Center Taipei Medical University Hospital Taipei Taiwan Research Center of Big Data and Meta-analysis Wanfang Hospital Taipei Medical University Taipei Taiwan

Background Effective management of hyperlipidemia is crucial for preventing cardiovascular diseases. However, traditional monitoring systems often lack efficiency, particularly in navigating electronic health records (EHRs) to identify and track at-risk patients. Objective This study aims to evaluate the impact of a Hyperlipidemia Medication Reminder System (HLD-MRS) implemented in a district hospital to streamline EHR navigation and enhance patient management. Methods A pre-post prospective study was conducted at a district hospital. This study designed the HLD-MRS to integrate patient data, guideline recommendations, and risk factor assessments into a single interface, simplifying EHR navigation. This study compared EHR navigation times and patient tracking rates before and after HLD-MRS implementation across the Cardiology, Endocrinology, and Family Medicine departments. Results Among 750 patients with follow-up appointments, 334 were identified as having HLD or being at high-risk status. The HLD-MRS significantly reduced mean EHR navigation time from 83.9 s (SD = 8.6) to 53.8 s (SD = 6.6) across all departments (p < 0.001). The proportion of actively monitored HLD patients increased from 42.5 % to 56.6 %, while cases with unknown or withheld assessment status decreased from 57.5 % to 28.4 %. Conclusion The HLD-MRS improved efficiency in EHR navigation and increased the frequency of active patient monitoring. This guideline-driven decision support system shows promise for enhancing hyperlipidemia care in high-volume outpatient settings.

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Exploring ultra-high-intensity wakefields in carbon nanotube arrays: An effective plasma-density approach

arXiv

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arXiv 2022年

作者： Bonatto, A. Xia, G. Apsimon, O. Bontoiu, C. Kukstas, E. Rodin, V. Yadav, M. Welsch, C.P. Resta-López, J. Graduate Program in Information Technology and Healthcare Management The Beam Physics Group Federal University of Health Sciences of Porto Alegre Porto Alegre RS 90050-170 Brazil Department of Physics and Astronomy The University of Manchester ManchesterM13 9PL United Kingdom The Cockcroft Institute Sci-Tech Daresbury WarringtonWA4 4AD United Kingdom Department of Physics The University of Liverpool LiverpoolL69 3BX United Kingdom Icmuv Instituto de Ciencia de Los Materiales Universidad de Valencia Valencia46071 Spain

Charged particle acceleration using solid-state nanostructures has attracted attention in recent years as a method of achieving ultra-high-gradient acceleration in the TV/m domain. More concretely, metallic hollow nanostructures could be suitable for particle acceleration through the excitation of wakefields by a laser or a high-intensity charged particle beam in a high-density solid-state plasma. For instance, due to their special channelling properties as well as optoelectronic and thermo-mechanical properties, carbon nanotubes could be an excellent medium for this purpose. This article investigates the feasibility of generating ultra-high gradient acceleration using carbon nanotube arrays, modelled as solid-state plasmas in conventional particle-in-cell simulations performed in a two-dimensional axisymmetric (quasi-3D) geometry. The generation of beam-driven plasma wakefields depending on different parameters of the solid structure is discussed in detail. Furthermore, by adopting an effective plasma-density approach, existing analytical expressions, originally derived for homogeneous plasmas, can be used to describe wakefields driven in periodic non-uniform plasmas. Copyright © 2022, The Authors. All rights reserved.

关键词： Plasma density

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Comparison of endoscopic third ventriculostomy versus cerebrospinal fluid shunt procedures for the treatment of pediatric hydrocephalus in Taiwan

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Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2024年第9期40卷 2883-2891页

作者： Shu-Mei Chen Li-Ying Chen Jiann-Her Lin Nicole Salazar Tu-Hsueh Yeh Wei-Lun Lo Tai-Ngar Lui Yi-Chen Hsieh Li-Nien Chien Department of Neurosurgery Taipei Medical University Hospital Taipei Medical University Taipei Taiwan. Department of Surgery School of Medicine Taipei Medical University Taipei Taiwan. Health Data Analytics and Statistics Center Office of Data Science Taipei Medical University Taipei Taiwan. Julius L. Chambers Biomedical/Biotechnology Institute and Department of Biological & Biomedical Sciences North Carolina Central University Durham NC USA. Department of Neurology Taipei Medical University Hospital Taipei Taipei Medical University Taipei Taiwan. Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Neurosurgery Shuang Ho Hospital Taipei Medical University Taipei Taiwan. The PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wu-Hsing Street Taipei Taiwan. ychsieh@tmu.edu.tw. Institute of Health and Welfare Policy College of Medicine National Yang Ming Chiao Tung University No.155 Sec. 2 Linong St. Beitou District Taipei Taiwan. linien.chien@nycu.edu.tw. Graduate Institute of Data Science College of Management Taipei Medical University Taipei Taiwan. linien.chien@nycu.edu.tw.

PURPOSE:Pediatric hydrocephalus is the most common cause of surgically treatable neurological disease in children. Controversies exist whether endoscopic third ventriculostomy (ETV) or cerebrospinal fluid (CSF) shunt placement is the most appropriate treatment for pediatric hydrocephalus. This study aimed to compare the risk of re-operation and death between the two procedures. METHODS:We performed a retrospective population-based cohort study and included patients younger than 20-years-old who underwent CSF shunt or ETV for hydrocephalus from the Taiwan National health Insurance Research Database. RESULTS:A total of 3,555 pediatric patients from 2004 to 2017 were selected, including 2,340 (65.8%) patients that received CSF shunt placement and 1215 (34.2%) patients that underwent ETV. The incidence of all-cause death was 3.31 per 100 person-year for CSF shunt group and 2.52 per 100 person-year for ETV group, with an adjusted hazard ratio (HR) of 0.79 (95% confidence interval [CI] = 0.66-0.94, p = 0.009). The cumulative incidence competing risk for reoperation was 31.2% for the CSF shunt group and 26.4% for the ETV group, with an adjusted subdistribution HR of 0.82 (95% CI = 0.70-0.96, p = 0.015). Subgroup analysis showed that ETV was beneficial for hydrocephalus coexisting with brain or spinal tumor, central nervous system infection, and intracranial hemorrhage. CONCLUSION:Our data indicates ETV is a better operative procedure for pediatric hydrocephalus when advanced surgical techniques and instruments are available.

关键词： Cerebrospinal shunt Pediatric hydrocephalus Reoperation Third ventriculostomy

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Microencapsulation of Pediococcus pentosaceus using cupuassu flour-based as wall material: Application and impact on Petit Suisse cheese

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Food Bioscience 2025年

作者： Katherine Gutiérrez-Álzate Gabriele Barreto Bruna Samara S. Rekowsky Leticia Rodrigues Deborah Murowaniecki Otero Marion Pereira da Costa Program in Food Science (PGAli) Faculty of Pharmacy Federal University of Bahia (UFBA) Salvador CEP 40170-115 BA Brazil Laboratorio de Inspeção e Tecnologia de Leite e Derivados (LAITLACTEOS) Federal University of Bahia (UFBA) Salvador CEP 40170-110 BA Brazil Faculty of Technology SENAI/CIMATEC National Service of Industrial Learning–SENAI Salvador Bahia Brazil SENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS) Senai Cimatec University Center Salvador 41650-010 Brazil Graduate Program in Animal Science in the Tropics (PPGCAT) School of Veterinary Medicine and Zootchniques Federal University of Bahia (UFBA) Ondina Salvador 40170-110 BA Brazil Biotechnology Laboratory Center of Excellence in Alternative Proteins SENAI CIMATEC University Center Salvador 41650-010 Brazil Graduate Program in Food Nutrition and Health Nutrition School Federal University of Bahia (UFBA) Campus Canela Salvador 40110-907 BA Brazil

Microencapsulation enhances probiotic viability under adverse conditions. This study introduces cupuassu ( Theobroma grandiflorum ) flour, a novel plant-based by-product, as a wall material for spray-dried Pediococcus pentosaceus microcapsules. In addition, the study also aims to explore the application and impact of this innovative material on Petit Suisse cheese, presenting unique findings that contribute to the advancement of dairy science. Five formulations were developed using sodium alginate (1%) with varying levels of cupuassu flour (0, 1, 2 and 3%) and inulin (1%). The microcapsules were characterized for moisture, dispersibility, hygroscopicity, and particle size, as well as by FTIR spectroscopy, thermal behavior (TGA/DTG), and morphology by SEM. Selected microcapsules were incorporated into Petit Suisse cheese, and their effects on pH, viscosity, color, and probiotic viability were monitored during 28 days of refrigerated storage. Results showed encapsulation efficiencies between 73.2% and 82.2%, and viability above 6.4 log CFU/g after 75 days at -18 °C. Cupuassu flour improved the physicochemical stability and thermal resistance of the microcapsules. In the dairy matrix, microcapsules influenced texture and acidity while ensuring probiotic retention. This study highlights the potential of cupuassu flour as a functional and sustainable biopolymer, expanding the technological applications of probiotics in the dairy industry.

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ABCB1 Regulates Immune Genes in Breast Cancer

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Breast cancer (Dove Medical Press) 2023年 15卷 801-811页

作者： Han-Kun Chen Yi-Ling Chen Chih-Yang Wang Wei-Pang Chung Jung-Hua Fang Ming-Derg Lai Hui-Ping Hsu Department of Surgery Chi Mei Medical Center Tainan Taiwan. Department of Health and Nutrition Chia Nan University of Pharmacy and Science Tainan Taiwan. PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 70403 Taiwan. Center of Applied Nanomedicine National Cheng Kung University Tainan Taiwan. Laboratory Animal Center College of Medicine National Cheng Kung University Tainan Taiwan. Department of Biochemistry and Molecular Biology National Cheng Kung University Tainan Taiwan. Institute of Basic Medical Sciences College of Medicine National Cheng Kung University Tainan Taiwan. Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan.

Background:Resistance to standard chemotherapy is a critical problem for breast cancer patients. The ATP-binding cassette (ABC) superfamily transporters actively pump out drugs and play an important role in chemoresistance. ABCB1 (ABC subfamily B, member 1, also named as multidrug resistance protein 1, MDR1) and suppressive myeloid-derived suppressor cells (MDSCs) potentially involve in chemoresistance of breast cancer. The relationship between ABCB1 and immune genes in breast cancer has not been widely studied. Methods:Microarray and RNA sequencing data were obtained from The Cancer Genome Atlas Breast Invasive Carcinoma in Genomic Data Commons Data Portal and Gene Expression Omnibus database. A patient-derived xenograft (PDX) model of HER2 breast cancer was established to investigate the association between and immune genes in breast cancer. Results:Expression of increased in doxorubicin-selected MCF-7/ADR cells. High expression of mRNA is correlated with lymph-node metastasis and worse overall survival in patients with breast cancer. is positively correlated with , and . In the HER2 stage IIA breast cancer PDX model, both doxorubicin and paclitaxel suppressed growth of P2 tumors. IL6, CSF1, CSF3, and PTGS2 expression were suppressed by paclitaxel but not doxorubicin. Intrasplenic MDSCs, including CD11bLy6G and CD11bLy6C cells, were more abundant than intratumor MDSCs in PDX-carrying nude mice. Clinically, the patient developed cancer recurrence after adjuvant chemotherapy with doxorubicin-based regimen and was well controlled after paclitaxel-trastuzumab combined therapy. Conclusion:ABCB1 was a poor predictor of HER2 LN breast cancer. Regulation of immune genes by ABCB1 contributed to cancer recurrence and treatment effect. The PDX model was suitable for investigation the expression of target genes and expansion of immune cells.

关键词： ABC transporters ABCB1 breast cancer myeloid-derived suppressor cells patient-derived xenograft

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Dynamic analysis and multi-objective optimization of an integrated solar energy system for Zero-Energy residential complexes

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Energy Conversion and Management 2025年 341卷

作者： Saleh Mobayen Ehsanolah Assareh Ali Dezhdar Siamak Hoseinzadeh Davide Astiaso Garcia Graduate School of Intelligent Data Science National Yunlin University of Science and Technology Douliu Yunlin 640301 Taiwan Built Environment and Engineering Program College of Sport Health and Engineering (CoSHE) Victoria University Melbourne Australia Strategic Research Institute (SRI) Asia Pacific University of Technology and Innovation (APU) Technology Park Malaysia Kuala Lumpur Malaysia Department of Renewable Energy Technology Materials and Energy Research Center Dezful Branch Islamic Azad University Dezful Iran Department of Planning Design Technology of Architecture Sapienza University of Rome Via Flaminia 72 00196 Rome Italy Department of Astronautical Electrical and Energy Engineering Sapienza University of Rome Via Eudossiana 18 Rome Italy

This study introduces and evaluates a novel, integrated solar energy system for achieving sustainable and zero-energy residential buildings. The proposed system integrates photovoltaic-thermal (PVT) solar panels, heat pumps, electrolyzers, fuel cells, reverse osmosis desalination units, and thermal storage tanks to simultaneously supply electricity, heating, cooling, and potable water. A primary challenge in solar energy systems—the intermittency of energy production—is addressed using energy storage solutions, including hydrogen-based electrolysis and fuel cell systems, which stabilize the supply across day-night cycles. The energy system is designed to meet the energy demands of a 160-unit residential complex in San Diego, each unit covering 110 m 2 . A dynamic simulation over an entire year is performed using TRNSYS software. System optimization is conducted via Response Surface Methodology (RSM), targeting three objective functions: total power capacity, life cycle cost (LCC), and thermal comfort represented by the predicted percentage dissatisfied (PPD) index. Optimization system is based on five key decision variables: solar PVT area, fuel cell capacity, electrolyzer capacity, heat pump capacity, and hydrogen tank size. Results demonstrate that, under optimized configurations, the system achieves an annual electricity output of 29,145.8 kWh/year, an LCC of $894,228, and a PPD index of 6.8 %, fully meeting the residential complex’s electricity demand of 200 MWh/year. The results validate the effectiveness of the hybrid system in enhancing efficiency, ensuring system reliability, and mitigating environmental impacts, thus offering a scalable solution for zero-energy building applications.

关键词： Building Energy Solar PVT Panels Fuel Cell Heat Pump Multi-Objective Optimization

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Evaluation of Pollution Sources of Zinc in Tokyo Bay Based on Zinc Isotope Ratio in Sediment Core

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Journal of Geoscience and Environment Protection 2019年第8期7卷 141-154页

作者： Masahiro Sakata Shohei Okuizumi Asami Suzuki Mashio Takeshi Ohno Shuhei Sakata Graduate Program in Environmental Health Sciences University of Shizuoka Shizuoka Japan Graduate School of Natural Science and Technology Kanazawa University Kanazawa Japan Department of Chemistry Faculty of Science Gakushuin University Tokyo Japan

This study evaluated the sources of Zn pollution in Tokyo Bay, Japan, on the basis of δ66Zn in a sediment core. The Zn concentration in sediments in the 1980s-2000s was considerably higher than the background concentration, suggesting that there remain important sources of Zn in the bay. The δ66Zn (+0.51‰) of anthropogenic Zn estimated in the core was significantly higher than those (approximately –0.1‰ - +0.2‰) of treated water from sewage treatment plants and vehicle-related sources. A large number of electroplating plants are located in Tokyo areas. It is assumed that Zn in effluents from electroplating operations is isotopically heavier owing to a negative isotopic effect on Zn electroplating. This tends to support the hypothesis that river bottom sediments, which were contaminated with Zn in the untreated effluents from electroplating plants in the past, are the principal sources of anthropogenic Zn in Tokyo Bay in the 1980s-2000s.

关键词： Zinc Pollution Sources Sediment Core Zinc Isotope Ratio Tokyo Bay

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A biomimetic micropillar wound dressing with flavone and polyphenol control release in vitro and in vivo

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Journal of the Taiwan Institute of Chemical Engineers 2024年 160卷

作者： Cheng, Tien-Hsin Lin, Ruei-Hong Cheng, Yu-Shen Shih, Pin-Keng Show, Pau Loke Chen, Hsiao-Yi Nakmee, Pattarawadee Sumthong Chang, Jui-Jen Huang, Dong-Ming Wang, Hui-Min David Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Xingda Rd. South Dist. Taichung402 China Department of Neurological Institute Taichung Veterans General Hospital Taichung China Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung China Department of Surgery China Medical University Hospital Taichung Taiwan School of Medicine China Medical University Taichung Taiwan Department of Chemical Engineering Khalifa University Abu Dhabi United Arab Emirates Faculty of Science at Sriracha Kasetsart University Sriracha Campus 199 Moo 6 Sukhumvit Rd. Chonburi Sriracha20230 Thailand Department of Medical Research China Medical University Hospital China Medical University Taichung China Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County China Regenerative Medicine and Cell Therapy Research Center Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung China

Background: Wound healing is a complex and dynamic process involving the replacement of devitalized and missing cellular structures and tissue layers. Methods: This study involved developing a drug-loaded biomimetic micropillar wound dressing based upon inspiration from witnessing the adhesive ability in a gecko's footpad. The conformal adhesion was set up by applying a soft elastomer thin film on the developed wound dressing surfaces. The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. Results: The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. The results indicate that the developed biomimetic micropillar patches could release the loaded drugs and significantly increase cell viability and collagen content to 20 % ∼ 25 % in vitro and in vivo. Conclusion: In summation, the primary purpose of this study has been to design a novel encapsulated carrier (micropillar patch) for use in adjustable drug release, while combining with the biomimetic microstructure to reach wound healing through percutaneous absorption. © 2024 Taiwan Institute of Chemical Engineers

关键词： Chemical stability

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