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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction (vol 53, pg 65, 2021)

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NATURE GENETICS 2021年第3期53卷 413-413页

作者： Conti, David V. Darst, Burcu F. Moss, Lilit C. Saunders, Edward J. Sheng, Xin Chou, Alisha Schumacher, Fredrick R. Al Olama, Ali Amin Benlloch, Sara Dadaev, Tokhir Brook, Mark N. Sahimi, Ali Hoffmann, Thomas J. Takahashi, Atushi Matsuda, Koichi Momozawa, Yukihide Fujita, Masashi Muir, Kenneth Lophatananon, Artitaya Wan, Peggy Le Marchand, Loic Wilkens, Lynne R. Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Nordestgaard, Borge G. Nielsen, Sune F. Weischer, Maren Bojesen, Stig E. Roder, Martin Andreas Iversen, Peter Batra, Jyotsna Chambers, Suzanne Moya, Leire Horvath, Lisa Clements, Judith A. Tilley, Wayne Risbridger, Gail P. Gronberg, Henrik Aly, Markus Szulkin, Robert Eklund, Martin Nordstrom, Tobias Pashayan, Nora Dunning, Alison M. Ghoussaini, Maya Travis, Ruth C. Key, Tim J. Riboli, Elio Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Albanes, Demetrius Weinstein, Stephanie J. Mucci, Lorelei A. Giovannucci, Edward Lindstrom, Sara Kraft, Peter Hunter, David J. Penney, Kathryn L. Turman, Constance Tangen, Catherine M. Goodman, Phyllis J. Thompson, Ian M., Jr. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Parent, Marie-Elise Stanford, Janet L. Ostrander, Elaine A. Geybels, Milan S. Koutros, Stella Freeman, Laura E. Beane Stampfer, Meir Wolk, Alicja Hakansson, Niclas Andriole, Gerald L. Hoover, Robert N. Machiela, Mitchell J. Sorensen, Karina Dalsgaard Borre, Michael Blot, William J. Zheng, Wei Yeboah, Edward D. Mensah, James E. Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Wu, Yudong Zhao, Shan-Chao Sun, Zan Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. West, Catharine M. L. Burnet, Neil Barnett, Gill Maier, Christiane Schnoeller, Thomas Luedeke, Manuel Kibel, Adam S. Drake, Bettina F. Cussenot, Olivier Cancel-Tassin, Gerald Center for Genetic Epidemiology Department of Preventive Medicine Keck School of Medicine University of Southern California/Norris Comprehensive Cancer Center Los Angeles CA USA The Institute of Cancer Research London UK Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland OH USA Seidman Cancer Center University Hospitals Cleveland OH USA Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Strangeways Research Laboratory Cambridge UK Stroke Research Group Department of Clinical Neurosciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics University of California San Francisco CA USA Institute for Human Genetics University of California San Francisco CA USA Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan Department of Genomic Medicine National Cerebral and Cardiovascular Center Research Institute Suita Japan Laboratory of Clinical Genome Sequencing Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan Biobank Tokyo Japan Laboratory for Genotyping Development RIKEN Center of Integrative Medical Sciences Yokohama Japan Laboratory for Cancer Genomics RIKEN Center of Integrative Medical Sciences Yokohama Japan Division of Population Health Health Services Research and Primary Care School of Health Sciences Faculty of Biology Medicine and Health University of Manchester Manchester UK Warwick Medical School University of Warwick Coventry UK Epidemiology Program University of Hawaii Cancer Center Honolulu HI USA Behavioral and Epidemiology Research Group Research Program American Cancer Society Atlanta GA USA Institute of Biomedicine University of Turku Turku Finland Department of Medical Genetics Genomics Laboratory Division Turku University Hospital Turku Finland Department of Urolog

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.

关键词： Epidemiology Genome-wide association studies Personalized medicine Prostate cancer

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A fuzzy expert system-based adaptive learning approach to improving students’ learning performances by considering affective and cognitive factors

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Computers and Education: Artificial Intelligence 2020年 1卷

作者： Hwang, Gwo-Jen Sung, Han-Yu Chang, Shao-Chen Huang, Xing-Ci Graduate Institute of Digital Learning and Education National Taiwan University of Science and Technology 43 Sec.4 Keelung Rd. Taipei106 Taiwan Department of Allied Health Education and Digital Learning National Taipei University of Nursing and Health Sciences No.365 Ming-te Road Peitou District Taipei City Taiwan Department of International Bachelor Program in Informatics and the Department of Information Communication Yuan Ze University No. 135 Yuandong Rd. Zhongli Dist. Taoyuan City320 Taiwan

Scholars have indicated the importance of providing guidance and support for individual learners. In the past decades, most studies have developed adaptive learning systems to address this issue mainly based on students’ cognitive status, such as their learning achievements. However, several educators have pointed out the need to take learners’ affective status into account. Therefore, this study proposed an expert system approach by taking into account both the affective and cognitive status of individual learners. An adaptive learning system was implemented based on the proposed approach. In addition, an experiment was conducted in a fifth-grade Mathematics course to compare the learning performances and perceptions of the students who learned with the adaptive learning system with affective and cognitive status analysis, a cognitive-status-based adaptive learning system, and a conventional learning system. The ANCOVA results revealed that the adaptive learning model with the affective and cognitive performance analysis mechanism outperformed the other two approaches in terms of improving the students’ learning achievement (F = 3.12, p © 2020 The Author(s)

关键词： Expert systems

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Observation of Active Galactic Nuclei with the Large-Sized Telescope prototype of the Cherenkov Telescope Array 38

Observation of Active Galactic Nuclei with the Large-Sized T...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Takeishi, R. Álvarez Crespo, N. Arbet-Engels, A. Baquero Larriva, A. Baxter, J. Biederbeck, N. Caroff, S. Di Marco, G. Fallah Ramazani, V. Green, D. Heckmann, L. Láinez, M. Nickel, L. Nievas Rosillo, M. Pons, E. Priyadarshi, C. Sanchez, D.A. Vázquez Acosta, M. Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Antonelli, L.A. Aramo, C. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Bhattacharjee, P. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heller, M. HerreraLlorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Jimenez Martinez, I. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lamanna, G. Lamastra, A. Institute for Cosmic Ray Research University of Tokyo Chiba Kashiwa277-8582 Japan Grupo de Electronica Universidad Complutense de Madrid Av. Complutense s/n Madrid28040 Spain Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador Department of Physics TU Dortmund University Otto-Hahn-Str. 4 Dortmund44227 Germany Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules - IN2P3 Annecy74000 France Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Tenerife La Laguna Spain Institut für Theoretische Physik Lehrstuhl IV: Plasma-Astroteilchenphysik Ruhr-Universität Bochum Universitätsstraße 150 Bochum44801 Germany The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Department of Physics Tokai University Japan Departament de Física Quàntica i Astrofísica Institut de Ciències delCosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Uni

Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory. It will consist of three different sizes of telescopes, with a collective improvement of about an order of magnitude in sensitivity, compared with the current generation gamma-ray telescopes. LargeSized Telescopes (LSTs) will be the most sensitive at energies from tens of GeV up to a few TeVs, and will be the best suited to observe gamma-ray sources such as Active Galactic Nuclei (AGN). The first Large-Sized Telescope prototype (LST-1), inaugurated in 2018 and currently in commissioning phase, has accumulated more than one thousand hours of data to date. From 2020 to 2022, we have detected various gamma-ray sources, and prominent among them are several well-known AGN, like Mrk 421, Mrk 501, 1ES 1959+650, 1ES 0647+250, PG 1553+113, etc. We report on light curves and energy spectra reconstructed out of these observations down to energies of tens of GeV, which is very close to the energy threshold of LST-1. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Active Galactic Nuclei

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Application of Emerging Innovations in Microbiome Science to Space Development and Settlement Systems 73

Application of Emerging Innovations in Microbiome Science to...

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73rd International Astronautical Congress, IAC 2022

作者： Nastasi, Nicholas Anderson, Matthew Z. Balasubrahmaniam, Neeraja Bope, Ashleigh Britt, Rodney D. Cochran, Samuel J. Gill, Samuel J. Hegarty, Bridget Lee, Jiyoung Stamps, Blake W. Stickney, Amanda Taylor, Christopher G. Tram, Nguyen K. Van Dusen, John Varaljay, Vanessa A. Weir, Mark H. Horack, John M. Oglesbee, Michael Sullivan, Matthew B. Dannemiller, Karen C. Department of Civil Environmental & Geodetic Engineering Ohio State University ColumbusOH United States Division of Environmental Health Sciences College of Public Health Ohio State University ColumbusOH United States Environmental Sciences Graduate Program Ohio State University ColumbusOH United States Department of Microbiology College of Arts and Sciences Ohio State University ColumbusOH United States Department of Microbial Infection and Immunity Ohio State University ColumbusOH United States Center for Perinatal Research The Abigail Wexner Research Institute Nationwide Children's Hospital Department of Pediatrics Ohio State University ColumbusOH United States Department of Civil and Environmental Engineering Case School of Engineering Case Western Reserve University ClevelandOH United States Department of Food Science and Technology Ohio State University ColumbusOH United States Infectious Diseases Institute Ohio State University ColumbusOH United States Soft Matter Materials Branch Materials and Manufacturing Directorate Air Force Research Laboratory Wright - Patterson AFBOH United States Department of Plant Pathology College of Food Agriculture and Environmental Science Ohio State University ColumbusOH United States Department of Anesthesiology & Pain Medicine Nationwide Children's Hospital ColumbusOH United States Airman Systems Directorate 711th Human Performance Wing Air Force Research Laboratory WPAFBOH United States Sustainability Institute Ohio State University ColumbusOH United States Department of Mechanical and Aerospace Engineering College of Engineering John Glenn College of Public Affairs Ohio State University ColumbusOH United States Department of Veterinary Biosciences College of Veterinary Medicine Ohio State University ColumbusOH United States Center of Microbiome Science Ohio State University ColumbusOH United States

Future human spaceflight beyond low-Earth orbit will bring substantial changes and new requirements to the development of fully sustainable, healthy indoor human environments across a range of gravitational, radiative, and thermal conditions. One key aspect is understanding (and potentially leveraging) microorganisms that must coexist with humans, plants, and animals in enclosed habitats (their microbiota or microbiomes). Modern, genome-resolved microbiome science provides an opportunity to better understand how we can utilize microbes to optimize space missions and protect human health and well-being long-term. Microorganisms will be critical to mission success due to their direct or indirect interactions with 1) humans, 2) other living systems (e.g., plant and animal life as a food source and for experimentation), and 3) the built environment. For example, the human gut microbiome is a complex community that has important implications for human health and performance that include mental health, nutrition intake, and immune system function. The health of plant microbiomes is also critical for sustainable, dependable, and nutritious food production. Humans, plants, and other living systems (e.g., animals used in experimentation) will also shed microbes into the built environment, which may impact human exposure, plant health, system integrity, and planetary protection from microbial contamination in both forward and reverse directions. Microbes from all three systems will interact, resulting in potentially important 'non-linear' system implications that must be understood for the overall long-term sustainability of hardware, crew, and other living systems. This paper discusses recent advances in technology that expand measurement capabilities to ultra-low-biomass samples and now allow for better understanding of microbial taxa, community structure and drivers, and functional capacity, which together will empower microbiome-optimized deep-space human exploration miss

关键词： Bacteria

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Women's Cardiac Rehabilitation Barriers: Results of the International Council of Cardiovascular Prevention and Rehabilitation's First Global Assessment

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Canadian Journal of Cardiology 2023年第11期39卷 S375-S383页

作者： Ghisi, Gabriela Lima de Melo Kim, Won-Seok Cha, Seungwoo Aljehani, Raghdah Cruz, Mayara Moura Alves Vanderlei, Luiz Carlos Marques Pepera, Garyfallia Liu, Xia Xu, Zhimin Maskhulia, Lela Venturini, Elio Chuang, Hung-Jui Pereira, Danielle Gomes Trevizan, Patricia Fernandes Kouidi, Evangelia Batalik, Ladislav Ghanbari Firoozabadi, Mahdieh Burazor, Ivana Jiandani, Mariya Prakash Zhang, Ling Tourkmani, Nidal Grace, Sherry L. KITE - Toronto Rehabilitation Institute University Health Network University of Toronto Toronto ON Canada Seoul National University Bundang Hospital Seongnam-si South Korea Rehabilitation Department King Abdullah Medical City Makkah Saudi Arabia São Paulo State University (UNESP) School of Technology and Sciences Presidente Prudente Brazil Department of Physiotherapy Faculty of Health Sciences University of Thessaly Thessaly Greece Chengdu Wanda UPMC Hospital Chengdu China Shanghai Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China TSMU Sports Medicine and Rehabilitation Clinical Centre Cardiac Rehabilitation Tbilisi Georgia Department of Cardiac Rehabilitation Cecina Hospital Cecina Italy Department of Physical Medicine and Rehabilitation National Taiwan University Hospital Taipei Taiwan Graduate Program in Rehabilitation Sciences Department of Physical Therapy Federal University of Minas Gerais Minas Gerais Belo Horizonte Brazil Laboratory of Sports Medicine Department of Physical Education and Sports Science Thessaloniki Greece Department of Rehabilitation University Hospital Brno Brno Czech Republic Yazd Cardiovascular Research Center Non-Communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran Institute for Cardiovascular Diseases “Dedinje” and Belgrade University Faculty of Medicine Belgrade Serbia Physiotherapy School and Centre Seth G S Medical College and KEMH Parel Mumbai India Susan Wakil School of Nursing and Midwifery Faculty of Medicine and Health University of Sydney Camperdown Australia Rehabilitation Clinic “Mons. G. Calaciura ” Biancavilla Catania Italy “Gibiino” Cardiovascular Diagnostic Center Catania Italy Faculty of Health York University Toronto ON Canada

Background: Cardiac rehabilitation (CR) programs are underutilized globally, especially by women. In this study we investigated sex differences in CR barriers across all world regions, to our knowledge for the first time, the characteristics associated with greater barriers in women, and women's greatest barriers according to enrollment status. Methods: In this cross-sectional study, the English, Simplified Chinese, Arabic, Portuguese, or Korean versions of the Cardiac Rehabilitation Barriers Scale was administered to CR-indicated patients globally via Qualtrics from October 2021 to March 2023. Members of the International Council of Cardiovascular Prevention and Rehabilitation community facilitated participant recruitment. Mitigation strategies were provided and rated. Results: Participants were 2163 patients from 16 countries across all 6 World health Organization regions;916 (42.3%) were women. Women did not report significantly greater total barriers overall, but did in 2 regions (Americas, Western Pacific) and men in 1 (Eastern Mediterranean;all P < 0.001). Women's barriers were greatest in the Western Pacific (2.6 ± 0.4/5) and South East Asian (2.5 ± 0.9) regions (P < 0.001), with lack of CR awareness as the greatest barrier in both. Women who were unemployed reported significantly greater barriers than those not (P < 0.001). Among nonenrolled referred women, the greatest barriers were not knowing about CR, not being contacted by the program, cost, and finding exercise tiring or painful. Among enrolled women, the greatest barriers to session adherence were distance, transportation, and family responsibilities. Mitigation strategies were rated as very helpful (4.2 ± 0.7/5). Conclusions: CR barriers—men's and women's—vary significantly according to region, necessitating tailored approaches to mitigation. Efforts should be made to mitigate unemployed women's barriers in particular. © 2023 Canadian Cardiovascular Society

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Reinfection risk of novel coronavirus(COVID-19):A systematic review of current evidence

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World Journal of Virology 2020年第5期9卷 79-90页

作者： SeyedAhmad SeyedAlinaghi Shahram Oliaei Shaghayegh Kianzad Amir Masoud Afsahi Mehrzad MohsseniPour Alireza Barzegary Pegah Mirzapour Farzane Behnezhad Tayebeh Noori Esmaeil Mehraeen Omid Dadras Fabricio Voltarelli Jean-Marc Sabatier Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High Risk BehaviorsTehran University of Medical SciencesTehran ***Iran HBOT Research Center Golestan HospitalIslamic Republic of IranNavy and AJA Medical UniversityTehran ***Iran School of Medicine Iran University of Medical SciencesTehran ***Iran Department of Radiology School of MedicineUniversity of CaliforniaSan Diego(UCSD)CaliforniaCA 587652458United States School of Medicine Islamic Azad UniversityTehran ***Iran Department of Virology School of Public HealthTehran University of Medical SciencesTehran ***Iran Department of Health Information Technology Zabol University of Medical SciencesZabol ***Iran Department of Health Information Technology Khalkhal University of Medical SciencesKhalkhal ***Iran Department of Global Health and Socioepidemiology Graduate School of MedicineKyoto UniversityKyoto 215789652Japan Graduation Program of Health Sciences Faculty of MedicineFederal University of Mato GrossoCuiaba 458796523Brazil UniversitéAix-Marseille Institutde Neuro-physiopathologie(INP)UMR 7051Facultéde Pharmacie27 Bd Jean MoulinMarseille 546789235France

BACKGROUND There is recently a concern regarding the reinfection and reactivation of previously reCoVered coronavirus disease 2019(CoVID-19)*** To summarize the recent findings and reports of CoVID-19 reinfection in patients previously reCoVered from the *** This study was a systematic review of current evidence conducted in August *** authors studied the probable reinfection risk of novel coronavirus(CoVID-19).We performed a systematic search using the keywords in online *** investigation adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)checklist to ensure the reliability and validity of this study and *** We reviewed 31 *** studies described reCoVered patients with *** one study reported reinfected patients who *** 26 studies,there was no information about the status of the *** studies indicated that reinfection is not probable and that post-infection immunity is at least temporary and *** Based on our review,we concluded that a positive polymerase chain reaction retest could be due to several reasons and should not always be considered as reinfection or reactivation of the *** relevant studies in positive retest patients have shown relative and probably temporary immunity after the reCoVery of the disease.

关键词： Reactivation Reinfection Postinfection Coronavirus CoVID-19 SARSCoV-2

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Meta-analysis study of the therapeutic impact of Mesenchymal stem cells derived exosomes for chronic kidney diseases

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Biochemistry and Biophysics Reports 2025年 43卷 102072页

作者： Himanshu Gunjan Pandey, Ramendera Pati Mukherjee, Riya Chang, Chung-Ming Graduate Institute of Biomedical Sciences Chang Gung University No. 259 Wenhua 1st Road Guishan District Taoyuan City 33302 Taiwan Master & Ph.D. Program in Biotechnology Industry Chang Gung University No. 259 Wenhua 1st Road Guishan District Taoyuan City 33302 Taiwan School of Health Sciences and Technology (SoHST) UPES Bidholi Uttarakhand Dehradun 248007 India Department of Biotechnology and Microbiology SRM University Delhi-NCR Haryana Sonepat India Department of Medical Biotechnology and Laboratory Science Chang Gung University No. 259 Wenhua 1st Road Guishan District Taoyuan City 33302 Taiwan

Mesenchymal stem cell-derived exosomes (EXOs) represent a promising avenue for treating chronic kidney diseases (CKD), though their precise impact remains somewhat elusive. To address this gap, we conducted a systematic analysis, scouring databases and clinical trial repositories for relevant studies from 2019 to 2023. Seventeen papers were meticulously selected for their focus on mesenchymal stem cell-derived exosomes (MSC-EXOs) and their potential in CKD treatment. Our comprehensive meta-analysis, incorporating 15 preclinical and 6 clinical studies, underscores the efficacy of MSC-EXOs in improving renal function while attenuating tubular injury, inflammation, apoptosis, collagen deposition, and renal fibrosis. Notably, post-treatment with MSC-EXOs exhibited significant associations with various CKD markers, with pooled proportions indicating a considerable impact on blood urea nitrogen (BUN) and serum creatinine (SCR) levels. Subgroup analyses based on animal models further elucidated heterogeneity within the studies. In conclusion, MSC-EXOs demonstrate promise in enhancing renal function and reducing CKD risk, as evidenced by both preclinical and clinical data. Their efficacy in lowering SCR and BUN levels while enhancing filtration rate suggests MSC-EXOs as a viable and secure alternative to cell-based therapies, thereby providing valuable insights for personalized CKD treatments despite inherent limitations. © 2025 The Authors

关键词： Chronic kidney diseases Exosome Mesenchymal stem cells Meta-analysis Renal fibrosis

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Assessment on Improvement of Early Detection Systems in Electrical Rooms of High-Tech Facilities 8

Assessment on Improvement of Early Detection Systems in Elec...

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2017 8th International Conference on Fire Science and Fire Protection Engineering, ICFSFPE 2017

作者： Chen, Yu-Jen Shu, Chi-Min Ho, San-Ping Ho, Hsin-Hsiu Chang, Hue-Pei Doctoral Program Graduate School of Engineering Science and Technology National Yunlin University of Science and Technology Douliou Yunlin64002 Taiwan Department of Safety Health and Environmental Engineering YunTech Douliou Yunlin64002 Taiwan Department of Occupational Safety and Health Chang Jung Christian University Tainan71101 Taiwan

Past air sampling detection (ASD) systems had no definitive positioning;most allocation of sampling points was based on experience. This research discovered that sampling points inside the electrical rooms were significantly affected by the ambient airflow, causing the detection system to have difficulties in fire detection. Fire dynamics simulator (FDS) was used to simulate very early smoke detection apparatus (VESDA) effectiveness within the protection area of an electrical room. Results showed that ASD sampling points in electrical rooms should be placed above high-voltage transformers and capacitors, while rearranging the high risk machines together to avoid long detection pipelines, which increases the transportation time of the gas, thus hindering early detection by the ASD system. Field tests using a smoke detector tester yielded transportation times of 33 s, which was in very good agreement with the simulated results of 35 s by ASPIRE, showing the accuracy of using software to simulate transportation times. Therefore, this research combined FDS with the transportation times of different pipeline designs to conduct performance assessment of VESDA. After appropriate rearrangement of machines, VESDA detection times dropped from 106.0-171.0 s during the original setup to 21.0-31.7 s, assuring the facility to have more time for emergency response. However, it was noticed that FDS software did not have the estimation tool for VESDA transportation times;therefore software such as ASPIRE should be used to calculate the gas transportation times inside the detection pipelines, and then compiled with FDS results to avoid underestimation of actuation times. © 2017 The Authors. Published by Elsevier Ltd.

关键词： Pipelines

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Correction : Low carbon futures: assessing the status of decarbonisation efforts at universities within a 2050 perspective

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Energy, Sustainability and Society 2023年第1期13卷 1-2页

作者： Walter Leal Filho Diogo Guedes Vidal Maria Alzira Pimenta Dinis Wim Lambrechts Claudio R. P. Vasconcelos Petra Molthan‑Hill Ismaila Rimi Abubakar Rachel M. Dunk Amanda Lange Salvia Ayyoob Sharifi European School of Sustainability Science and Research Hamburg University of Applied Sciences Ulmenliet 20 21033 Hamburg Germany Department of Natural Sciences Manchester Metropolitan University Chester Street Manchester M11 5GD UK Department of Life Sciences Faculty of Sciences and Technology Center for Functional Ecology‑Science for People and The Planet (CFE) TERRA Associate Laboratory University of Coimbra Calçada Martim de Freitas 3000‑456 Coimbra Portugal UFP Energy Environment and Health Research Unit (FP-ENAS) University Fernando Pessoa (UFP) Praça 9 de Abril 349 4249‑004 Porto Portugal Department of Marketing and Supply Chain Management Faculty of Management Open Universiteit The Netherlands (OUNL) Postbus 2960 6401 DL Heerlen The Netherlands Laboratory of Sustainability Engineering and Consumption Federal University of Paraíba João Pessoa PB Brazil Algoritmi Research Centre School of Engineering University of Minho 4800‑058 Guimarães Portugal Business Sustainability Nottingham Trent University England UK College of Architecture and Planning Imam Abdulrahman Bin Faisal University (Formerly University of Dammam) P.O. Box 1982 Dammam 31441 Saudi Arabia School of Science and the Environment Manchester Metropolitan University Chester Street Manchester M1 5GD UK Graduate Program in Civil and Environment Engineering University of Passo Fundo Campus I‑BR 285 São José Passo Fundo RS 99052‑900 Brazil Graduate School of Humanities and Social Sciences and Network for Education and Research on Peace and Sustainability Hiroshima University Higashi-Hiroshima 739-8530 Japan

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Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

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Nature genetics 2023年第3期55卷 519-520页

作者： Ceres Fernandez-Rozadilla Maria Timofeeva Zhishan Chen Philip Law Minta Thomas Stephanie Schmit Virginia Díez-Obrero Li Hsu Juan Fernandez-Tajes Claire Palles Kitty Sherwood Sarah Briggs Victoria Svinti Kevin Donnelly Susan Farrington James Blackmur Peter Vaughan-Shaw Xiao-Ou Shu Jirong Long Qiuyin Cai Xingyi Guo Yingchang Lu Peter Broderick James Studd Jeroen Huyghe Tabitha Harrison David Conti Christopher Dampier Mathew Devall Fredrick Schumacher Marilena Melas Gad Rennert Mireia Obón-Santacana Vicente Martín-Sánchez Ferran Moratalla-Navarro Jae Hwan Oh Jeongseon Kim Sun Ha Jee Keum Ji Jung Sun-Seog Kweon Min-Ho Shin Aesun Shin Yoon-Ok Ahn Dong-Hyun Kim Isao Oze Wanqing Wen Keitaro Matsuo Koichi Matsuda Chizu Tanikawa Zefang Ren Yu-Tang Gao Wei-Hua Jia John Hopper Mark Jenkins Aung Ko Win Rish Pai Jane Figueiredo Robert Haile Steven Gallinger Michael Woods Polly Newcomb David Duggan Jeremy Cheadle Richard Kaplan Timothy Maughan Rachel Kerr David Kerr Iva Kirac Jan Böhm Lukka-Pekka Mecklin Pekka Jousilahti Paul Knekt Lauri Aaltonen Harri Rissanen Eero Pukkala Johan Eriksson Tatiana Cajuso Ulrika Hänninen Johanna Kondelin Kimmo Palin Tomas Tanskanen Laura Renkonen-Sinisalo Brent Zanke Satu Männistö Demetrius Albanes Stephanie Weinstein Edward Ruiz-Narvaez Julie Palmer Daniel Buchanan Elizabeth Platz Kala Visvanathan Cornelia Ulrich Erin Siegel Stefanie Brezina Andrea Gsur Peter Campbell Jenny Chang-Claude Michael Hoffmeister Hermann Brenner Martha Slattery John Potter Konstantinos Tsilidis Matthias Schulze Marc Gunter Neil Murphy Antoni Castells Sergi Castellví-Bel Leticia Moreira Volker Arndt Anna Shcherbina Mariana Stern Bens Pardamean Timothy Bishop Graham Giles Melissa Southey Gregory Idos Kevin McDonnell Zomoroda Abu-Ful Joel Greenson Katerina Shulman Flavio Lejbkowicz Kenneth Offit Yu-Ru Su Robert Steinfelder Temitope Keku Bethany van Guelpen Thomas Hudson Heather Hampel Rachel Pearlman Sonja Berndt Richard Hayes Marie Elena Martinez Sushma Thomas Douglas Corley Paul Pharoah Susanna Larsson Yun Yen Heinz-Jo Edinburgh Cancer Research Centre Institute of Genomics and Cancer University of Edinburgh Edinburgh UK. Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain. Colon Cancer Genetics Group Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK. Danish Institute for Advanced Study Department of Public Health University of Southern Denmark Odense Denmark. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University Medical Center Nashville TN USA. Division of Genetics and Epidemiology Institute of Cancer Research London UK. Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA. Genomic Medicine Institute Cleveland Clinic Cleveland OH USA. Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA. Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain. Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain. Consortium for Biomedical Research in Epidemiology and Public Health Madrid Madrid Spain. Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain. Department of Biostatistics School of Public Health University of Washington Seattle WA USA. Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK. Department of Public Health Richard Doll Building University of Oxford Oxford UK. Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA. Department of Preventive Medicine USC Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA USA. Center for Public Health Genomics Department of Public Health Sciences University of Virginia Charlottesville VA USA. De

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