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Correction: Spatial organization of B lymphocytes and prognosis prediction in patients with gastric cancer

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2025年 2025 May 16页

作者： Ryan Yong Kiat Tay Manavi Sachdeva Haoran Ma Young-Woo Kim Myeong-Cherl Kook Hyunki Kim Jae-Ho Cheong Lindsay C Hewitt Katharina Nekolla Günter Schmidt Takaki Yoshikawa Takashi Oshima Tomio Arai Supriya Srivastava Ming Teh Xuewen Ong Su Ting Tay Taotao Sheng Joseph J Zhao Patrick Tan Heike I Grabsch Raghav Sundar Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road Singapore 119228 Singapore. Department of Haematology-Oncology National University Cancer Institute National University Hospital Singapore Singapore. Cancer and Stem Cell Biology Program Duke-NUS Medical School Singapore Singapore. Department of Cancer Policy and Population Health National Cancer Center Graduate School of Cancer Science and Policy and Center for Gastric Cancer and Department of Surgery National Cancer Center Goyang Republic of Korea. Center for Gastric Cancer Department of Pathology National Cancer Center Goyang Republic of Korea. Department of Pathology Yonsei University College of Medicine Seoul Republic of Korea. Department of Surgery Yonsei University College of Medicine Seoul Republic of Korea. Department of Pathology GROW Research Institute for Oncology and Reproduction Maastricht University Medical Center+ Maastricht The Netherlands. Department of Precision Medicine GROW School for Oncology and Reproduction Maastricht University Center+ Maastricht The Netherlands. Computational Pathology Oncology R&D AstraZeneca Munich Germany. Department of Surgery Kanagawa Cancer Center Yokohama Japan. Department of Surgery Yokohama City University Yokohama Japan. Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan. Department of Pathology Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan. Department of Medicine National University of Singapore Singapore Singapore. Department of Pathology National University Hospital Singapore Singapore. Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore. Cancer Science Institute of Singapore National University of Singapore Singapore Singapore. Cellular and Molecular Research National Cancer Centre Singapore Singapore. Singhealth/Duke-NUS Institute of Precision Medicine National Heart Centre Singapore

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Author Correction: Antibodies from dengue patients with prior exposure to Japanese encephalitis virus are broadly neutralizing against Zika virus

Communications biology

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Communications biology 2024年第1期7卷 252页

作者： Gielenny M Salem Jedhan Ucat Galula Shang-Rung Wu Jyung-Hurng Liu Yen-Hsu Chen Wen-Hung Wang Sheng-Fan Wang Cheng-Sheng Song Fan-Chi Chen Adrian B Abarientos Guan-Wen Chen Cheng-I Wang Day-Yu Chao Graduate Institute of Microbiology and Public Health College of Veterinary Medicine National Chung Hsing University Taichung City 402 Taiwan. Institute of Oral Medicine School of Dentistry College of Medicine National Cheng Kung University Tainan City 701 Taiwan. Institute of Basic Medical Sciences College of Medicine National Cheng Kung University Tainan City 701 Taiwan. Graduate Institute of Genomics and Bioinformatics College of Life Sciences National Chung Hsing University Taichung City 40227 Taiwan. School of Medicine College of Medicine National Sun Yat-Sen University Kaohsiung City 80424 Taiwan. Center for Tropical Medicine and Infectious Disease Research Kaohsiung Medical University Kaohsiung City 80708 Taiwan. Division of Infectious Diseases Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City 80708 Taiwan. Department of Medical Laboratory Science and Biotechnology Kaohsiung Medical University Kaohsiung City 80708 Taiwan. Doctoral Program in Microbial Genomics National Chung Hsing University and Academia Sinica Taichung City 402 Taiwan. Singapore Immunology Network Agency for Science Technology and Research (A*STAR) 8A Biomedical Grove Immunos Singapore 138648 Singapore. Graduate Institute of Microbiology and Public Health College of Veterinary Medicine National Chung Hsing University Taichung City 402 Taiwan. dychao@nchu.edu.tw. Doctoral Program in Microbial Genomics National Chung Hsing University and Academia Sinica Taichung City 402 Taiwan. dychao@nchu.edu.tw. Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung City 402 Taiwan. dychao@nchu.edu.tw.

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Systematic Review with Meta-Analysis: Efficacy and Safety of Direct-Acting Antivirals for Chronic Hepatitis C Genotypes 5 and 6

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BioMed Research International 2019年第0期2019卷 000-000页

作者： Due, Ong The Chaikledkaew, Usa Genuino, Anne Julienne M. Sobhonslidsuk, Abhasnee Thakkinstian, Ammarin Mahidol University Health Technology Assessment (MUHTA) Graduate Program Bangkok Thailand Health Strategy and Policy Institute Vietnam Ministry of Health Hanoi Viet Nam Social and Administrative Pharmacy Excellence Research (SAPER) Unit Department of Pharmacy Faculty of Pharmacy Mahidol University Bangkok Thailand Health Technology Assessment Unit Health Regulation Team Department of Health Philippines Manila Philippines Division of Gastroenterology and Hepatology Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand Section for Clinical Epidemiology and Biostatistics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

Direct-acting antivirals (DAAs) are modern treatments for chronic hepatitis C infection, but majority of available evidence on its treatment effect covers genotypes 1 to 4. Therefore, the efficacy and safety of DAAs for genotypes 5 and 6 need to be analysed. Studies were identified from Medline, Scopus, and CENTRAL and a Chinese database CNKI, from inception until Dec 4, 2018. Clinical trials were included if they enrolled patients with genotypes 5 and/or 6 infection, any type of second-generation DAAs was studied, and sustained virological response was assessed at the 12^th week after treatment (SVR12) as outcome measure. Meta-analysis using metaprop statistical program was applied for pooling proportions if data were sufficient (i.e., at least 2 studies). Thirteen studies were included in the analysis. Four studies assessed the efficacy of four DAA regimens in genotype 5 patients, which were mainly sofosbuvir (SOF) plus pegylated-interferon/ribavirin (PR) or other DAAs, with SVR12 ranging from 94.4% to 100%. Twelve studies assessed the efficacy of seven DAA regimens among genotype 6 patients, but only two DAA regimens (i.e., SOF + PR and SOF/ledipasvir) had sufficient data for pooling. The pooled SVR12 rates (95% CI) were 99.6% (92.2 to 100) for SOF + PR and 99.2% (96.5 to 100) for SOF/ledipasvir. No treatment-related serious adverse event was reported, while the nonserious adverse events were comparable to other genotypes. In conclusion, DAAs are effective and may be safe for the treatment of chronic hepatitis C genotypes 5 and 6. However, our evidence is based on noncomparative studies;hence, further larger-scale randomized controlled trials in these genotypes are still required. © 2019 Ong The Due et al.

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The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases

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Clinical immunology (Orlando, Fla.) 2024年 260卷 109897页

作者： Hsing-Fang Lu Chen-Hsing Chou Ying-Ju Lin Shunsuke Uchiyama Chikashi Terao Yu-Wen Wang Jai-Sing Yang Ting-Yuan Liu Henry Sung-Ching Wong Sean Chun-Chang Chen Fuu-Jen Tsai Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan. PhD Program for Health Science and Industry College of Health Care China Medical University Taichung Taiwan Department of Health Services Administration China Medical University Taichung Taiwan. Genetic Center Department of Medical Research China Medical University Hospital Taichung Taiwan School of Chinese Medicine China Medical University Taichung Taiwan. Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Clinical Research Center Shizuoka General Hospital Shizuoka Japan The Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan. Department of Medical Research China Medical University Hospital China Medical University Taichung 404327 Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Chinese Medicine China Medical University Taichung Taiwan Department of Biotechnology and Bioinformatics Asia University Taichung Taiwan. Electronic address: d0704@mail.cmuh.org.tw.

Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA1*03:02 - HLA-DQB1*03:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10), corresponding to HLA-DQA1 Asp160 and HLA-DQB1 Leu87 amino acid residues. The genetic correlation showed significance between IgE and allergic diseases including asthma, atopic dermatitis, and pollinosis. IgE PRS was significantly correlated with total IgE levels. Furthermore, the top decile IgE polygenic risk score (PRS) group had the highest risk of asthma for the Taiwan Biobank and Biobank Japan cohorts. IgE PRS may be used to aid in predicting the occurrence of allergic reactions before symptoms occur and biomarkers are detectable. Our study provided a more comprehensive understanding of the impact of genomic variants, including complex HLA alleles, on serum IgE levels.

关键词： Allergy genome-wide association study human leukocyte antigen immunoglobulin E

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Correction: Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAD+/ SIRT1 axis

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Journal of biomedical science 2024年第1期31卷 61页

作者： B Linju Yen Li-Tzu Wang Hsiu-Huang Wang Chin-Pao Hung Pei-Ju Hsu Chia-Chi Chang Chien-Yu Liao Huey-Kang Sytwu Men-Luh Yen Regenerative Medicine Research Group Institute of Cellular & System Medicine National Health Research Institutes (NHRI) No.35 Keyan Road Zhunan 35053 Taiwan. blyen@nhri.edu.tw. Department of Obstetrics & Gynecology National Taiwan University (NTU) Hospital & College of Medicine NTU No.1 Section 1 Jen‑Ai Road Taipei 10051 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University No. 250 Wuxing Street Taipei 11042 Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University No.250 Wuxing Street Taipei 11042 Taiwan. Regenerative Medicine Research Group Institute of Cellular & System Medicine National Health Research Institutes (NHRI) No.35 Keyan Road Zhunan 35053 Taiwan. Graduate Institute of Life Sciences National Defense Medical Center (NDMC) No.161 Section Minquan East Road Taipei 11490 Taiwan. National Institute of Infectious Diseases & Vaccinology NHRI No.35 Keyan Road Zhunan 35053 Taiwan. Graduate Institute of Microbiology & Immunology NDMC No.161 Section 6 Minquan East Road Taipei 11490 Taiwan. Department of Obstetrics & Gynecology National Taiwan University (NTU) Hospital & College of Medicine NTU No.1 Section 1 Jen‑Ai Road Taipei 10051 Taiwan. mlyen@ntu.edu.tw.

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Mitochondrial activation via calcium peroxide/carrageenan/soybean lecithin-derived polypyrrole phototherapeutic microparticles

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Colloids and Surfaces B: Biointerfaces 2025年 254卷 114787页

作者： Chuang, Sih-Chi Yu, Shih-An Hung, Pei-Chia Chuang, Andrew E.-Y. Liang, Jia-Wei Sun, Chia-Lu Rethi, Lekshmi Fang, Hsu-Wei Nguyen, Hieu Trung Tsai, Yao-Tung Weng, Pei-Wei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Doctoral Program of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei10608 Taiwan Taipei Medical University Derived Company-Hsuan Chen Technology CO. LTD. New Taipei City22055 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan WELLCARE Health Care Supply Co. Ltd. Taipei Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh city Ho Chi Minh City700000 Viet Nam Department of Orthopaedic Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City11490 Taiwan Division of Traumatology Department of Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City11490 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan

Mitochondria, often referred to as the "powerhouses" of eukaryotic cells, play a critical role in maintaining cellular homeostasis and supporting essential life functions, particularly in cell survival and apoptosis. This study introduces a composite formulation—combining carrageenan (Car), calcium peroxide (CaO2), and microparticles, derived from soybean oil lecithin, enhanced with photothermally active polypyrrole (PPy)—to create Car-Lec-PPy MP, aimed at promoting mitochondrial activation in cells. The investigation focuses on intercellular mitochondrial transfer and activation as a therapeutic strategy. The formulation seeks to stimulate mitochondrial biogenesis and enhance cellular resilience through targeted mitochondrial activation, leveraging the synergistic effects of near-infrared (NIR) therapy. In the in vivo experiment, phototherapeutic Car-Lec-PPy MP was administered to rodent muscle tissue. The results showed increased expression of heat-shock proteins and reduced oxidative stress in the treated muscle. Preliminary findings suggest that this approach not only boosts mitochondrial activity but also improves cell proliferation and survival, presenting significant potential for applications in regenerative medicine and cellular therapy. © 2025 Elsevier B.V.

关键词： Mitochondria

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Retraction notice to "Hydrological and climate impacts on river characteristics of Pahang River Basin, Malaysia" [ Heliyon 9 2023 e21573]

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Heliyon 2025年第1期11卷 e41351页

作者： Mohd Khairul Amri Kamarudin Mohd Ekhwan Toriman Noorjima Abd Wahab Mohd Armi Abu Samah Khairul Nizam Abdul Maulud Firdaus Mohamad Hamzah Ahmad Shakir Mohd Saudi Sunardi Sunardi Faculty of Applied Social Science University Sultan Zainal Abidin Gong Badak Campus 21300 Terengganu Malaysia. East Coast Environmental Research Institute (ESERI) University Sultan Zainal Abidin Gong Badak Campus Nerus 21300 Kuala Malaysia. Faculty of Social Sciences and Humanities National University of Malaysia 43600 Bangi Selangor Malaysia. Kulliyyah of Science International Islamic University Malaysia 25200 Kuantan Pahang Malaysia. Earth Observation Center Institute of Climate Change National University of Malaysia 43600 Bangi Selangor Malaysia. Department of Mathematics Defense Base Center National Defence University of Malaysia Sungai Besi Camp 57000 Kuala Lumpur Malaysia. Department of Environmental Health Institute of Medical Science Technology Universiti Kuala Lumpur Kajang Selangor Malaysia. Graduate Program on Environmental Studies Postgraduate School Universitas Padjadjaran Jl. Dipati Ukur No. 35 Bandung 40132 Indonesia.

[This retracts the article DOI: 10.1016/***.2023.e21573.].

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Front Cover: A New Bispyrroloiminoquinone Alkaloid From a Thai Collection ofClavelinasp. (Asian J. Org. Chem. 7/2021)

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Asian Journal of Organic Chemistry 2021年第7期10卷

作者： Dr. Tanja Grkovic Prof. Dr. Somsak Ruchirawat Prof. Dr. Prasat Kittakoop Dr. Paul G. Grothaus Jason R. Evans John R. Britt Dr. David J. Newman Prof. Dr. Chulabhorn Mahidol Dr. Barry R. O'Keefe Natural Products Branch Developmental Therapeutics Program Division of Cancer Treatment and Diagnosis National Cancer Institute Frederick Maryland 21702-1201 USA Molecular Targets Program Center for Cancer Research National Cancer Institute Frederick Maryland 21702-1201 USA Laboratory of Natural Products Chulabhorn Research Institute Kamphang Phet 6 Road Bangkok 10210 Thailand Chemical Biology Program Chulabhorn Graduate Institute Kamphang Phet 6 Road Bangkok 10210 Thailand Center of Excellence on Environmental Health and Technology CHE Ministry of Education Bangkok Thailand Natural Products Support Group Frederick National Laboratory for Cancer Research Frederick Maryland 21702-1201 USA

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FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare

arXiv

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arXiv 2023年

作者： Lekadir, Karim Feragen, Aasa Fofanah, Abdul Joseph Frangi, Alejandro F. Buyx, Alena Emelie, Anais Lara, Andrea Porras, Antonio R. Chan, An-Wen Navarro, Arcadi Glocker, Ben Botwe, Benard O. Khanal, Bishesh Beger, Brigit Wu, Carol C. Cintas, Celia Langlotz, Curtis P. Rueckert, Daniel Mzurikwao, Deogratias Fotiadis, Dimitrios I. Zhussupov, Doszhan Ferrante, Enzo Meijering, Erik Weicken, Eva González, Fabio A. Asselbergs, Folkert W. Prior, Fred Krestin, Gabriel P. Collins, Gary S. Tegenaw, Geletaw S. Kaissis, Georgios Misuraca, Gianluca Tsakou, Gianna Dwivedi, Girish Kondylakis, Haridimos Jayakody, Harsha Woodruf, Henry C. Mayer, Horst Joachim Aerts, Hugo JWL Walsh, Ian Chouvarda, Ioanna Buvat, Irène Tributsch, Isabell Rekik, Islem Duncan, James Kalpathy-Cramer, Jayashree Zahir, Jihad Park, Jinah Mongan, John Gichoya, Judy W. Schnabel, Julia A. Kushibar, Kaisar Riklund, Katrine Mori, Kensaku Marias, Kostas Amugongo, Lameck M. Fromont, Lauren A. Maier-Hein, Lena Alberich, Leonor Cerdá Rittner, Leticia Phiri, Lighton Marrakchi-Kacem, Linda Donoso-Bach, Lluís Martí-Bonmatí, Luis Cardoso, M. Jorge Bobowicz, Maciej Shabani, Mahsa Tsiknakis, Manolis Zuluaga, Maria A. Bielikova, Maria Fritzsche, Marie-Christine Camacho, Marina Linguraru, Marius George Wenzel, Markus De Bruijne, Marleen Tolsgaard, Martin G. Ghassemi, Marzyeh Ashrafuzzaman, Md Goisauf, Melanie Yaqub, Mohammad Abadía, Mónica Cano Mahmoud, Mukhtar M.E. Elattar, Mustafa Rieke, Nicola Papanikolaou, Nikolaos Lazrak, Noussair Díaz, Oliver Salvado, Olivier Pujol, Oriol Sall, Ousmane Guevara, Pamela Gordebeke, Peter Lambin, Philippe Brown, Pieta Abolmaesumi, Purang Dou, Qi Lu, Qinghua Osuala, Richard Nakasi, Rose Zhou, S. Kevin Napel, Sandy Colantonio, Sara Albarqouni, Shadi Joshi, Smriti Carter, Stacy Klein, Stefan Petersen, Steffen E. Aussó, Susanna Awate, Suyash Raviv, Tammy Riklin Cook, Tessa Mutsvangwa, Tinashe E.M. Rogers, Wendy A. Niessen, Wiro J. Puig-Bosch, Xènia Zeng, Yi Mohammed, Yunusa G. Aquino, Yves Saint James Salahuddin, Zohaib Starmans, Martijn P.A. Department de Matemàtiques i Informàtica Universitat de Barcelona Barcelona Spain Barcelona Spain DTU Compute Technical University of Denmark Kgs Lyngby Denmark Department of Mathematics and Computer Science Faculty of Science and Technology Milton Margai Technical University Freetown Sierra Leone Center for Computational Imaging & Simulation Technologies in Biomedicine Schools of Computing and Medicine University of Leeds Leeds United Kingdom Cardiovascular Science and Electronic Engineering Departments KU Leuven Leuven Belgium Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Faculty of Engineering of Systems Informatics and Sciences of Computing Galileo University Guatemala City Guatemala Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Department of Medicine Women’s College Research Institute University of Toronto Toronto Canada Universitat Pompeu Fabra BarcelonaBeta Brain Research Center Barcelona Spain Department of Computing Imperial College London London United Kingdom School of Biomedical & Allied Health Sciences University of Ghana Accra Ghana Department of Midwifery & Radiography School of Health & Psychological Sciences City University of London United Kingdom Kathmandu Nepal European Heart Network Brussels Belgium Department of Thoracic Imaging University of Texas MD Anderson Cancer Center Houston United States IBM Research Africa Nairobi Kenya Departments of Radiology Medicine and Biomedical Data Science Stanford University School of Medicine Stanford United States Institute for AI and Informatics in Medicine Klinikum rechts der Isar Technical University Munich Munich Germany Department of Computing Imperial College London London United Kingdom Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania United Republic of Ioannina Greece Almaty AI Lab Almaty Kazakhstan

Background: Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. In recent years, concerns have been raised about the clinical, technical, ethical and legal risks associated with healthcare AI. To increase adoption in the real world, it is essential that AI technologies are trusted and accepted by patients, clinicians, health organisations and authorities. This paper describes the FUTURE-AI framework as the first international consensus guideline for trustworthy AI in healthcare. Methods: The FUTURE-AI consortium was founded in 2021 and now comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two-year period, the consortium established guiding principles and best practices for trustworthy and deployable AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. Findings: The FUTURE-AI framework was established based on six guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 30 best practices were defined, addressing technical, clinical, socio-ethical and legal dimensions of trustworthy AI. The recommendations cover the entire lifecycle of healthcare AI, from design, development and validation to regulation, deployment, and monitoring. Interpretation: FUTURE-AI is a structured, risk-informed framework which provides guidance for constructing healthcare AI tools that will be trusted, deployed and adopted in real-world clinical practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of healthcare AI. Copyright © 2023, The Authors. All rights

关键词： Clinical research

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Assessment on Improvement of Early Detection Systems in Electrical Rooms of High-Tech Facilities

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Procedia Engineering 2018年 211卷 235-246页

作者： Yu-Jen Chen Chi-Min Shu San-Ping Ho Hsin-Hsiu Ho Hue-Pei Chang Doctoral Program Graduate school of Engineering Science and Technology National Yunlin University of Science and Technology Douliou Yunlin Taiwan 64002 Department of Safety Health and Environmental Engineering YunTech Douliou Yunlin Taiwan 64002 Department of Occupational Safety and Health Chang Jung Christian University Tainan Taiwan 71101

Past air sampling detection (ASD) systems had no definitive positioning; most allocation of sampling points was based on experience. This research discovered that sampling points inside the electrical rooms were significantly affected by the ambient airflow, causing the detection system to have difficulties in fire detection. Fire dynamics simulator (FDS) was used to simulate very early smoke detection apparatus (VESDA) effectiveness within the protection area of an electrical room. Results showed that ASD sampling points in electrical rooms should be placed above high-voltage transformers and capacitors, while rearranging the high risk machines together to avoid long detection pipelines, which increases the transportation time of the gas, thus hindering early detection by the ASD system. Field tests using a smoke detector tester yielded transportation times of 33 s, which was in very good agreement with the simulated results of 35 s by ASPIRE, showing the accuracy of using software to simulate transportation times. Therefore, this research combined FDS with the transportation times of different pipeline designs to conduct performance assessment of VESDA. After appropriate rearrangement of machines, VESDA detection times dropped from 106.0–171.0 s during the original setup to 21.0–31.7 s, assuring the facility to have more time for emergency response. However, it was noticed that FDS software did not have the estimation tool for VESDA transportation times; therefore software such as ASPIRE should be used to calculate the gas transportation times inside the detection pipelines, and then compiled with FDS results to avoid underestimation of actuation times.

关键词： electrical rooms transportation time fire dynamics dimulator vesda aspire

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