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Briavioid D, a rare 7β,8β-epoxybriarane from Briareum violaceum

Tetrahedron Letters 2023年 118卷

作者： Thanh Hao Huynh Chou-Yuan Ko Hsin-Tzu Liu Yen-Po Chen Mingzi M. Zhang Lun Kelvin Tsou Zhi-Hong Wen Su-Ying Chien Ping-Jyun Sung Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan National Museum of Marine Biology and Aquarium Pingtung 944401 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung 804201 Taiwan Department of Medical Research Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien 970473 Taiwan Department of Obstetrics and Gynecology Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Zhunan Miaoli 350401 Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Zhunan Miaoli 350401 Taiwan Institute of BioPharmaceutical Sciences National Sun Yat-sen University Kaohsiung 804201 Taiwan Instrumentation Center National Taiwan University Taipei 106319 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung 807378 Taiwan Ph.D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City 242062 Taiwan

A rare 7β,8β-epoxybriarane, briavioid D ( 1 ), has been isolated from a cultured octocoral Briareum violaceum . The structure of 1 was deduced by extensive 2D NMR studies. Single-crystal X-ray diffraction analysis was performed to identify the structure of 1 and this compound was found to reduce the release of iNOS to 85.77 %, at a concentration of 10 μM.

关键词： Briareum violaceum Briavioid Briarane X-ray iNOS

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Fluorescent phenylthiazoles: Application as latent fingermark and their cytotoxicity against NOK-SI cell line

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Chemical Data Collections 2021年 33卷

作者： Bruno Nunes da Rosa Kristiane de Cássia Mariotti Bruna Silveira Pacheco Caroline Carapina da Silva Neftalí Lenin Villarreal Carreño Caroline Nicolodi Tais Poletti Allison Carlos Assunção Silva Adriana Fernandes da Silva Janice Luehring Giongo Rodrigo de Almeida Vaucher Tiago Franco de Oliveira Claudio Martin Pereira de Pereira Laboratory of Lipidomics and Bioorganic Bioforensics Research Group Federal University of Pelotas 96010 900 Pelotas RS Brazil National Institute of Forensic Science and Technology (INCT Forensic) Porto Alegre (RS) Pelotas (RS) Brazil Identification Group Brazilian Federal Police 90610-093 Porto Alegre RS Brazil Materials Science and Engineering Technology Development Center Federal University of Pelotas 96010-000 Pelotas RS Brazil Post-Graduate Program in Dentistry Department of Restorative Dentistry Dental School Federal University of Pelotas 96010 Pelotas RS Brazil Laboratory of Biochemistry Research and Molecular Biology of Microorganisms (LaPeBBiOM) Federal University of Pelotas 96010-900 Pelotas RS Brazil Pharmacosciences Department Federal University of Health Sciences of Porto Alegre Porto Alegre RS Brazil

Fingerprints are unique to each individual who contributes to human identification in forensic cases. In this sense, the present work aimed to synthesize 1H-pyrazol-1-yl-4-phenylthiazoles and apply them as powder agents to reveal latent finger marks as an alternative and low cost related to powders found on the market. The compounds were characterized by infrared; fluorescence; 1H NMR; 13C NMR; laser diffractometer and SEM. In addition, cytotoxicity was also evaluated in oral keratinocytes showing high cell viability. The result of the hemolytic assay revealed that compound 2a does not present red cell cytotoxicity. The prepared powders were applied to fingermarks deposited on different surfaces providing quality visualization at level three so that human identification is possible.

关键词： Forensic chemistry Fingermark Thiazoles Cytotoxicity Development powder

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Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses

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Cell Reports Medicine 2021年第12期2卷 100478-100478页

作者： Wu, Junru Vodovotz, Yoram Abdelhamid, Sultan Guyette, Francis X. Yaffe, Michael B. Gruen, Danielle S. Cyr, Anthony Okonkwo, David O. Kar, Upendra K. Krishnamoorthi, Neha Voinchet, Robert G. Billiar, Isabel M. Yazer, Mark H. Namas, Rami A. Daley, Brian J. Miller, Richard S. Harbrecht, Brian G. Claridge, Jeffrey A. Phelan, Herbert A. Zuckerbraun, Brian S. Johansson, Pär I. Stensballe, Jakob Morrissey, James H. Tracy, Russell P. Wisniewski, Stephen R. Neal, Matthew D. Sperry, Jason L. Billiar, Timothy R. Department of Surgery University of Pittsburgh Pittsburgh PA United States Pittsburgh Trauma Research Center University of Pittsburgh Pittsburgh PA United States Department of Cardiology & Center of Pharmacology The 3rd Xiangya Hospital Central South University Changsha China Eight-Year Program of Medicine Xiangya School of Medicine Central South University Changsha China Department of Emergency Medicine Medicine University of Pittsburgh Pittsburgh PA United States Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA United States Department of Surgery Beth Israel Deaconess Medical Center Harvard Medical School Boston MA United States Department of Neurological Surgery University of Pittsburgh Pittsburgh PA United States The Institute for Transfusion Medicine Pittsburgh PA United States Department of Surgery University of Tennessee Health Science Center Knoxville TN United States Department of Surgery JPS Health Network in Fort Worth TX United States Department of Surgery University of Louisville Louisville KY United States Metro Health Medical Center Case Western Reserve University Cleveland OH United States Department of Surgery University of Texas Southwestern Dallas TX United States Section for Transfusion Medicine Capital Region Blood Bank Rigshospitalet Copenhagen University Hospital Copenhagen Denmark Department of Anesthesia and Trauma Center Centre of Head and Orthopaedics Rigshospitalet Copenhagen University Hospital Copenhagen Denmark Emergency Medical Services The Capital Region of Denmark Hillerød Denmark Departments of Biological Chemistry & Internal Medicine University of Michigan Medical School Ann Arbor MI United States Department of Pathology & Laboratory Medicine and Biochemistry University of Vermont Larner College of Medicine Colchester VT United States Graduate School of Public Health University of Pittsburgh Pittsburgh PA United States The PAMPer study group is detai

Trauma is a leading cause of death and morbidity worldwide. Here, we present the analysis of a longitudinal multi-omic dataset comprising clinical, cytokine, endotheliopathy biomarker, lipidome, metabolome, and proteome data from severely injured humans. A “systemic storm” pattern with release of 1,061 markers, together with a pattern suggestive of the “massive consumption” of 892 constitutive circulating markers, is identified in the acute phase post-trauma. Data integration reveals two human injury response endotypes, which align with clinical trajectory. Prehospital thawed plasma rescues only endotype 2 patients with traumatic brain injury (30-day mortality: 30.3 versus 75.0%;p = 0.0015). Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) was identified as the most predictive circulating biomarker to identify endotype 2-traumatic brain injury (TBI) patients. These response patterns refine the paradigm for human injury, while the datasets provide a resource for the study of critical illness, trauma, and human stress responses. © 2021

关键词： endotype host response metabolomics multi-omics outcome PAMPer trial proteomics systemic storm thawed plasma trauma

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LST-1 observations of an enormous flare of BL Lacertae in 2021

arXiv

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arXiv 2023年

作者： Nozaki, Seiya Asano, Katsuaki Escudero, Juan Emery, Gabriel Priyadarshi, Chaitanya Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Crespo, N. Alvarez Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Larriva, A. Baquero Baroncelli, L. de Almeida, U. Barres Barrio, J.A. Batkovic, I. Baxter, J. González, J. Becerra Bernardini, E. Bernardos, M.I. Medrano, J. Bernete Berti, A. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Lavergne, M. de Bony De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Mengual, J. Delgado della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ramazani, V. Fallah Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Coromina, L. Freixas Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. López, R. Garcia Gasbarra, C. Gasparrini, D. Geyer, D. Paiva, J. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Llorente, J. Herrera Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Martinez, I. Jimenez Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Le Flour, T. Linhoff, M. Longo, F. López-Coto, R. Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Aix Marseille Univ CNRS IN2P3 CPPM Marseille France The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Department of Physics Tokai University Japan Institute for Cosmic Ray Research University of Tokyo Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Max-Planck-Institut für Physik Germany INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain CIEMAT Spain Department of Physics TU Dortmund University Germany INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy Palacky University Olomouc Faculty of Science Czech Republic University of Alcalá UAH Spain P

The first prototype of LST (LST-1) for the Cherenkov Telescope Array has been in commissioning phase since 2018 and already started scientific observations with the low energy threshold around a few tens of GeV. In 2021, LST-1 observed BL Lac following the alerts based on multi-wavelength observations and detected prominent gamma-ray flares. In addition to the daily flux variability, LST-1 also detected sub-hour-scale intra-night variability reaching 3–4 times higher than the gamma-ray flux from the Crab Nebula above 100 GeV. In this proceeding, we will report the analysis results of LST-1 observations of BL Lac in 2021, especially focusing on flux variability. © 2023, CC BY.

关键词： Gamma rays

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Comparative study of marine fish freshness based on the handling method in Puncak Permai modern market and Simo Gunung traditional market, Surabaya

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IOP Conference Series: Earth and Environmental Science 2020年第1期441卷

作者： M Sari J Triastuti H Pramono Sudarno Graduate of Aquaculture Study Program Majoring in Fisheries Product Technology Faculty of Fisheries and Marine Universitas Airlangga Mulyorejo Surabaya East Java 60115 Indonesia Department of Marine Faculty of Fisheries and Marine Universitas Airlangga Mulyorejo Surabaya East Java 60115 Indonesia Department of Fish Health Management and Aquaculture Faculty of Fisheries and Marine Universitas Airlangga Mulyorejo Surabaya East Java 60115 Indonesia

Fish handling conditions on the market nowadays mainly in the traditional market is less a principle handling with caution, fast, and clean, making the selling fish polluted with chemical, physical, and microbiological pollutants. The fish handling on the modern market is generally better than the traditional markets. Puncak Permai and Simo Gunung Market provide fresh fish more than any other market in Surabaya, making these markets become the main destination for consumers, therefore this study was conducted to observe the fish freshness in both markets. The purpose of this study was to compare the freshness and observe the handling way of traders situating in both markets. This research used a survey method that was conducted for seven times sampling with three days of interval sampling. This study took three types of marine fish. The main parameters observed were pH and organoleptic values, while the supporting parameters were interviewed data. The result showed that the handling method had a significant effect (p<0.05) on the organoleptic condition of all samples observed, but it had no significant effect (p>0.05) on the pH level.

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels

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Pharmacopsychiatry 2021年第2期55卷 73-86页

作者： Jose de Leon Georgios Schoretsanitis Robert L. Smith Espen Molden Anssi Solismaa Niko Seppälä Miloslav Kopeček Patrik Švancer Ismael Olmos Carina Ricciardi Celso Iglesias-Garcia Ana Iglesias-Alonso Edoardo Spina Can-Jun Ruan Chuan-Yue Wang Gang Wang Yi-Lang Tang Shih-Ku Lin Hsien-Yuan Lane Yong Sik Kim Se Hyun Kim Anto P. Rajkumar Dinora F. González-Esquivel Helgi Jung-Cook Trino Baptista Christopher Rohde Jimmi Nielsen Hélène Verdoux Clelia Quiles Emilio J. Sanz Carlos De Las Cuevas Dan Cohen Peter F.J. Schulte Aygün Ertuğrul A. Elif Anıl Yağcıoğlu Nitin Chopra Betsy McCollum Charles Shelton Robert O. Cotes Arun R. Kaithi John M. Kane Saeed Farooq Chee H. Ng John Bilbily Christoph Hiemke Carlos López-Jaramillo Ian McGrane Fernando Lana Chin B. Eap Manuel Arrojo-Romero Flavian Ş. Rădulescu Erich Seifritz Susanna Every-Palmer Chad A. Bousman Emmanuel Bebawi Rahul Bhattacharya Deanna L. Kelly Yuji Otsuka Judit Lazary Rafael Torres Agustin Yecora Mariano Motuca Sherry K.W. Chan Monica Zolezzi Sami Ouanes Domenico De Berardis Sandeep Grover Ric M. Procyshyn Richard A. Adebayo Oleg O. Kirilochev Andrey Soloviev Konstantinos N. Fountoulakis Alina Wilkowska Wiesław J. Cubała Muhammad Ayub Alzira Silva Raphael M. Bonelli José M. Villagrán-Moreno Benedicto Crespo-Facorro Henk Temmingh Eric Decloedt Maria R. Pedro Hiroyoshi Takeuchi Masaru Tsukahara Gerhard Gründer Marina Sagud Andreja Celofiga Dragana Ignjatovic Ristic Bruno B. Ortiz Helio Elkis António J. Pacheco Palha Adrián LLerena Emilio Fernandez-Egea Dan Siskind Abraham Weizman Rim Masmoudi Shamin Mohd Saffian Jonathan G. Leung Peter F. Buckley Stephen R. Marder Leslie Citrome Oliver Freudenreich Christoph U. Correll Daniel J. Müller Mental Health Research Center Eastern State Hospital Lexington KY USA Department of Psychiatry University of Kentucky Lexington KY USA Psychiatry and Neurosciences Research Group (CTS-549) Institute of Neurosciences University of Granada Granada Spain Biomedical Research Centre in Mental Health Net (CIBERSAM) Santiago Apostol Hospital University of the Basque Country Vitoria Spain Department of Psychiatry Psychotherapy and Psychosomatics Psychiatric Hospital University of Zürich Zürich Switzerland The Zucker Hillside Hospital Psychiatry Research Northwell Health Glen Oaks New York USA Center for Psychopharmacology Diakonhjemmet Hospital Oslo Norway Section for Pharmacology and Pharmaceutical Biosciences Department of Pharmacy University of Oslo Oslo Norway Faculty of Medicine and Health Technology Tampere University Tampere Finland Department of Psychiatry Tampere University Hospital Tampere Finland Department of Psychiatry Satasairaala Finland National Institute of Mental Health Klecany Czech Republic Department of Psychiatry Charles University Third Faculty of Medicine Prague Czech Republic Clinical Pharmacology Unit and Pharmacy Department Vilardebó Hospital Administración de Servicios de Salud Montevideo Uruguay Clinical Pharmacology Unit and Outpatient Clinic Vilardebó Hospital Administración de Servicios de Salud Montevideo Uruguay Universidad de Oviedo. CIBERSAM. INEUROPA. ISPA-FIMBA Oviedo Spain Hospital Valle del Nalón Langreo Spain Hospital Universitario Central de Asturias Oviedo Spain Department of Clinical and Experimental Medicine University of Messina Messina Italy Laboratory of Clinical Psychopharmacology Beijing Anding Hospital Capital Medical University Beijing China The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders Beijing Anding Hospital Capital Medical University Beijing China Department of Psychiatry Beijing Anding Hospital Capital Medical University Beijing China Depart

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and it produces four times higher worldwide pneumonia mortality than that by agranulocytosis or myocarditis. For trough steady-state clozapine serum concentrations, the therapeutic reference range is narrow, from 350 to 600 ng/mL with the potential for toxicity and ADRs as concentrations increase. Clozapine is mainly metabolized by CYP1A2 (female non-smokers, the lowest dose; male smokers, the highest dose). Poor metabolizer status through phenotypic conversion is associated with co-prescription of inhibitors (including oral contraceptives and valproate), obesity, or inflammation with C-reactive protein (CRP) elevations. The Asian population (Pakistan to Japan) or the Americas’ original inhabitants have lower CYP1A2 activity and require lower clozapine doses to reach concentrations of 350 ng/mL. In the US, daily doses of 300–600 mg/day are recommended. Slow personalized titration may prevent early ADRs (including syncope, myocarditis, and pneumonia). This guideline defines six personalized titration schedules for inpatients: 1) ancestry from Asia or the original people from the Americas with lower metabolism (obesity or valproate) needing minimum therapeutic dosages of 75–150 mg/day, 2) ancestry from Asia or the original people from the Americas with average metabolism needing 175–300 mg/day, 3) European/Western Asian ancestry with lower metabolism (obesity or valproate) needing 100–200 mg/day, 4) European/Western Asian ancestry with average metabolism needing 250–400 mg/day, 5) in the US with ancestries other than from Asia or the original people from the Americas with lower clozapine metabolism (obesity or valproate) needing 150–300 mg/day, and 6) in the US with ancestries other than from Asia or the original people from

关键词： Native American continental ancestry group Asian continental ancestry group clozapine/adverse effects clozapine/blood clozapine/metabolism clozapine/therapeutic use clozapine/toxicity CYP1A2 drug labeling European continental ancestry group infection inflammation mortality/drug effects sex smoking.

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Genome-wide association study of long COVID

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Nature Genetics 2025年 1-16页

作者： Lammi, Vilma Nakanishi, Tomoko Jones, Samuel E. Andrews, Shea J. Karjalainen, Juha Cortés, Beatriz O’Brien, Heath E. Ochoa-Guzman, Ana Fulton-Howard, Brian E. Broberg, Martin Haapaniemi, Hele H. Kanai, Masahiro Pirinen, Matti Schmidt, Axel Mitchell, Ruth E. Mousas, Abdou Mangino, Massimo Huerta-Chagoya, Alicia Sinnott-Armstrong, Nasa Cirulli, Elizabeth T. Vaudel, Marc Kwong, Alex S. F. Maiti, Amit K. Marttila, Minttu M. Posner, Daniel C. Rodriguez, Alexis A. Batini, Chiara Minnai, Francesca Dearman, Anna R. Warmerdam, C. A. Robert Sequeros, Celia B. Winkler, Thomas W. Jordan, Daniel M. Rešcenko, Raimonds Miano, Lorenzo Lane, Jacqueline M. Chung, Ryan K. Guillen-Guio, Beatriz Leavy, Olivia C. Carvajal-Silva, Laura Aguilar-Valdés, Kevin Frangione, Erika Guare, Lindsay Vergasova, Ekaterina Marouli, Eirini Striano, Pasquale Zainulabid, Ummu Afeera Kumar, Ashutosh Ahmad, Hajar Fauzan Edahiro, Ryuya Azekawa, Shuhei Maj, Carlo Pensel, Max C. Miller, Abigail Nöthen, Markus M. Behzad, Pari Schultz, Sonja Heggemann, Julia Balla, Daniella Morrison, David R. Mooser, Vincent Perley, Danielle Ragoussis, Jiannis Rousseau, Simon Shi, Fangyi Lathrop, G. Mark Yanishevsky, Solomia Laurent, Laetitia Auld, Daniel Bertrand, Mylene Boisclair, Ariane Bourque, Guillaume Bujold, David Durand, Madeleine Adra, Darin St-Cyr, Janick Niemi, Mari E. K. Iyengar, Sudha K. Cai, Tianxi Cho, Kelly Sarvadhavabhatla, Sannidhi Donaire, Maria Sophia Valenzuela-Jorquera, Héctor Lamoza, Eduardo Arévalo, Tamara V. Retamales-Ortega, Rocío Sanhueza, Sergio Selman, Carolina S. Silva, Andrea X. Alarcon, Teresa A. Martínez, Matías F. Quiroga, Romina Zuñiga-Pacheco, Paula Zapata-Contreras, Daniela Yáñez, Cristian E. Quiñones, Luis A. Tobar-Calfucoy, Eduardo A. Monardes-Ramírez, Virginia A. Signore, Iskra A. Guajardo, Lissette G. Figueroa, Alvaro Oróstica, Karen Y. Muñoz, Christian A. Fuentes-Guajardo, Macarena Bocchieri, Pamela Cabrera, Camilo Echeverria, Cesar A. Cerpa, Leslie C. Donoso, Gerardo Gutiérrez-Richards, Scarlett Nova-Lamperti, Estefania Saez Hidalgo Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland Department of Human Genetics McGill University Montreal QC Canada Centre for Clinical Epidemiology Department of Medicine Lady Davis Institute Jewish General Hospital McGill University Montreal QC Canada Kyoto-McGill International Collaborative Program in Genomic Medicine Graduate School of Medicine Kyoto University Kyoto Japan Department of Genome Informatics Graduate School of Medicine the University of Tokyo Tokyo Japan Research Fellow Japan Society for the Promotion of Science Tokyo Japan Department of Psychiatry and Behavioral Sciences University of California San Francisco San Francisco CA United States Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA United States Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA United States Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA United States Genomes for Life-GCAT Lab CORE Program Germans Trias i Pujol Research Institute (IGTP) Badalona Spain Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) Barcelona Spain Sano Genetics Limited London United Kingdom Unidad de Biología Molecular y Medicina Genómica Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City NY United States Broad Institute Cambridge MA United States Analytical and Translational Genetics Unit Massachusetts General Hospital Harvard Medical School Boston MA United States Department of Mathematics and Statistics University of Helsinki Helsinki Finland Department of Public Health University of Helsinki Helsinki Finland Institute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn Germany MRC Integrat

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID. © The Author(s) 2025.

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Democratising Knowledge Representation with BioCypher

arXiv

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arXiv 2022年

作者： Lobentanzer, Sebastian Aloy, Patrick Baumbach, Jan Bohar, Balazs Charoentong, Pornpimol Danhauser, Katharina Doğan, Tunca Dreo, Johann Dunham, Ian Fernandez-Torras, Adrià Gyori, Benjamin M. Hartung, Michael Hoyt, Charles Tapley Klein, Christoph Korcsmaros, Tamas Maier, Andreas Mann, Matthias Ochoa, David Pareja-Lorente, Elena Popp, Ferdinand Preusse, Martin Probul, Niklas Schwikowski, Benno Sen, Bünyamin Strauss, Maximilian T. Turei, Denes Ulusoy, Erva Heidrun Wodke, Judith Andrea Saez-Rodriguez, Julio Heidelberg University Faculty of Medicine Heidelberg University Hospital Institute for Computational Biomedicine Bioquant Heidelberg Germany The Barcelona Institute of Science and Technology Catalonia Barcelona Spain Catalonia Barcelona Spain Institute for Computational Systems Biology University of Hamburg Germany Earlham Institute Norwich United Kingdom Biological Research Centre Szeged Hungary Heidelberg University Im Neuenheimer Feld 267 Heidelberg69120 Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Department of Pediatrics Dr. von Hauner Children’s Hospital University Hospital LMU Munich Germany Biological Data Science Lab Department of Computer Engineering Hacettepe University Ankara Turkey Department of Bioinformatics Graduate School of Health Sciences Hacettepe University Ankara Turkey Computational Systems Biomedicine Lab Department of Computational Biology Institut Pasteur Université Paris Cité Paris France Bioinformatics and Biostatistics Hub Institut Pasteur Université Paris Cité Paris France Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Open Targets Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Laboratory of Systems Pharmacology Harvard Medical School Boston United States Imperial College London London United Kingdom Quadram Institute Bioscience Norwich United Kingdom Proteomics Program Novo Nordisk Foundation Centre for Protein Research University of Copenhagen Copenhagen Denmark Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Neuherberg Germany Medical Informatics Laboratory University Medicine Greifswald Germany

Standardising the representation of biomedical knowledge among all researchers is an insurmountable task, hindering the effectiveness of many computational methods. To facilitate harmonisation and interoperability despite this fundamental challenge, we propose to standardise the framework of knowledge graph creation instead. We implement this standardisation in BioCypher, a FAIR (findable, accessible, interoperable, reusable) framework to transparently build biomedical knowledge graphs while preserving provenances of the source data. Mapping the knowledge onto biomedical ontologies helps to balance the needs for harmonisation, human and machine readability, and ease of use and accessibility to nonspecialist researchers. We demonstrate the usefulness of this framework on a variety of use cases, from maintenance of task-specific knowledge stores, to interoperability between biomedical domains, to on-demand building of task-specific knowledge graphs for federated learning. BioCypher (https://***) frees up valuable developer time;we encourage further development and usage by the community. © 2022, CC BY-NC-ND.

关键词： Ontology

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Cover Feature: Chemo-Biological Upcycling of Poly(ethylene terephthalate) to Multifunctional Coating Materials (ChemSusChem 19/2021)

引用

ChemSusChem 2021年第19期14卷

作者： Prof. Hee Taek Kim Mi Hee Ryu Ye Jean Jung Sooyoung Lim Hye Min Song Prof. Jeyoung Park Prof. Sung Yeon Hwang Dr. Hoe-Suk Lee Prof. Young Joo Yeon Dr. Bong Hyun Sung Prof. Uwe T. Bornscheuer Prof. Si Jae Park Prof. Jeong Chan Joo Prof. Dongyeop X. Oh Department of Food Science and Technology Chungnam National University Daejeon 34134 (Republic of Korea Research Center for Bio-based Chemicals Korea Research Institute of Chemical Technology Daejeon 34114 & Ulsan 44429 (Republic of Korea Department of Chemical Engineering and Materials Science Graduate Program in System Health Science & Engineering Ewha Womans University Seoul 03760 (Republic of Korea Advanced Materials and Chemical Engineering University of Science and Technology (UST) Daejeon 34113 (Republic of Korea Department of Biochemical Engineering Gangneung-Wonju National University Gangneung-si Gangwon-do 25457 (Republic of Korea Synthetic Biology and Bioengineering Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 (Republic of Korea Department of Biotechnology & Enzyme Catalysis Institute of Biochemistry University of Greifswald 17487 Greifswald Germany Department of Biotechnology The Catholic University of Korea Bucheon-si Gyeonggi-do 14662 (Republic of Korea

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