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Contributors to the Lab on a Chip cell and tissue engineering in microsystems special issue

Lab on a Chip 2007年第6期7卷 667-671页

作者： Bhatia, Sangeeta N. Chen, Christoper Bashir, Rashid Beebe, David J. Desai, Tejal Gottwald, Eric Khademhosseini, Ali Langer, Robert S. Piel, Matthieu Takayama, Shuichi Thorsen, Todd Tien, Joe Voldman, Joel Vunjak-Novakovic, Gordana Wu, Mingming Yu, Hanry Massachusetts Institute of Technology Harvard-MIT Division of Health Sciences and Technology Department of Electrical Engineering and Computer Science United States Laboratory for Multiscale Regenerative Technologies United States Department of Innovation University of Pennsylvania Department of Bioengineering United States Cell Biology and Physiology Program Cell Growth and Cancer Program Tissue Microfabrication Laboratory Department of Electrical and Computer Engineering and Biomedical Engineering Purdue University United States Department of Electronics University of Glasgow United Kingdom Department of Physiology and Bioengineering University of California San Francisco CA United States California Institute for Quantitative Biomedical Research UCSF/UC Berkeley Graduate Group in Bioengineering United States Laboratory of Therapeutic Micro and Nanotechnology Institute for Biological Interfaces Germany 3D-Cell Culture Techniques Group Institute for Biological Interfaces Germany Department of Medicine and Health Sciences and Technology Massachusetts Institute of Technology (MIT) United States Institut Curie UMR 144 IC/CNRS France Biomedical Engineering Department University of Michigan United States Department of Biomedical Engineering Macromolecular Science and Engineering Program United States Sibley School of Mechanical and Aerospace Engineering School of Chemical and Molecular Engineering Cornell University United States National University of Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR Singapore

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Nonpolypoid neoplastic lesions of the colorectal mucosa

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GASTROINTESTINAL ENDOSCOPY 2008年第4期68卷 S3-S47页

作者： Kudo, Shin ei Lambert, Rene Allen, John I. Fujii, Hiroaki Fujii, Takahiro Kashida, Hiroshi Matsuda, Takahisa Mori, Masaki Saito, Hiroshi Shimoda, Tadakazu Tanaka, Shinji Watanabe, Hidenobu Sung, Joseph J. Feld, Andrew D. Inadomi, John M. O'Brien, Michael J. Lieberman, David A. Ransohoff, David F. Soetikno, Roy M. Triadafilopoulos, George Zauber, Ann Teixeira, Claudio Rolim Rey, Jean Franigois Jaramillo, Edgar Rubio, Carlos A. Van Gossum, Andre Jung, Michael Vieth, Michael Jass, Jeremy R. Hurlstone, Paul D. [a]Current affiliations: Hiroaki Fujii MD Department of Pathology (II) Juntendo University School of Medicine Tokyo Japan. Takahiro Fujii MD TF Clinic Ginza Tokyo Japan. Hiroshi Kashida MD Shin ei Kudo MD Digestive Disease Center Northern Yokohama Hospital Showa University Yokohama Japan. Takahisa Matsuda MD Division of Endoscopy Tadakazu Shimoda MD Clinical Laboratory Division National Cancer Centre Hospital Tokyo Japan. Masaki Mori MD PhD FACS Department of Surgery Medical Institute of Bioregulation Kyushu University Hospital Beppu Japan. Hiroshi Saito MD Cancer Screening Technology Division Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan. Shinji Tanaka MD Department of Endoscopy Hiroshima University Hospital Hiroshima Japan. Hidenobu Watanabe MD Division of Molecular and Diagnostic Pathology Graduate School of Medical and Dental Sciences Niigata University Niigata Japan. Joseph J. Sung MD Institute of Digestive Diseases Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong. John I. Allen MD Medical Director Minnesota Gastroenterology University of Minnesota School of Medicine Minneapolis Minnesota USA. Andrew D. Feld MD Clinical Associate Professor of Medicine Central Division of Gastroenterology Group Health Cooperative University of Washington Seattle Washington USA. John M. Inadomi MD Director GI Health Outcomes Research Program University of California San Francisco Division of Gastroenterology San Francisco General Hospital San Francisco California USA. Michael J. O'Brien MD Department of Pathology Boston University Medical Center Boston Massachusetts USA. David A. Lieberman MD Division of Gastroenterology Portland VA Hospital Portland Oregon USA. David F. Ransohoff MD Bioinformatics Department of Medicine University of North Carolina Chapel Hill North Carolina USA. Roy M. Soetikno MD Gastroenterology Section Veterans Affairs Palo Alto Health

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The use of KDD to identify eligible patients for case management programs

The use of KDD to identify eligible patients for case manage...

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9th International Congress on Nursing Informatics, NI 2006

作者： Kobus, Luciana Schleder Gonçalves Honorato, Sandra Da Silva Dias, João College of Nursing Pontificia Universidade Catolica Do Paraná Curitiba Paraná Brazil Health Technology Graduate Program Pontificia Universidade Catolica Do Paraná Curitiba Paraná Brazil

ISBN: (纸本)158603622X

Patients diagnosed with co-morbidities are clinically compromised, facing social and psychological challenges. The identification of high risk patients is a key question to maximize their quality of life and the health System's resources. Objective: to determine patterns that identify eligible patients for Case Management programs, with KDD and AI tools. Methodology: analysis, selection and correction, formatting and mining of data, analysis of results, data submission to an AI tool. Results: solid recommendations on benefits that health Systems could obtain by using these tools, regarding the acknowledgement of their users profile and the use of predictive modeling. © 2006 The authors and IOS Press. All rights reserved.

关键词： Decision support systems

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Synthesis and properties of benzo[a] phenoxazinium chalcogen analogues as novel broad-spectrum antimicrobial photosensitizers. (vol 49, pg 5291, 2006)

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JOURNAL OF MEDICINAL CHEMISTRY 2006年第24期49卷 7252-7252页

作者： Foley, James W. Song, Xiangzhi Demidova, Tatiana N. Jalil, Fatima Hamblin, Michael R. Rowland Institute at Harvard Harvard University Cambridge Massachusetts 02142 Wellman Center for Photomedicine Massachusetts General Hospital Boston Massachusetts 02114 Graduate Program in Cell Molecular and Developmental Biology Sackler School of Graduate Biomedical Sciences Tufts University School of Medicine Boston Massachusetts 02111 Aga Khan Medical School Karachi Pakistan Department of Dermatology Harvard Medical School Boston Massachusetts 02115 and HarvardMIT Division of Health Sciences and Technology 77 Massachusetts Avenue E25-519 Cambridge Massachusetts 02139.

The goal of this investigation was to develop improved photosensitizers for use as antimicrobial drugs in photodynamic therapy of localized infections. Replacement of the oxygen atom in 5-(ethylamino)-9-diethylaminobenzo[a]phenoxazinium chloride (1) with sulfur and selenium afforded thiazinium and selenazinium analogues 2 and 3, respectively. All three dyes are water soluble, lipophilic, and red light absorbers. The relative photodynamic activities of the chalcogen series were evaluated against a panel of prototypical pathogenic microorganisms: the Gram-positive Enterococcus faecalis, the Gram-negative Escherichia coli, and the fungus Candida albicans. Selenium dye 3 was highly effective as a broad-spectrum antimicrobial photosensitizer with fluences of 4−32 J/cm² killing 2−5 more logs of all cell types than sulfur dye 2, which was slightly more effective than oxygen analogue 1. These data, taken with the findings of uptake and retention studies, suggest that the superior activity of selenium derivative 3 can be attributed to its much higher triplet quantum yield.

关键词： GRAM-NEGATIVE BACTERIA PHOTODYNAMIC THERAPY MALIGNANT-TUMORS SINGLET OXYGEN INFECTIONS AGENTS CELLS BLUE BENZOPHENOTHIAZINE INACTIVATION Sulfur dyes Photosensitizers Singlet Oxygen Photosensitizing Agents Gram-Negative Bacteria Agents quantum yield antimicrobial Infection Selenium Inactivation chalcophile elements

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The Social Affordances of the Internet for Networked Individualism

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Journal of Computer-Mediated Communication 2006年第3期8卷

作者： Barry Wellman Anabel Quan-Haase Jeffrey Boase Wenhong Chen Keith Hampton Isabel Díaz Kakuko Miyata In 1965 moved from his Bronx High School of Science slide rule to IBM cards and an 029 keypunch in the bowels of Harvard University. Since then he's been primarily interested in the interplay between large-scale social processes and how people use technology to be connected at work and in the community. His NetLab research network is trying to get a handle on how the Internet fits into everyday life. Wellman founded the International Network for Social Network Analysis in 1976. He is a recent Chair of the Community section of the American Sociological Association has been nominated for the Chair of the Communication and Information Technology section of the ASA the Virtual Community focus area leader for SIGGROUP/ACM and a Executive Cmmittee member of the Association for Internet Researchers. Wellman's (co)edited books are: Social Structures: A Network Approach (2d ed CSPI 2003) Networks in the Global Village (Westview Press 1999) and The Internet in Everyday Life (Blackwell Publishers 2002). Address:Centre for Urban & Community Studies University of Toronto 455 Spadina Avenue Toronto Canada M5S 2G8. Fax: +1-416-978-7162 Address:Centre for Urban & Community Studies University of Toronto 455 Spadina Avenue Toronto M5S 2G8 Canada. Address:Massachusetts Institute of Technology 77 Mass. Ave. Room 9-522 Cambridge MA 02139. Address:IN3 Av. Tibidabo 47 08035 Barcelona Spain. Phone: +*** Fax: +***. Address:Department of Sociology Meiji Gakuin University 1-2-37 Shirokanedai Minato-ku Tokyo 108-8636 JAPAN. Phone: +81-3-5421-5565 Fax: +81-3-5421-5697. Doctoral student at the Faculty of Information Studies University of Toronto. She has been a Fellow of the Knowledge Media Design Institute and the McLuhan Program in Culture and Technology. Her articles address the nature of Internet-related social change for social integration and information flow. Her articles have examined the implications of these changes for communities and her thesis focuses on organizations. University of Toronto doctoral

We review the evidence from a number of surveys in which our NetLab has been involved about the extent to which the Internet is transforming or enhancing community. The studies show that the Internet is used for connectivity locally as well as globally, although the nature of its use varies in different countries. Internet use is adding on to other forms of communication, rather than replacing them. Internet use is reinforcing the pre-existing turn to societies in the developed world that are organized around networked individualism rather than group or local solidarities. The result has important implications for civic involvement.

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Variation in routine psychiatric workload: The role of financing source, managed care participation, and mental health workforce competition

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Mental health Services Research 2002年第3期4卷 141-150页

作者： Pingitore, David P. Scheffler, Richard M. Schwalm, Douglas Zarin, Deborah A. West, Joyce C. University of California Berkeley United States Center for Mental Health Services Research University of California Berkeley CA United States School of Public Health University of California Berkeley CA United States Graduate Program in Economics University of California Berkeley CA United States Technology Assessment Program Agency for Healthcare Research and Quality Rockville MD United States American Psychiatric Practice Research Network Washington United States

This study was conducted to examine the association between psychiatrists' demographic characteristics, payment source, and managed care participation and psychiatrists' practice workload, and between the supply of other mental health providers in a psychiatrist's county of practice and psychiatrists' practice workload. Data from the 1996 American Psychiatric Association National Survey of Psychiatric Practice were merged with national countywide measures of mental health workforce and environmental data from the 1996 Area Resource File. In comparison to male psychiatrists, female psychiatrists treat fewer patients per week, provide less total hours of weekly patient care, and obtain fewer new monthly referrals. An increase in psychiatrists' managed care participation was associated with only minor increases in the number of patients per week, weekly time spent in clinical care, and number of new monthly referrals. The supply of other mental health providers was not associated with variation in practice workload. Once psychiatrists participate in managed care plans, an increase in their participation rate does not significantly expand clinical practice workload. The supply of other mental health providers was not significantly associated with variation in psychiatrists' workload, which suggests that substitution effects may not be evident with this aspect of psychiatric practice.

关键词： Managed care Mental health workforce Psychiatric services

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Research: The Emergency Contraception Collaborative Prescribing Experience in Washington State

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Journal of the American Pharmaceutical Association (1996) 2001年第1期41卷 60-66页

作者： Sunshine D. Sommers Nathorn Chaiyakunapruk Jacqueline S. Gardner Jennifer Winkler pharmaceutical outcomes evaluator Group Health Cooperative Puget Sound Wash. Graduate student Department of Pharmacy University of Washington Seattle and instructor Faculty of Pharmaceutical Sciences Naresuan University Pitsanuloke Thailand. Associate professor Department of Pharmacy University of Washington Seattle. Program assistant Program for Appropriate Technology in Health Seattle Wash.

Objective To describe how prescribers and pharmacists view the Emergency Contraceptive Pills (ECP) program, and to evaluate pharmacists’ performance through the use of a consumer survey. Design Self-administered provider satisfaction surveys were mailed 6 months after the program’s inception. Consumer satisfaction surveys were distributed at the point of ECP service for return by mail. Setting The program encouraged pharmacists and prescribers in western Washington to enter into collaborative prescribing agreements, increasing consumers’ access to ECP. Patients or Other Participants Pharmacists who had attended ECP training sessions, prescribers who had authorized pharmacists to prescribe ECP, and women who had been prescribed ECP by pharmacists. Main Outcome Measures Providers’ reasons for participating, attitudes toward the ECP program, and experiences with ECP as a result of the program; feedback from women receiving ECP from pharmacists. Results 309 pharmacist surveys and 55 prescriber surveys were sent, of which 159 (51%) and 27 (49%), respectively, were returned. Meeting patient needs and having a professional responsibility to participate were commonly reported reasons for ECP program involvement. Both pharmacists and prescribers (92%) reported being "satisfied" or "very satisfied" with their prescribing agreements. On the 470 consumer surveys returned out of 7,000 distributed (6.5%), pharmacists were rated highly satisfactory for their interactions with patients and the quality of information about ECP use given, but less satisfactory for information about adverse effects, recognition and follow-up of ECP failure, and regular contraceptive methods. Conclusion All participants expressed satisfaction with the ECP program. This example should support the initiation of similar programs in other states.

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Occupational Hazard Exposure and at Risk Drinking

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Workplace health & Safety 1999年第1期47卷 9 - 16页

作者： Karen M. Conrad Sylvia E. Furner Yunji Qian Department of Public Health Mental Health and Administrative Nursing and Occupational Health Nursing Graduate Program College of Nursing School of Public Health University of Illinois Chicago IL Braun Technology Group Chicago IL

This study examined associations between workers' reported exposure to occupational hazards and at risk drinking. A sample of 15, 907 working adults was drawn from the 1985 National health Interview Survey (NHIS) (weighted sample represented 85, 395, 000 workers). This was the only year the NHIS included questions on both occupational hazard exposure and at risk drinking. Occupational hazard exposures included chemical/biological substances, physical hazards, injury risk, and mental stress. At risk drinking was defined as binge drinking and drinking and driving. Prevalence adjusted odds ratios were estimated. Sixty percent of workers reported exposure to one or more occupational hazards with considerable variation among and within occupations. In all, 31% reported binge drinking and 15% drove after drinking too much. In a multivariate analysis that controlled for background characteristics, workers who reported occupational hazard exposures were 1.2 to 1.4 times more likely to engage in binge drinking than workers without exposures. Similar results were found for drinking/driving. All multivariate results were statistically significant. Findings suggest workers who report occupational hazard exposures are at greater risk of both binge drinking and drinking/driving. Occupational and environmental health nurses can lead workplace initiatives to reduce occupational hazard exposure and, simultaneously, invest in health promotion efforts to curb at risk drinking among workers.

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Carbon monoxide from cookstoves in developing countries: 2. Exposure potentials

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Chemosphere - Global Change Science 1999年第1期1卷 367-375页

作者： Zhang, J. Smith, K.R. Uma, R. Ma, Y. Kishore, V.V.N. Lata, K. Khalil, M.A.K. Rasmussen, R.A. Thorneloe, S.T. Environmental and Occupational Health Sciences Institute Robert Wood Johnson Medical School and Rutgers University 170 Frelinghuysen Road Piscataway NJ 08854 USA Program on Environment East-West Center Honolulu HI USA University of California Berkeley CA USA Tata Energy Research Institute New Delhi India Tsinghua University Beijing People's Republic of China Portland State University Portland OR USA Oregon Graduate Institute of Science and Technology Beaverton OR USA US Environmental Protection Agency Research Triangle Park NC USA

In this paper, we estimate carbon monoxide (CO) concentrations and exposures in a well-mixed, hypothetical village kitchen using measured CO emission factors and published typical values for house, fuel, and activity parameters. The estimate was made to compare CO exposure potentials for a range of no-flue fuel/stove combinations. Based upon this quantitative comparison, recommendations were made on CO exposure reduction by fuel/stove switching. If their house conditions and activity patterns are comparable to those typical values assumed in our estimation, people using biomass and coal cookstoves could have daily CO exposures greater than the exposure equivalents of health-based national standards and WHO guidelines.

关键词： Carbon monoxide exposure Indoor air pollution Cookstoves Domestic fuels Developing countries

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Carbon monoxide from cookstoves in developing countries: 1. Emission factors

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Chemosphere - Global Change Science 1999年第1期1卷 353-366页

作者： Zhang, J. Smith, K.R. Uma, R. Ma, Y. Kishore, V.V.N. Lata, K. Khalil, M.A.K. Rasmussen, R.A. Thorneloe, S.T. Environmental and Occupational Health Sciences Institute Robert Wood Johnson Medical School and Rutgers University 170 Frelinghuysen Road Piscataway NJ 08854 USA Program on Environment East-West Center Honolulu HI USA University of California Berkeley CA USA Tata Energy Research Institute New Delhi India Tsinghua University Beijing People's Republic of China Portland State University Portland Oregon USA Oregon Graduate Institute of Science and Technology Beaverton Oregon USA US Environmental Protection Agency Research Triangle Park North Carolina USA

Cookstoves in developing countries are individually small, but so numerous that, depending on emission factors, they could be significant influences on global and regional carbon monoxide (CO) inventories. This paper presents a new database of CO emission factors for commonly used cookstoves in developing countries. The emission factors were determined using a carbon balance approach for 56 types of fuel/stove combinations in China and India. These include various stoves (e.g., traditional, improved, mud, brick, and metal, with and without chimney) using animal dung, different species of crop residues and wood, root fuel, charcoal, kerosene, and several types of coals and gases. The chosen fuel/stove combinations represent a large fraction of the total in developing countries. Thus, the database can be used to improve estimates of CO emission inventories. The CO emission factors ranged widely, from 3.0×10-2 g/kg for the coal gas/traditional stove to 2.8×102 g/kg for the charcoal/Angethi stove, nearly 4 orders of magnitude. Since stove efficiencies and fuel energy contents were measured simultaneously, CO emission factors on the basis of a standard cooking task (energy delivered) were also determined and reported in this paper. Task-based emission factors are particularly useful for comparing the air pollution potential of different fuel/stove combinations and assessing the impacts of substitutions.

关键词： Carbon monoxide Emission factors Cookstoves Biomass fuels Fossil fuels Developing countries

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