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Unintended pregnancy: a framework for prevention and options for midlife women in the US

Women's midlife health 2017年第1期3卷 8页

作者： Versie Johnson-Mallard Elizabeth A Kostas-Polston Nancy Fugate Woods Katherine E Simmonds Ivy M Alexander Diana Taylor 1Department of Family Community and Health System Science Robert Wood Johnson Nurse Faculty Scholar Alum University of Florida College of Nursing Gainesville FL USA. 2Daniel K. Inouye Graduate School of Nursing Uniformed Services University of the Health Sciences Bethesda MD USA. 3Biobehavioral Nursing and Health Informatics Interim Associate Dean for Diversity Equity and Inclusion University of Washington School of Nursing Seattle WA USA. 4MGH Institute of Health Professions Boston MA USA. Director of Advance Practice Programs Storrs CT USA. 6UCSF School of Nursing Research Faculty Advancing New Standards in Reproductive Health Program (ANSIRH) UCSF Bixby Center for Global Reproductive Health University of California San Francisco CA USA.

Recently unintended pregnancies have been described as "a new kind of mid-life crisis." Given the high prevalence of unwanted or mistimed pregnancy in the US, we examined the sexual and reproductive health patterns of sexually active midlife women. An examination of the prevalence of unintended pregnancy among midlife women revealed a gap in data indicating unmet sexual and reproductive health needs of midlife women. The application of a framework for primary, secondary and tertiary prevention for unintended pregnancy may assist with guiding care for women and identifying implications for reproductive health policy and potential political interference as they relate to sexual and reproductive health in midlife women.

关键词： Abortion Age Contraception Framework Menopause Pregnancy Reproductive health Sex Transition Women

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IDF2022-1112 The gut microbiome of obese postpartum women with and without gestational diabetes mellitus and of their babies

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Diabetes Research and Clinical Practice 2023年 197卷 110364-110364页

作者： Dualib, P. Taddei, C. Fernandes, G. Carvalho, C. Sparvoli, L.G. Bittencourt, C. Tande, I. Mattar, R. Ferreira, S. Dib, S. Almeida-Pititto, B. UNIFESP Department of Medicine- Escola paulista de Medicina São Paulo Brazil Universidade de São Paulo Department of Clinical and Toxicological Analysis São Paulo Brazil Instituto René Rachou – Fiocruz Minas DepaBiosystems Informatics and Genomics Group Belo Horizonte Brazil UNIFESP Graduate Program in Endocrinology and Metabology São Paulo Brazil Centro Universitário Estácio de Sá Nutrition Course Belo Horizonte Brazil UNIFESP Departament of Obstetrics- Escola Paulista de Medicina São Paulo Brazil Universidade de São Paulo Department of Epidemiology- School of Public Health São Paulo Brazil UNIFESP Department of Medicine- Escola Paulista Medicina São Paulo Brazil UNlFESP Department of Preventive Medicine- Escola Paulista de Medicina São Paulo Brazil

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Adverse events following the first, second and third doses of a COVID-19 vaccine in hemodialysis patients

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Renal failure 2023年第1期45卷 2172432页

作者： Mei-Fen Pai Kuei-Ting Tung Shih-Ping Hsu Yu-Sen Peng Wan-Yu Lin Ju-Yeh Yang Hon-Yen Wu Yen-Ling Chiu Kai-Hsiang Shu Wan-Chuan Tsai Division of Nephrology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Internal Medicine National Taiwan University Hospital and College of Medicine Taipei City Taiwan. School of Life Science National Taiwan Normal University Taipei City Taiwan. Department of Applied Cosmetology Lee-Ming Institute of Technology New Taipei City Taiwan. Department of Electrical Engineering Yuan Ze University Taoyuan City Taiwan. Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei City Taiwan. Center for General Education Lee-Ming Institute of Technology New Taipei City Taiwan. Faculty of Medicine School of Medicine National Yang-Ming University Taipei City Taiwan. Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan City Taiwan.

BACKGROUND:This study aimed to identify adverse events following the first three doses of COVID-19 vaccines in hemodialysis (HD) patients. Risk factors associated with postvaccination adverse events were explored. METHODS:Postvaccination adverse events in 438 HD patients who received 3 doses of COVID-19 vaccines were prospectively assessed. The adverse events among three doses were compared using generalized linear mixed models. Factors associated with adverse events were assessed with multivariate analyses. RESULTS:The vast majority of participants received Oxford/AstraZeneca ChAdOx1 as their first two doses and Moderna mRNA-1273 as their third dose. Overall, 79%, 50% and 84% of the participants experienced at least one adverse event after their first, second, and third doses, respectively. These adverse events were mostly minor, short-lived and less than 5% reported daily activities being affected. Compared with the first dose, the second dose caused a lower rate of adverse events. Compared with the first dose, the third dose elicited a higher rate of injection site reactions and a lower rate of systemic reactions. Multivariate analyses showed that every 10-year increase of age (odds ratio 0.67, 95% confidence intervals 0.57-0.79) was associated with decreased risk of adverse events, while female sex (2.82, 1.90-4.18) and arteriovenous fistula (1.73, 1.05-2.84) were associated with increased risk of adverse events. Compared with Oxford/AstraZeneca ChAdOx1, Moderna mRNA-1273 was associated with an increased risk of injection site reactions. CONCLUSIONS:COVID-19 vaccination was well tolerated in HD patients. Age, sex, dialysis vascular access and vaccine types were associated with postvaccination adverse events.

关键词： COVID-19 ChAdOx1 Hemodialysis adverse event mRNA-1273 vaccination

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Author Correction: Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants

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Nature communications 2020年第1期11卷 4426页

作者： Margaret K R Donovan Agnieszka D'Antonio-Chronowska Matteo D'Antonio Kelly A Frazer Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA. Department of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA. Department of Pediatrics and Rady Children's Hospital University of California San Diego La Jolla CA 92093 USA. Department of Pediatrics and Rady Children's Hospital University of California San Diego La Jolla CA 92093 USA. madantonio@health.ucsd.edu. Department of Pediatrics and Rady Children's Hospital University of California San Diego La Jolla CA 92093 USA. kafrazer@health.ucsd.edu. Institute for Genomic Medicine University of California San Diego La Jolla CA 92093 USA. kafrazer@health.ucsd.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Monitoring the pointing of the prototype LST-1 using star reconstruction in the Cherenkov camera

arXiv

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arXiv 2021年

作者： Abe, H. Aguasca, A. Agudo, I. Antonelli, L.A. Aramo, C. Armstrong, T. Artero, M. Asano, K. Ashkar, H. Aubert, P. Baktash, A. Bamba, A. Larriva, A. Baquero Baroncelli, L. de Almeida, U. Barres Barrio, J.A. Batkovic, I. González, J. Becerra Bernardos, M.I. Berti, A. Biederbeck, N. Bigongiari, C. Blanch, O. Bonnoli, G. Bordas, P. Bose, D. Bulgarelli, A. Burelli, I. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Cassol, F. Cerruti, M. Chai, Y. Cheng, K. Chikawa, M. Chytka, L. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. de Angelis, A. de Bony de Lavergne, M. Deleglise, G. Delgado, C. Mengual, J. Delgado Volpe, D. della Depaoli, D. Di Pierro, F. Di Venere, L. Díaz, C. Dominik, R.M. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Elsässer, D. Emery, G. Escudero, J. Fiasson, A. Foffano, L. Fonseca, M.V. Coromina, L. Freixas Fukami, S. Fukazawa, Y. Garcia, E. López, R. Garcia Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Green, D. Grespan, P. Gunji, S. Hackfeld, J. Hadasch, D. Hahn, A. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Llorente, J. Herrera Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Inada, T. Inome, Y. Iori, M. Ishio, K. Iwamura, Y. Jacquemont, M. Martinez, I. Jimenez Jouvin, L. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kong, A. Kubo, H. Kushida, J. Lamanna, G. Lamastra, A. Le Flour, T. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Luque-Escamilla, P.L. Majumdar, P. Makariev, M. Mandat, D. Manganaro, M. Mannheim, K. Mariotti, M. Marquez, P. Marsella, G. Martí, J. Martinez, O. Martínez, G. Martínez, M. Marusevec, P. Mas, A. Maurin, G. Mazin, D. Guillen, E. Mestre Micanovic, S. Miceli, D. Miener, T. Miranda, J.M. Miranda, L.D.M. Mirzoyan, R. Mizuno, T. Molina, E. Montaruli, T. Monteiro, I. Moralejo, A. Morcuende, D. Moretti, E. Morselli, A. Mrakovcic, K. Murase, K. Nagai, A. Nakamori, T. Nickel, L. University of Geneva quai Ernest Ansermet 24 Geneva Switzerland Institute for Cosmic Ray Research University of Tokyo Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Instituto de Astrofísica de Andalucía-CSIC INAF Osservatorio Astronomico di Roma INFN Sezione di Napoli Aix Marseille Univ CNRS IN2P3 CPPM The Barcelona Institute of Science and Technology IRFU CEA Université Paris-Saclay LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Graduate School of Science University of Tokyo EMFTEL department IPARCOS Universidad Complutense de Madrid INAF Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Centro Brasileiro de Pesquisas Físicas INFN Sezione di Padova Università degli Studi di Padova Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Max-Planck-Institut für Physik Department of Physics TU Dortmund University Saha Institute of Nuclear Physics INFN Sezione di Trieste Università degli Studi di Udine INFN Sezione di Catania University of Geneva Département de Physique Nucléaire et Corpusculaire Palacky University Olomouc Faculty of Science CIEMAT Port d'Informació Científica INFN Sezione di Torino Dipartimento di Fisica Universitá degli Studi di Torino INFN Sezione di Bari Università di Bari University of Rijeka Department of Physics Institute for Theoretical Physics and Astrophysics Universität Würzburg Physics Program Graduate School of Advanced Science and Engineering Hiroshima University INFN Sezione di Bari Politecnico di Bari Faculty of Physics and Applied Informatics University of Lodz University of Split FESB Department of Physics Yamagata University Institut für Theoretische Physik Lehrstuhl IV: Plasma-Astroteilchenphysik Ruhr-Universität Bochum Tohoku University Astronomical Institute Josip Juraj Strossmayer University of Osijek Department of Physics INFN Sezione di Roma La

The first Large-Sized Telescope (LST-1) proposed for the forthcoming Cherenkov Telescope Array (CTA) has started to operate in 2019 in La Palma. The large structure of LST-1 - with a 23 m mirror dish diameter - imposes a strict control of its deformations that could affect the pointing accuracy and its overall performance. According to CTA specifications that are conceived to resolve e.g. the fine structure of galactic sources, the LST post-calibration pointing accuracy should be better than 14 arcseconds. To fulfill this requirement, the telescope pointing precision is monitored with two dedicated CCD cameras located at the dish center. The analysis of their images allows us to disentangle different systematic deformations of the structure. In this work, we investigate a complementary approach that offers the possibility to monitor the pointing of the telescope during the acquisition of sky data. After properly cleaning the events from the Cherenkov showers, the reconstructed positions of the stars imaged in the camera field of view are compared to their nominal expected positions in catalogues. This provides a direct measurement of the telescope pointing, that can be used to cross-check the other methods and as a real-time monitoring of the optical properties of the telescope and of the pointing corrections applied by the bending models. Additionally, this method benefits from not relying on specific hardware or dedicated observations. In this contribution we will illustrate this analysis and show results based on simulations of LST-1. Copyright © 2021, The Authors. All rights reserved.

关键词： Deformation

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Erratum for Wang et al., "Clinically Applicable System for Rapidly Predicting Enterococcus faecium Susceptibility to Vancomycin"

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Microbiology spectrum 2022年第1期10卷 e0261021页

作者： Hsin-Yao Wang Chia-Ru Chung Chao-Jung Chen Ko-Pei Lu Yi-Ju Tseng Tzu-Hao Chang Min-Hsien Wu Wan-Ting Huang Ting-Wei Lin Tsui-Ping Liu Tzong-Yi Lee Jorng-Tzong Horng Jang-Jih Lu Department of Laboratory Medicine Chang Gung Memorial Hospitalgrid.413801.f at Linkou Taoyuan City Taiwan. Ph.D. Program in Biomedical Engineering Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Computer Science and Information Engineering National Central Universitygrid.37589.30 Taoyuan City Taiwan. Graduate Institute of Integrated Medicine China Medical Universitygrid.254145.3 Taichung Taiwan. Proteomics Core Laboratory China Medical Universitygrid.254145.3 Hospital Taichung Taiwan. Graduate Program in Biomedical Information Yuan-Ze University Taoyuan City Taiwan. Department of Information Management Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Graduate Institute of Biomedical Informatics Taipei Medical University Taipei City Taiwan. Clinical Big Data Research Center Taipei Medical University Hospital Taipei City Taiwan. Graduate Institute of Biomedical Engineering Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Division of Haematology/Oncology Department of Internal Medicine Chang Gung Memorial Hospitalgrid.413801.f at Linkou Taoyuan City Taiwan. Biosensor Group Biomedical Engineering Research Center Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Pathology Kaohsiung Chang Gung Memorial Hospitalgrid.413801.f and Chang Gung University College of Medicine Kaohsiung Taiwan. School of Life and Health Sciences The Chinese University of Hong Kong Shenzhen China. Warshel Institute for Computational Biology The Chinese University of Hong Kong Shenzhen China. Department of Bioinformatics and Medical Engineering Asia University Taichung City Taiwan. School of Medicine Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Medical Biotechnology and Laboratory Science Chang Gung Universitygrid.145695.a Taoyuan City Taiwan.

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Correction: A COVID-19 Pandemic Artificial Intelligence-Based System With Deep Learning Forecasting and Automatic Statistical Data Acquisition: Development and Implementation Study

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Journal of medical Internet research 2021年第7期23卷 e31085页

作者： Cheng-Sheng Yu Shy-Shin Chang Tzu-Hao Chang Jenny L Wu Yu-Jiun Lin Hsiung-Fei Chien Ray-Jade Chen Department of Family Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Family Medicine Taipei Medical University Hospital Taipei Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan. Clinical Big Data Research Center Taipei Medical University Hospital Taipei Taiwan. Division of Plastic Surgery Department of Surgery Taipei Medical University Hospital and School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Division of General Surgery Department of Surgery Taipei Medical University Hospital Taipei Taiwan.

[This corrects the article DOI: 10.2196/27806.].

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Understanding the origin of the extended γ-ray emission and the physical nature of HESS J1841-055 using observations at TeV energies with the MAGIC telescopes 37

Understanding the origin of the extended γ-ray emission and...

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37th International Cosmic Ray Conference, ICRC 2021

作者： Acciari, V.A. Ansoldi, S. Antonelli, L.A. Arbet Engels, A. Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. Barres de Almeida, U. Barrio, J.A. Batković, I. Becerra González, J. Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bökenkamp, H. Bonnoli, G. Bošnjak, Ž. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colak, S.M. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D'Amico, G. D'Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Pierro, F. Di Venere, L. Do Souto Espiñeira, E. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Fallah Ramazani, V. Fattorini, A. Fonseca, M.V. Font, L. Fruck, C. Fukami, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Green, David Green, J.G. Hadasch, D. Hahn, A. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hütten, M. Inada, T. Ishio, K. Iwamura, Y. Jiménez Martínez, I. Jormanainen, J. Jouvin, L. Karjalainen, M. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, Alicia Loporchio, S. Machado de Oliveira Fraga, B. Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Maraschi, L. Mariotti, M. Martínez, M. Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Nakamori, T. Nava, L. Neustroev, V. Nigro, C. Nilsson, K. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J.M. Pavletić, L. Peñil, P. Persic, M. Pihet, M. Prada Moroni, P.G. Prandini, E. Priyadarshi, C. Brazil Spain Croatian MAGIC Group Ruđer Bošković Institute Croatia Croatia Croatian MAGIC Group Josip Juraj Strossmayer University of Osijek Department of Physics Croatia Croatian MAGIC Group University of Rijeka Department of Physics Croatia Croatia Germany Technische Universität Dortmund Germany ETH Zürich Switzerland Finnish MAGIC Group Finnish Centre for Astronomy with ESO University of Turku Finland Finnish MAGIC Group Astronomy Research Unit University of Oulu Finland Instituto de Astrofísica de Andalucía-CSIC Spain Instituto de Astrofísica de Canarias La LagunaE-38200 Spain Universidad de La Laguna Dpto. Astrofísica La Laguna TenerifeE-38206 Spain Spain INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica Università e del Politecnico di Bari Italy INFN MAGIC Group INFN Sezione di Perugia Italy INFN MAGIC Group INFN Roma Tor Vergata The University of Tokyo Japan Japanese MAGIC Group Department of Physics Kyoto University Japan Japanese MAGIC Group Department of Physics Tokai University Japan Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Japan Japanese MAGIC Group Department of Physics Yamagata University Japan Japanese MAGIC Group Department of Physics Konan University Japan University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Poland IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Max-Planck-Institut für Physik MünchenD-80805 Germany Università di Padova INFN Italy Università di Pisa INFN Pisa Italy Università di Siena INFN Pisa Italy Saha Institute of Nuclear Physics India Inst. for Nucl. Research and Nucl. Energy Bulgarian Academy of Sciences Bulgaria Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Universitat de Barcelona ICCUB IEEC-UB Spain Università

With the improved sensitivity with respect to the previous generation, current space-borne and ground-based gamma-ray telescopes have made the number of γ-ray sources detected at GeV-TeV energies increase many folds over the last decade. Many of the detected extended gamma-ray sources are not associated with any known sources at other wavelengths. Understanding the nature of these sources and the origin of the observed high energy gamma-ray emission remains a great challenge. Using the MAGIC telescopes, we have observed one such unassociated gamma-ray source, named HESS J1841-055 at TeV energies. We investigate the physical nature and origin of the γ-ray emission from this extended source. In this paper, we present the results of our detailed investigation on this source using MAGIC data and other multi-waveband information on nearby sources. The results included in this proceeding and shown in this presentation were published in ref. [1]. The details about the analysis, interpretation and modelling can be found in the aforementioned reference. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0)

关键词： Gamma rays

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Democratising Knowledge Representation with BioCypher

arXiv

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arXiv 2022年

作者： Lobentanzer, Sebastian Aloy, Patrick Baumbach, Jan Bohar, Balazs Charoentong, Pornpimol Danhauser, Katharina Doğan, Tunca Dreo, Johann Dunham, Ian Fernandez-Torras, Adrià Gyori, Benjamin M. Hartung, Michael Hoyt, Charles Tapley Klein, Christoph Korcsmaros, Tamas Maier, Andreas Mann, Matthias Ochoa, David Pareja-Lorente, Elena Popp, Ferdinand Preusse, Martin Probul, Niklas Schwikowski, Benno Sen, Bünyamin Strauss, Maximilian T. Turei, Denes Ulusoy, Erva Heidrun Wodke, Judith Andrea Saez-Rodriguez, Julio Heidelberg University Faculty of Medicine Heidelberg University Hospital Institute for Computational Biomedicine Bioquant Heidelberg Germany The Barcelona Institute of Science and Technology Catalonia Barcelona Spain Catalonia Barcelona Spain Institute for Computational Systems Biology University of Hamburg Germany Earlham Institute Norwich United Kingdom Biological Research Centre Szeged Hungary Heidelberg University Im Neuenheimer Feld 267 Heidelberg69120 Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Department of Pediatrics Dr. von Hauner Children’s Hospital University Hospital LMU Munich Germany Biological Data Science Lab Department of Computer Engineering Hacettepe University Ankara Turkey Department of Bioinformatics Graduate School of Health Sciences Hacettepe University Ankara Turkey Computational Systems Biomedicine Lab Department of Computational Biology Institut Pasteur Université Paris Cité Paris France Bioinformatics and Biostatistics Hub Institut Pasteur Université Paris Cité Paris France Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Open Targets Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Laboratory of Systems Pharmacology Harvard Medical School Boston United States Imperial College London London United Kingdom Quadram Institute Bioscience Norwich United Kingdom Proteomics Program Novo Nordisk Foundation Centre for Protein Research University of Copenhagen Copenhagen Denmark Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Neuherberg Germany Medical Informatics Laboratory University Medicine Greifswald Germany

Standardising the representation of biomedical knowledge among all researchers is an insurmountable task, hindering the effectiveness of many computational methods. To facilitate harmonisation and interoperability despite this fundamental challenge, we propose to standardise the framework of knowledge graph creation instead. We implement this standardisation in BioCypher, a FAIR (findable, accessible, interoperable, reusable) framework to transparently build biomedical knowledge graphs while preserving provenances of the source data. Mapping the knowledge onto biomedical ontologies helps to balance the needs for harmonisation, human and machine readability, and ease of use and accessibility to nonspecialist researchers. We demonstrate the usefulness of this framework on a variety of use cases, from maintenance of task-specific knowledge stores, to interoperability between biomedical domains, to on-demand building of task-specific knowledge graphs for federated learning. BioCypher (https://***) frees up valuable developer time;we encourage further development and usage by the community. © 2022, CC BY-NC-ND.

关键词： Ontology

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Author Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma

引用

Nature 2024年第8006期628卷 E1页

作者： Guangchun Han Ansam Sinjab Zahraa Rahal Anne M Lynch Warapen Treekitkarnmongkol Yuejiang Liu Alejandra G Serrano Jiping Feng Ke Liang Khaja Khan Wei Lu Sharia D Hernandez Yunhe Liu Xuanye Cao Enyu Dai Guangsheng Pei Jian Hu Camille Abaya Lorena I Gomez-Bolanos Fuduan Peng Minyue Chen Edwin R Parra Tina Cascone Boris Sepesi Seyed Javad Moghaddam Paul Scheet Marcelo V Negrao John V Heymach Mingyao Li Steven M Dubinett Christopher S Stevenson Avrum E Spira Junya Fujimoto Luisa M Solis Ignacio I Wistuba Jichao Chen Linghua Wang Humam Kadara Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Graduate Program in Developmental Biology Baylor College of Medicine Houston TX USA. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. Department of Biostatistics Epidemiology and Informatics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Thoracic Head and Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cardiovascular and Thoracic Surgery The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Medicine The University of California Los Angeles Los Angeles CA USA. Lung Cancer Initiative at Johnson & Johnson Boston MA USA. Section of Computational Biomedicine School of Medicine Boston University Boston MA USA. Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. JChen16@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. JChen16@***. Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. lwang22@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. lwang22@***. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX USA. hkadara@***. The University of Texas Health Houston Graduate School of Biomedical Sciences Houston TX USA. hkadara@***.

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