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International Symposium on Health informatics and Bioinformatics (HIBIT)

作者： Levent Çarkacwğlu Ceyhun Gedikoğlu Yeşim Aydin Son Bioinformatics Graduate Program Middle East Technical University 06800 Ankara Turkey Bioinformatics Graduate Program Middle East Technical University Ankara Turkey Health Informatics Department Middle East Technical University Ankara Turkey

Single Nucleotide Polymorphisms (SNP) is a DNA sequence variation that occurs when a single nucleotide differs between members of a biological species or paired chromosomes in an individual. Studies on SNP data are important for scientists to shed light on identifying genetic variations underlying complex diseases. While recent advances in high-throughput genotyping technologies are resulting in data accumulation at large scales, the need for collection and service of this data under a standard format and globally normalized and structured metadata that houses the structured SNP data is becoming essential. Here, we present iSNP that is a regularly updated, machine curated database that holds SNP and its associated metadata from publicly available databases under a structured standard format that can be efficiently utilized within different applications.

关键词： Databases Bioinformatics Genomics Humans Diseases

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Evaluation of Process Variability on Current for Nanotechnologies Devices

Evaluation of Process Variability on Current for Nanotechnol...

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IEEE Latin American Symposium on Circuits and Systems

作者： Cristina Meinhardt Ricardo Reis Computer Science Center - C3 Federal University of Rio Grande - FURG Graduate Program in Computing Institute of Informatics Federal University of Rio Grande do Sul - UFRGS

ISBN: (纸本)9781467312073

The continuous shrinking of devices has introduced new challenges to integrated circuit design, mainly to deal with the parametric variations in process parameters. This paper presents an evaluation of the process variability on the current Ids of nanotechnologies devices, individually and simultaneously, taking into account the correlation among them. The results show that the deviation from mean value is quite significant ≈ 16% for high performance models. The variation of L has the dominant effect on the overall variation of the device in high performance models while the dominant effect on the overall variation of the device in low power models still being due to Vth variations. Lastly, the effect of process parameter variations deteriorates with technology scaling, with a considerable increase in the deviation from the 22nm to 16nm technology.

关键词： Cutting parameters Nanotechnologies currents electric current HIGH-PERFORMANCE parameter variation Deviation mean value powered models

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From laptops to supercomputers: a single highly scalable code base for spiking neuronal network simulations

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BMC Neuroscience 2013年第1期14卷 1-2页

作者： Susanne Kunkel Abigail Morrison Markus Diesmann Maximilian Schmidt Jochen M Eppler Moritz Helias Hans E Plesser Jun Igarashi Tomoki Fukai Gen Masumoto Shin Ishii Simulation Laboratory Neuroscience - Bernstein Facility Simulation and Database Technology Institute for Advanced Simulation Jülich Aachen Research Alliance Jülich Research Centre Germany Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) Jülich Research Centre and JARA Germany Bernstein Center Freiburg Albert-Ludwig University of Freiburg Germany Institute of Cognitive Neuroscience Faculty of Psychology Ruhr-University Bochum Germany Medical Faculty RWTH University Aachen Germany Laboratory for Neural Circuit Theory RIKEN Brain Science Institute Wako Japan Department of Mathematical Sciences and Technology Norwegian University of Life Sciences Aas Norway High-Performance Computing Team RIKEN Computational Science Research Program Kobe Japan Integrated Systems Biology Laboratory Department of Systems Science Graduate School of Informatics Kyoto University Japan

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Code Compression in ARM Embedded Systems Using Multiple Dictionaries

Code Compression in ARM Embedded Systems Using Multiple Dict...

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IEEE International Conference on Computational Science and Engineering, CSE

作者： Wanderson Roger Azevedo Dias Edward David Moreno Institute of Computing-IComp Post-graduate Program in Informatics-PPGI Federal University of Amazonas Manaus Amazonas Brazil Center for Exact Sciences and Technology-CCET Department of Computer Science-DComp Federal University of Sergipe Aracaju Sergipe Brazil

This paper presents a new code compression method where we use different dictionaries, all of them are based in traditional Huffman algorithm. Our method reduces code size by up to 34.5% (including all extra costs) and presents an improvement of almost 7% over the traditional Huffman method. We performed simulations using Simple Scalar and analyzes using the applications from benchmark MiBench and use the embedded processor ARM.

关键词： Dictionaries Embedded systems Analytical models Benchmark testing Memory management Decoding Energy consumption

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Poster abstracts

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Sleep and Biological Rhythms 2016年第1期5卷 A1-A189页

作者： J. Ferrie M. Shipley F. Cappuccio E. Brunner M. Miller M. Kumari M. Marmot A. Coenen J. L. Castillo F. Araya G. Bustamante L. Montecino C. Torres S. Oporto J. Gronli E. Fiske R. Murison B. Bjorvatn E. Sorensen R. Ursin C. M. Portas S. Rajaraman A. Gribok N. Wesensten T. Balkin J. Reifman N. Dursunoglu S. Ozkurt S. Baser O. Delen S. Sarikaya P. Sadler P. Mitchell D. Françon M. Decobert B. Herve A. Richard G. Griebel P. Avenet B. Scatton G. L. Fur D. Eckert A. Jordan A. Wellman S. Smith A. Malhotra D. White D. Bruck I. Thomas A. Kritikos W. Oertel K. Stiasny-Kolster D. Garcia-Borreguero W. Poewe B. Hoegl R. Kohnen E. Schollmayer J. Keffel C. Trenkwalder A. Valle S. Roizenblatt F. Fregni P. Boggio S. Tufik K. Ward L. Robertson L. Palmer P. Eastwood D. Hillman J. Lee S. Mukherjee V. de Padova G. Barbato G. Ficca I. Zilli P. Salzarulo M. Veldi T. Hion V. Vasar M. Kull L. Nowak J. Davis Y. Latzer O. Tzischinsky S. Crowley M. Carskadon M. Anca-Herschkovitsch D. Frey J. Ortega C. Wiseman C. Farley K. Wright A. Campbell A. Neill K. Spiegel R. Leproult E. Tasali N. Scherberg E. van Cauter A. T. Noradina N. A. Karim I. Norlinah A. A. Raymond R. Sahathevan B. Hamidon E. Werth R. Poryazova R. Khatami C. Bassetti R. G. Beran L. Ainley G. Holand J. Duncan H. Kinney B. Davis B. Hood S. Frey C. Schmidt M. Hofstetter P. Peigneux C. Cajochen W.-P. Hu J.-D. Li C. Zhang L. Boehmer J. Siegel Q.-Y. Zhou Y. Sagawa H. Kondo T. Takemura H. Kanayama Y. Kaneko M. Sato T. Kanbayashi Y. Hishikawa T. Shimizu A. Viola L. James L. Schlangen D.-J. Dijk R. Andretic Y.-C. Kim K.-A. Han F. Jones R. Greenspan L. Sanford L. Yang X. Tang K. Dieter E. Uta H. Sven M. Richard N. Oyane S. Pallesen F. Holsten Y. Inoue M. Fujita N. Emura K. Kuroda N. Uchimura A. Johnston J. Astbury G. Kennedy K. Hoedlmoser M. Schabus T. Pecherstorfer S. Moser G. Gruber P. Anderer W. Klimesch N. Naidoo M. Ferber A. Pack D. Neu O. Mairesse G. Hoffmann A. Dris L. Lambrecht P. Linkowski P. Verbanck O. Le Bon N. Matsuura M. Yamao N. Adachi R. Aritomi Y. Komada H. Tanaka S. Shirak University College London London UK University College London London USA Warwick Medical School London UK Warwick Medical School Coventry USA Radboud University Nijmegen Nijmegen Netherlands Department of Neurology University of Chile Santiago Chile Neurology Service Hospital del Salvador Santiago Chile Family Health Center Juan Pablo II Santiago Chile Department of Biomedicine Section on Physiology Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care University of Bergen Bergen Norway Norwegian Competence Center for Sleep Disorders Haukeland University Hospital Bergen Norway Department of Child and Adolescent Psychiatry Haukeland University Hospital Univeristy of Bergen Bergen Norway Department of Biomedicine University of Bergen Bergen Norway US Army Medical Research and Materiel Command Fort Detrick Frederick USA Walter Reed Army Institute of Research Silver Spring USA Department of Behavioral Biology Walter Reed Army Institute of Research Silver Spring USA Faculty Department of Pulmonology Pamukkale University Medical Denizli Turkey University of Ballarat Ballarat Australia Sanofi-Aventis Recherche et Developpement Paris France Brigham and Women’s Hospital Harvard Medical School Boston USA The University of Queensland Adelaide Australia School of Psychology University of Queensland Brisbane Australia The University of Queensland Brisbane Australia Victoria University Melbourne Australia Department of Psychology Victoria University Melbourne Australia School of Psychology Victoria University Melbourne Australia Philips-Universität Marburg Germany Philips-Universitaet-Marburg Marburg Germany Instituto de Investigaciones del Sueno Madrid Spain Universitätsklinik für Neurologie Innsbruck Austria Universitaetsklinik fuer Neurologie Innsbruck Austria IMEREM GmbH Nuernberg Germany Schwarz Pharma AG Monheim Germany

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Linked open data and the design of information infrastructure for emergency management systems

Linked open data and the design of information infrastructur...

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8th International Conference on Information Systems for Crisis Response and Management, ISCRAM 2011

作者： Borges, Marcos R.S. De Faria Cordeiro, Kelli Campos, Maria Luiza M. Marino, Tiago Graduate Program in Informatics Universidade Federal Do Rio de Janeiro Brazil

ISBN: (纸本)9789724922478

Correct information is a vital resource during disasters. Without adequate information, response actions may be ineffective. What is the source of information of emergency management systems? Besides that originated from sensors, the emergency team and the public in general, a very relevant source is government data, such as demographic and geographic data, road maps, etc. The heterogeneity of information formats is a well-known problem that affects organizations and communities that want to access public data. Today, most public agencies provide access to their data, but the great majority is unreadable by automated mechanisms. Besides, most of them do not provide a dictionary meaning for the published content. A solution to this problem is of particular importance to emergency response organizations that need access to all information available to better respond to disasters and crisis. The linked open data (LOD) initiative allows the interconnection of data, using standards in the context of the semantic web approach. In ideal conditions, government agencies publish their public data, thus allowing the use of automated data concerned consumers, whether they are other government agencies or citizens. Efforts aimed to link government data are growing in several countries around the world. This talk presents the LOD concepts and describes an architecture that uses LOD in the design of an Emergency Management System. It describes a scheme for collecting available data from government agencies, such as departments of health, transport, works, that can supply information needs during an emergency response operation.

关键词： Risk management

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Cardiorespiratory fitness level correlates inversely with excess post-exercise oxygen consumption after aerobic-type interval training

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BMC Research Notes 2012年第1期5卷 1-4页

作者： Matsuo, Tomoaki Ohkawara, Kazunori Seino, Satoshi Shimojo, Nobutake Yamada, Shin Ohshima, Hiroshi Tanaka, Kiyoji Mukai, Chiaki Space Biomedical Research Office Japan Aerospace Exploration Agency (JAXA) Tsukuba Ibaraki 305-8505 2-1-1 Sengen Japan Faculty of Informatics and Engineering University of Electro-Communications Chofu Tokyo 182-8585 1-5-1 Chofugaoka Japan Health Promotion and Exercise Program National Institute of Health and Nutrition Shinjuku Tokyo 162-8636 1-23-1 Toyama Japan Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Ibaraki 305-8574 1-1-1 Tennodai Japan

Background: The purpose of this study was to reveal any association between cardiorespiratory fitness level and excess post-exercise oxygen consumption (EPOC) using three cycling protocols with varying degrees of exercise intensity, i.e., sprint interval training (SIT), high-intensity interval aerobic training (HIAT), and continuous aerobic training (CAT). Findings. Ten healthy men, aged 20 to 31 years, attended a cross-over experiment and completed three exercise sessions: SIT consisting of 7 sets of 30-s cycling at 120% VO₂ with a 15-s rest between sets;HIAT consisting of 3 sets of 3-min cycling at 80∼90% VO₂ with a 2-min active rest at 50% VO₂ between sets;and CAT consisting of 40 min of cycling at 60∼65% VO₂. During each session, resting VO₂, exercise VO₂, and a 180-min post-exercise VO₂ were measured. The net exercise VO ₂ during the SIT, HIAT, and CAT averaged 14.7 ± 1.5, 31.8 ± 4.1, and 71.1 ± 10.0 L, and the EPOCs averaged 6.8 ± 4.0, 4.5 ± 3.3, and 2.9 ± 2.8 L, respectively. The EPOC with SIT was greater than with CAT (P < 0.01) and HIAT (P = 0.12). Correlation coefficients obtained between subjects' VO₂ and the ratio of EPOC to net exercise VO₂ for SIT, HIAT, and CAT were -0.61 (P = 0.06), -0.79 (P < 0.01), and -0.42 (P = 0.23), respectively. Conclusions: Our data suggest that cardiorespiratory fitness level correlates negatively with the magnitude of EPOC, especially when performing aerobic-type interval training. © 2012 Matsuo et al.;licensee BioMed Central Ltd.

关键词： Aerobic fitness Cycling Energy expenditure Exercise physiology Maximal oxygen consumption

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A clonal selection algorithm for the container stacking problem

A clonal selection algorithm for the container stacking prob...

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2011 3rd World Congress on Nature and Biologically Inspired Computing, NaBIC 2011

作者： Carraro, Luiz Antonio De Castro, Leandro Nunes Computer and Informatics Faculty Graduate Program in Electrical Engineering Mackenzie University Sáo Paulo Brazil

ISBN: (纸本)9781457711237

Due to increasing demand, container terminals face the challenges of increasing its service capacity and minimize the time of ships loading and unloading. The assignment of storage locations for reshuffled containers is a problem to the efficiency of container terminals operations, as a wrong assignment may result in several future reshuffles. This paper proposes a meta-heuristic based on the Clonal Selection Algorithm to minimize reshuffle when retrieving containers from a stack. The model competitiveness in accuracy and time are established by extensive numerical experiments comparing with an existing Integer program model. The preliminary results obtained here suggest the proposed model is a promising optimization tool for the container stacking problem. © 2011 IEEE.

关键词： Containers

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American Journal Geriatric Pharmacotherapy 2012年第2期10卷 139-150页

作者： Boyce, Richard D. Handler, Steven M. Karp, Jordan F. Hanlon, Joseph T. Department of Biomedical Informatics University of Pittsburgh Pittsburgh PA United States Geriatric Pharmaceutical Outcomes and Geroinformatics Research and Training Program University of Pittsburgh Pittsburgh PA United States Division of Geriatric Medicine University of Pittsburgh Pittsburgh PA United States Geriatric Research Education and Clinical Center Center for Health Equity Research and Promotion Veterans Affairs Pittsburgh Healthcare System Pittsburgh PA United States Department of Psychiatry Department of Anesthesiology University of Pittsburgh Pittsburgh PA United States Department of Pharmacy and Therapeutics School of Pharmacy University of Pittsburgh Pittsburgh PA United States Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh PA United States

Background: Antidepressants are among the most commonly prescribed psychotropic agents for older patients. Little is known about the best source of pharmacotherapy information to consult about key factors necessary to safely prescribe these medications to older patients. Objective: The objective of this study was to synthesize and contrast information in the package insert (PI) with information found in the scientific literature about age-related changes of antidepressants in systemic clearance and potential pharmacokinetic drug-drug interactions (DDIs). Methods: A comprehensive search of two databases (MEDLINE and EMBASE from January 1, 1975 to September 30, 2011) with the use of a combination of search terms (antidepressants, pharmacokinetics, and drug interactions) was conducted to identify relevant English language articles. This information was independently reviewed by two researchers and synthesized into tables. These same two researchers examined the most up-to-date PIs for the 26 agents available at the time of the study to abstract quantitative information about age-related decline in systemic clearance and potential DDIs. The agreement between the two information sources was tested with κ statistics. Results: The literature reported age-related clearance changes for 13 antidepressants, whereas the PIs only had evidence about 4 antidepressants (κ < 0.4). Similarly, the literature identified 45 medications that could potentially interact with a specific antidepressant, whereas the PIs only provided evidence about 12 potential medication-antidepressant DDIs (κ < 0.4). Conclusion: The evidence-based literature compared with PIs is the most complete pharmacotherapy information source about both age-related clearance changes and pharmacokinetic DDIs with antidepressants. Future rigorously designed observational studies are needed to examine the combined risk of antidepressants with age-related decline in clearance and potential DDIs on important health outcomes

关键词： aged antidepressants drug interactions drug product package inserts pharmacokinetics

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Commentary on the new American geriatric society beers criteria for potentially inappropriate medication use in older adults

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American Journal Geriatric Pharmacotherapy 2012年第2期10卷 151-159页

作者： Marcum, Zachary A. Hanlon, Joseph T. School of Medicine (Geriatrics) University of Pittsburgh Pittsburgh PA United States School of Pharmacy (Pharmacy and Therapeutics) University of Pittsburgh Pittsburgh PA United States Center for Health Equity Research and Promotion (CHERP) Veterans Affairs Pittsburgh Healthcare System (VAPHS) Pittsburgh PA United States Geriatric Research Education and Clinical Center (GRECC) VAPHS Pittsburgh PA United States Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program University of Pittsburgh Pittsburgh PA United States Graduate School of Public Health (Epidemiology) University of Pittsburgh Pittsburgh PA United States Clinical and Translational Science Institute University of Pittsburgh Pittsburgh PA United States

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