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Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019

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The Lancet HIV 2021年第10期8卷 e633-e651页

作者： Jahagirdar, Deepa Walters, Magdalene K. Novotney, Amanda Brewer, Edmond D. Frank, Tahvi D. Carter, Austin Biehl, Molly H. Abbastabar, Hedayat Abhilash, E.S. Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Adekanmbi, Victor Adeyinka, Daniel Adedayo Adnani, Qorinah Estiningtyas Sakilah Afzal, Saira Aghababaei, Soodabeh Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmadi, Keivan Ahmadi, Sepideh Ahmadpour, Ehsan Ahmed, Muktar Beshir Rashid, Tarik Ahmed Salih, Yusra Ahmed Aklilu, Addis Akram, Tayyaba Akunna, Chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Alanezi, Fahad Mashhour Aleksandrova, Ekaterina A. Alene, Kefyalew Addis Ali, Liaqat Alipour, Vahid Almustanyir, Sami Alvis-Guzman, Nelson Ameyaw, Edward Kwabena Amu, Hubert Andrei, Catalina Liliana Andrei, Tudorel Anvari, Davood Arabloo, Jalal Aremu, Olatunde Arulappan, Judie Atnafu, Desta Debalkie Quintanilla, Beatriz Paulina Ayala Ayza, Muluken Altaye Azari, Samad Darshan, B.B. Banach, Maciej Bärnighausen, Till Winfried Barra, Fabio Barrow, Amadou Basu, Sanjay Bazargan-Hejazi, Shahrzad Belay, Habtamu Gebrehana Berheto, Tezera Moshago Bezabhe, Woldesellassie Mequanint Bezabih, Yihienew Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bibi, Sadia Bijani, Ali Bisignano, Catherine Bolarinwa, Obasanjo Afolabi Boloor, Archith Boltaev, Azizbek A. Briko, Nikolay Ivanovich Buonsenso, Danilo Burkart, Katrin Butt, Zahid A. Cao, Chao Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Cowden, Richard G. Dachew, Berihun Assefa Dadras, Omid Dagnew, Amare Belachew Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi das Neves, José Degenhardt, Louisa Demeke, Feleke Mekonnen Desta, Abebaw Alemayehu Deuba, Keshab Dhamnetiya, Deepak Dhungana, Govinda Prasad Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Doan, Linh Phuong Dorostkar, Fariba Edinur, Hisham Atan Effiong, Andem Eftekharzadeh, Sahar El Sayed Zaki, Maysaa Elayedath, Rajesh Elhadi, Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States School of Social Work University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Vagelos College of Physicians and Surgeones Columbia University Medical Center New York NY United States Division of Data Analytics and Delivery for Impact WHO Geneva Switzerland Advanced Diagnostic and Interventional Radiology Research Centre Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Centre Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Paediatric Chronic Kidney Disease Research Centre Tehran University of Medical Sciences Tehran Iran Department of Psychiatry Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Centre Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Centre Tehran University of Medical Sciences Tehran Iran Research Centre for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Centre Tehran University of Medical Sciences Tehran Iran Department of Botany Sree Narayana Guru College Chelannur Kozhikode India Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Mass Communication Department University of Sharjah Sharjah United Arab Emirates Department of Health-Care Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Department of Population Medicine Ca

Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROSCIENCE 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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0.9 V, 5 nW, 9 ppm/oC resistorless sub-bandgap voltage reference in 0.18μm CMOS

0.9 V, 5 nW, 9 ppm/oC resistorless sub-bandgap voltage refer...

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IEEE Latin American Symposium on Circuits and Systems (LASCAS)

作者： Oscar E. Mattia Hamilton Klimach Sergio Bampi Microelectronics Graduate Program Federal University of Rio Grande do Porto Alegre RS Brazil Electrical Engineering Department Sul Federal University of Rio Grande do Porto Alegre RS Brazil Informatics Institute Federal University of Rio Grande do Porto Alegre RS Brazil

In this work a novel resistorless sub-bandgap voltage reference (BGR) is introduced. It is a self-biased and small area topology that works in the nano-ampere current consumption range, and under 1 V of power supply. The analytical behavior of the circuit is described, and simulation results for a standard 0.18 μm CMOS process are analysed. A reference voltage of 479 mV is demonstrated, with a temperature coefficient of 8.79 ppm/°C for the 0 to 125°C range, while the power consumption of the whole circuit is 4.86 nW under a 0.9 V power supply at 27 o C. The estimated silicon area is 0.0012 mm 2 .

关键词： MOSFET Threshold voltage Topology Junctions Photonic band gap

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Estimating computer systems power consumption for time scaled experiments

Estimating computer systems power consumption for time scale...

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IEEE International Conference on Consumer Electronics - Berlin (ICCE-Berlin)

作者： Bruna M. J. C. Vilar Arthur V. De N. Silva Igor M. B. Ulisses Jaidilson Jó da Silva Angelo Perkusich Fred M. Bublitz Post-Graduate Program in Electrical Engineering - PPgEE - COPELE Embedded Systems and Pervasive Computing Laboratory Center of Electrical Engineering and Informatics Universidade Federal de Campina Grande Campina Grande PB BR Embedded Systems and Pervasive Computing Laboratory Center of Electrical Engineering and Informatics Federal University of Campina Grande Campina Grande Brazil Electrical Engineering Department (DEE) Paraíba State University (UEPB)

Power policies are widely applied at computer systems such as desktops, notebooks, and smartphones. For example, the timeout policy to turn off the display. A power management policy must be tested by measuring the power consumption of an experimental platform running workloads. Such tests must be fast enough to feedback the development process with valuable information about the power policy performance. In this work, we have presented a methodology for estimating computer systems power consumption for time scaled experiments. Using the proposed methodology, we have reduced the overall time for developing a power management policy.

关键词： Computers Power demand Switches Power measurement Indexes Time measurement Turning

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0.7 V supply, 8 nW, 8 ppm/°C resistorless sub-bandgap voltage reference

0.7 V supply, 8 nW, 8 ppm/°C resistorless sub-bandgap volta...

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Midwest Symposium on Circuits and Systems (MWSCAS)

作者： Oscar E. Mattia Hamilton Klimach Sergio Bampi Microelectronics Graduate Program Federal University of Rio Grande do Sul Porto Alegre RS Brazil Electrical Engineering Department Federal University of Rio Grande do Sul Porto Alegre RS Brazil Informatics Institute Federal University of Rio Grande do Sul Porto Alegre RS Brazil

In this work a new resistorless sub-bandgap voltage reference topology is presented. It is a self-biased and small area circuit that works in the nano-ampere consumption range, and under 1 V of power supply. The behavior of the circuit is analitically described, a design methodology is proposed and simulation results are presented for a standard 0.18 μm CMOS proCess. A reference voltage of 463 mV is demonstrated, with a temperature coefficient of 8 ppm/°C for the 0 to 125 °C range, while the power consumption of the whole circuit is 8.25 nW under a 0.75 V power supply at 27 °C. The estimated silicon area is 0.0043 mm 2 .

关键词： MOSFET Threshold voltage Logic gates Power demand Topology

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A hybrid methodology for nesting irregular shapes: Case study on a textile industry ?

A hybrid methodology for nesting irregular shapes: Case stud...

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6th IFAC/ACM Conference on Management and Control of Production and Logistics, MCPL 2013

作者： Junior, Bonfim A. Pinheiro, Placido R. Saraiva, Rommel D. Graduate Program in Applied Informatics University of Fortaleza Av. Washington Soares 1321-J30 60.811-905 Fortaleza Brazil

The aim of this paper is to describe a hybrid methodology that combines a Genetic Algorithm and a Bottom-Left Greedy procedure for solving the two-dimensional Nesting Problem. The No-Fit Polygon construct is applied for obtaining local optima. Furthermore, a shrinking algorithm is incorporated to the metaheuristic engine to identify good quality solutions. Computational experiments performed on standard benchmark problems, as well as a practical case study developed in a textile industry, are also reported and discussed here in a manner as to testify the potentialities behind the novel approach. © IFAC.

关键词： Textile industry

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A hybrid methodology for tackling the irregular strip packing problem

A hybrid methodology for tackling the irregular strip packin...

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11th IFAC Workshop on Intelligent Manufacturing Systems, IMS 2013

作者： Junior, Bonfim A. Pinheiro, Placido R. Saraiva, Rommel D. Graduate Program in Applied Informatics University of Fortaleza Av. Washington Soares 1321 - J30 60.811-905 Fortaleza Brazil

ISBN: (纸本)9783902823335

This paper presents a hybrid approach for tackling the irregular strip packing problem, which requires a set of polygons to be placed within a rectangular object. The methodology includes a meta-heuristic engine (e.g., a genetic algorithm) that determines the order in which polygons are handled by a placement heuristic. In addition, differently from several approaches presented in the literature, we investigate the application of the no-fit polygon as a placement tool for obtaining local optima. The results are further improved by a shrinking algorithm that works within the meta-heuristic component. To assess the potentials of the proposed methodology, computational experiments performed on a set of difficult benchmark instances of the irregular strip packing problem are discussed here for evaluation purposes. © 2013 IFAC.

关键词： Genetic algorithms

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Interval-valued Intuitionistic Fuzzy TODIM

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Procedia Computer Science 2014年 31卷 236-244页

作者： Renato A. Krohling André G.C. Pacheco Department of Production Engineering & Graduate Program in Computer Science PPGI UFES – Federal University of Espirito Santo Av. Fernando Ferrari 514 CEP 29075-910 Vitória Espírito Santo Brazil Department of Informatics UFES – Federal University of Espirito Santo Av. Fernando Ferrari 514 CEP 29075-910 Vitória Espírito Santo Brazil

The TODIM (an acronym in Portuguese for Interative Multi-criteria Decision Making) method has recently been extended firstly to fuzzy and next to intuitionistic fuzzy environments with promising results. In this paper, we further consider the extension of TODIM to interval-valued intuitionistic fuzzy (IVIF) environments. Two case studies are used to illustrate the approach to multi-criteria decision making. Experimental results show the effectiveness of the presented method.

关键词： Multi-criteria decision making (MCDM) interval-valued intuitionistic fuzzy numbers IVIF-TODIM TODIM.

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Dynamic timeout power policy for network interfaces

Dynamic timeout power policy for network interfaces

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IEEE International Conference on Consumer Electronics - Berlin (ICCE-Berlin)

作者： Bruna M. J. C. Vilar Fabiano De M Silva Saulo O. D. Luiz J. J. Silva Hyggo Almeida Angelo Perkusich Post-Graduate Program in Electrical Engineering - PPgEE COPELE Embedded Systems and Pervasive Computing Laboratory Universidade Federal de Campina Grande Campina Grande PB BR Center of Electrical Engineering and Informatics Federal University of Campina Grande Campina Grande Brazil Embedded Systems and Pervasive Computing Laboratory Federal University of Campina Grande

Network interfaces are present in a variety of battery powered computer systems, such as notebooks, ultrabooks, tablets and mobile phones. Considering that the battery life is still a constraint, there are opportunities for power management by reducing the power consumption of idle network interfaces. In this work, a dynamic timeout power policy for network interfaces is presented, incorporating workload estimation and a problem optimization at runtime, thus providing power savings and suitable performance.

关键词： Heuristic algorithms Network interfaces Power demand Optimization Mobile handsets Internet Stochastic processes

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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Nature genetics 2018年第5期50卷 766-767页

作者： Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Montreal Heart Institute Université de Montréal Montreal Quebec Canada. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University School of Medicine Nashville TN USA. Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Genetics of Obesity and Related Metabolic Traits Program Icahn School of Medicine at Mount Sinai New York NY USA. Department of Epidemiology University of North Carolina Chapel Hill NC USA. Human Genetics Center University of Texas School of Public Health University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences University of Texas Health Science Center at Houston Houston TX USA. Broad Institute of MIT and Harvard Cambridge MA USA. Department of Genetics Harvard Medical School Boston MA USA. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA USA. Center for Applied Genomics Division of Human Genetics Children's Hospital of Philadelphia Philadelphia PA USA. Quantinuum Research LLC San Diego CA USA. Estonian Genome Center University of Tartu Tartu Estonia. Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Nashville TN USA. Institute for Translational Genomics and Population Sciences LABioMed at Harbor-UCLA Medical Center Torrance CA USA. Wellcome Trust Sanger Institute Hinxton UK. Department of Mathematical and Statistical Sciences University of Colorado Denver CO USA. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Department of Biological Sciences Faculty of Arts and Sciences Eastern Mediterranean University Famagusta Cyprus. Max Planck Institute of Immunobiology and Epigenetics Freiburg Germany. Department of Biostatistics and Center for Statistical Genetics University of M

In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.

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