检索结果-内蒙古大学图书馆

Understanding the origin of the extended γ-ray emission and the physical nature of HESS J1841-055 using observations at TeV energies with the MAGIC telescopes 37

Understanding the origin of the extended γ-ray emission and...

引用

37th International Cosmic Ray Conference, ICRC 2021

作者： Acciari, V.A. Ansoldi, S. Antonelli, L.A. Arbet Engels, A. Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. Barres de Almeida, U. Barrio, J.A. Batković, I. Becerra González, J. Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bökenkamp, H. Bonnoli, G. Bošnjak, Ž. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colak, S.M. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D'Amico, G. D'Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Pierro, F. Di Venere, L. Do Souto Espiñeira, E. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Fallah Ramazani, V. Fattorini, A. Fonseca, M.V. Font, L. Fruck, C. Fukami, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Green, David Green, J.G. Hadasch, D. Hahn, A. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hütten, M. Inada, T. Ishio, K. Iwamura, Y. Jiménez Martínez, I. Jormanainen, J. Jouvin, L. Karjalainen, M. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, Alicia Loporchio, S. Machado de Oliveira Fraga, B. Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Maraschi, L. Mariotti, M. Martínez, M. Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Nakamori, T. Nava, L. Neustroev, V. Nigro, C. Nilsson, K. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J.M. Pavletić, L. Peñil, P. Persic, M. Pihet, M. Prada Moroni, P.G. Prandini, E. Priyadarshi, C. Brazil Spain Croatian MAGIC Group Ruđer Bošković Institute Croatia Croatia Croatian MAGIC Group Josip Juraj Strossmayer University of Osijek Department of Physics Croatia Croatian MAGIC Group University of Rijeka Department of Physics Croatia Croatia Germany Technische Universität Dortmund Germany ETH Zürich Switzerland Finnish MAGIC Group Finnish Centre for Astronomy with ESO University of Turku Finland Finnish MAGIC Group Astronomy Research Unit University of Oulu Finland Instituto de Astrofísica de Andalucía-CSIC Spain Instituto de Astrofísica de Canarias La LagunaE-38200 Spain Universidad de La Laguna Dpto. Astrofísica La Laguna TenerifeE-38206 Spain Spain INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica Università e del Politecnico di Bari Italy INFN MAGIC Group INFN Sezione di Perugia Italy INFN MAGIC Group INFN Roma Tor Vergata The University of Tokyo Japan Japanese MAGIC Group Department of Physics Kyoto University Japan Japanese MAGIC Group Department of Physics Tokai University Japan Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Japan Japanese MAGIC Group Department of Physics Yamagata University Japan Japanese MAGIC Group Department of Physics Konan University Japan University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Poland IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Max-Planck-Institut für Physik MünchenD-80805 Germany Università di Padova INFN Italy Università di Pisa INFN Pisa Italy Università di Siena INFN Pisa Italy Saha Institute of Nuclear Physics India Inst. for Nucl. Research and Nucl. Energy Bulgarian Academy of Sciences Bulgaria Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Universitat de Barcelona ICCUB IEEC-UB Spain Università

With the improved sensitivity with respect to the previous generation, current space-borne and ground-based gamma-ray telescopes have made the number of γ-ray sources detected at GeV-TeV energies increase many folds over the last decade. Many of the detected extended gamma-ray sources are not associated with any known sources at other wavelengths. Understanding the nature of these sources and the origin of the observed high energy gamma-ray emission remains a great challenge. Using the MAGIC telescopes, we have observed one such unassociated gamma-ray source, named HESS J1841-055 at TeV energies. We investigate the physical nature and origin of the γ-ray emission from this extended source. In this paper, we present the results of our detailed investigation on this source using MAGIC data and other multi-waveband information on nearby sources. The results included in this proceeding and shown in this presentation were published in ref. [1]. The details about the analysis, interpretation and modelling can be found in the aforementioned reference. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0)

关键词： Gamma rays

来源：评论

学校读者我要写书评

暂无评论

Using Multiple Active Teaching-Learning Approaches in Software Project Management: A longitudinal analysis of students’ motivation and learning

Using Multiple Active Teaching-Learning Approaches in Softwa...

引用

Frontiers in Education (FIE) Conference

作者： Pablo Schoeffel Raul Sidnei Wazlawick Vinicius Faria Culmant Ramos Graduate Program in Computer Science Federal University of Santa Catarina Florianópolis Brazil Department of Informatics and Statistics Federal University of Santa Catarina Florianópolis Brazil Department of Information and Communication Technologies Federal University of Santa Catarina Araranguá Brazil

ISBN: (纸本)9781538611753;9781538611746

This article describes the instructional design and evaluation of a course about project management in a software engineering post-graduation program using different teaching approaches and with a focus on active learning. We use four different approaches: digital educational game, non-digital educational game, hands-on activity, and experiential activity. Each one of the activities is evaluated for the aspects of motivation, user experience, and learning, following the MEEGA evaluation model and Cidral's experiential activity model. To verify the perceptions of students over time, we also assess graduated students that have concluded this course after two to four years, considering the aspects of motivation and learning. Results indicate a high level of approval for dynamic activities, regarding both motivation and learning. Activities with greater impact on motivation and learning are dynamics and educational games, group practical activities, and group theoretical activities. Among the factors that most influence students' motivation, we highlight: active learning, teacher knowledge, the taste of the area, and teaching methods. We realized that there was no significant variation in the perception of the activities by students over time.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Democratising Knowledge Representation with BioCypher

arXiv

引用

arXiv 2022年

作者： Lobentanzer, Sebastian Aloy, Patrick Baumbach, Jan Bohar, Balazs Charoentong, Pornpimol Danhauser, Katharina Doğan, Tunca Dreo, Johann Dunham, Ian Fernandez-Torras, Adrià Gyori, Benjamin M. Hartung, Michael Hoyt, Charles Tapley Klein, Christoph Korcsmaros, Tamas Maier, Andreas Mann, Matthias Ochoa, David Pareja-Lorente, Elena Popp, Ferdinand Preusse, Martin Probul, Niklas Schwikowski, Benno Sen, Bünyamin Strauss, Maximilian T. Turei, Denes Ulusoy, Erva Heidrun Wodke, Judith Andrea Saez-Rodriguez, Julio Heidelberg University Faculty of Medicine Heidelberg University Hospital Institute for Computational Biomedicine Bioquant Heidelberg Germany The Barcelona Institute of Science and Technology Catalonia Barcelona Spain Catalonia Barcelona Spain Institute for Computational Systems Biology University of Hamburg Germany Earlham Institute Norwich United Kingdom Biological Research Centre Szeged Hungary Heidelberg University Im Neuenheimer Feld 267 Heidelberg69120 Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Department of Pediatrics Dr. von Hauner Children’s Hospital University Hospital LMU Munich Germany Biological Data Science Lab Department of Computer Engineering Hacettepe University Ankara Turkey Department of Bioinformatics Graduate School of Health Sciences Hacettepe University Ankara Turkey Computational Systems Biomedicine Lab Department of Computational Biology Institut Pasteur Université Paris Cité Paris France Bioinformatics and Biostatistics Hub Institut Pasteur Université Paris Cité Paris France Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Open Targets Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Laboratory of Systems Pharmacology Harvard Medical School Boston United States Imperial College London London United Kingdom Quadram Institute Bioscience Norwich United Kingdom Proteomics Program Novo Nordisk Foundation Centre for Protein Research University of Copenhagen Copenhagen Denmark Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Neuherberg Germany Medical Informatics Laboratory University Medicine Greifswald Germany

Standardising the representation of biomedical knowledge among all researchers is an insurmountable task, hindering the effectiveness of many computational methods. To facilitate harmonisation and interoperability despite this fundamental challenge, we propose to standardise the framework of knowledge graph creation instead. We implement this standardisation in BioCypher, a FAIR (findable, accessible, interoperable, reusable) framework to transparently build biomedical knowledge graphs while preserving provenances of the source data. Mapping the knowledge onto biomedical ontologies helps to balance the needs for harmonisation, human and machine readability, and ease of use and accessibility to nonspecialist researchers. We demonstrate the usefulness of this framework on a variety of use cases, from maintenance of task-specific knowledge stores, to interoperability between biomedical domains, to on-demand building of task-specific knowledge graphs for federated learning. BioCypher (https://***) frees up valuable developer time;we encourage further development and usage by the community. © 2022, CC BY-NC-ND.

关键词： Ontology

来源：评论

学校读者我要写书评

暂无评论

Implementation of Mobile game for Religion Learning

Implementation of Mobile game for Religion Learning

引用

IEEE International Conference on Teaching, Assessment and Learning for Engineering (TALE)

作者： Edy Sulistiyo Vindy Nizirwan Anwar Diana Teresia Spits Warnars Setya Chendra Wibawa Goenawan Brotosaputro Dedy Prasetya Kristiadi Harco Leslie Hendric Spits Warnars Kiyota Hashimoto Electrical Engineering Department Universitas Negeri Surabaya Jawa Timur Indonesia Game Application & Technology Program School of Computer Science Bina Nusantara University Jakarta Indonesia Faculty of Computer Science Esa Unggul University Jakarta Indonesia Information Systems Department Bina Nusantara University Jakarta Indonesia Informatics Department Universitas Negeri Surabaya Jawa Timur Indonesia Information System Department Universitas Budi Luhur Jakarta Indonesia Computer Science department Raharja University Tangerang Indonesia Computer Science Department BINUS Graduate Program – Doctor of Computer Science Bina Nusantara University Jakarta Indonesia Faculty of Technology and Environment Prince Songkla University Phuket Campus Thailand

ISBN: (数字)9781728126654

ISBN: (纸本)9781728126661

Currently, the growth of information and technology is rapid. It makes a lot of things in various fields including education becoming more effective and efficient. In education, one of its implementation which is a game is proven to be a useful tool to support conventional teaching methods and bring a more natural understanding of learning materials. Moreover, as a product of the popular culture in modern society, video game mirrors the general culture practice in real life and reflects it via its own culture inside the game. This makes a video game can give a contribution to the social construction of reality as it affects the player's view towards learning in real life and vice versa. From there, we see that there is an opportunity for learning about religion to be supported by its utilization to provide an interactive and fun learning experience. In this paper, we discuss how a video game is implemented to support religious learning. The game was developed with the scrum method where we surveyed to gather the user requirements before the design step. The game design was made by using the use case diagram and storyboard, and it was built using Unity version 2017.3.0f3.

关键词： Games Land mobile radio Education Computer science Operating systems Information systems Media

来源：评论

学校读者我要写书评

暂无评论

Alteration of perivascular spaces in early cognitive decline

引用

Alzheimer's & Dementia 2020年第S5期16卷

作者： Farshid Sepehrband Giuseppe Barisano Nasim Sheikh-Bahaei Jeiran Choupan Ryan P Cabeen Malcolm S Crawford Wendy J Mack Helena C Chui John M Ringman Arthur W Toga Alzheimer’s Disease Neuroimaging Initiative Alzheimer’s Disease Research Center Keck School of Medicine University of Southern California Los Angeles CA USA Laboratory of Neuro Imaging Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California Los Angeles CA USA Neuroscience Graduate Program University of Southern California Los Angeles CA USA School of Medicine University of California Irvine Irvine CA USA

Background Vascular contributions to early cognitive decline are increasingly recognized, prompting further investigation into the nature of related changes in perivascular space (PVS). Here we investigated the association between PVS volume fraction and early cognitive decline, neurofibrillary tau and Amyloid-b uptake and APOE status. Method Data were obtained from the ADNI-3 database. A total of 685 participants with magnetic resonance imaging (MRI) data were assessed, and 596 participants (326 female [54.6%]) with complete data that passed quality control and inclusion criteria were included (cognitively normal participants age: 73.04 ± 7.36; mild cognitive impairment participants age = 75.56 ± 8.16). PVS volume fraction and brain volume were estimated from MRI using an automated in-house pipeline; Amyloid-b and Tau status were determined from PET images and CSF samples; Demographic, cognitive information and cardiovascular risk factors were also collected. Cognitive assessment scores were used to categorized individuals into cognitively normal and mild cognitive impairment subjects. Analysis models were adjusted for age, sex and years of educations. Result A significantly lower PVS volume fraction in mild cognitive impairment was observed compared to the cognitively normal group in both left ( p =0.00047) and right ( p =0.0009) anterosuperior medial temporal lobe (Figure 1). PVS volume fraction of the centrum semi-ovale of the white matter was higher in mild cognitive impairment compared to cognitively normal participants, but not statistically significant after adjusting for age, sex, education and brain volume ( p =0.07). PVS volume fraction in anterosuperior medial temporal lobe was significantly associated with Tau PET standardized uptake value ratio in right entorhinal cortex (beta (SE) = -0.02 (0.007); p =0.006). PVS volume fractions across different regions were independent of Amyloid load or APOE e4 status. Conclusion We show that, compared to a cognitiv

关键词：

来源：评论

学校读者我要写书评

暂无评论

Escada: Predicting Virtual Machine Network Bandwidth Demands for Elastic Provisioning in IaaS Clouds 4

Escada: Predicting Virtual Machine Network Bandwidth Demands...

引用

4th IEEE International Conference on Cloud and Autonomic Computing, ICCAC 2017

作者： Marques, Jonatas Adilson Obelheiro, Rafael Rodrigues Institute of Informatics Federal University of Rio Grande Do sul Porto Alegre Brazil Graduate Program in Applied Computing Department of Computer Science Santa Catarina State University Joinville Brazil

ISBN: (纸本)9781538619391

In Infrastructure as a Service clouds, customers lease virtual resources (e.g., CPU, memory, network) offered by cloud providers, paying for the allocated capacity of resources, regardless of their effective use. In this context, it is in the interest of the customers to reserve resources with sufficient capacity so that their applications achieve good performance while, at the same time, minimizing their expenses with idle capacities. The correct provisioning of resources is also invaluable to providers, who seek to maximize the resource usage of their physical infrastructures, avoiding spending maintenance costs with unused hardware such as high capacity servers and networking devices. We introduce Escada, a novel model for network bandwidth prediction to guide the provisioning of virtual machines. Escada is application-oblivious and dynamically adapts to changes in a virtual machine workload profile. The network flows of a virtual machine are monitored and used to estimate its total required bandwidth over a time period. A prediction algorithm is then applied to the entire history of estimates to predict the virtual machine future required bandwidth. Our experimental evaluation shows that the estimates provided by Escada are useful for guiding the prediction of network bandwidth requirements, providing accurate bandwidth estimates even when the network is under-provisioned. Furthermore, Escada correctly adjusts its prediction algorithm faster than the state-of-the-art model and predicts more reliably during the adjusting period. © 2017 IEEE.

关键词： Virtual machine

来源：评论

学校读者我要写书评

暂无评论

A framework for digital forensics analysis based on semantic role labeling

A framework for digital forensics analysis based on semantic...

引用

IEEE International Conference on Intelligence and Security informatics, ISI

作者： Ravi Barreira Vládia Pinheiro Vasco Furtado Graduate Program in Applied Informatics University of Fortaleza (UNIFOR) Fortaleza Ceará Brasil

ISBN: (纸本)9781509067282

This article describes a framework for semantic annotation of texts that are submitted for forensic analysis, based on Frame Semantics, and a knowledge base of Forensic Frames - FrameFOR. We demonstrate through experimental evaluations that the application of the Semantic Role Labeling (SRL) techniques and Natural Language Processing (NLP) in digital forensic increases the performance of the forensic experts in terms of agility, precision and recall.

关键词： Semantics Mobile handsets Labeling Knowledge based systems Digital forensics Object recognition

来源：评论

学校读者我要写书评

暂无评论

SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES). V. Confusion-limited Submillimeter Galaxy Number Counts at 450 µm and Data Release for the COSMOS Field

arXiv

引用

arXiv 2024年

作者： Gao, Zhen-Kai Lim, Chen-Fatt Wang, Wei-Hao Chen, Chian-Chou Smail, Ian Chapman, Scott C. Zheng, Xian Zhong Shim, Hyunjin Kodama, Tadayuki Ao, Yiping Chang, Siou-Yu Clements, David L. Dunlop, James S. Ho, Luis C. Hsu, Yun-Hsin Hwang, Chorng-Yuan Hwang, Ho Seong Koprowski, M.P. Scott, Douglas Serjeant, Stephen Toba, Yoshiki Urquhart, Sheona A. No. 1 Section 4 Roosevelt Rd. Taipei10617 Taiwan Graduate Institute of Astronomy National Central University 300 Zhongda Road Zhongli Taoyuan32001 Taiwan Centre for Extragalactic Astronomy Department of Physics Durham University South Road DurhamDH1 3LE United Kingdom Department of Physics and Atmospheric Science Dalhousie University Halifax HalifaxNSB3H 3J5 Canada Purple Mountain Observatory Key Laboratory for Radio Astronomy Chinese Academy of Sciences 10 Yuanhua Road Nanjing210023 China School of Astronomy and Space Science University of Science and Technology of China Anhui Hefei230026 China Department of Earth Science Education Kyungpook National University 80 Daehak-ro Buk-gu Daegu41566 Korea Republic of Astronomical Institute Tohoku University 6-3 Aramaki Aoba Miyagi Sendai980-8578 Japan Institute of Astronomy Department of Physics National Tsing Hua University Hsinchu30013 Taiwan Imperial College London Blackett Laboratory Prince Consort Road LondonSW7 2AZ United Kingdom SUPA Institute for Astronomy University of Edinburgh Royal Observatory EdinburghEH9 3HJ United Kingdom Kavli Institute for Astronomy and Astrophysics Peking University Beijing100871 China Department of Astronomy School of Physics Peking University Beijing100871 China Department of Philosophy National Taiwan University No. 1 Section 4 Roosevelt Rd. Taipei10617 Taiwan Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Institute of Astronomy Faculty of Physics Astronomy and Informatics Nicolaus Copernicus University Grudziadzka 5 Torun87-100 Poland Department of Physics and Astronomy University of British Columbia 6224 Agricultural Road VancouverBCV6T 1Z1 Canada School of Physical Sciences The Open University Milton KeynesMK7 6AA United Kingdom

We present confusion-limited SCUBA-2 450-µm observations in the COSMOS-CANDELS region as part of the JCMT Large program, SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES). Our maps at 450 and 850 µm cover an area of 450 arcmin2. We achieved instrumental noise levels of σ450 = 0.59 mJy beam−1 and σ850 = 0.09 mJy beam−1 in the deepest area of each map. The corresponding confusion noise levels are estimated to be 0.65 and 0.36 mJy beam−1. Above the 4 (3.5) σ threshold, we detected 360 (479) sources at 450 µm and 237 (314) sources at 850 µm. We derive the deepest blank-field number counts at 450 µm, covering the flux-density range of 2 to 43 mJy. These are in agreement with other SCUBA-2 blank-field and lensing-cluster observations, but are lower than various model counts. We compare the counts with those in other fields and find that the field-to-field variance observed at 450 µm at the R = 6′ scale is consistent with Poisson noise, so there is no evidence of strong 2-D clustering at this scale. Additionally, we derive the integrated surface brightness at 450 µm down to 2.1 mJy to be (Equation presented) Jy deg−2, contributing to (41±4)% of the 450-µm extragalactic background light (EBL) measured by COBE and Planck. Our results suggest that the 450-µm EBL may be fully resolved at (Equation presented) mJy, which extremely deep lensing-cluster observations and next-generation submillimeter instruments with large aperture sizes may be able to achieve. © 2024, CC BY.

关键词： Galaxies

来源：评论

学校读者我要写书评

暂无评论

Visualization of Roll Call Data for Supporting Analyses of Political Profiles

Visualization of Roll Call Data for Supporting Analyses of P...

引用

Brazilian Symposium on Computer Graphics and Image Processing (SIBGRAPI)

作者： Rodrigo Nunes Moni da Silva Andre Spritzer Carla Dal Sasso Freitas Graduate Program in Computer Science Federal Univ. of Rio Grande do Su1 Porto Alegre RS Brazil Institute of Informatics Federal Univ. of Rio Grande do Su1 Porto Alegre RS Brazil

In this paper, we propose a web-based application where the user can instantiate multiple, coordinated panels for exploring data concerning the votes of representatives in Brazil's lower legislative house (the Chamber of Deputies). Open data about roll calls made available by the Chamber allowed us to build a set of interactive visualizations to let users explore deputies' votes and build an understanding of their political profiles. Based on the set of roll call voting results from 1991 to 2016, our application displays the political behaviour of parties in a timeline from which users can select periods and instantiate panels showing the political spectrum of deputies using different methods of dimensionality reduction. Deputies can be separated in clusters based on their position in the political spectrum, and other panels can be instantiated showing details about each cluster. Users can select parts of the timeline and simultaneously analyze the behavior of parties and one or more deputies. Roll calls are represented as a combination of heatmaps and histograms. We illustrate the use of the different visualization techniques in a case study on party cohesiveness over time.

关键词： Data visualization Principal component analysis Dimensionality reduction History Tools Voting Radar

来源：评论

学校读者我要写书评

暂无评论

The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases

引用

Clinical immunology (Orlando, Fla.) 2024年 260卷 109897页

作者： Hsing-Fang Lu Chen-Hsing Chou Ying-Ju Lin Shunsuke Uchiyama Chikashi Terao Yu-Wen Wang Jai-Sing Yang Ting-Yuan Liu Henry Sung-Ching Wong Sean Chun-Chang Chen Fuu-Jen Tsai Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan. PhD Program for Health Science and Industry College of Health Care China Medical University Taichung Taiwan Department of Health Services Administration China Medical University Taichung Taiwan. Genetic Center Department of Medical Research China Medical University Hospital Taichung Taiwan School of Chinese Medicine China Medical University Taichung Taiwan. Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Clinical Research Center Shizuoka General Hospital Shizuoka Japan The Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan. Department of Medical Research China Medical University Hospital China Medical University Taichung 404327 Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Chinese Medicine China Medical University Taichung Taiwan Department of Biotechnology and Bioinformatics Asia University Taichung Taiwan. Electronic address: d0704@mail.cmuh.org.tw.

Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA1*03:02 - HLA-DQB1*03:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10), corresponding to HLA-DQA1 Asp160 and HLA-DQB1 Leu87 amino acid residues. The genetic correlation showed significance between IgE and allergic diseases including asthma, atopic dermatitis, and pollinosis. IgE PRS was significantly correlated with total IgE levels. Furthermore, the top decile IgE polygenic risk score (PRS) group had the highest risk of asthma for the Taiwan Biobank and Biobank Japan cohorts. IgE PRS may be used to aid in predicting the occurrence of allergic reactions before symptoms occur and biomarkers are detectable. Our study provided a more comprehensive understanding of the impact of genomic variants, including complex HLA alleles, on serum IgE levels.

关键词： Allergy genome-wide association study human leukocyte antigen immunoglobulin E

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：