O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell ...
O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J. Fornace Jr. O4 A unique integrated system to discern pathogenesis of central nervous system tumors Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S. Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri O5 RPL27A is a target of miR-595 and deficiency contributes to ribosomal dysgenesis Heba Alkhatabi O6 Next generation DNA sequencing panels for haemostatic and platelet disorders and for Fanconi anaemia in routine diagnostic service Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp O7 Targeted sequencing panels and their utilization in personalized medicine Adel M. Abuzenadah O8 International biobanking in the era of precision medicine Jim Vaught O9 Biobank and biodata for clinical and forensic applications Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida O10 Tissue microarray technique: a powerful adjunct tool for molecular profiling of solid tumors Jaudah Al-Maghrabi O11 The CEGMR biobanking unit: achievements, challenges and future plans Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad O12 Phylomedicine of tumors Sudhir Kumar, Sayaka Miura, Karen Gomez O13 Clinical implementation of pharmacogenomics for colorectal cancer treatment Angel Carracedo, Mahmood Rasool O14 From association to causality: translation of GWAS findings for genomic me
Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While tr...
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Organizations have been relying on collaboration for productivity improvement and knowledge sharing. The first step to foster collaboration in organizations is to make it explicit. With this aim, the Collaboration Mat...
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Organizations have been relying on collaboration for productivity improvement and knowledge sharing. The first step to foster collaboration in organizations is to make it explicit. With this aim, the Collaboration Maturity Model (CollabMM) was proposed and evaluated. The lessons learned during model applications in previous work pointed out the need to review both the model and its evaluation instruments. A literature review also showed some improvement opportunities. Therefore, the objective of this work is to develop a roadmap to highlight the main opportunities of evolution in CollabMM. These opportunities will compose our research agenda in this topic and guide future work.
Background: In bioinformatics projects, scientific workflow systems are widely used to manage computational procedures. Full-featured workflow systems have been proposed to fulfil the demand for workflow management. H...
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Background: In bioinformatics projects, scientific workflow systems are widely used to manage computational procedures. Full-featured workflow systems have been proposed to fulfil the demand for workflow management. However, such systems tend to be over-weighted for actual bioinformatics practices. We realize that quick deployment of cutting-edge software implementing advanced algorithms and data formats, and continuous adaptation to changes in computational resources and the environment are often prioritized in scientific workflow management. These features have a greater affinity with the agile software development method through iterative development phases after trial and error. Here, we show the application of a scientific workflow system Pwrake to bioinformatics workflows. Pwrake is a parallel workflow extension of Ruby's standard build tool Rake, the flexibility of which has been demonstrated in the astronomy domain. Therefore, we hypothesize that Pwrake also has advantages in actual bioinformatics workflows. Findings. We implemented the Pwrake workflows to process next generation sequencing data using the Genomic Analysis Toolkit (GATK) and Dindel. GATK and Dindel workflows are typical examples of sequential and parallel workflows, respectively. We found that in practice, actual scientific workflow development iterates over two phases, the workflow definition phase and the parameter adjustment phase. We introduced separate workflow definitions to help focus on each of the two developmental phases, as well as helper methods to simplify the descriptions. This approach increased iterative development efficiency. Moreover, we implemented combined workflows to demonstrate modularity of the GATK and Dindel workflows. Conclusions: Pwrake enables agile management of scientific workflows in the bioinformatics domain. The internal domain specific language design built on Ruby gives the flexibility of rakefiles for writing scientific workflows. Furthermore, readability
We research the multimedia information hiding (MIH) which is a technology to overlay digital information on multimedia contents such as picture, sound, document, etc. As application to disaster management of MIH, we h...
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We research the multimedia information hiding (MIH) which is a technology to overlay digital information on multimedia contents such as picture, sound, document, etc. As application to disaster management of MIH, we have developed a new technology called "PAIH" (Public Address information Hiding) which is a technology to overlay information such as position or destination on siren sound of urgent vehicles. Siren sound is allowed to degrade of sound quality, but PAIH is required to decode correct information from siren sound with pitch shift (Doppler effect) or under noisy environment.
Both Data hiding and data compression are very important technologies in the field of image processing. It seems that there is no relationship between data hiding and data compression because most of the data hiding m...
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The nonlinear effects of partial erasure and transition shift, however, often limit the performance attained by the partial response maximum likelihood (PRML) detector because of model mismatch. Conventionally, the no...
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As magnetic recording densities grow, the nonlinear distortions, known as transition shift and partial erasure, arise and limit the performance of the detector. Despite that the transition shift can be compensated by ...
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The clinical data stored in the health information system can be categorized as two types including structuralized data and non-structuralized ones. In the paper, a data extraction system is developed to assist data r...
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